Prevalence Of Iron Deficiency Anemia Research Articles

What Makes Bangladeshi Pregnant Women More Compliant to Iron-Folic Acid Supplementation: A Nationally Representative Cross-Sectional Survey Result.

Iron-Folic Acid Supplementation (IFAS) is an effective strategy to prevent iron deficiency anemia during pregnancy. We aimed to explore the key factors associated with compliance to IFA tablets in Bangladesh. This study analyzed the 2017-2018 Bangladesh Demographic and Health Survey data of 3828 pregnant women aged 15-49 years. We categorized compliance into two categories; at least 90 days and full 180 days of consumption. We performed multivariable logistic regression to identify the association between key factors and IFAS compliance. The prevalence of consumption of IFA tablets for at least 90 days was 60.64%, and only 21.72% of women consumed the IFA for the full 180 days. About three-quarters of the women (73.36%) having at least four antenatal care visits (ANC) consumed IFA for at least 90 days, whereas only three in ten women (30.37%) consumed IFA for a minimum of 180 days. For compliance with IFA for at least 90 days, respondent's age of 20-34 years (aOR 1.26, 95% CI 1.03-1.54), respondent's educational qualification of secondary (aOR 1.77, 95% CI 1.16-2.70) or higher (aOR 2.73, 95% CI 1.65-4.53), husband's educational qualification of secondary (aOR 1.33, 95% CI 1.00-1.77) or higher (aOR 1.75, 95% CI 1.22-2.52), and having received at least four antenatal care (ANC) visits from medically skilled providers (aOR 2.53, 95% CI 2.14-3.00) were significantly associated with higher odds of compliance. For compliance with IFA for at least 180 days, respondent's educational qualification of higher (aOR 2.45, 95% CI 1.34-4.48), and having received at least four ANC visits from medically skilled providers (aOR 2.43, 95% CI 1.97-3.00) were significantly associated with higher odds of compliance. Intimate partner violence was negatively associated with compliance with IFA for at least 180 days (aOR 0.62, 95% CI 0.48-0.81). The full compliance to IFAS is still sub-optimal in Bangladesh. Further precise context-specific intervention strategies must be developed and implemented with fidelity.

The relationship between iron deficiency anemia with restless leg syndrome and sleep quality in workers working in a textile factory in Iran: a cross-sectional study

BackgroundThe aim of this study is to investigate the relationship between iron deficiency anemia with restless leg syndrome (RLS) and sleep quality in workers working in a textile factory in Iran. This cross-sectional study was conducted on 216 workers working in a textile factory in Iran. In addition to demographic and occupational variables, Pittsburgh Sleep Quality Index (PSQI) and RLS questionnaires were used for the data collection. To investigate iron deficiency anemia, 2 CC of blood was taken from the brachial artery with the help of a 10-CC syringe with a blue or pink tip. Then, relevant data were entered into SPSS26 and analyzed.ResultsThe mean (S. D.) age of the workers was 32.23 (6.14) and 60.6% of them were women. The prevalence of iron deficiency anemia was 21.2 and 69.5% in men and women, respectively. Most of the workers were in moderate condition in terms of RLS severity, and 78.2% had sleep disorders. There was an inverse and significant correlation between age (β= −0.200), work experience (β= −0.160), hemoglobin (β= −0.149), and ferritin (β= −0.186) with global PSQI score (P value<0.05). Also, an inverse and significant correlation was observed between age (β= −0.164), hemoglobin (β= −0.548), and ferritin (β= −0.410) with RLS score (P value<0.05). However, there was a direct and significant correlation between TIBC level and RLS score (β= 0.227) and global PSQI score (β= 0.395) (P value<0.05).ConclusionsIntervention programs to reduce iron deficiency anemia and periodic screening programs to identify sleep disorders and RLS in textile factory workers seem necessary.

