Joint Laboratory Research Articles

Model-Based Adaptive Machine Learning Approach in Concrete Mix Design.

Concrete mix design is one of the most critical issues in concrete technology. This process aims to create a concrete mix which helps deliver concrete with desired features and quality. Contemporary requirements for concrete concern not only its structural properties, but also increasingly its production process and environmental friendliness, forcing concrete producers to use both chemically and technologically complex concrete mixtures. The concrete mix design methods currently used in engineering practice are joint analytical and laboratory procedures derived from the Three Equation Method and do not perform well enough for the needs of modern concrete technology. This often causes difficulties in predicting the final properties of the designed mix and leads to precautionary oversizing of concrete properties for fear of not providing the required parameters. A new approach that would make it possible to predict the newly designed concrete mix properties is highly desirable. The answer to this challenge can be methods based on machine learning, which have been intensively developed in recent years, especially in predicting concrete compressive strength. Machine learning-based methods have been more or less successful in predicting concrete compressive strength, but they do not reflect well the variability that characterises the currently used concrete mixes. A new adaptive solution that allows estimating concrete compressive strength on the basis of the concrete mix main ingredient composition by including two observations for a given batch of concrete is proposed herein. In presented study, a machine learning model was built with a deep neural network architecture, trained on an extensive database of concrete recipes, and translated into a mathematical formula. Testing on four concrete mix recipes was performed, which were calculated according to contemporary design methods (Bolomey and Fuller method), and a comparative analysis was conducted. It was found out that the new algorithm performs significantly better than that without adaptive features trained on the same dataset. The presented algorithm can be used as a concrete strength checking tool for the concrete mix design process.

Theory-Driven Design of Electrocatalysts for the Two-Electron Oxygen Reduction Reaction Based on Dispersed Metal Phthalocyanines

Theory-Driven Design of Electrocatalysts for the Two-Electron Oxygen Reduction Reaction Based on Dispersed Metal Phthalocyanines

Global artificial intelligence systems and technology market: formation and development trends

Every day more and more companies rely on artificial intelligence, from small startups to large companies, among which stand out not only the IT giants Google, Microsoft, Facebook, IBM, but even those that seemingly far from this topic - for example, General Motors and Boeing created a joint laboratory for AI research. It becomes obvious that AI technology is the real mainstream of our time. The article examines the global market for artificial intelligence systems and technologies. The authors described the peculiarities of the formation of this market and the main trends and segments in its development. The goal of research - identify the dynamics, features and trends of the global market for artificial intelligence systems and technologies. The methodology of system analysis, the dialectical method of scientific cognition, methods of historical, logical and comparative analysis are used. The concept of artificial intelligence has been systematized, the dynamics of the global market for artificial intelligence systems and technologies have been revealed, as well as in the regional context. The relationship between its dynamics and the sharp jump in performance of information processing algorithms, which became possible due to the fast computer based on GPUs, an avalanche-like data growth and the emergence of almost unlimited possibilities for storage and technology access, has been detected. It is shown that the global market for artificial intelligence technologies is in a phase of inflated expectations and with a high enough level of risk for investors. The main trends and segments in the development of the global market for artificial intelligence systems and technologies have been identified. These include deep learning technologies, the convergence of AI technologies with other technologies such as analytics, ERP, the Internet of Things, blockchain, and even quantum computing, which has the greatest impact, the development of cognitive intelligence systems, and the creation of a cognitive computer. It is shown that business leaders consider AI fundamental and absolutely necessary for the development of future business opportunities. It has been proven that the rapid development of AI systems and technologies is not just another technological innovation, but the technological platform of the Fourth Industrial Revolution, which is associated with hopes for accelerating the economic growth of the world economy, increasing the competitiveness of countries and companies.

