Iodine Of Pregnant Women Research Articles

Dietary and urinary iodine in pregnant women from Eastern Croatia

Uvod: Jod je mikronutrijent neophodan za održanje zdravlja, a štitnjača ima ključnu ulogu u metabolizmu joda. Prenizak i previsok unos joda imaju negativan utjecaj na funkciju štitnjače, te je adekvatan prehrambeni unos joda iznimno važan u kritičnim razdobljima života, među kojima se ističe trudnoća. Cilj i metode: Cilj ovoga presječnog opažajnog istraživanja bio je analizirati prehrambeni unos joda i koncentraciju joda u urinu, koja je najbolji indikator prehrambenog unosa joda, kod trudnica s područja istočne Hrvatske pred termin poroda. Istraživanje je obuhvatilo 24 trudnice koje su zaprimljene na Kliniku za ginekologiju i opstetriciju Kliničkog bolničkog centra Osijek do poroda. Rezultati: Medijan prehrambenog unosa joda procijenjen je na 569,94 μg/dan, što je 2,8 puta više od preporučenog unosa od 200 µg/dan, a kod 10/24 trudnice (42 %) procijenjen je prehrambeni unos joda viši od maksimalno preporučenih 600 µg/dan. Osim soli, najveći doprinos dnevnom unosu joda potječe iz jogurta, kravljeg mlijeka, suhomesnatih proizvoda, jaja, bijelog kruha i oslića, što je očekivano obzirom na tradicionalne prehrambene obrasce istočne Hrvatske. Medijan koncentracije joda u urinu je 134,63 μg/L, a čak je 75 % trudnica imalo koncentraciju joda u urinu ispod minimalno preporučenih 150 µg/L. Prehrambeni unos joda i koncentracija joda u urinu nisu statistički značajno korelirali, no prehrambeni unos joda je bio viši kod mlađih trudnica (ρ=-0,490), te kod pretilih, u odnosu na trudnice povećane tjelesne mase (p=0,022) i normalne tjelesne mase (p=0,037) koje su imale najvišu koncentraciju joda u urinu. Zaključak: Prevalencija bolesti štitnjače je u porastu u svim fazama života, a trudnoća je kritično razdoblje kada je uloga joda još izraženija. Rezultati ovoga istraživanja ukazuju na raskorak između statusa joda (promatranog kroz koncentraciju joda u urinu) i prehrambenog unosa joda; unatoč visokom prehrambenom unosu joda, koncentracija joda u urinu većine trudnica je ispod minimalno preporučene. Potrebno je provesti analize sadržaja joda u hrani, posebice različitih tipova soli s ciljem kreiranja baze podataka s točnim podacima o sadržaju joda, što bi omogućilo točniju procjenu prehrambenog unosa joda. To je preduvjet za osmišljavanje javnozdravstvenih aktivnosti usmjerenih na unos joda prehranom i zdravlje štitnjače.

Serum iodine concentration and its associations with thyroid function and dietary iodine in pregnant women in the southeast coast of China: a cross-sectional study.

Iodine deficiency is a major public health problem in pregnant women. Serum iodine (SI) may represent a useful biomarker for iodine nutrition evaluation. We aimed to assess the relationship between serum iodine concentration (SIC) and urinary iodine concentration (UIC), dietary iodine, thyroid function, and thyroid diseases in pregnant women in the southeast coast of China, and to provide a normal reference range of SIC for pregnant women. A multistage random sampling method was used to select the study population. We collected urine and blood samples from pregnant women and determined UIC and SIC as well as thyroid function using Arsenic-Cerium Catalytic Spectrophotometry, inductively coupled plasma mass spectrometry, and Beckman Coulter Access2 chemiluminescent immunoanalyzer and kit, respectively, and administered a questionnaire on dietary iodine intake in pregnant women. There was a significant negative correlation between SI and thyroid-stimulating hormone (TSH) (r = -0.141) and a significant positive correlation between SI and free triiodothyronine (FT3) (r = 0.106), free thyroxine (FT4) (r = 0.236), triiodothyronine (TT3) (r = 0.229), total thyroxine (TT4) (r = 0.433), and dietary iodine intake (r = 0.068). There was a significant difference in SI levels of pregnancy between the second (78.13 μg/L) and third trimester (75.37 μg/L) (p = 0.018). SI levels between inadequate intake (74.58 μg/L) and appropriate intake (77.92 μg/L) groups were statistically different (p = 0.036). Low SIC was a risk factor for the development of hypothyroxinemia (adjusted OR = 3.14, 95% confidence interval: 1.75-5.66). The reference range for SIC in normal pregnant women is 45.03-112.44 μg/L. SI may be a composite indicator of iodine nutritional status and thyroid function.

