The purpose of the paper is to present an approach to detect, isolate, and accommodate the aircraft sensor and actuator faults using unknown input observers (UIOs). Full-order observers, reduced-order observers, and UIOs are widely used in state estimations. After the estimation of states, fault detection can be provided by conducting residual analysis. Despite of the existence of unknown inputs, fault detection and isolation are implemented for a very large, four-engined, cargo jet aircraft model. Sensor accommodation is realized via switching under redundant sensor existence assumption. Actuator accommodation is provided by gain scheduling. Hence, if a fault occurs in an actuator corresponding to the control surfaces, the remainder (n−1) actuators are used to avoid hazardous flight. Sensor and actuator faults are detected by using residuals. Sensor faults are effective on the outputs, while actuator faults are effective on the state equations. Fault isolation is implemented by taking into account that each residual is sensitive to all of the other faults but one fault. Fault detection, isolation, and a recommended accommodation are shown through the simulations to be functional.