Johnson Etal Research Articles

The heart of VIALE-A: Cardiac complications of hypomethylating agents and venetoclax in acute myeloid leukaemia.

As we commemorate 50 years since the introduction of classical 7 + 3 induction chemotherapy for acute myeloid leukaemia (AML), we also embark upon new territory with the advent of novel targeted therapeutics, including BH3 mimetics. To date, we do not have much large-scale longitudinal data regarding the toxicities of such novel therapies. Johnson etal. perform a comprehensive analysis of cardiac toxicities with hypomethylating agents and venetoclax and offer valuable insight into risk-benefit analysis when considering front-line therapy for AML. Commentary on: Johnson etal. Cardiac events in newly diagnosed acute myeloid leukaemia during treatment with venetoclax + hypomethylating agents. Br J Haematol 2024;204:1232-1237.

Characterizing high-frequency wave interaction in rigid porous bilayer materials: Insights from acoustic parameter sensitivity analysis

This study aims to investigate the sensitivity of high-frequency acoustic parameters in rigid air-saturated porous bilayer materials using the equivalent fluid theory. The interaction between the fluid and solid phases of the porous medium incorporates visco-inertial and thermal exchange, characterized by two functions: the dynamic tortuosity α(ω) proposed by Johnson etal. and the dynamic compressibility β(ω) proposed by Allard, refined by Sadouki for the low-frequency domain of ultrasound. Various parameters, including porosity, tortuosity, viscous characteristic length, thermal characteristic length, as well as viscous and thermal shape factors, are examined in this study. A 10% variation in these parameters is considered to assess their impact on the amplitudes of transmitted waves. The findings of this study contribute to a deeper understanding of high-frequency wave behavior in porous bilayer materials. The investigation sheds light on the sensitivity of the parameters and provides valuable insights for the design and optimization of such materials in engineering, technology, and applied sciences.

Keep both eyes on the prize: Hunting mice use binocular vision and specialized retinal neurons to capture prey

In this issue of Neuron, Johnson etal. show that mice rely on binocular vision when hunting insect prey. Specific types of retinal output neurons support this behavior. They have functional properties and brain connections well-suited to their role.

T-bet+ Memory B Cells Stay in Place

Memory B cells (MBCs) expressing the transcription factor T-bet have been described in normal and dysregulated immune responses. In this issue of Immunity, Johnson etal. report that T-bet+ MBCs, formed in response to a primary influenza infection, contribute to protective antibody titers and persist mainly in the spleen with restricted trafficking between tissues.

Direct Sodium Channel Regulation by Calmodulin

Many aspects of the sophisticated mechanism of sodium channel regulation by Ca2+ and calmodulin remain unresolved and controversial. In this issue of Structure, Johnson etal. (2018) provide compelling structural and functional evidence clarifying considerably how calmodulin engages the inactivation gate of the sodium channel and the consequences for regulation.

A Talented Duo: IFIT1 and IFIT3 Patrol Viral RNA Caps

Hosts respond to viral infection by expressing interferon-stimulated genes, of which IFITs are potent inhibitors of viral RNA translation. Johnson etal. (2018) solved the structure of the IFIT1-IFIT3 complex bound cap 0 RNA and explored their concerted antiviral activity.

T Cell LEGO: Identifying the Master Builders and What They Do

Understanding how cell fate decisions are made during cellular differentiation and the mechanisms that drive them is a holy grail of cell biology. In this issue of Immunity, Hu etal. (2018) and Johnson etal. (2018) demonstrate that key transcriptional regulators and global changes in nuclear architecture underlie differentiation decisions during Tcell development.

Resolving Late-Stage Intermediates of Eukaryotic Ribosome Assembly

The assembly of eukaryotic ribosomes requires about 200 assembly factors promoting RNA modification, folding, cleavage, and ribosomal protein association. In this issue of Structure, Johnson etal. (2017) report structures of several late-stage intermediates of pre-40S ribosomal subunit assembly. This work provides detailed testable insights into assembly factor function.

Recommendations for choosing an analysis method that controls Type I error for unbalanced cluster sample designs with Gaussian outcomes: J. L. JOHNSONET AL.

Recommendations for choosing an analysis method that controls Type I error for unbalanced cluster sample designs with Gaussian outcomes: J. L. JOHNSONET AL.