IMPLEMENTASI STANDAR SARANA DAN PRASARANA PENDIDIKAN PADA MADRASAH ALIYAH NEGERI 3 BANYUWANGI

The objectives set in this study are: (1) To find out the implementation of Sarpras standards in MAN 3 Banyuwangi; (2) To find out the factors that are the strengths and weaknesses in implementing the standard of education sarpras at MAN 3 Banyuwangi; (3) To find out what factors are the weaknesses in applying educational infrastructure standards in MAN 3 Banyuwangi; (3) To find out the right strategy to be applied in MAN 3 Banyuwangi. This research method uses descriptive qualitative, data collection through interviews, observation and documentation. Data analysis using SWOT analysis and data validity techniques using triangulation. The results of his research: (1) Implementation of standard facilities and infrastructure at MAN 3 Banyuwangi, namely the suitability of facilities and infrastructure at the educational unit level MAN 3 Banyuwangi has 27 study groups. This is in accordance with the standards of Permendiknas Number 24 of 2007 which states that "one SMA / MA has a minimum of 3 study groups and a maximum of 27 study groups"; (2) Supporting factors that are owned are MAN 3 Banyuwangi (86%) facilities and infrastructure in accordance with the education unit so that it helps support the learning process (2) The supporting factor that becomes its strength is the innovation of facilities and infrastructure outside the SNP, opportunities come from government support in the form of APBN funds and new student enrollments are opportunities for the fulfillment of sarpras at MAN 3 Banyuwangi. While the inhibiting factor is weakness, there is still a joint laboratory for practicing biology, chemistry and physics subject matter, and the number of latrines that do not meet the ratio of the number of students. While the threats are the existence of a favorite school around MAN 3 Banyuwangi; (3) Infrastructure Strategy at MAN 3 Banyuwangi; always maintain the existence of madrasas, the need for a team of maintenance and control of sarpras. In addition, it is also necessary to complete the facilities, furniture and practical tools for the laboratory and provide a special place for each laboratory room.

Current Variation in Joint Aspiration Practice for the Evaluation of Pediatric Septic Arthritis.

Introduction:Pediatric septic arthritis (SA) is a condition that can be associated with significant morbidity. Although previous research has been on predictive care pathways, scrutiny of the literature continues to reveal wide differences in the patient evaluation and management. The purpose of this study was to define the differences in joint aspiration for the evaluation of pediatric SA across pediatric tertiary care institutions in the United States.Methods:Surgeons from 18 pediatric tertiary care centers across the United States were surveyed on current institutional practices regarding joint aspiration, laboratory studies, MRI usage, and treatment timing in the evaluation for SA. Responses were recorded by institution and analyzed to generate descriptive statistics.Results:Responses were received from all institutions asked to participate. Overall, joint specific practice variation exists regarding the person completing the aspiration, where the aspiration is performed, utilization of image guidance, and the utilization of anesthesia. Additional areas of variation included the method and calculation of cell count and the routine use of MRI.Discussion:Significant practice variations exist across pediatric tertiary care centers for the evaluation of pediatric SA. Using these data, future prospective studies can be used to unify institutional practices to minimize practice variation and ultimately improve the care delivery to pediatric patients presenting with SA.

