Spatial mobility constraints such as, safe place and space, safe time, safe distance, safe travel and legitimate size/location of the business are pervasive in the lives of women entrepreneurs yet understudied in the literature. We therefore ask the questions: How do gendered spaces constrain (or enable) women entrepreneurs in initiating or expanding their venture? How are these spatial constraints negotiated by women entrepreneurs? Using an intersectional spatial approach to women entrepreneurship and based on interviews with women entrepreneurs in India, we show the enactment of spaces via spatial mobility constraints and the enactment on spaces through forms of spatial mobility work such as safety work, temporal work, body work and perceptual work in women entrepreneurship. The study contributes to the women entrepreneurship literature by first, introducing a novel intersectional spatial approach to women entrepreneurship through the concepts of spatial mobility constraints and spatial mobility work, remaining sensitive to the class-based differences. Second, the study contributes by presenting the everyday lived experiences of women entrepreneurs from the context of the Global South, specifically India, thereby, de-centring the ‘first world’ issues and assumptions in the women entrepreneurship literature to highlight the relevant local issues in women entrepreneurship in India.