Under the call of the national scientific and technological power, the research in the field of sensor technology has made rapid progress. Many smart devices integrating various technical heights have entered the homes of ordinary people. Making these smart devices increasingly intelligent has greatly improved people’s lifestyles and even changed their lives. With the development of blockchain technology and the development of 5G communication equipment and applications, the industrial model of Blockchain and the Internet of Things can also become an important guide for the development of the Internet of Things. Therefore, this paper studies the optimization strategy of the IoT operation mode based on Blockchain. The research results have shown that the IoT operation mode based on Blockchain is superior to the traditional IoT operation mode in terms of node energy consumption, life cycle, and flux performance. Under the IoT operation mode of the Blockchain, the node energy consumption is reduced by about 1.19J on average, and the flux performance is increased by about 21 on average. This showed that the IoT operation model based on Blockchain is feasible.