ChemInform Research Articles

Regulation of the Inflammatory Profile of Blood Serum in Human Breast Cancer: Prominent Roles for TNF-alpha and RPR Pathways on Breast Surgery

Background: The objective of this study is to compare the effects between the combination of PECS Block II with GA and GA alone on the inflammation levels in breast cancer, measure by Tumor Necrosis Factor-Alpha (TNF-α) and the red blood cell distribution width to platelet ratio (RPR). Methods: Experimental analytical study with parallel randomized control trial was done in 48 breast cancer patients who underwent breast removal surgery at Dr. Kariadi Hospital between August – October 2023. Patients were randomly allocated into 2 groups, control (GA only) and treatment (PECS Block II + GA). Demographic data were obtained preoperatively, blood samples were collected 24 hours before and after surgery. TNF-α levels were analyzed using enzyme-linked immunosorbant assay (ELISA), while RPR were obtained from complete blood count. Independent t and mann-whitney tests were used, with a p-value <0,05 was considered significant. Results: Postoperative TNF-α levels were similar in both groups (8.15 ± 5.31 vs 6.21 ± 5.58; p=0,135), but the difference between TNF-α levels was significantly higher in treatment group (-5.08 ± 3.70; p = 0.001). Postoperative RPR levels were higher in control group than treatment group (0,64 ± 0,28 vs 0,50 ± 0,20; p=0,031), where the difference between RPR levels was higher in treatment group (-0,07 ± 0,19; p = 0,037). Conclusion: Inflammatory biomarkers, in the form of TNF-α and RPR in breast cancer surgery were found to be lower with the usage of the combination of PECS Block II with general anesthesia than with general anesthesia only.

Corrigendum: Research progress of breast cancer surgery during 2010–2024: a bibliometric analysis

Corrigendum: Research progress of breast cancer surgery during 2010–2024: a bibliometric analysis

Nilai Ekonomi dan Manfaat Pemeliharaan Sapi Madura Upaya Meningkatkan Penghasilan Petani

Raising Madurese cattle has a significant economic impact, affecting the sustainability of the local economy and the welfare of farmers as well as bringing non-negligible benefits to social and environmental welfare. This study aims to analyse the economic value and benefits of raising Madurese cattle. The urgency of this research is the economic contribution, uniqueness, and potential of its research on the economic value and benefits of raising Madura cattle is very important and urgent. The results of this study show that Madura cattle rearing provides positive economic value and has the potential to be a stable source of additional income for farmers with a net profit of Rp 6,961,000 during the rearing period. Meanwhile, the value of benefits obtained from cattle rearing include increasing family assets or savings, being a financial guarantee during emergencies, as agricultural labour (ploughing tegal) and producing organic fertiliser to improve soil fertility. Strategies that need to be carried out for cattle development to increase farmers' income are four elements, namely improving the quality of superior cattle breeds through the application of artificial insemination technology, increasing access to capital for farmers, increasing training and animal husbandry technology, and quality animal feed fermentation technology.

A survey of current trends in postgraduate year 2 pediatric pharmacy residencies and growth of pediatric ambulatory care pharmacy practice.

In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. This study sought to characterize current trends in the program structure of postgraduate year 2 (PGY2) pediatric pharmacy residencies and to describe the growth of pediatric ambulatory care as a practice specialty. A 99-question survey was designed to collect information regarding the current structure of PGY2 pediatric pharmacy residency programs. The survey was distributed electronically to PGY2 residency program directors (RPDs) and was open for 6 weeks from September to November 2023. 75 distinct programs were eligible for participation; 43 programs (response rate, 57.3%) were included in the final analysis. Of the 43 respondents, 14 (32.6%) indicated their program was at a stand-alone children's hospital. The majority of programs (22 of 43, 51.2%) require residents to spend 7 to 9 months of their residency year on required rotations. Nineteen of 40 respondents (47.5%) indicated their residents staff in both clinical and operational areas. The most commonly reported frequency was every third weekend. Most respondents indicated requiring up to 15 presentations of varying types. A total of 41 respondents participated in the ambulatory care section of the survey; 75% of respondents (30 of 40) reported there has been growth in the number of pharmacists in pediatric ambulatory care at their institution in the last 5 years. This study describes the current state of PGY2 pediatric pharmacy residency programs, including educational opportunities and trends in staffing and academic activity requirements. This study also adds to available literature on pediatric ambulatory care and potential opportunities for resident-led expansion.