Methods for testing vowel perception in the field

Based on procedures developed by Johnson etal. [J. Acoust. Soc. Am. 91, 2387(A) (1992)] programs have been written for Macintosh and MS-DOS portable computers for experiments on the perception of vowel quality in the field. In one version, vowels determined by 15 different values of F1 and 22 values of F2, with F3 determined by algorithm, were digitized and stored. In the basic experiment listeners try to match one of these stimuli to a selection of their own vowels. Listeners can hear any of the stored stimuli by clicking with a mouse on a square in a 22×15 matrix. In other experiments, listeners estimate the distance between pairs of stimuli, or select the better match to one of their own vowels from pairs of vowels that are algorithmically varied from trial to trial in accordance with the previously selected better match. A later version of these programs, not yet tested in the field, generates vowels in real time. The advantage of this system is that the fundamental frequency, the vowel duration, and the third formant can be manipulated by the subject. This is important when matching vowels in languages in which tone or length or rhotacization is contrastive.

Secretion of trials during gliding motility of Eimeria nieschulzi (Apicomplexa, Coccidia) sporozoites visualized by a monoclonal antibody and immuno-gold-silver enhancement.

Surface proteins of sporozoites and merozoites of pathogenic Sporozoa (Plasmodium, Toxoplasma, Cryptosporidium, Eimeria) are increasing in interest as subjects of research and are promising candidates for vaccines against these parasites (Brothers etal. 1988; Heidrich 1986; Johnson etal. 1983; Luft et al. 1987; Whitmire et al. 1989). However, little is known about the biological significance of these surface proteins. Surface proteins are in close interaction with the host cell during the invasion of parasites, reflecting a close relationship between motility and invasion (King 1988; Russell 1983). Little is known about the synthesis of these surface components or their integration into the parasite's cell membrane. Sporozoites of E. nieschulzi were excysted and incubated on glass slides in a moist chamber at 37~ using Dulbecco's modified Eagle's medium (DMEM; Gibco). After 5, 10 and 15 min, sporozoites were fixed in saturated formalin vapor and air-dried. An incubation with the monoclonal antibody (mcab) 3C3 (Tomavo et al. 1989) directly coupled to 5 nm colloidal gold was followed by silver enhancement using AuroProbe LM (Janssen Pharmaceutica, Beerse, Belgium). After 5-30 min, revelation slides were examined by light microscopy using bright-field and phase contrast (Zeiss, Photomikroskop II). Sporozoites that were allowed to glide on the glass slide for 5-15 rain left behind trails of 20-60gm in length and 0.3-0.5 gm in width (Figs. 1-4). Also, the surface of the sporozoites re-

Spin waves in paramagnetic Boltzmann gases

As the temperature is lowered we get an interesting temperature regionɛd≪T≪ħ2/mr02(whereɛd is the quantum degeneracy temperature,m the mass of a gas molecule,r0 the radius of interparticle interaction) in which the thermal de Broglie wavelength Λ of a particle is considerably greater than its sizer0 though Λ turns out to be less than the mean interparticle distanceN−1/3≫Λ≫r0. Although the gas molecules obey the classical Boltzmann-Maxwell statistics the system as a whole begins to exhibit a larger number of essentially quantum macroscopic collective features. One of the most interesting and dramatic features is the possibility of propagation of weakly damped spin oscillations in spin-polarized gases (external magnetic field, optical pumping). Such oscillations can propagate both in the low-frequencyθτ≪1 regime and the high frequencyθτ≫1. The last case is highly non-trivial for a Boltzmann gas with a short range interaction between particles. The weakness of relaxation damping of spin modes implies that the degree of polarization is high enough 1>/|α|≫|a|/Λ, whereα=(N+−N−)N,a is the two-particles-wave scattering length. Under these conditions the spectrum of magnons has the form (Bashkin 1981, 1984; Lhuillier and Laloe 1982) $$\omega = \Omega _H + \left( {{{K^2 \nu _{\rm T}^2 } \mathord{\left/ {\vphantom {{K^2 \nu _{\rm T}^2 } {\Omega _{int} }}} \right. \kern-\nulldelimiterspace} {\Omega _{int} }}} \right)\left( {{{1 - i} \mathord{\left/ {\vphantom {{1 - i} {\Omega _{int} }}} \right. \kern-\nulldelimiterspace} {\Omega _{int} }}\tau } \right), \Omega _{int} = {{ - 4\pi ahN\alpha } \mathord{\left/ {\vphantom {{ - 4\pi ahN\alpha } m}} \right. \kern-\nulldelimiterspace} m}, \nu _{\rm T}^2 = {T \mathord{\left/ {\vphantom {T m}} \right. \kern-\nulldelimiterspace} m}$$ (1) where ΩH is the Larmor precession frequency for spins in the magnetic fieldH. Collisionless Landau damping restricts the region of applicability of (1) with not too large wave vectorsKvT≪|Ωint|. The existence of collective spin waves has been experimentally confirmed in NMR-experiments with gaseous atomic hydrogen H↑ (Johnsonet al 1984). The presence of undamped spin oscillations means automatically the existence of long range correlations for transverse magnetization. Such correlations decrease with the distance according to the power law $$\delta _{ik} \left( r \right) = 2\left| a \right|\frac{{\left( {\beta N\alpha } \right)^2 }}{\gamma }\delta _{ik} $$ (2) . Hereβ is the molecule magnetic moment. Spin waves being even damped can nevertheless reveal themselves atT≳ħ2/mr02 or when |α|≲r0/Λ. The first experimental discovery or damped spin waves in gaseous3He↑ has been done in Nacheret al 1984. Oscillations of magnetization can also propagate in some condensed media such as liquid3He-4He solutions, semimagnetic semiconductors etc.