Iodine Intake and its Interindividual Variability in Brazilian Pregnant Women: EMDI Brazil Study.

Data on pregnant women's iodine intake are limited in Brazil. The aim of the study was to evaluate the contribution of foods, food groups, and food subgroups to the Brazilian pregnant women's iodine intake, and identify which food items explain the interindividual variability of their intake. A cross-sectional study with food consumption data of 2247 pregnant women from 24-h recallswas developed. Food items were classified according to the FAO/WHO GIFT classification, and their contribution to iodine intake and interindividual variability was assessed by the proportion of means method and linear regression, respectively. The mean usual iodine intake was 163.1 mcg (95% CI: 162.9-163.2). The food groups "spices and condiments," "cereals and their products," and "milk and milk products"; and the food subgroups "herbs and spices," "wheat and wheat-based products," "milk: fresh and processed," "dough-based sweets," and "eggs: fresh and processed" contributed to at least 80% ofthe iodine intake. Of these, only the food subgroups "milk," "dough-based sweets," and "eggs" did not explain the higher proportion (> 80%) of the interindividual variability. The contribution of "salt," "white French bread," "fluid whole milk," and "rice" to the iodine intake and its interindividual variability is highlighted. This study confirms the importance of "salt" as a dietary source of iodine and that few food groups and subgroups explained the difference in the iodine intake among pregnant women. Despite that, Brazilian staple foods, such as "rice," "beans," "eggs," "milk," and "bread" were identified as important for iodine intake and could be included in nutritional guidelines targeted to Brazilian pregnant women.

Біологічна роль йоду та йодна недостатність як патогенетичний фактор виникнення тиреоїдної патології у вагітних та її профілактика

У статті знайшли відображення найбільш важливі наукові відомості про значення йоду в біологічній природі, його участь у різноманітних біологічних процесах, в утворенні тиреоїдних гормонів та реалізації їх ефектів на рівні різних органів і клітин, що пояснюють виникнення йодозалежних захворювань. Значна увага в статті приділяється ролі йоду в синтезі тиреоїдних гормонів при вагітності та з’ясуванню причин підвищеної потреби в цьому елементі при даному стані. Проведений аналіз результатів багаторічних епідеміологічних досліджень, спрямованих на вивчення йодного забезпечення вагітних у різних регіонах України, співробітниками відділу епідеміології ендокринних захворювань ДУ «Інститут ендокринології та обміну речовин ім. В.П. Комісаренка НАМН України». Значна кількість цих досліджень виконана за підтримки МОЗ України, Дитячого фонду ЮНІСЕФ в Україні, а також центру СDC в Атланті (США), який протягом понад 15 років здійснював контроль за якістю досліджень одного з найважливіших показників йодного статусу населення України — йодурії. Стаття підготовлена як науковий інформаційний матеріал для ендокринологів, акушерів-гінекологів, гігієністів, сімейних лікарів, громадськості, МОЗ України у зв’язку з необхідністю законодавчого вирішення проблеми профілактики йодозалежних захворювань в Україні.

Physico-chemical indicators of kefir with biologically active iodine in the process of fermentation

Iodine is a natural trace element that is necessary for the human body. The function of iodine in the human body is the synthesis of thyroid hormones. Iodine deficiency has many negative consequences for the human body. Iodine deficiency is especially dangerous for pregnant women and children. Insufficient iodine in pregnant women increases the risk of miscarriage and birth of a child with cognitive impairment. Iodine deficiency in children has the following consequences: delayed physical development, delayed intellectual development, decreased mental activity, drowsiness, lethargy. Expanding food with iodine is a necessary step to overcome the problem of iodine deficiency.The quality of dairy products in Ukraine is very high. Due to the mandatory implementation of the HACCP system, manufacturers are improving equipment and production technologies. Accordingly, the requirements for the quality of raw materials increase in proportion to the competitiveness of the enterprise. That is why it is important to develop dairy products that will be in demand among consumers.Kefir with a biologically active additive “Iodis-concentrate” is a source of the required amount of iodine for the body. Jodis-concentrate is a certified biologically active additive that is widely used in the food industry. It has already found application in water production and the meat industry. The article presents a comparative analysis of changes in titrated acidity and active acidity (pH) in control and experimental samples of kefir during fermentation with the addition of biologically active iodine. The source of iodine was a biologically active additive "Iodis-concentrate". It is shown that the titrated acidity in both samples of kefir – control and experimental – had the same dynamics before growth during fermentation, which indicates no effect of the addition of biologically active iodine on the dynamics of titrated acidity. The same tendency to decrease the active acidity (pH) in control and experimental samples of kefir during fermentation with a difference within the significant error, indicating no effect of adding biologically active iodine to kefir on active acidity (pH).

