Abusing intoxicating substances such as alcohol and drugs in the construction industry poses a serious threat to the safety of workers. It is a pervasive problem that often results in fatal accidents and other relevant risks. This paper aimed to investigate the impacts of substance abuse at job sites, the perception of industry professionals about the issue, and the current practices of the industry. The objective was to compare the perception of the industry to the findings of the background study conducted in this area. To achieve this goal, the authors conducted a survey to analyze (1) the difference in perception between onsite and administrative teams regarding the issue of onsite substance abuse, (2) comparing possibilities of occurrence of diverse impacts of substance abuse as per the industry perspective, and (3) effectiveness of the available mitigation practices according to industry professionals. The results show that (1) there is a significant difference in perception regarding the existence and the seriousness of the problem of substance abuse in the construction companies between the onsite and the administrative teams, (2) though fatal accidents are the worst possible impact, loss in productivity is considered as the most common impact, and (3) drug-testing is not considered as the best mitigation practice by construction professionals. It was concluded that there is a need for education on the seriousness of drug abuse as well as extensive research for developing more efficient mitigation systems.