In 2008 BSCS will celebrate 50 years of leadership in science education. During our history BSCS has endeavored to improve all students' understanding of science and technology by developing curriculum materials, providing professional development, and conducting research studies. In general, these activities have been, and continue to be, central to the BSCS mission. So, we begin our celebration. This editorial is the first of several this year and next. NABT has been very generous in opening the pages of The American Biology Teacher to BSCS. This gesture exemplifies the cooperation between the two organizations. Here I express my gratitude and appreciation tot the long, productive, and collaborative association BSCS has had with NABT. An anniversary, and certainly a 50th, affords an opportunity for reflection. In this editorial I offer some reflections on the history of BSCS, as some of the observations get to the heart of larger issues in science education. I conclude the essay with a contemporary perspective. Beginning at a Board of Directors meeting and the Nobel Laureate geneticist H. J. Muller pounding on a table and asserting that 100 years without Darwin is enough, BSCS has steadfastly defended biological evolution as a central idea of biology and integral to our programs. In recent years I have expressed this theme with the broader idea that BSCS programs must maintain the integrity of science by including evolution and enhancing students' and teachers' understanding of the nature of science. Biological evolution will continue to be central to our programs. Closely related to maintaining the integrity of science, BSCS has continually advocated teaching science as inquiry. During these 50 years the form and function of inquiry in our programs has expanded from emphasis on laboratories designed to help students understand biological concepts, to activities that facilitate the development of cognitive abilities associated with inquiry, e.g., reasoning and critical thinking. BSCS continues to develop programs and provide professional development that emphasizes a narrative of inquiry versus rhetoric of conclusion, as Joe Schwab once characterized BSCS programs versus that of other textbooks. BSCS represents innovation in science education. Being innovative presents any organization with continual intellectual and economic challenges. One must identify the appropriate balance between maintaining the old and advancing the new. The 50 years would indicate stability, most, but not all, of the time. For those associated with BSCS, innovation comes in the form of science content, curricular design, and the professional development of science education leaders. Mostly known for curricular materials and professional development, BSCS as an organization contributes to science education through products and services that address contemporary societal needs, incorporate advances in science, and include the latest research on student learning. Some contributions of BSCS are clear and direct; for instance, we produce programs such as BSCS Science: An Inquiry Approach. Other contributions are less clear, but important nonetheless; for example, BSCS staff advises on international, national, state, and district policies, produce publications in journals and books, and deliver presentations on new content and pedagogy at professional meetings, such as NABT. I am confident and proud to state that BSCS has made a difference in science education. There is one innovation that has been more successful than I ever could have imagined. That is the BSCS 5E Instructional Model. We originally developed this instructional model in the late 1980s and included it in most programs since that time. However, the dissemination and success of the model far exceeds the adoption of BSCS programs or implementation in professional development institutes. The BSCS 5E Instructional Model is known internationally, is now included in state frameworks for science AND other disciplines, adapted by other science programs, and widely used in classroom practices. …