Jatropha Multifida Research Articles

The Efficacy Of Jatropha Multifida In The Management Of Oral Candidiasis: A Preliminary Study

Background: Oral candidiasis is presently a common problem affecting children in third world countries. This is probably due to the increasing prevalence of human immunodeficiency virus infections, poverty and malnutrition, which predisposes to candida infections. There are anecdotal reports suggesting the efficacy of the Nigerian grown species of Jatropha multifida herbs in the management of oral candidiasis. Aims of the study: To determine the efficacy of Jatropha multifida in the management of oral candidiasis and compare its efficacy with that of oral Nystatin. Subjects and Method: All the clinically detected cases of children with oral candidiasis at the children's outpatient department of the State Hospital, Osogbo and children's welfare clinic of the Wesley Guild Hospital, Ilesa were randomized into either Jatropha multifadum Juice extract therapy or the Nystatin group. The juice extracts from the Jatropha multifada leaves were applied to the tongue and the oral mucosal areas affected by candida lesions as a single application in the patients randomized to this group. Oral Nystatin was administered 4 times a day, for 7 consecutive days to the children randomized to the Nystatin group. Results: A total of 5 patients (3 boys and 2 girls) were studied with their ages ranging from 2 to 10 months. Clearance of the white lesions on the tongue was defined as cure and this was recorded within 24 hours in the patients on Jatropha multifada juice extracts, while those on oral Nystatin showed features of cure at 48 hours. Conclusion: Jatropha multifada is efficacious in the management of oral candidiasis. Compared to oral Nystatin suspension, it has the advantages of acting faster and being efficacious as a single dose. Its use in the management of oral candidiasis is recommended in third world countries where it is easily cultivated and accessible.

Antifungal activity of some Tanzanian plants used traditionally for the treatment of fungal infections

Using the ethnobotanical approach, some Tanzanian plants reported to be used by traditional healers for the treatment of oral candidiasis and fungal infections of the skin were collected and screened for their antifungal activity against Candida albicans, Candida glabrata, Candida tropicalis, Candida parapsilosis, Candida krusei and Cryptococcus neoformans. A total of 65 crude methanol extracts belonging to 56 plant species and 38 families were screened using the broth microdilution method, according to the guidelines of the Clinical and Laboratory Standard Institute (CLSI) (formerly, National Committee for Clinical and Laboratory Standards) [National Committee for Clinical Laboratory Standards, 2002. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. Approved Standard-2nd Edition M27-A2, National Committee for Clinical Laboratory Standards, Wayne, PA, USA]. Among the tested plant species, 45% (25 species) showed antifungal activity against one or more of the test fungi. The most susceptible yeasts were Cryptococcus neoformans, followed by Candida krusei, Candida tropicalis, and Candida parapsilosis. The least susceptible were Candida albicans and Candida glabrata. Strong antifungal activity was exhibited by extracts of Clausena anisata Oliv., Sclerocariya birrea Sond, Turraea holstii Gurk, Sterculia africana (Lour) Fiori, Acacia robusta subsp. Usambarensis (Taub) Brenan, Cyphosterma hildebrandti (Gilg), Desc, Elaeodendron buchannanii (Lows), Acacia nilotica (L.) Wild ex Del, Jatropha multifida L., and Pteridium aquilinum (L.) Kuhn .

Screening of 16 poisonous plants for antibacterial, anthelmintic and cytotoxic activity in vitro

Acetone extracts of the leaves of 16 plants known to have toxic effects when ingested by livestock were screened for biological activity, on the basis that toxic plants have proven pharmacological activity. The plants were tested for antibacterial effects against two Gram-negative ( Escherichia coli and Pseudomonas aeruginosa ) and two Gram-positive ( Enterococcus faecalis and Staphylococcus aureus ) bacteria. Anthelmintic activity against the free-living test nematode Caeno-rhabditis elegans was assessed. The potential cytotoxicity of the extracts was investigated using the brine shrimp lethality assay. Gossypium herbaceum, Lantana camara, L. rugosa, Thevetia peruviana and Sorghum bicolor inhibited the growth of all test bacteria with MIC values ranging from 0.39mg ml − 1 to 6.3mg ml − 1 . A few plants, namely Gossypium herbaceum, Hertia pallens, Jatropha multifida and Lantana rugosa , showed notable effects against the nematodes at a concentration of 1mg ml − 1 . Only Hertia pallens (LC 50 = 0.54mg ml − 1 ) and Lantana rugosa (LC 50 = 0.69mg ml − 1 ) exhibited cytotoxic activity as indicated by the brine shrimp assay. These results establish the limited applicability of the brine shrimp assay to determine the toxicity of plant extracts.