Pregnant Women's Iodine Status and Their Knowledge, Attitude, and Practice towards Iodized Salt in Esfarayen and Jajrom Cities in 2016-2017

Background: Evaluation of status of iodine during pregnancy is crucial. Therefore, this study was conducted to investigate it in pregnant women and to evaluate their knowledge, attitude, and practice toward consuming iodized salt. Methods: In a cross-sectional study, 150 pregnant women were selected by census method based on the inclusion criteria. The participants' status of iodine was measured by measuring their urinary iodine concentration. Furthermore, the women's knowledge, attitude, and practice were investigated regarding iodized salt intake by a valid questionnaire. Results: Median concentrations of the urinary iodine in total population and Esfarayen people 139.05 (92.0-216.5) and 131.19 (211.43-86.43) μg/l, respectively which were lower than the World Health Organization recommendations (150-249 μg/l), while it was within the recommended range in Jajrom people 176.12 (101.76-248.62) μg/l. Although most people in the total population and Esfarayen people had moderate level of knowledge, attitude, and practice, most mothers in Jajrom had good knowledge and attitude scores along with moderate scores of practices. A significant direct correlation was found between attitude level and urinary iodine concentration (P = 0.043, r = 0.17). Conclusions: In total population, the median urinary iodine concentration was lower than the recommended level. Furthermore, knowledge, attitude, and practice of most people were at the moderate level.

Relationship between thyrotropin and urine iodine in Han and Uygur nationalities pregnancy women in People's Hospital of Xinjiang Uygur Autonomous Region

Objective: To investigate the relationship between thyrotropin (TSH) and urine iodine in pregnant women of Han and Uygur ethnic groups in People's Hospital of Xinjiang Uygur Autonomous Region. Methods: A total of 1 568 pregnant who completed screening of TSH and urine iodine in People's Hospital of Xinjiang Uygur Autonomous Region hospital from August 2014 to December 2017 were included in the study, 956 cases were Han and the other 612 were Uygur. Basic clinical data, serum TSH, thyroid peroxidase autoantibody (TPOAb) , and urine iodine levels were retrospectively analyzed. Results: (1) General results: The median urine iodine level was 162.6 μg/L (53.4-539.3 μg/L) , and the distribution of urine iodine classification was iodine deficiency 42.9% (672/1 568) , iodine appropriate 36.7% (576/1 568) , iodine slightly high 17.1% (268/1 568) and iodine excess 3.3% (52/1 568) respectively. (2) The median urine iodine levels of Han and Uygur pregnant women were 169.1 μg/L (54.6-583.4 μg/L) and 156.3 μg/L (53.1-539.3 μg/L) respectively, and the difference was statistically significant (P<0.05) .The distribution of urine iodine status in pregnancy between Han and Uygur was significantly different, which were 40.9% (391/956) vs. 45.9% (281/612) in iodine deficiency, 35.4% (338/956) vs. 38.9% (238/612) in iodine appropriate, 20.2% (193/956) vs. 12.3% (75/612) in iodine slightly high and 3.6% (34/956) vs. 2.9% (18/612) in iodine excess. (3) High serum TSH level proportion was significantly higher in Uygur ethnic group, early pregnancy, thyroid peroxidase antibody positive and anti-thyroglobulin antibody positive group when compared with Han, late pregnancy, thyroid peroxidase antibody negative and anti-thyroglobulin antibody negative groups (all P<0.05) . There were no significant differences in different age groups and iodine nutrition groups (P>0.05) . (4) There was no correlation between urinary iodine and TSH levels in all pregnant women (P>0.05) , neither in Han or Uygur group. When further stratified by gestational age, age, and antibody level, there was a positive correlation between urine iodine and serum TSH level in Han pregnant women >30 years old (P<0.05) , and there was a negative correlation in the third trimester in Uygur (P<0.05) . When serum antibody level, gestational week and age were controlled. There was no correlation between urine iodine and serum TSH level in neither group. Conclusions: (1) In Han and Uygur pregnant women, the median urine iodine level and the distribution of urine iodine classification between two ethnic groups are significantly different. (2) The correlation between urine iodine and serum TSH is not identified in Han or Uygur pregnant women.