Prevalence and predictors of iron deficiency anemia among pregnant women in Bolosso Bomibe district, Wolaita Zone, Southern Ethiopia Community-based cross-sectional study

: Iron-deficiency anemia is defined as anemia, a condition in which there less than the normal hemoglobin (Hb) accompanied by an indication of iron deficiency. Nearly half of all pregnant women worldwide suffer from anemia, and iron deficiency accounts for about half the world’s anemia burden. Most of the studies conducted on iron-deficiency anemia during pregnancy were conducted at the institution level and associated factors are not well studied and documented. Hence, the aim of this study is to determine the prevalence of iron-deficiency anemia and associated factors among pregnant women in Bolosso Bomibe District, Southern Ethiopia, 2019. Community-based cross-sectional quantitative study was conducted from April to June 2019. Multistage sampling was used to include 270 study participants in 6 kebeles. The structured and pretested questionnaire, middle upper arm circumference (MUAC), Hb, serum ferritin, and C-reactive protein were used as a tool to collect data. The data was compiled and entered to EpiData version 3.1 and exported to Statistical Package for Social Sciences (SPSS) version 23.00 packages for analysis. Univariate, bivariate, and multivariable logistic regression with odds ratio along with the 95% confidence intervals (CI) was computed and interpreted. p value < 0.05 was declared as statistically significant. The prevalence of iron-deficiency anemia was 11.3% (95% CI: 8.9–15.7). Factors associated with iron-deficiency anemia were ANC follow-up for the recent pregnancy (adjusted odds ratio [AOR] = 3, 95% CI: 1.15−8.9, and years b/n successive pregnancy (AOR = 4,95% CI: 1.2–12.4). Prevalence of iron-deficiency anemia was low, which is a mild public health concern among pregnant women in Bolosso Bombe District. The factors associated with iron-deficiency anemia in this study population were MUAC, ANC follow-up, birth spacing among successive pregnancy, and duration of menstrual bleeding. Thus, there should be the integration of concerned stakeholders for implementation of different interventions to solve these problems.

Development and testing of a nutrition education tool on iron supplementation for pregnant women

Background: Although iron supplementation may prevent iron deficiency anaemia (IDA) during pregnancy, a nutrition education tool highlighting the importance of iron supplementation during pregnancy is also important. Objectives: The aim was to develop and test a nutrition education tool on iron supplementation for pregnant women. Design: A cross-sectional study was conducted. Setting: Mutare City Clinic, Manicaland province, Zimbabwe. Subjects: Sixty-seven pregnant women in their second or third trimesters of pregnancy and attending Mutare City Clinic for antenatal care (ANC) participated in the study. Outcome measures: The preferences of pregnant women regarding form, structure and content of the nutrition education tool were established using eight focus-group discussions (FGDs) in which 67 pregnant women participated. Three additional FGDs were conducted with another 28 pregnant women to assess the user-friendliness and acceptability of the developed tool. Results: A pamphlet was the most preferred tool, with English being the most preferred language, along with some Shona phrases. Women wanted information on IDA, dosage, duration and side-effects of iron supplementation and iron food sources to be included in the pamphlet. The participants identified clinics, pharmacies and churches as ideal sites for dissemination of the tool. Conclusions: A pamphlet on iron supplementation in simple English with some Shona phrases was the nutrition education tool most preferred by the pregnant women. Offering the pamphlet together with iron supplements to pregnant women could improve compliance with iron supplements. However, follow-up ANC consultations are important for effective implementation of all key messages in the pamphlet.