FRI0505 TOCILIZUMAB DISCONTINUATION AFTER REMISSION ACHIEVEMENT IN PATIENTS WITH ADULT STILL’S DISEASE

Background:The efficacy of tocilizumab, an interleukin (IL)-6 receptor inhibitor, has been proved in patients with adult Still’s disease on suppressing systemic inflammation and decreasing glucocorticoid dose. However, whether tocilizumab can be discontinued after remission achievement is unclear.Objectives:To clarify the possibility of tocilizumab discontinuation in patients with adult Still’s disease who achieved remission with tocilizumab.Methods:Consecutive patients with adult Still’s disease diagnosed according to the Yamaguchi’s criteria in our hospital from April 2012 until September 2019 were retrospectively reviewed. Patients who were in good control with tocilizumab were included in the analysis, and their clinical courses were collected from their medical charts. Patients were divided according to the presence of recurrence after tocilizumab discontinuation and compared.Results:Among 42 patients with adult Still’s disease who had a history of intravenous tocilizumab of 8mg/kg use, 13 patients discontinued tocilizumab following a good disease control. During the mean observation period of 26.4 months, six patients (46%) remained in remission while seven patients (54%) developed recurrence after tocilizumab discontinuation. The sex and the mean observation period were not different between the patients with recurrence and those without (71% vs 50%, p=0.43; 27.3 months vs 25.4 months, p=0.93, respectively), but the age at tocilizumab discontinuation tended to be higher in the recurrence group than the non-recurrence group (64.0 years vs 46.5 years, p=0.08). The disease activity including swollen joint counts and laboratory data at tocilizumab discontinuation were comparable between the two groups (serum ferritin levels, 88 ng/mL vs 122 ng/mL, p=0.67). While the duration of tocilizumab use was not different between the two groups (29.4 months vs 39.5 months, p=0.40), the mean interval of tocilizumab infusion at tocilizumab discontinuation in the recurrence group was 3.6 weeks, shorter than the 6.7 weeks in the non-recurrence group (p=0.03). The median dose of prednisolone at tocilizumab discontinuation was 5.0 mg/day in the recurrence group and 0.0 mg/day in the non-recurrence group (p=0.06). In the recurrence group, the duration from the last tocilizumab administration to recurrence was 7.8 months, and the median dose of prednisolone at recurrence was 5.0 mg/day.Conclusion:Patients with adult Still’s disease remaining in remission with a longer interval of tocilizumab administration and a lower dose of prednisolone was likely to succeed in withdrawal of tocilizumab.Disclosure of Interests:Hiroya Tamai: None declared, Yuko Kaneko Speakers bureau: Dr. Kaneko reports personal fees from AbbVie, personal fees from Astellas, personal fees from Ayumi, personal fees from Bristol-Myers Squibb, personal fees from Chugai, personal fees from Eisai, personal fees from Eli Lilly, personal fees from Hisamitsu, personal fees from Jansen, personal fees from Kissei, personal fees from Pfizer, personal fees from Sanofi, personal fees from Takeda, personal fees from Tanabe-Mitsubishi, personal fees from UCB, Tsutomu Takeuchi Grant/research support from: Eisai Co., Ltd, Astellas Pharma Inc., AbbVie GK, Asahi Kasei Pharma Corporation, Nippon Kayaku Co., Ltd, Takeda Pharmaceutical Company Ltd, UCB Pharma, Shionogi & Co., Ltd., Mitsubishi-Tanabe Pharma Corp., Daiichi Sankyo Co., Ltd., Chugai Pharmaceutical Co. Ltd., Consultant of: Chugai Pharmaceutical Co Ltd, Astellas Pharma Inc., Eli Lilly Japan KK, Speakers bureau: AbbVie GK, Eisai Co., Ltd, Mitsubishi-Tanabe Pharma Corporation, Chugai Pharmaceutical Co Ltd, Bristol-Myers Squibb Company, AYUMI Pharmaceutical Corp., Eisai Co., Ltd, Daiichi Sankyo Co., Ltd., Gilead Sciences, Inc., Novartis Pharma K.K., Pfizer Japan Inc., Sanofi K.K., Dainippon Sumitomo Co., Ltd.

Clinical symptoms of joint damage in Lö fgren's syndrome

Objective: to investigate joint damage and laboratory and instrumental features in Löfgren's syndrome (LS) in patients referred to the Rheumatology Center.Patients and methods. The five-year investigation enrolled 142 patients of both sexes (31 men and 111 women; mean age, 39.3±11.1 years) with erythema nodosum (EN) accompanied by polyarthralgias or arthritis. All the patients underwent comprehensive clinical, laboratory and instrumental examinations, including joint ultrasound and chest computed tomography.Results and discussion. Disseminated EN that was correlated with the level of CRP was detected in 96% of cases (p=0.006; r=0.38). The signs of joint damage with predominantly periarticular changes in the ankle joints were observed in 124 (87%) patients. There was a relationship of the duration of the articular syndrome to that of inflammatory changes in subcutaneous tissue and to the number of nodules (p=0.02; r=0.45). The level of CRP had a significant direct correlation with the number of nodules (p=0.008; r=0.29) and the severity of the articular syndrome (p=0.003; r=0.29). Elevated levels of angiotensin-converting enzyme were found in 97 (78%) patients. Joint damage was significantly more frequently combined with X-ray Stage I sarcoidosis (Sr) (p=0.03). The Stage II Sr showed a male preponderance (p=0.04) and a 4.8-fold increase in the merging of subcutaneous nodes into conglomerates (p=0.002).Conclusion. Joint damage may be one of the first signs of LS, which requires that physicians of various specialties should coordinate their actions to timely diagnose, assess activity, and choose an adequate therapeutic approach.