A scientometric analysis of highly cited papers in Indian spine research (1995-2024): navigating the impact.

The spine research within India has seen significant advancement, yet detailed examinations of its impact and evolution still need to be made sparse. To conduct a comprehensive scientometric review of the most frequently cited papers in Indian spine research from 1995 to 2024, aiming to map the field's evolution and its global impact. Utilizing the Scopus database, a search was performed with keywords related to spine research, identifying 105 highly cited papers. This study focused on trends in publications, document types, affiliations, collaboration networks, and citation patterns. The period between 2005 and 2014 saw a significant increase in publications, with a notable emphasis on international collaborations, especially with the United States and Canada. Clinical research, particularly on the lumbar spine and surgical advancements, emerged as the primary focus. The average citations per document stood at 102.37, with original research articles constituting 73.33% of the total. Collaboration spanned across 31 countries, with the United States being the foremost partner. Indian institutions like Ganga Hospital, Coimbatore, and the All India Institute of Medical Science, New Delhi, were among the top contributors. Indian authors, notably with S. Rajasekaran leading, followed by AK Jain. The findings highlght the pivotal role of Indian spine research in contributing to the global knowledge base, highlighting significant areas of strength and opportunities for future research. The study offers valuable insights for researchers, policymakers, and healthcare planners, aiming to enhance spinal health care in India and internationally.

Association of poor sleep quality with clinical variables in nontuberculous mycobacterial pulmonary disease.

The high prevalence of poor sleep quality in patients with chronic respiratory diseases makes it an important clinical topic. However, the prevalence and characteristics of poor sleep quality in those with nontuberculous mycobacterial pulmonary disease and its association with clinical variables remain unclear. This retrospective study involved patients with nontuberculous mycobacterial pulmonary disease between June 2017 and May 2022. The prevalence of poor sleep quality was measured by the Pittsburgh Sleep Quality Index was used to and its association with clinical variables including age, sex, laboratory data, pulmonary function, respiratory symptoms, mental health, health-related quality of life, and physical function was assessed. The median age of 233 participants was 65 years, with poor sleep quality present in 123 patients (52.8%) who were older, female, and unemployed with dyspnea, anxiety symptoms, low health-related quality of life, and low exercise capacity. Many reported that they "cannot get to sleep within 30min," "wake up in the middle of the night or early morning," "have to get up to use the bathroom," "cannot breathe comfortably," or "cough or snore loudly." Multivariate logistic regression analysis indicated a significant association between poor sleep quality, female sex, and low health-related quality of life. Our results suggested that for the patients in this study, a multidisciplinary management that considers poor sleep quality is required and assessment of sleep quality as a screening is needed.

Postoperative fever following surgery for oral cancer: Incidence, risk factors, and the formulation of a machine learning-based predictive model.

Postoperative fever (POF) is a common occurrence in patients undergoing major surgery, presenting challenges and burdens for both patients and surgeons yet. This study endeavors to examine the incidence, identify risk factors, and establish a machine learning-based predictive model for POF following surgery of oral cancer. A total of seven hundred and twenty-seven consecutive patients undergoing radical resection of oral cancer were retrospectively investigated. The analysis encompassed 34 parameters, incorporating demographic and clinical characteristics, biochemical and hematological assay results, surgical-related data, hospitalization costs and stay in hospital. Six machine learning models were compared by the area under the receiver operating characteristic curve (AUC). The best-performing models were selected for further analyze, including feature importance evaluation and nomogram analysis, identifying key POF risk factors, and establish a comprehensive prediction model. A total of 466 patients with surgery for oral cancer met the criteria, with an average age of (54.2 ± 11.1) years, including an POF group (n = 197) and a non-POF group (n = 269). The fever group has greater hospitalization costs, longer lengths of stay, and higher infection biochemical indicators (leucocyte ratio and erythrocyte sedimentation rate). Furthermore, Among the 6 machine learning models, logistic regression models performed best, with the higher AUC and accuracy. In univariate and multivariate logistic analysis showed that age, sex, reoperation, Charlson Comorbidity Index score (CCI), leukocyte, bleeding and blood transfusion were independent risk factors for POF of patients following surgery in oral cancer. Then seven variables were selected to establish the nomogram for predict the probability of POF by nomogram algorithm. Postoperative fever patients following radical resection of oral cancer have greater burden. Machine learning algorithms can be effectively used to identify potential risk factors of POF, which may enhance individualized treatment plans in oral cancer patient during perioperative period.