A reply to Heath et al. On assortative mating for educational level.

Heathet al. (Behav. Genet.15:349–369, 1985), using data from a Norwegian twin registry and selected British and American samples, contend that assortative mating for educational level has not declined over the past 35 years. This is in contrast to the findings of Johnsonet al. Behav. Genet.10:1–8, 1980), who reviewed the assortative mating literature, and Ahernet al. (Behav. Genet.13:95–98, 1983), who analyzed data from the Hawaii Family Study of Cognition (HFSC). These authors found a decline in assortative mating for both intelligence and education. Heath and coworkers' criticism of the reliability of HFSC measures is rebutted, then new analyses are presented to show that the decline in assortative mating for both itelligence and education can be detected in self-report data from HFSC parents of Japanese ancestry, although not for parents of Caucasian ancestry. Data from a large-scale survey of alcohol use in Hawaii also indicate a decline in assortative mating for education. The differences in secular changes in assortative mating for educational level in Norway and in Hawaii appear to be real, not artifacts of measurement.

Dust in Jupiter's magnetosphere: Time variations

The stability to temporal variations of the Jovian dust ring is a property which may soon be measured, and can in principle give a clue as to the origin of the ring. In this analysis fluctuations in the ring topology and intensity are determined over various relevant time scales, assuming the origin model proposed by Johnson etal. (1980) and Morfill etal. (1980a, b) to apply. It is concluded that the ring is a quasi-permanent and quasi-stable feature of the Jovian system.

Binding of 5-hydroxytryptamine to acidic lipids in an aqueous medium.

Abstract—The affinities of 5‐hydroxy‐[3H]tryptamine (5‐HT) for cerebroside sulfate, 1‐phosphatidylinositol, 1‐phosphatidylinositol 4‐phosphate, 1‐phosphatidylinositol 4,5‐bisphosphate, phosphatidic acid, and phosphatidyl serine were determined in an aqueous medium. They were observed to be, in general, much lower than and poorly correlated with the values previously reported by Johnsonet al (1977a), measured in isobutanol. This suggested that these lipids probably are not 5‐HT receptors and that drug affinities measured in organic media must be evaluated with caution.

Europe: What Next?, Europe: Out of the Impasse, Economics: Britain and the EEC, The Atlantic Commonwealth and Britain Faces Europe 1957–1967

Europe: What Next?, Europe: Out of the Impasse, Economics: Britain and the EEC, The Atlantic Commonwealth and Britain Faces Europe 1957–1967 Get access Europe: What Next? By Eric Deakins and Edmond Marshall. London: Fabian Society. 1969. 19 pp. (Fabian Tract, 389.) 3s.Europe: Out of the Impasse. By Norman Hart and Ernest Wistrich. London: Fabian Society. 1969. 20 pp. (Fabian Tract 398.) 3s.Economics: Britain and the EEC. By Harry G. Johnsonet al. London: Longmans. 1969. 111 pp. Index. 40s.The Atlantic Commonwealth. By George E. G. Catlin. Harmondsworth: Penguin Books. 1969. 116 pp. (Penguin Special S273.) UK 4s. 6d. A$0.80. NZ$0.70. S. Africa R0.55. C$0.95.Britain Faces Europe 1957–1967. By Robert L. PfaltzgraffPhiladelphia: University of Pennsylvania Press; London: Oxford University Press. 1969. 228 pp. Bibliog. Index. 58s. W. Horsfall Carter W. Horsfall Carter Search for other works by this author on: Oxford Academic Google Scholar International Affairs, Volume 46, Issue 4, October 1970, Pages 803–805, https://doi.org/10.2307/2614587 Published: 01 October 1970