Development of an application for mobile phones (App) based on the collaboration between the Spanish Society of Rheumatology and Spanish Society of Family Medicine for the referral of systemic autoimmune diseases from primary care to rheumatology

Management of systemic autoimmune diseases is challenging for physicians in their clinical practice. Although not common, they affect thousands of patients in Spain. The family doctor faces patients with symptoms and non-specific cutaneous, mucous, joint, vascular signs or abnormal laboratory findings at the start of the disease process and has to determine when to refer patients to the specialist. To aid in disease detection and better referral, the Spanish Society of Rheumatology and the Spanish Society of Family Medicine has created a group of experts who selected 26 symptoms, key signs and abnormal laboratory findings which were organized by organ and apparatus. Family doctors and rheumatologists with an interest in autoimmune systemic diseases were selected and formed mixed groups of two that then elaborated algorithms for diagnostic guidelines and referral. The algorithms were then reviewed, homogenized and adapted to the algorithm format and application for cell phone (apps) download. The result is the current referral document of systemic autoimmune diseases for the family doctor in paper format and app (download). It contains easy-to-use algorithms using data from anamnesis, physical examination and laboratory results usually available to primary care, that help diagnose and refer patients to rheumatology or other specialties if needed.

Thinking on the Construction of Joint Laboratory about Civil Aviation ATC Electronic Equipment Maintenance Engineering

Thinking on the Construction of Joint Laboratory about Civil Aviation ATC Electronic Equipment Maintenance Engineering

Examining the Association between Severity of Child Neglect and Quality of Parenting

Child neglect is the most prevalent form of child maltreatment (CM) in the U.S. and is consistently associated with negative outcomes for children. Although some research suggests that differences in parenting exist across the spectrum of maltreatment severity, little is known about whether and how severity of neglect relates to observed parenting quality. The present study tested whether mothers who engage in documented, higher severity neglect of their children would display less warm, affiliative parenting, and more harsh, controlling parenting while interacting with their preschool child, than less severely neglectful mothers, and non-CM mothers. A sample of 121 mother-preschooler dyads [low severity neglect (n = 29), high severity neglect (n = 40), and non-CM (n = 52)] participated, and parenting behaviors were coded during a joint laboratory challenge task. This study explored associations between severity of child neglect perpetration through coding of child protective services case records; and quality of observed parenting, using observational, micro-social coding of parenting behaviors. Regression analyses showed that high severity neglecting mothers displayed significantly less warm, affiliative parenting than lower severity neglecting and non-CM mothers, and more harsh, controlling parenting relative to their non-CM peers. Further, there were no differences between low severity neglect and non-CM mothers in the amount of warm, affiliative parenting observed. These findings advance our understanding of child neglect by revealing important differences in quality of observed parenting across the spectrum of neglect severity. Implications for conceptualizing child neglect and targeted intervention strategies are discussed.

