The purpose of this study to examine and analyze the influence of organizational support and leader-member exchange (LMX) on work empowerment and its impact on improving organizational commitment Functional Medical Staff of Government General Hospital in Jakarta. The research was conducted using quantitative approach that forms the causal relationship between variables. There are 2 General Government Hospital and 2 Centre for Local Government General Hospital, Medical Staff by Functional analysis unit (SMF). The number of samples used in this study amounted to 92 SMF with census sampling technique. The data analysis techniques are used in this study are grouped into two, namely descriptive statistics analysis techniques and inferential statistical analysis techniques by using PLS (Partial Least Square). This study found that high support for the organization (Perceived Organizational Support) and leader-member exchange quality (Leader Member Exchange) is high, can provide an increase in job empowerment Functional Medical Professional Staff (SMF) General Hospital Central and Local Government in Jakarta which ultimately impact on increasing the organizational commitment. High perceived organizational support by SMF unable to increase organizational commitment directly. However, the application of SMF in a professional job empowerment was found to improve organizational commitment.