Background: World Health Organization (WHO) estimates that more than half of all drugs in the world are prescribed, dispensed and sold in an inappropriate manner and half of patients use drugs inappropriately, thus enabling irrational drug use. If the drug is used irrationally, it can have a negative impact. The purpose of this study was to evaluate the rationality of drug use at the Paal Lima Public Health Center for the period January - March 2023 based on the National Rational Drug Use (POR) indicator.
 Method: This study used an observational method with retrospective data collection, namely prescription data for non-pneumonic acute respiratory infections (ARI), non-specific diarrhea, and myalgia during the period January - March 2023. The data were analyzed descriptively by calculating the use of antibiotics, injections, and the average drug items which were then displayed in percentage form. There were 509 prescriptions for non-pneumonic acute respiratory infections (ARI) cases, 74 prescriptions for non-specific diarrhea cases, and 120 prescriptions for myalgia cases.
 Result: The results of the study showed that for the period January - March 2023 it was found that the use of antibiotics in cases of non-pneumonic acute respiratory infections (ARI) was 19.65%, the use of antibiotics in cases of non-specific diarrhea was 35.14%, the use of injections in cases of myalgia was 0%, and the average number of drug items per prescriptions of 3.68 items.
 Conclusion: Overall, the rationality of drug use at the Paal Lima Public Health Center has not met the requirements, so it needs to be improved.
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