Experimental and numerical study of dynamic responses of a new combined TLP type floating wind turbine and a wave energy converter under operational conditions

This paper deals with a novel concept by combining a tension leg platform (TLP) type floating wind turbine and a heave-type wave energy converter, that is referred as the ‘TWWC’ (TLP-WT-WEC- Combination) system herein. Dynamic responses of the TWWC system under operational seas cases (in South China Sea) have been investigated by using both time-domain numerical simulation and scale model tests (1:50). For the numerical model, hydrodynamic loads of the TLP and the WEC are calculated by the AQWA code, which is available for modeling multi-body systems including both mechanical and hydrodynamic couplings between the TLP and the WEC. The aerodynamic loads of the wind turbine are calculated based on the NREL 5 MW wind turbine. The scale model tests have been done in Harbin Institute of Technology’s wind tunnel & wave flume joint laboratory. The power-take-off (PTO) system of the WEC device is simulated by two nonlinear air-dampers, and aerodynamic loads of the wind turbine are simulated by a scaled rotating wind turbine model with equivalent mean thrust effect. Main dynamic characteristics of the TWWC system under operational sea cases have been clarified. Numerical and experimental results are presented and compared. Good agreements are achieved, although the numerical model tends to overestimate dynamic responses of the TWWC system due to ignoring the viscous damping effect in the scale test model. The validated numerical model of the TWWC system will be useful for future optimal design of the WEC PTO system.

Changes in Prescription Routines for Treating Hypothyroidism Between 2001 and 2015: An Observational Study of 929,684 Primary Care Patients in Copenhagen.

Background: Increased public attention toward health and quality-of-life issues has led to more intensified screening for various medical conditions, including hypothyroidism. A falling serum thyrotropin (s-TSH) at initiation of levothyroxine (LT4) treatment has been reported in the United Kingdom between 2001 and 2009, indicating a falling TSH threshold, which may lead to less benefit from therapy and possibly overtreatment. The aim of this study was to investigate changes in s-TSH threshold used by general practitioners to initiate LT4 therapy between 2001 and 2015 in Copenhagen. Methods: Retrospective analysis was conducted of all s-TSH measurements between 2001 and 2015 performed at the general practitioners' joint laboratory merged with The Danish Register of Medicinal Products Statistics and The Danish National Patient Registry. For each year, both the median s-TSH at therapy initiation and the estimated treatment threshold were calculated from all s-TSH measurements performed in that year, representing the s-TSH level where the estimated probability of starting LT4 therapy was 50%. Results: A total of 929,684 individuals with 2,975,277 s-TSH measurements were included in the calculations. The size and composition of the study population remained virtually unchanged. During the study period, the number of performed s-TSH measurements increased from 110,886 to 292,911 (164%), and the number of patients initiating LT4 therapy increased from 786 to 1825 (132%), though this was comparably unchanged from 2010 to 2015. The median s-TSH at therapy initiation decreased from 10 mIU/L (interquartile range 5.2-29.7 mIU/L) in 2001 to 6.8 mIU/L (interquartile range 5.1-11 mIU/L) in 2015, while the estimated treatment threshold decreased from 28.3 mIU/L [confidence interval 21.0-40.2 mIU/L] in 2001 to 14.2 mIU/L [confidence interval 12.0-18.0 mIU/L] in 2007. In 2015, 25% of patients started LT4 therapy with s-TSH ≤5 mIU/L, and during the entire period, 50% of patients started therapy with a single s-TSH measurement >5 mIU/L. Conclusions: This study performed on a sizeable primary care population demonstrates a considerable fall in the threshold for initiating LT4 therapy in hypothyroid patients. This increases the risk of futile treatment as well as overtreatment.

Introduction to the International Symposium on Chemistry, Flavor, and Health Effects of Tea

A symposium entitled "Chemistry, Flavor, and Health Effects of Tea" was held at the 256th American Chemical Society (ACS) Meeting in August 2018 in Boston, MA, U.S.A., and was sponsored by the ACS Division of Agricultural and Food Chemistry and the International Joint Laboratory on Tea Chemistry and Health Effects, Anhui Agricultural University, China. The purpose of the symposium was to bring together the leading tea researchers throughout the world to discuss the current state of knowledge as well as research needs with respect to chemistry and health beneficial properties of tea. Speakers from North America, Europe, and Asia delivered a total of 35 oral presentations. The presentations covered such diverse topics as polyphenol chemistry and flavor chemistry of tea, metabolomics application to identify the changes of phytochemical composition during processing, and health beneficial effects of drinking tea. This paper is intended to provide a brief summary of the presentations.

