BackgroundThe development of medical social work is an indispensable part of the Healthy China Strategy. However, the medical service field has the fewest social workers in all service fields in China. Creating favorable working conditions can reduce the turnover intention of social workers in the medical service field. So it is necessary to integrate the existing theoretical models to deeply analyze the multiple influencing paths of working conditions on the medical social workers’ turnover intention in the context of China.MethodsThe data we used came from the China Social Work Longitudinal Survey (CSWLS) conducted in 56 cities across the country in 2019. It adopted a multi-stage random sampling method and the sample of medical social workers was selected according to their current service field and the sample size finally entering the model was 382. We tested the relationships with the Structural Equation Model (SEM) by STATA 16.0.ResultsJob-related stress play the most significant role in explaining the formation mechanism of medical social workers’ turnover intention. On the one hand, job-related stress can reduce the job satisfaction of medical social workers, further increasing their turnover intention; on the other hand, job-related stress can increase job burnout of medical social workers, further reducing their job satisfaction and ultimately increasing the turnover intention. Job satisfaction plays a full mediating effect between the job burnout of medical social workers and their turnover intention. The social support and job autonomy provided by social work agencies have limited effects on decreasing the turnover intention of medical social workers.ConclusionsThe two paths of job-related stress affecting turnover intention successfully integrate the Job Demands-Resources Model and the Price-Mueller Turnover Model into the same theoretical framework providing a theoretical basis for reducing the turnover intention and behavior of social workers in the medical service field, improving the management level in the medical service system and promoting the overall healthy and sustainable development of medical social work in China.