Iron Deficiency Anemia among Alaska Natives May Be Due to Fecal Loss Rather than Inadequate Intake

To define more fully the nature of a persistently high prevalence of iron deficiency anemia observed among Alaska Native children, we examined dietary iron intake, hemoglobin concentrations, and storage iron (serum ferritin) based on multiple cross-sectional surveys of Alaska Natives between 1983 and 1989. Approximately 30 to 50% of the children studied <12 y of age had depleted iron stores. Anemia and depleted iron stores also were prevalent among adult men and women, about twice as prevalent as in the U.S. population based on the Second National Health and Nutrition Examination Survey (NHANES II). The higher rate of iron deficiency, occurring even when the dietary assessment found Alaska Native iron intake to be higher than the U.S. average with an ample intake of food high in bioavailable iron, suggests blood loss as a possible cause of the unusual pattern of iron deficiency observed. In a pilot study of stool blood loss in two villages, 65% of the samples had a significantly elevated stool heme concentration. Further investigation of iron deficiency due to gastrointestinal blood loss for the Alaska Native is warranted.

Prevalence of iron deficiency anemia in hospitalized infants

Iron is vital, as it is essential for many metabolic processes, including oxygen transport, electron transport, DNA synthesis and repair. Iron balance in the body is regulated carefully so that iron losses are compensated by sufficient iron absorption. Iron deficiency is a common cause of anemia and is typically due to insufficient intake, poor absorption or overt or occult blood loss. The World Health Organization has recognized iron deficiency anemia as the most common nutritional deficiency in the world with 30% of the population being affected. This study was conducted to estimate the prevalence of iron deficiency anemia in 152 hospitalized infants between 1-12 months old. Iron deficiency anemia resulted highly prevalent in this age group, 45% of infants had Hemoglobin level &lt;10g/dl. Despite nutrition, there are other social-economic factors that play a role in the high prevalence of iron deficiency anemia in infants. Conclusively it is stated that, as iron deficiency impairs neurologic development and growth in infants, an adequate clinical attention and evaluation should be directed towards it. Routine screening starting at 9 to 12 months is recommended to help preventing the development of anemia. It is also important adequate weaning and early introduction of iron-rich foods, 4-6 months of age.

Prevalence of iron deficiency anemia in hospitalized infants

Prevalence of iron deficiency anemia in hospitalized infants

The effect of iron tablets' side effects on the level of compliance to consuming iron tablets in pregnant woman: A systematic review

Iron tablet is one of the methods of preventing iron deficiency anemia during pregnancy. The consequences of ingestion include nausea, vomiting, constipation, diarrhea, epigastric pain, and dark stools. Pregnant women do not continue iron supplementation due to considering the negative effects. This behavior of not continuing to take the iron pills decreases the compliance of pregnant women to iron supplementation. This systematic literature review aims to assess the effect of iron tablets' side effects on the level of compliance to consuming iron tablets in pregnant woman. Four major electronic databases were used to explore a literature search: PubMed, Scopus, ScienceDirect, and Web of Science. There are fifteen eligible studies that fulfil the inclusion criteria. The PRISMA methodology was used to evaluate articles critically. EPHPP's technique for evaluating the quality of quantitative research was used to evaluate the quality of the kinds of literature (Effective Public Health Practice Project). Systematically, the findings are analyzed and summarized. Two main themes are used to classify the findings. Non-compliance and perceived risk to pregnancy can occur as a result of the first ANC visit at more than 16 weeks and less than 4 ANC visits during pregnancy. This is due to the lack of exposure to information and education from health professionals about iron tablets, the advantages of iron tablets, the side effects of iron tablets, and foods and beverages that could inhibit or accelerate the absorption of iron tablets.

Iron Deficiency and Anemia in Male and Female Adolescent Athletes Who Engage in Ball Games.