HLA Class II-DRB,-DQA and –DQB Genotypes in Peripheral Blood Shows Shifts During the Course of Sepsis

Abstract Undeniably, sepsis is still a profoundly damaging and life-threatening condition for many individuals. With multiple changes in sepsis patients it is difficult to precisely classify an individual’s response in sepsis as proinflammatory or immunosuppressed. The aim of this study was to investigate genetically determined predisposition to developed sepsis by analysis of distribution of human leukocyte antigen (HLA) class II genes. Samples from patients with sepsis were collected at Pauls Stradiņš Clinical University Hospital, Latvia, in an intensive care unit between October 2016 and May 2017. The study group included 62 patients with sepsis, who were genotyped for HLA-DR; DQ using real time polymerase chain reaction – sequence specific primer (RT PCR-SSP). As a control group, data of 100 individuals were taken from the genetic bank of RSU Joint Laboratory of Clinical Immunology and Immunogenetics. The summarised results showed that the frequency of alleles DRB1*04:01 (OR = 5.54; 95% CI = 1.88–16.29); DRB1*07:01 (OR = 19.03; 95% CI = 2/37–152.82); DQA1*05:01 (OR = 14.17; 95% CI = 5.67–35.4); and DQB1*02:01 (OR = 50.00; 95% CI = 2.90–861.81) were significantly increased in patients with sepsis compared to the control group patients. The frequency of DRB1*16:01 (OR = 0.17, 95% CI = 0.04–0.59); DRB1*17:01 (OR = 0.04; 95% CI = 0.00–0.69); DQA1*01:01 (OR = 0.04; 95% CI = 0.00–0.31); DQA1*01:02 (OR = 0.03; 95% CI = 0.00–0.23); DQB1*02:02 (OR = 0.12; 95% CI = 0.03–0.42) alleles was lower in sepsis patients than in control subjects. The most frequent HLA-DRB1/DQA1/DQB1 haplotypes that was significantly increased in patients with sepsis were: DRB1*01:01/DQA1*05:01/DQB1*03:01 (OR = 12.6; 95% CI = 1.51–105.0; p < 0.003). Sepsis patients with pneumonia and alleles and DRB1 04:01; 07:01, DQB1 02:01 had the highest mortality rate. Undoubtedly, our preliminary data showed that development of sepsis can be associated with alleles and haplotypes of HLA class II genes. For more precise conclusion the research should be continued to include a larger patient group.

Demographic, clinical, and laboratory features of Turkish patients with gouty arthritis: A prospective cohort study.

ObjectiveWe have conducted this study to evaluate clinical and laboratory findings and to gather and evaluate information that would be useful in clinical practice, such as demographics, joint involvement patterns, laboratory anomalies, treatments applied, and responses obtained in patients diagnosed with gout.MethodsIn our study, the demographic, clinical, and laboratory characteristics of 94 patients diagnosed with gout were evaluated. The patients were re-evaluated with regard to their clinical and laboratory findings at the end of the 1st and 3rd months, their responses to the treatment were observed, and where necessary, new treatment adjustments were made.ResultsSeventy-nine (84%) of the patients were men, and 15 (16%) were women. The ages of the patients ranged between 22 and 86 years with the average age being 57.5 years. The joint involvement during a gouty arthritis attack was most frequently observed in the 1st metatarsophalangeal joint (87.2%), followed by the ankle joint (26.9%), and the knee joint (23.7%). The joint involvement pattern was evaluated to reveal that the acute monoarticular arthritis was observed in 87 patients (93.5%), followed by acute oligoarticular arthritis coming in second in terms of frequency (26.9%). An average attack was determined to last 10.7 days, and the average number of attacks in a year was 2.69. In our study, the colchicine treatment in 24 of our patients, in whom it was determined during the admission and follow-up process that they have not had gouty arthritis attack in the past 3 months, was stopped. Five (20.8%) patients whose colchicine treatment was stopped later developed gouty arthritis attacks, and the colchicine treatment was restarted. On the other hand, 10 out of 38 patients (26.3%), who have either been continuing or had never been on colchicine treatment, were observed to experience a gouty arthritis attack during their 1st and 3rd month check-ups.ConclusionIn patients with gout, it is recommended that the related diseases, as well as the triggering factors (alcohol, drug use, and dietary effect), be determined, the necessary lifestyle changes be made, and the treatments started.