Antibacterial activity of Jatropha multifida roots

Hexane, ethyl acetate, chloroform and methanol successive extracts of Jatropha multifida yellow rootbark, red rootbark and rootwood effectively inhibited the growth of B. subtilis and S. aureus at concentration of 200 μg/disk.

Rare jatropha multifida intoxication in two children

Two children were admitted to the Emergency Department (ED) after ingesting a large amount of fruit of a plant identified as Jatropha multifida . They were mildly obtunded, had intractable vomiting, and seemed dehydrated. Intravenous fluid replacement and urine alkalinization were initiated. After stabilization, their 5-day hospital stays were uneventful except for a subclinical rise of liver enzymes. Jatropha species contain the toxalbumin ricin, which causes severe vomiting and diarrhea, dehydration, shock, and renal and hepatic impairment. Ricin also has cardiotoxic and hemolytic effects and several deaths have been documented. Children are attracted by the shape and the color of the Jatropha fruits. Mortality can be prevented by immediate fluid and electrolyte replacement.

Multifidin—A cyanoglucoside in the latex of Jatropha multifida

A novel non-cyanogenic cyanoglucoside, 1-cyano-3-β- d-glucopyranosyloxy-(Z)-1-methyl-1-propene, was isolated from the latex of Jatropha multifida. The compound was named multifidin.

Inhibitory activity of Jatropha multifida latex on classical complement pathway activity in human serum mediated by a calcium-binding proanthocyanidin

This study isolates and characterizes the anti-complement constituent(s) present in the latex of Jatropka multifida, in an attempt to explain the traditional application of the latex in the treatment of infected wounds. Guided by the inhibition of classical pathway (CP) complement activity in human serum, a polymer was isolated which could be characterized as a proanthocyanidin. The polymer inhibits CP activation of the complement cascade, while alternative pathway (AP) activation is relatively insensitive to the polymer. This is due to the selective depletion of Ca 2+, but not Mg 2+, from the incubation medium.

Labaditin, a novel cyclic decapeptide from the latex of Jatropha multifida L. (Euphorbiaceae) : Isolation and sequence determination by means of two-dimensional NMR

An immunologically active novel cyclic decapeptide, consisting of 1 Ala, 2 Gly, 1 Ile, 2 Thr, 2 Trp and 2 Val, has been isolated from the latex of Jatropha multifida L. (Euphorbiaceae). The structure was elucidated by means of amino acid analysis and FAB-mass spectroscopy. The amino acid sequence was obtained by two-dimensional 1H-NMR spectroscopy (COSY and NOESY). Latex; Decapeptide, cyclic; Labaditin; NMR, 1H-; Peptide isolation; ( Jatropha multifida, Euphorbiaceae)

An ethnopharmacognostic approach to the search for immunomodulators of plant origin.

The search for immunomodulating plant constituents through basic and field inquiries into the literature and practices of traditional Indian medicine is treated. The strategy of data collecting proceeds through aspects of an ethnobotanical, an ethnopharmaceutical, an ethnopharmacological, and an ethnomedical nature. In the experimental immunopharmacognostic phase, immunomodulatory compounds are isolated and purified through action-guided fractionation procedures. The results described here refer to activities found on human complement activation and on PMN leucocytes activation. The immunomodulating plant compounds included in this report were isolated from Azadirachta indica bark, Woodfordia fructicosa flowers, Picrorhiza kurroa roots, and Jatropha multifida latex.

