The response of a very large floating structure (VLFS) must take into consideration the elastic deformation of the structure (commonly termed hydroelastic response) under wave action. Conventionally, the hydroelastic response could be computed by using the coupled finite element-boundary element (FE-BE) method, where the mat-like structure is modelled using plate theory and the water modelled using the potential theory. The FE-BE method requires the structure to be discretised into finer elements and the wetted surface boundary to be represented by smaller panels to accurately capture the hydroelastic response of the structure. Thus, the coupled FE-BE method could be computationally expensive when the structure gets larger or when subjected to waves of smaller wavelengths. To accelerate the computational time in predicting the hydroelastic response of the VLFS, a surrogate model trained using the feed-forward neural network is proposed. The hydroelastic responses under different wavelengths, structural stiffnesses and wave directions are first generated where these data are split into three groups for training, validation, and testing (prediction) purposes. The accuracy of the prediction in terms of correlation coefficient R is compared for the different train datasets, the number of neurons and hidden layers as well as the optimisation techniques. The finding shows that an accuracy of close to 99% to the ground truth could be achieved with only 80% of the train dataset. The hydroelastic response under irregular wave conditions predicted using the feed-forward neural network framework is also presented.