Perioperative Pain Management in Patients With Cancer-Related Pain: A Narrative Review.

The number of cancer patients, cancer survivors, and cancer surgeries is expected to continue to grow and anesthesiologists will benefit from having a framework on how to approach treating perioperative pain in the oncologic population. This article presents general considerations for formulating a perioperative pain management plan including cancer-specific contraindications for epidurals and nerve blocks, common procedures for pain after thoracic and abdominal surgeries, and alternative pain management techniques.

Practical considerations for choosing transoral laser microsurgery versus transoral robotic surgery for supraglottic laryngeal cancers

Purpose of review To review the pros and cons of treating supraglottic laryngeal cancer with transoral laser microsurgery (TOLM) or transoral robotic surgery (TORS). Recent findings The use of TORS is limited by the cost and the availability of the robots despite a faster learning curve than TOLM. The laryngeal exposure difficulty, the use of long instruments, and the restricted view of the surgical field consist of the primary limitations of TOLM, which are addressed in TORS technology through a 30° view of surgical fields, and the 180° amplitude of the instruments. The indications of TOLM and TORS are similar and include cT1-T2 and some selected cT3 with moderate invasion of the preepiglottic space. The rates of positive margins in TORS-SGL are lower than those of TOLM-supraglottic laryngectomy (SGL), while both approaches report similar duration of hospital stays. Patients treated with TORS report higher rates of percutaneous gastrostomy and temporary tracheotomy compared to TOLM. The feeding tube and oral diet re-start appear comparable between both groups. The overall survival, disease-free survival, local, regional, and relapse-free survival rates of TORS are reported to be higher than those found for TOLM SGL. Summary TORS and TOLM SGL are well tolerated and effective approaches for cT1, cT2, and some selected cT3 LSCC. The functional and surgical outcomes appear comparable. TORS could have superior survival and loco-regional outcomes than TOLM, which could be attributed to the fastest TORS learning curve, and its superiority in terms of tumor/operating field visualization, and instrument movements.

New Year 2025 in Polish Archives of Internal Medicine.

New Year 2025 in Polish Archives of Internal Medicine.

Towards a comprehensive improvement in pediatric post-surgical care.

Towards a comprehensive improvement in pediatric post-surgical care.

A qualitative process evaluation of SBIRT implementation in pediatric trauma centers using the Science to Service Laboratory implementation strategy.

Screening, Brief Intervention, and Referral to Treatment (SBIRT) is an evidence-based practice that can identify adolescents who use alcohol and other drugs and support proper referral to treatment. Despite an American College of Surgeons mandate to deliver SBIRT in pediatric trauma care, trauma centers throughout the United States have faced numerous patient, provider, and organizational level barriers to SBIRT implementation. The Implementing Alcohol Misuse Screening, Brief Intervention, and Referral to Treatment Study (IAMSBIRT) aimed to implement SBIRT across 10 pediatric trauma centers using the Science-to-Service Laboratory (SSL), an empirically supported implementation strategy. This manuscript aimed to assess trauma center staff preferences and experience with the didactic training, performance feedback, and ongoing coaching elements of the SSL via a retrospective qualitative process evaluation. Nurses, social workers, and site leaders that participated in IAMSBIRT were recruited to complete qualitative exit interviews guided by the Consolidated Framework for Implementation Research. Qualitative interviews were recorded, transcribed, and analyzed by two coders using a directed content analysis approach in NVivo software. Codes were then translated into frequently endorsed themes by the IAMSBIRT study research team. Thirty-six exit interviews were conducted with site leaders, social workers, and nurses across the 10 IAMSBIRT pediatric trauma centers. Findings revealed key strengths as well as areas for improvement across the IAMSBIRT preparation phase and the three elements of the SSL: didactic training, performance feedback, and ongoing coaching. Trauma center staff generally reported that all three elements of the SSL were high quality and helpful for supporting SBIRT implementation. However, staff also noted that performance feedback and ongoing coaching were generally only available to center leadership or to individuals selected by leadership, making it challenging for non-leaders to troubleshoot SBIRT delivery. Findings from the qualitative process evaluation revealed discrepancies in the experience of the SSL strategy between those in leadership roles and those involved in direct care delivery. These results suggest the need for several modifications to the SSL strategy, including increasing engagement of direct care staff in all elements of the SSL throughout the implementation process. Clinicaltrials.gov NCT03297060 . Registered 29 September 2017.