The aim of this study was to assess the prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) among male adolescent athletes who participate in non-calorie-restricting sports, and to compare the results with female athletes of the same age and sports. Data of the hemoglobin concentration (Hb) and serum ferritin (sFer) levels of male (n = 350) and female (n = 126) basketball and football players, aged 11-18, from two sport medicine centers in Israel were gathered and analyzed. Mild ID was defined as sFer ≤ 30 µg/L, moderate as sFer ≤ 20 µg/L, and severe as sFer ≤ 10 µg/L. IDA was defined as sFer ≤ 20 µg/L and Hb < 13 g/dL for males and sFer ≤ 20 µg/L and Hb < 12 g/dL for females. The prevalence of mild ID was 41.1% and 53.2%, moderate was 17.4% and 27.8%, and severe was 2% and 4.8% in males and females, respectively. The prevalence of IDA was 2.6% in males and 4% in females. Mild and moderate ID was significantly higher among females. In conclusion, non-anemic ID, which is known to be common among female athletes, especially in sports requiring leanness, is also highly prevalent among adolescent males playing ball games. Therefore, screening for hemoglobin and sFer is recommended for young athletes of both genders and in all sports.

Prevalence of Iron Deficiency Anemia Indicated for Intravenous Iron Treatment in the Korean Population.

We aimed to investigate the number and prevalence of patients indicated for intravenous iron treatment in a large Korean population using criteria based on laboratory test results in an effort to extract indirect information on the need for intravenous iron treatment. Between 1 January 2019 and 31 December 2021, a total of 83,994 Korean patients (30,499 men and 53,495 women) with a median age of 46 years (interquartile range, 30-61) were evaluated using iron deficiency anemia-associated laboratory tests and serum creatinine tests of estimated glomerular filtration rates. The overall prevalence of anemia (Hb ≤ 11 g/dL) was 16.5%, and the proportion of patients with possible chronic kidney disease who had an estimated glomerular filtration rate < 60 mL/min/1.73 m2 was 11.4%. The number of patients indicated for reimbursable intravenous iron treatment was higher in women than in men, higher in older patients, and higher in 2021 than in 2019 (all p < 0.001). The prevalence of patients indicated for reimbursable intravenous iron treatment was up to 30.0% in those ≥ 80 years of age in 2019. The results of this study provide basic knowledge about the use of iron deficiency anemia-associated laboratory tests in planning nutritional support programs using an intravenous iron formulation in Korea.

PENGARUH PENYULUHAN TERHADAP PENGETAHUAN DAN SIKAP MENGONSUMSI TABLET TAMBAH DARAH

Iron supplementation tablets (TTD) are dietary supplements containing iron that can be given to adolescent girls to prevent iron deficiency anemia (ADB). Although the administration of TTD in adolescent girls has been implemented, the lack of knowledge and unsupportive attitude toward consuming TTD in adolescent girls can reduce the effectiveness on preventing ADB. This study aims to determine the effect of health education on knowledge and attitude of consuming TTD, a review of adolescent girls at SMP Negeri 25 Banjarmasin. Quasi-experimental research method with one-group pretest-posttest design. The research subjects were 30 people with random sampling technique. Data collection techniques using knowledge and attitude questionnaires. The analysis using the Wilcoxon Signed Ranks test showed that there was a significant difference between knowledge (p=0.00) and attitude (p=0.019) before and after health education for adolescent girls. In conclusion, health education can increase the knowledge and attitude of consuming TTD in adolescent girls

Математическое прогнозирование рисков железодефицитных состояний у женщин

Purpose. Based on the study of medico-social, medico-biological and psychological factors, to assess the risks of iron deficiency in women. The results obtained will be used to develop a relevant program for the prevention of iron deficiency anemia and latent iron deficiency in primary health care. Materials and methods. The medical and social study was conducted on the basis of the city polyclinics of Kazan, the samples included two groups of women: 394 patients with laboratory-confirmed iron deficiency, including its clinical manifestations, and 373 women with a confirmed absence of iron deficiency and without probable complaints. The following methods were used in the study: bibliographic, socio-hygienic, psychological testing, sociological, information-analytical, mathematical-statistical, organizational experiment. Results. New data have been established on the factors affecting the volume of tissue iron stores in women: statistically significant associations of serum ferritin with sleep quality parameters and carbohydrate intake. The risks of iron deficiency anemia and latent iron deficiency were assessed, and subranges for individual risk groups were calculated. Findings. Statistically significant associations were found in the ferritin-total protein model with late bedtime (p &lt;0,001), discrete sleep patterns (p &lt;0,001), situational anxiety (p &lt;0,001), and daily sugar intake (p = 0,021). According to mathematical forecasting, the greatest influence on the development of IDA in women is “going to bed” (R=2,1). Women who go to bed after midnight and from 23.00 to midnight are at risk of iron deficiency anemia, the risk of which is 2 times higher than in women who fall asleep before 23.00. The probability of latent iron deficiency in women with a high level of personal and situational anxiety is 28–29 times higher than in women with a low level of anxiety (R=29,254 and R=28, respectively).