植物群落构建的生态过滤机制研究进展

PDF HTML阅读 XML下载 导出引用 引用提醒 植物群落构建的生态过滤机制研究进展 DOI: 10.5846/stxb201804260946 作者: 作者单位: 北京师范大学,北京师范大学,北京师范大学,北京师范大学 作者简介: 通讯作者: 中图分类号: 基金项目: 国家重点研发计划重点专项课题（2016YFC0501906）；环境模拟与污染控制国家重点联合实验室项目（17L03ESPC） Research progress on ecological filtering mechanisms for plant community assembly Author: Affiliation: Beijing Normal University,Beijing Normal University,Beijing Normal University,Beijing Normal University Fund Project: the National Key R&D Program of China (2016YFC0501906); the State Key Joint Laboratory of Environmental Simulation and Pollution Control (Beijing Normal University)(17L03ESPC) 摘要 | 图/表 | 访问统计 | 参考文献 | 相似文献 | 引证文献 | 资源附件 | 文章评论 摘要:生物多样性的形成和维持机制，即群落构建机制，一直以来都是群落生态学研究的核心问题。植物群落构建的确定性过程主要是生态过滤机制（包括环境过滤和生物过滤，其中生物过滤包括种间竞争和种内功能性状变异）作用的结果。学者们构建了大量的理论、方法、模型来解释和验证生态过滤机制对群落构建的影响，并取得了显著的成果。然而，关于生态过滤机制在不同尺度的作用、生态过滤机制的各要素分解和量化等方面的研究仍有诸多疑问。重点综述了环境过滤、种间竞争和种内功能性状变异的最新研究进展，并指出了现有研究的不足之处。在未来的研究中，应注重生态过滤机制的各要素分解和量化，加强研究手段的综合运用，关注时空动态变化对植物群落构建的影响，重视对不同植物群落构建机制的共性和个性特征的认识，同时强调与其他生态过程、群落构建机制的整合。通过这些尝试，有助于人们更好的理解植物群落构建过程中的生态过滤机制的作用。 Abstract:The formation and maintenance of biodiversity, that is, plant community assembly mechanisms, has been a central issue in community ecology for decades. The deterministic process of plant community assembly is mainly the result of ecological filtering, including environmental and biological filtering (interspecific competition and intraspecific functional trait variation). Previous scholars have developed a large number of theories, methods, and models to explain and verify the impact of ecological filtering on community assembly. However, uncertainty remains about the role of ecological filtering mechanisms in different scales, and the decomposition and quantification of various factors in the ecological filtering mechanism. In this paper, we made a detailed review on the research progress of environmental filtering, interspecific competition, and intraspecific functional trait variation. We further proposed a guide to focus on the decomposition and quantification of ecological filtering mechanisms, development of comprehensive research methods, effects of spatio-temporal dynamics on community assembly, understanding the commonness and personality characteristics of different community assembly mechanisms, and emphasizing the integration with other ecological processes and community building mechanisms. These attempts may help us better understand the role of the ecological filtering in plant community assembly. 参考文献 相似文献 引证文献

Research on Hybrid Simulation Test Method for Cooperative Deformation of Membrane and Frame Composite Structures

In this paper, based on the joint laboratory of Mechanics Test Center of Nanjing University of Science and Technology and Walter+Bai, the PTFE coated fabric film material is taken as the test object, and the A/D signal exchange between the numerical substructure and the experimental substructure is realized by PMI serial port program, and the hybrid simulation static test is carried out. The phenomenon that the supporting structure of the frame is deformed due to the interaction in the tension process of the membrane structure is simulated, and then the unloading effect on the membrane surface is produced. The test results show that the communication performance of PMI serial port program is good, and the time consumption produced by signal exchange process can be ignored. The accuracy and stability of the hybrid simulation test system are verified by comparing the mixed simulation test results with the pure numerical simulation theoretical solution. Through the comprehensive analysis of the test data such as stress, strain, displacement, loading and unloading times, some suggestions are put forward for the design of membrane and frame composite structure.