A Rectal Cancer Surgery Dataset: Use of artificial intelligence to aid automation of error identification

Minimally invasive surgery is complex and prone to variation not routinely objectively measured. We established an association between skills and patient outcomes. The evolving application of artificial intelligence techniques could assist intraoperative analysis. In this study, we analysed 77 rectal cancer operations’ videos from a multicentre RCT that were recorded unedited and underwent blinded manual analysis using a validated, bespoke performance assessment tool (LapTMEpt) and the Objective Clinical Human Reliability Analysis (OCHRA). The OCHRA methodology involved segmentation of the 77 operations and manually annotating each case for the enacted errors and near misses. We provide a detailed description of the errors and near misses of over 380 hours of video analysis, containing 1377 errors. This dataset can inform machine learning to assist progress toward a fully automated, objective assessment of surgical skills.

Exploring Vascular Complications in Ovarian Cancer Surgery: A Narrative Literature Review with a New Management Proposal Algorithm

Exploring Vascular Complications in Ovarian Cancer Surgery: A Narrative Literature Review with a New Management Proposal Algorithm

Evaluation of severe hypoglycemia management in children and adolescents with type 1 diabetes in a Belgian tertiary pediatric care center: impact of intranasal glucagon and cost analysis.

To evaluate the management and costs of severe hypoglycemia (SH) in children and adolescents with type 1 diabetes (T1D) in our Belgian tertiary pediatric care center. In the EPI-GLUREDIA study, clinical parameters from children and adolescents with T1D were retrospectively analyzed from July 2017 to June 2024. The characteristics of SH and its treatment were collected during the medical consultation following the SH episode. Between July 2017 and June 2024, 208 cases of SH were recorded in 113 children and adolescents with T1D, with an average age of 13.6years and T1D duration of 6.2years. Oral glucose was the most common treatment (47.4%), while glucagon was used in only 25.4% of cases and more frequently in boys (30.8%) than in girls (18.7%). Notably, only 43% of SH episodes were treated according to international guidelines. A significant increase in glucagon use was observed after reimbursement of its intranasal form in Belgium in January 2022. After 2022, glucagon use significantly increased (28/81 vs. 25/129; p = 0.013), particularly among teachers and educators (18/49 vs. 10/78; p = 0.002). The average direct cost of treating SH was €187.9, with costs ranging from €0 to €1092.5 depending on the treatment method.Conculusion: Our study underscores the difficulty in managing SH in young people with T1D, with only 43% being treated as per guidelines. Since 2022, the increased use of the intranasal form of glucagon in Belgium led to reduced healthcare costs and improved care of patients experiencing SH.

Highly Efficient Biosynthesis of Rebaudioside M9 through Enzyme Screening and Structure-Guided Engineering.

Steviol glycosides (SGs) are highly valued for their sweetness, safety, and zero calories, but their bitter taste and low solubility limit their application. Modifying glycosyl units is a promising strategy to improve sensory qualities. In this study, we identified the enzyme UGT94E13 through phylogenetic analysis and enzyme screening, which catalyzes the glycosylation of rebaudioside M2 (Reb M2) at the C-13 position, producing the novel β-1,6-O-glycosylated product rebaudioside M9 (Reb M9). Subsequently, the catalytic activity of UGT94E13 toward Reb M2 was enhanced 12.0-fold through a structure-guided enzyme engineering strategy, and the mechanism behind this enhancement was analyzed. Finally, an enzymatic cascade system comprising the optimal mutant UGT94E13-F169A/I185A and sucrose synthase AtSuSy was constructed and optimized, achieving efficient synthesis of Reb M9 with a yield of 98.3% and a titer of 42.8 g·L-1. Overall, this study provides an effective method for enhancing glycosylation of SGs and a reference for the glycosylation modification of natural products.

Building the Future of Clinical Diagnostics: An Analysis of Potential Benefits and Current Barriers in CRISPR/Cas Diagnostics.