Comparison of efficacy of needle-free injection versus injection by needle for iron supplementation of piglets: a double blind randomized controlled trial

BackgroundIn pig husbandry, most piglets receive an intramuscular injection with iron around three days of age for the prevention of hypochromic, microcytic anaemia. In recent years an increased interest is noted for needle-free injections, because of efficiency and safety for man and animal. This study aims to support the evidence on efficacy to extent the registration of a commercial iron supplement with a needle-free administration application. To this aim the study has two objectives: 1) to determine the effect of needle-free injection of the iron supplement on the mean blood Haemoglobin level at weaning, as primary outcome, and mean Haematocrit and mean Body weight of pigs at weaning as secondary outcome compared to no treatment, as main determinant of iron deficiency anaemia in piglets at time of weaning; 2) to compare the effects of needle-free administration of the iron supplement with regular injection by needle, with regard to the course over time of Haemoglobin, Haematocrit, piglet growth and the differentiated haematological and serum iron parameters.MethodsA double blind randomized controlled trial was conducted with 72 piglets, 8 piglets per litter from 9 litters. At three days of age pigs were selected, based on body weight, and random allocated to three study groups: a) control non-treated group (2 pigs per litter, 18 in total), b) a group with regular iron injection by needle injection (3 pigs per litter, 27 in total), c) a group that received iron by needle-free injection (3 pigs per litter, 27 in total). At four points in time (day 3, 14, 26 and 40) piglets were weighed and bled to analyse the dynamics of red blood counts and haematological parameters as well as serum iron parameters. The primary outcome parameter was the Haemoglobin (Hb) level on day 26. Of secondary importance were Haematocrit (Ht) and body weight (BW) at weaning and parameters with tertiary importance were the course of Hb, Ht and differentiated red blood cell parameters, serum iron, iron binding capacity and iron saturation. In the statistical analyses, linear mixed effect regression modelling was used to account for repeated measures within litters and pigs.ResultsThe analyses showed that needle-free administration was as efficacious to prevent iron deficiency anaemia at day 26 as administration using regular needle injection, compared to the control group. The mean level of Hb and Ht of pigs in the needle and needle-free group did not differ significantly. No side effects were observed.ConclusionIt is concluded that needle-free iron administration of the tested product is as efficacious as regular administration by needle injection.

Iron status and burden of anemia in children with recessive dystrophic epidermolysis bullosa.

To describe the prevalence, severity, and management of anemia in a cohort of children with recessive dystrophic epidermolysis bullosa (RDEB) and to highlight the use of soluble transferrin receptor (sTfR) to diagnose iron deficiency in this chronic inflammatory state. We studied a cohort of 114 patients with RDEB followed at a pediatric hospital-based Epidermolysis Bullosa Center from 2010 to 2020; data were prospectively tracked in a comprehensive clinical database that captured all visits, laboratory tests, iron infusions, and transfusions. The primary outcome was occurrence of anemia, which was assessed by age and sex, with and without transfusion support. Secondary outcomes included iron status using a combination of ferritin and sTfR levels, the cumulative incidence of parenteral iron therapy and transfusions, and survival. In RDEB, anemia begins in the first year of life and becomes more frequent and severe with age. The prevalence of iron deficiency anemia (IDA) estimated by ferritin was 33.6% (37/110), but the sTfR/log10 -ferritin ratio indicated a 1.5-fold higher true prevalence of IDA of 50.6% (41/81). 53.5% (61/114) received parenteral iron infusions, transfusions, or both. Higher ferritin was associated with earlier mortality. Individuals with RDEB have a high burden of anemia (IDA and anemia of inflammation) that requires frequent medical interventions. The sTfR/log10 -ferritin ratio improves the detection of iron deficiency in the context of inflammation and guides therapy.

