We investigate the predictions of inflation models with a non-minimal coupling to gravity for inflationary observables such as the spectral index and tensor-to-scalar ratio in a general setting. We argue that, depending on the relation between the Jordan frame potential and a function characterizing the non-minimal coupling, one can classify the model into three categories each of which gives distinctive predictions for the inflationary observables. We derive general predictions for each class and also investigate some explicit models to discuss how the general features arise. Our results would be useful to design an inflation model consistent with observational constraints with a non-minimal coupling to gravity.