Isolation and Structure Elucidation of a New Phloroglucinol Dervative and its Glucoside from the Latex ofJatropha multifida

Isolation and Structure Elucidation of a New Phloroglucinol Dervative and its Glucoside from the Latex of<i>Jatropha multifida</i>

Multifidol and multifidol glucoside from the latex of Jatropha multifida

Two naturally occurring and immunologically active acylphloroglucinols (named multifidol and multifidol glucoside have been isolated from the latex of Jatropha multifida and identified as (2-methylbutyryl)phloroglucinol and 1-[(2-methylbutyryl)phloroglucinyll-β- d-glucopyranoside.

A strain of cassava latent virus occurring in coastal districts of Kenya

SUMMARYA strain of cassava latent geminivirus (CLV) was isolated from mosaic‐affected cassava plants from coastal districts of Kenya. This virus (CLV‐C) did not infect Nicotiana clevelandii, a diagnostic host of the type strain (CLV‐T); experimental host range was very restricted and CLV‐C only infected N. benthamiana and N. rustica out of several solanaceous hosts readily infected by CLV‐T.CLV‐C was also isolated from naturally infected Jatropha multifida (Euphorbiaceae) and Hewittia sublobata (Convolvulaceae).CLV‐C was propagated in N. benthamiana with difficulty and only those isolates derived from cassava plants infected with severe mosaic symptoms were maintained more or less successfully; these sources usually contained a higher concentration of CLV than plants with mild symptoms. Symptom variants generally remained unchanged when grafted into a highly susceptible South American cassava variety.CLV‐C and CLV‐T seemed to occur respectively only in coastal and western districts but their ranges overlapped in central Kenya where they could have been introduced in infected material.CLV‐C could be purified satisfactorily with the method used for CLV‐T but only after modifying the procedure by substituting phosphate for borate in the extraction buffer, n‐butanol for n‐butanol/chloroform in clarification of extracts, and phosphate for borate buffer when resuspending concentrated virus.A virus serologically indistinguishable from CLV‐T was isolated from mosaic‐ affected material obtained from Nigeria; East African and Nigerian isolates were essentially similar in host range and symptomatology. In gel‐diffusion serology tests, pronounced precipitation spurs developed between CLV‐T and CLV‐C indicating that the isolates were related but not identical serologically.Symptoms typical of cassava mosaic disease appeared in only three of 105 plants in experiments on transmission of CLV‐C and CLV‐T by whiteflies, when attempted acquisition of either clarified CLV‐infective sap or purified CLV was made through ‘Parafilm’ membranes. Because it is possible that the three infections resulted from contamination, they cannot constitute proof of transmission. The presence of CLV in relation to the etiology of cassava mosaic thus remains unresolved.

ISOLASI DAN SELEKSI CENDAWAN ENDOFIT DARI TANAMAN BETADIN (Jatropha multifida L.) DAN POTENSINYA SEBAGAI ANTIMIKROBA

This research aimed to isolate and select endophytic fungi that potentially as antimicrobial from betadin plants (Jatropha multifida L.). Isolation of endophytic fungi was carried out using surface sterilization and selection of endophytic fungi using well diffusion method. A total of 13 isolates of endophytic fungi were obtained from J. multifida L. From a total of 13 isolates, 11 isolates were able to inhibit the growth of Candida albicans, 11 isolate was able to inhibit the growth of Staphylococcus aureus and 10 isolates were able to inhibit the growth of Escherichia coli.

The Seedlings of Jatropha multifida L. and Persea gratissima Gärtn

Previous articleNext article FreeBriefer ArticlesThe Seedlings of Jatropha multifida L. and Persea gratissima GärtnTheo. HolmTheo. Holm Search for more articles by this author PDFPDF PLUS Add to favoritesDownload CitationTrack CitationsPermissionsReprints Share onFacebookTwitterLinkedInRedditEmail SectionsMoreDetailsFiguresReferencesCited by Volume 28, Number 1Jul., 1899 Article DOIhttps://doi.org/10.1086/327870 Views: 79Total views on this site Journal History This article was published in the Botanical Gazette (1876-1991), which is continued by International Journal of Plant Sciences (1992-present). PDF download Crossref reports no articles citing this article.