Relationship between Iron Deficiency Anaemia and Intestinal Helminthiasis among School Age Children in Abakaliki Metropolis

Background: In a world plagued by poverty, ignorance, malnutrition and disease especially in developing countries, children are particularly vulnerable to anaemia. A 2015 report by the WHO reveals that iron deficiency is a major cause of anaemia accounting for about 50% of cases worldwide. The importance of iron in growing children cannot be overemphasised especially with regards to neurologic and cognitive development. Iron deficiency has a negative impact on childhood growth and development. It also affects neuronal energy metabolism, the metabolism of neurotransmitters, myelination, and memory function. These undesirable consequences can be irreversible; thus, early detection through periodic screening exercise will enable prompt intervention. Aims: This community-based cross-sectional study aimed at assessing the prevalence of iron deficiency anaemia (IDA) among primary school children in Abakaliki, Nigeria, and investigating its association with intestinal parasitic infections. Materials and Methods: A total of 372 children aged 6–12 years were enrolled in the study. Sociodemographic data were collected, and stool samples were examined for intestinal parasites. Haemoglobin concentration, serum on, and total iron-binding capacity were measured to determine anaemia and iron deficiency status. Result: The results showed a high prevalence of intestinal parasitic infections had a significantly higher prevalence of IDA compared to those without infections. The study also revealed a significant association between IDA and lower socioeconomic status, as well as maternal and paternal educational attainment. These findings highlight the substantial burden of IDA among primary school children in Abakaliki and the role of intestinal parasitic infections in contributing to iron deficiency. Conclusion: The study emphasises the need for integrated interventions, including health education, improved school meal provision, iron supplementation, regular deworming programmes, and measures to control and prevent intestinal parasitic infections. By addressing these actors, efforts can be made to reduce the prevalence of IDA and its associated health consequences in the population.

Https://thejmch.com/index.php?journal=thejmch&amp;page=issue&amp;op=view&amp;path%5B%5D=42

Background: The prevalence of iron deficiency anemia is still high, especially in children under five. One effort to prevent iron deficiency anemia is exclusive breastfeeding for newborns. This study aims to analyze exclusive breastfeeding on the incidence of anemia in children under five. Subjects and Method: This study is a systematic review and meta-analysis, with PICO as follows: Population= toddlers aged &lt;5 years; Intervention= exclusive breastfeeding; Comparison= nonexclusive breastfeeding; Outcome= iron deficiency anemia. The articles used in this study were obtained from several databases including PubMed, Springer Link, Science Direct, and Google Scholar, which were published from 2012 to 2022. The keywords to search for articles are as follows: "Children" AND ("exclusive Breastfeeding" OR "formula" OR "mixed feeding") AND (anemia OR "Iron deficiency"). The articles included in this study were full-text articles with a cross-sectional study design. Articles are collected using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application. Results: A meta-analysis of 9 cross-sectional studies from Ethiopia, Taiwan, Bangladesh and China concluded that exclusive breastfeeding is effective in reducing the risk of anemia in children under five. Toddlers who are exclusively breastfed have a risk of developing anemia 0.55 times compared to those who are not exclusively breastfed, and the reduced risk is statistically significant (aOR= 0.55; 95% CI= 0.32 to 0.92; p= 0.020). Conclusion: Exclusive breastfeeding is effective in reducing the risk of anemia in children under five. Keywords: exclusive breastfeeding, anemia, toddlers. Correspondence: Fikri Dian Dinu Azizah. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A Surakarta 57126, Central Java, Indonesia. Email: fikridianda@gmail.com. Mobile: 08122- 5002311.