Advancements in molecular diagnostics, such as polymerase chain reaction and next-generation sequencing, have revolutionized disease management and prognosis. Despite these advancements in molecular diagnostics, the field faces challenges due to high operational costs and the need for sophisticated equipment and highly trained personnel besides having several technical limitations. The emergent field of CRISPR/Cas sensing technology is showing promise as a new paradigm in clinical diagnostics, although widespread clinical adoption remains limited. This perspective paper discusses specific cases where CRISPR/Cas technology can surmount the challenges of existing diagnostic methods by stressing the significant role that CRISPR/Cas technology can play in revolutionizing clinical diagnostics. It underscores the urgency and importance of addressing the technological and regulatory hurdles that must be overcome to harness this technology effectively in clinical laboratories.

P-1610. Assessing the Impact of Reflex Urine Cultures in Pediatrics

Abstract Background Obtaining a urine culture (UCx) in the absence of urinary symptoms and inflammation has been shown to result in misdiagnosis and over treatment of urinary tract infections (UTIs) and catheter-associated UTIs in adults. Reflex UCx is a diagnostic stewardship strategy to reduce unnecessary UCx by performing UCx only if a urinalysis (UA) meets criteria for infection. Although the AAP has recommendations for reflex UCx in pediatrics, there are little data to support this approach. We aimed to assess the potential impact of reflex UCx on reducing unnecessary UCx in children. Age, specimen type, and hospital location in children with positive and negative UCx. Methods We performed a retrospective review of children age 2 to 18 years at our network of 8 hospitals from the emergency department or inpatient settings from 11/1/2020 to 7/20/2023. We included children with a matched microscopic UA (mUA) and UCx on the same calendar day. Positive UCx was defined as ≥ 50,000 CFU/ml for catheterized specimens and ≥ 100,000 CFU/ml for clean catch or unspecified specimens. Pyuria was defined as ≥ 10 WBC/HPF. Manual chart review was performed for positive UCx when < 10 WBC/HPF to determine cases consistent with clinical UTI. Sensitivity, specificity, positive predictive value, and negative predictive value with 95% confidence intervals were calculated. Sensitivity, Specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) of Pyuria Compared to Positive Urine Culture and Clinical UTI. Results During the baseline period, 10,235 patients had a mUA and UCx, of which 893 (8.7%) UCx were positive. Median age, specimen types and hospital location are listed in Table 1. Of the positive UCx, 162 (18%) were associated with < 10 WBC/HPF. Of these cases, 44 (27%) had conditions that would have excluded them from reflex UCx per our hospital guideline: 36 (22%) had urologic abnormalities, 5 (3.1%) were pregnant, 3 (1.9%) were renal transplant recipients, and 0 (0%) had neutropenia. Of the remaining 118 positive cultures with < 10 WBC/HPF, 93 (79%) were not consistent with clinical UTI. Table 2 shows the sensitivity and negative predictive value (NPV) of pyuria for a positive UCx and clinical UTI. Conclusion In our study, we demonstrated the safety of a reflex UCx approach in a large pediatric population. Reflex UCx had low risk for missing clinical UTIs and would have reduced the number of unnecessary UCx during the pre-implementation period as 7349 (72%) would not have been performed. Reflex UCx should become standard of care in pediatrics. Disclosures Lars Westblade, PhD, Accelerate Diagnostics, Inc: Grant/Research Support|bioMerieux, Inc: Grant/Research Support|Element Materials Technology: Grant/Research Support|Hardy Diagnostics: Grant/Research Support|Roche Molecular Systems, Inc.: Advisor/Consultant|Roche Molecular Systems, Inc.: Grant/Research Support|Selux Diagnostics, Inc.: Grant/Research Support|Shionogi, Inc: Advisor/Consultant|Talis Biomedical: Advisor/Consultant

P-762. Prevalence and/or Recurrence of Non-Tubercular Mycobacterial Pulmonary Disease in Structural and Airway Lung Disease