Tackling Challenges in Industrially Relevant Homogeneous Catalysis: The Catalysis Research Laboratory (CaRLa), an Industrial-Academic Partnership.

Industrial-academic collaborations are broadly used for the development of new industrial processes. To achieve a strong and deep collaboration in the field of homogeneous catalysis, BASF and the Heidelberg University have been running the Catalysis Research Laboratory together in Heidelberg since 2006. This Perspective highlights the concept of this laboratory and our experiences over the past few years in this joint laboratory. How this collaboration works is explained in more detail using three selected projects: sodium acrylate based on CO2, the selective decomposition of cyclohexyl hydroperoxide to cyclohexanone, and the asymmetric amination of ketones with NH3/H2.

3rd China-Romania Science and Technology Seminar (CRSTS 2018)

FOREWORDAfter the establishment of the People’s Republic of China, Romania was among the first countries in the world to have developed diplomatic relations with China (October 5th, 1949) and, in the following decades, the political, economic and cultural relations between the two countries have continuously evolved, being based on friendship, confidence and reciprocal support. Thousands of cooperation projects in almost all sectors of industry, agriculture, education, science, culture etc. were implemented for the benefit of China and Romania. Whilst the post-1989 changes in the Romanian society partially affected the intensity of this fruitful cooperation, more and more Romanian decision-makers and representatives of the business sector, the academia, as well as of the scientific and cultural life have recently understood that reviving the cooperation with China should be a priority. And not only because of the tremendous economic and technological development of China nowadays, but also because of the long-lasting friendship and trust between the two countries.In recent years, Transilvania University of Brasov has been at the forefront of the academic and scientific cooperation between Romania and China. The establishment of the Confucius Institute in 2012, in partnership with Shenyang Jianzhu University, represented the impulse for a new stage of intensive cooperation between the two universities and also between the two countries. Hundreds of staff and student mobility exchanges, the participation in scientific events in China and Romania, the establishment of new cooperation partnerships in Beijing, Tianjin, Hunan province etc., the establishment of a Chinese language Bachelor’s study programme, the implementation of an international joint laboratory project and a “111” project, and the active involvement in the “16+1 cooperation” in the field of forestry and education are only a few examples of this excellent cooperation in recent years. Our university is fully committed to the further development of the academic and scientific cooperation between Romania and China, and we are convinced that the approaching of the 70th anniversary of the People’s Republic of China and 100 years of modern Romania, will represent the beginning of a new stage of intensive cooperation between the two countries for the benefit of our peoples.List of committees are available in this pdf.

Certolizumab pegol in a heterogeneous population of patients with moderate-to-severe rheumatoid arthritis.

Aim:To determine the efficacy and safety of certolizumab pegol for the treatment of rheumatoid arthritis in a real-world setting.Materials & methods:Patients with moderate-to-severe rheumatoid arthritis who initiated therapy with certolizumab were followed for 12 weeks. Response was assessed with Disease Activity Score of 28 joints, European Ligue Against Rheumatism criteria and Simplified Disease Activity Index. Predictors of response were analyzed with binary logistic regression models.Results:Statistically significant decreases in tender and swollen joint counts, laboratory parameters and use of corticosteroids and disease-modifying antirheumatic drugs were found. Disease activity also significantly diminished. Higher Disease Activity Score of 28 joints at baseline was the main predictor of response. No severe adverse events were reported.Conclusion:Certolizumab was effective and well tolerated, particularly in the subpopulation with higher inflammatory burden at baseline.