Influence of exopolysaccharide EPSKar1-iron complexation on iron bioavailability and alleviating iron deficiency anaemia in Wistar rats.

The prevalence of iron deficiency anaemia is a significant issue worldwide, affecting individuals of all ages and often associated with inadequate iron bioavailability. Despite the use of ferrous salt supplements to address anaemia, their limited bioaccessibility and bioavailability in human GIT and adverse impact on food properties remain significant challenges. Hence, this study aims to explore the iron chelation mechanism of an exopolysaccharide EPSKar1 to enhance iron bioaccessibility, bioavailability, and anti-anaemic effects using cell culture and an anaemic rat model. EPSKar1 was extracted from Lacticaseibacillus rhamnosus Kar1 and complexed with FeSO4 to form "EPSKar1-iron". This novel complex, besides being bio-accessible after in vitro gastric digestion, demonstrated 61.27 ± 1.96% iron bioavailability to the Caco-2 cells. In line with these in vitro findings, intragastric administration of the EPSKar1-iron complex to anaemic Wistar rats at 25 and 50 mg per kg body weight significantly restored blood haemoglobin levels and re-established the morphological features of red blood cells. Furthermore, the apparent digestibility co-efficient and iron uptake improved significantly without adversely affecting the serum biochemical parameters in these anaemic rats. The levels of iron-transport proteins including serum transferrin and ferritin in tissue and plasma have increased remarkably upon oral administration of EPSKar1-iron at a higher dose of 50 mg per kg body weight. Oral supplementation of EPSKar1-iron did not foster adverse histological changes in the liver, kidneys, and spleen. In fact, the treatment with the EPSKar1-iron complex had a restitution effect on the tissue architecture, thereby ameliorating the tissue lesions. These findings collectively indicate that the EPSKar1-iron complex shows nutraceutical potential in enhancing the bioavailability of iron and could be a promising approach to tackle iron deficiency anaemia.

Avaliação de programas para aplicação de ferro dextrano na prevenção da anemia ferropriva de leitões

ABSTRACT To evaluate the effect of different iron dextran application programs on the performance, fecal score, and skin color of suckling piglets, as well as sow performance, 288 piglets from 24 sows were allocated to four treatments in six replications with 12 piglets per experimental unit, in a block design. The treatments were as follows: T200_000, T200_100, T200_200, and T100_100, whose respective values (in mg) corresponded to the applications of the first dose of iron dextran on the second day of life and of the second dose on the 10th day. Piglets on T200_000 and T200_200 showed the highest feed intake. In the period from 10 to 22 days, piglets receiving T100_100 exhibited the highest fecal score. On the 10th day of age, the lowest lightness (L*) value on the ear was obtained with T200_100, and the highest with T100_100. Treatments T200_000, T200_100, and T200_200 generated the highest red color (a*) intensity on the ear, whereas T100_100 provided the lowest hue and parameter b* values on the leg and snout. On the 22nd day of age, the highest b* and hue values of the ear and snout were found in the group fed T100_100. In conclusion, all evaluated programs were efficient in preventing iron deficiency anemia in newborn piglets. To reduce expenses, we recommend administering a single dose of 200 mg of iron dextran to piglets on the second day of life.