Validation of a simple inductively coupled plasma mass spectrometry method for detecting urine and serum iodine and evaluation of iodine status of pregnant women in Beijing

Rapid and simple method for serum and urine iodine is necessary for iodine-related diseases. This study aimed to establish and validate a simple and rapid method for quantification of iodine in human urine and serum using inductively coupled plasma mass spectrometry (ICP-MS). Generally, samples were diluted using water with 1.5% isopropanol and 7 mmol hydrous ammonium before analysis by the ICP-MS. Performance of the method was validated, and the urine and serum iodine levels of 72 pregnant women were analyzed. Results showed that the lower limit of detection of the ICP-MS method was 0.87 µg/L. No significant memory effects were observed. Recovery in both serum and urine was approximately 100%. Compared with NIST SRM3668, bias was <1%, exhibiting good accuracy. The inter-run coefficients of variation (CVs) for serum and urine iodine were 2.8–3.5% and 3.5–6.7%, respectively, and total CVs for serum and urine iodine were 3.2–3.7% and 3.9–6.7%, respectively. Comparison of the iodine results obtained by the ICP-MS method and the conventional S–K method revealed excellent correlation (r = 0.984, mean bias = –1.7%). The median urine iodine of pregnant women (125.5 μg/L) was lower than that of WHO criteria for iodine deficiency (median urinary iodine <150 μg/L) while 55.6% of the individuals with urine iodine level less than 150 μg/L. The median serum iodine level of the pregnant women was 69.0 μg/L. In conclusion, a rapid and simple ICP-MS method for urine and serum iodine measurements has been established and validated, and the pregnant women in Beijing may still suffer from insufficient iodine intake.AbbreviationsCVcoefficients of variationHPLChigh-performance liquid chromatographyICP-MSinductively coupled plasma mass spectrometryKEDkinetic energy discriminationKIpotassium iodideLODlimit of detectionS–KSandell–Kolthoff reactionPUMCHPeking Union Medical College Hospital

Recent Trends of Trace Element Studies in Clinical Medicine in Japan

The deficiency or excess intake of trace elements, including zinc, copper, selenium and iodine, has often been reported. Zinc deficiency is often observed in infants fed breast milk with low zinc concentration, individuals administered chelating medicines, athletes and patients with diabetes mellitus, hepatic cirrhosis or nephrosis syndrome. Menkes disease is associated with severe copper deficiency, and there is no effective treatment. Deficiencies of selenium and iodine are observed in patients who receive special formulas of milk and enteral formula with low selenium and iodine concentrations, respectively. In contrast, neonatal transient hypothyroidism due to excess intake of iodine in pregnant women has also reported in Japan. It is expected that collaborative studies by researchers and clinicians will contribute to clarify the detail mechanism, diagnosis and treatment of these abnormalities.

Iodine nutrition status in clinically euthyroid pregnant women attending in BSMMU

Background: Iodine deficiency disorders (IDD) are common nutritional problem globally. All groups of people are affected by it, but the pregnant women and their neonates are most vulnerable.Objectives: This study was carried out to see the iodine status of pregnant women using median urinary iodine concentration (MUI) as a measure of outcome. Methods: This cross sectional observational study assessed the MUI in casual urine samples from 225 pregnant women (75 pregnants from each trimester) and 75 non-pregnant healthy controls. The urinary iodine content was estimated in urine sample using the method of Dunn et al. with the modification of Sandell &amp; Kolthoff (wet digestion method).Results: Median value of urinary iodine in pregnant women was 48.21Ug/L compared to 52.27

Concentraciones de yodo en orina y en sal de consumo en mujeres entre 12 a 49 años del Perú