Abstract Background Nontuberculous mycobacterial pulmonary disease (NTM-PD) frequently remains undetected, especially among patients with preexisting respiratory conditions who are prone to develop the disease. This study aims to explore the prevalence, species diversity, and outcomes of NTM-PD in India, an uncharted topic. Methods We conducted a prospective observational study, enrolling 69 patients with symptomatic chronic respiratory diseases or a history of Tuberculosis (TB). These patients underwent thorough clinical assessment, chest computed tomography scans, and either a single bronchoscopic sample or three sputum samples for microbiological analysis, along with relevant biochemical investigations. Diagnosis of NTM-PD followed the ATS 2020 diagnostic criteria. The growth of the organism was compared using patented indigenous media with or without p-nitrobenzoic acid. Results The prevalence of NTM-PD was 17.4%, with TB affecting 31.9% of cases. Baseline clinical symptoms and their duration showed no statistically significant differences, except NTM-PD patients with hemoptysis had significantly shorter symptom durations than other groups. Isolation rates were notably higher with the patented indigenous media compared to the mycobacterial growth indicator tube for both NTM (100% vs. 33.3%, p < 0.001) and Mycobacterium tuberculosis (M.Tb) (57.1% vs. 47.6%, p < 0.001). NTM-PD patients exhibited a significantly higher proportion of fibro-cavitary disease compared to other groups when comparing radiological findings. After monitoring NTM-PD patients following treatment, one patient (20%) experienced a recurrence of symptoms within six months, rest continue to be under follow-up. Conclusion In a high-burden TB setting, clinical suspicion and effort to look for NTM-PD is often low. Our study highlights the high prevalence of NTM-PD in individuals with chronic lung conditions/past history of TB. Patients with NTM-PD show higher rates of fibro-cavitary disease, possibly allowing the NTM to form biofilms and hence lead to relapses. Diagnosis of NTM-PD is thus important, to ensure desired treatment for the recommended duration and a thorough and prolonged post-treatment monitoring due to higher relapse risk. Disclosures All Authors: No reported disclosures

Racial and Ethnic Disparities in Pediatric Counseling on Nutrition, Lifestyle, and Weight

Pediatric obesity and hypertension are highly correlated. To mitigate both conditions, provision of counseling on nutrition, lifestyle, and weight to children with high blood pressure (BP) measurements is recommended. To examine racial and ethnic disparities in receipt of nutrition, lifestyle, and weight counseling among patients with high BP at pediatric primary care visits stratified by patients' weight status. This was a post hoc secondary analysis of the BP-CATCH study, a matched, stepped-wedge cluster randomized clinical trial investigating the best methods to screen children with high BP measurements and manage their care. Urban, suburban, and rural pediatric primary care practices across the US with a multidisciplinary team of at least 1 physician, 1 nurse and another practice associate, and a hypertension specialist for their practice group submitted baseline data from clinical encounters documented between November 2018 and January 2019. Practices identified the first 17 eligible patients with high BP measurements each month. This analysis was conducted from October 2023 to July 2024. Race and ethnicity (Black, Hispanic, White, and other [Asian, multiracial, other races, and unknown race]) and weight status (with or without obesity). Primary outcomes were receipt of counseling on nutrition, lifestyle, and weight during primary care visits. Baseline measures extracted from medical records included demographics, anthropometric measures, and systolic and diastolic BP. Of 2677 participants from 59 practices, 1516 (56.6%) were male; mean (SD) age was 10.8 (5.2) years. A total of 593 (21.1%) were Black; 414 (15.5%), Hispanic; 1111 (41.5%), White; and 559 (20.9%), other race and ethnicity. The overall crude unadjusted rates of receiving counseling were 63.5% (n = 1564 of 2463) for nutrition, 57.6% (n = 1419 of 2462) for lifestyle, 47.5% (n = 571 of 1202) for weight, and 46.4% (n = 1142 of 2461) for all counseling topics. Compared with the other 3 groups, Hispanic participants received significantly higher adjusted rates of nutrition (78.6%; 95% CI, 73.5%-83.8%), lifestyle (69.3%; 95% CI, 63.6%-74.9%), and all 3 (52.1%; 95% CI, 46.1%-58.2%) counseling topics. There were no significant differences in rates of receiving weight counseling between any pairs of groups. These findings were consistent in general among participants without obesity, and no significant pairwise differences were noted among participants with obesity except that nutrition counseling rates were significantly different between White participants and those reporting other race and ethnicity (68.3% [95% CI, 61.1%-75.4%] vs 81.6% [95% CI, 74.2%-89.1%]; Bonferroni-corrected P = .02). This secondary analysis of the BP-CATCH trial found that among children with high BP measurements, racial and ethnic disparities in receiving nutrition, lifestyle, and all 3 counseling topics were significant, although no significant disparities in receipt of weight counseling were noted. Racial disparities in receipt of counseling were not observed in participants with and without obesity. ClinicalTrials.gov Identifier: NCT03783650.