Оценка эффективности и комплаентности применения Вожея® у женщин на этапе прегравидарной подготовки и в ранние сроки беременности

Aim: to assess the clinical efficacy, safety and tolerability of Vojea® in the prevention of iron-deficiency anemia and folic acid deficiency in women during the preconception (pregravid) period and early stages of pregnancy, as well as to evaluate patient compliance with this product. Patients and Methods: this prospective multi-center observational study was performed in 2022 in four medical centers and women's health clinics of Ekaterinburg. The study included 87 women with latent iron deficiency (mean ferritin level below 15 ng/ml). The first group consisted of 37 women during the pregravid preparation period, and the second group consisted of 50 pregnant patients with up to 12 weeks of pregnancy. Patients received the Vojea® once daily for three months. Clinical and laboratory efficacy (the absence of objective anemia signs and the changes in hemoglobin level, folate and ferritin blood tests over time), as well as tolerability (the rate of adverse events, tolerability of the taken product evaluated using the visual analog scale) was assessed at days 30, 60 and 90 after the beginning of treatment. Results: beginning from the first month of treatment with the studied complex, some positive changes in clinical symptoms and laboratory findings were reported in both groups. By the third month of therapy, the increment of hemoglobin level in the pregravid preparation group was 17 (13.9%) units, the level of ferritin increased by 6.3 times (clinically significant after two months of the product intake), and the level of blood serum folates increased by 4.6 times. In group 2, the increment of hemoglobin level, as pregnancy was progressing, in three months of the product intake reached 19 units (17%), the level of ferritin increased by 5.9 times (clinically significant after two months of treatment), and the level of blood serum folates increased by 3.9 times. In group 1, adverse events were reported only in 2/37 (5.4%) patients who had dark stool color on the 2nd month of follow-up. In group 2, such adverse events as nausea were reported in 3/50 (6%) patients during the 1st month of product intake. All patients informed that the product was well tolerated which ensured high patient compliance. Conclusion: maintaining iron and folic acid homeostasis by oral intake of the Vojea® complex during three months in the preconception period and early stages of pregnancy is a feasible option based on its high efficacy and good tolerability with the minimal risk of side effects, encouraging high patient compliance. KEYWORDS: ferric pyrophosphate, folic acid, pregravid preparation, pregnancy, active metabolite of folic acid, methyltetrahydrofolate, glucosamine salt, Quatrefolic, micronized microencapsulated ferric iron, Vojea, compliance. FOR CITATION: Kononova I.N., Kareva E.N., Stebenyaeva E.V. et al. Assessment of the efficacy and compliance with Vojea® in women during the pregravid preparation and the early stages of pregnancy. Russian Journal of Woman and Child Health. 2023;6(2):95–104 (in Russ.). DOI: 10.32364/2618-8430-2023-6-2-95-104.

A prescription pattern of iron preparations among pregnant women with iron deficiency anemia attending antenatal clinic in a tertiary care hospital in Telangana, India

Background: Understanding and documenting the burden of Iron deficiency anemia (IDA) in pregnancy serves as feedback to realign the ongoing efforts in tackling it. Aim and Objectives: This study was conducted with the Objectives: (1) To estimate the prevalence of IDA in pregnancy (2) To determine the factors affecting the choice and the route of administration and (3) To compare the tolerability, efficacy, and adherence of oral and parenteral iron preparations. Material and Methods: A prospective observational study was conducted in an antenatal clinic at Mediciti Institute of Medical Sciences from April 1st, 2018 to March 31st, 2019 after obtaining Institutional Ethics Committee approval. Results: IDA was more in multigravida (66.17%). Majority of the participants were anaemic during their 2nd trimester (54.14%). By the time of delivery, 6 (33.33%), 34 (47.22%), and 20 (46.51%) participants enrolled in their first, second, and third trimesters, respectively, showed improved Hemoglobin (Hb) levels. Ferrous Sulphate (90.4%) and Iron Sucrose (98.53%) were the most prescribed oral and parenteral iron preparations, respectively. Among the participants on oral iron therapy, 30.65% had high adherence with Morisky’s Medication Adherence Scale and about 20.16% of participants had 100% adherence by pill count. Conclusion: Parenteral iron infusions, though brought about a significant rise in the mean Hb levels of the participants in a shorter time span than oral iron therapy, could not correct their anemic status by the time of their delivery. Almost half of the participants delivered in anemic status. Both the treatment modalities were well tolerated and the majority had good adherence.