Catastrophic tsunami events like those occurred in Papua New Guinea in 1998, Sumatra in 2004 and Japan in 2011, attracted the attention of the scientific community and promoted the development of different tools for assessing tsunami hazard. A preliminary step towards this goal is the knowledge of the events which might affect a specific coastal zone. In this context, we propose a method to identify the tsunami events possibly occurring in areas characterized by scarce data and a non-conservative environment. Accordingly, we propose different indices to summarize the knowledge on tsunami triggering mechanisms (earthquakes, landslides, volcanic eruptions), the characteristics of those mechanisms (magnitude of earthquakes, volume of landslide, Volcanic Explosivity Index) and tsunami features (water height, run-up, wave amplitude, propagation time). This knowledge, considered over a wider area than that of interest, allows for a paramount vision of possible hazardous events that could affect a particular coastal zone. Moreover, the tsunami simulation data and the analysis of potentially tsunamigenic slides which occurred on the Campania continental margins were also considered in the analysis. We focused our attention on Napoli megacity, because the high population density (about 1 million of people live on a territory of 117 km2), together with the presence of active volcanic areas (Ischia, Somma-Vesuvio and Campi Flegrei), make this city potentially exposed to tsunami risk. The main outcome of such an approach shows that in the near field a tsunami amplitude varying from a few centimetres (30–40 cm) to some metres (1–4 m) might be expected at the coastline if the tsunami event was triggered by volcanic activity, whereas no relevant tsunami event should be expected given the peculiar seismicity of the Neapolitan volcanic areas, with earthquakes rarely exceeding 4 Mw, if any possible cascade effects are overlooked. A morphometric analysis of high-resolution bathymetry collected between Ventotene Island and the Gulf of Salerno has shown that the submarine southern sectors of the Ischia Island and the Sorrento Peninsula are characterized by a high density of landslide scars, being thus a potential source area of landslide-generated tsunamis. However, despite the susceptibility of these areas to recurrent slope failures, only four submarine landslide scars were found to be potentially tsunamigenic with estimated tsunami amplitude of few metres at the coastline as predicted by coupling slide morphometry with tsunami amplitude equations. Concerning the tsunamis generated by earthquakes in the Western Mediterranean, only those triggered by high magnitude events (value ≥ 6–7 Mw) might affect the city of Napoli with an amplitude not exceeding 0.5 m, in about 30′.