To determine the concentrations of iodine in urine and salt intake in women between 12-49 years of age in Peru. An observational and cross-sectional study was performed. During 2012 and 2013, the study included women aged between 12-49 years living in Peruvian households selected through a probabilistic, stratified and multistage sample. The determination of iodine in urine was performed based on the Sandell-Kolthoff reaction spectrophotometry. The qualitative evaluation of iodine salt was performed by Yoditest and the quantitative by volumetric analysis. Processing was performed using complex samples with weights. Medians, interquartile range and percentiles were obtained. The median urinary iodine levels in the participants was 250.4 ug/L. The regions with elevated median urinary iodine levels were: Moquegua (389.3 ug/L); Tacna (320.5 ug/L); Madre de Dios (319.8 ug/L), and Ucayali (306.0 ug/L); while Puno (192.9 ug/L); Piura (188.1 ug/L) and Tumbes (180.5 ug/L) had medians within ranges recommended by the WHO. The median urinary iodine in pregnant women was 274.6 ug/L (IQR: 283 ug/L).82.5% of the samples had iodine salt ≥30 ppm and 1.9% had values of 0 ppm. The median urinary iodine in Peruvian women is higher than recommended by the WHO and the majority of the samples had adequate iodine concentrations according to WHO recommendations.

Iodine nutritional status of the vulnerable population in Henan province in 2011

To investigate the iodine nutritional status of the vulnerable population in Henan in 2011. From March to December 2011, 44 049 urinary samples of newly married women of childbearing age (363), pregnant women (31 874), lactating women (4893) and children under 2 years (6919) collected from hospitals, maternal and child care hospitals and outpatient department of family planning organizations from 8 cities of Henan province (only including the areas where water iodine was less than 100 µg/L) were tested for urine iodine concentration. The iodine nutritional status of different groups was analyzed. The median of urinary iodine for newly married women, pregnant women, lactating women and children under 2 years was 204.5, 190.9, 145.5 and 185.4 µg/L, respectively (χ(2) = 874.16, P < 0.01). The proportion of urinary iodine below 150 µg/L of pregnant women and below 100 µg/L of lactating women and children under 2 years was 33.0% (10 519/31 874), 24.9% (1218/4893) and 12.4% (855/6919), respectively. The proportion of urinary iodine above 300 µg/L of newly married women was 33.6% (122/363). The median of urinary iodine for pregnant women in the first, second and third trimester was 186.7, 193.8 and 182.5 µg/L, respectively (χ(2) = 55.19, P < 0.01). The median of urinary iodine for the breast-feeding, formula-feeding and mixed-feeding infant under the age of 1 year was 194.8, 85.6 and 176.0 µg/L, respectively (χ(2) = 179.25, P < 0.01). The overall iodine nutrient levels of the vulnerable population in Henan in 2011 were appropriate, but there were still some proportions of pregnant and lactating women with low iodine level. The iodine intake of the formula-feeding infants was not sufficient.

The iodine status in Hangzhou, Zhejiang province 2010

To explore the iodine level in the environment and the iodine status among the general population as well as the prevalence of thyroid nodules in Hangzhou city. Relationship between the prevalence of thyroid nodules and the policy of universal salt iodization in Hangzhou was also analyzed. Questionnaire, a 3-day weighed dietary record method, and 3 days' 24-hour dietary recall method were used to understand the iodine nutrition status and dietary intake of iodine among the general population in the city. Drinking water, edible salt and morning urine were collected to determine iodine content. All objects under survey underwent the thyroid B ultrasonic examination. Statistical analysis was done by SPSS 13.0 and SAS 9.1. (1) In total, 12 620 effective questionnaires were available, with 221 water samples, 12 730 urine samples, and 3593 salt samples collected. 12 515 objects underwent B ultrasonic examination, and 1848 received dietary investigation. (2) Water iodine level of Hangzhou was in the range of 0.20 - 5.99 µg/L, with the median level as 2.58 µg/L. (3) Average daily dietary intake of iodine for adult males in Hangzhou was 289.2 µg/d. The contribution of iodine intake from iodized salt was 74.4%. (4) The median of Hangzhou residents' urinary iodine was 178.80 µg/L, with the urinary iodine levels at 100 µg/L-, 200 µg/L-, < 100 µg/L, and ≥ 300 µg/L groups were 37.14%, 23.11%, 21.05%, and 18.69% respectively. Urinary iodine of pregnant women was 141.0 µg/L. (5) Incidence of thyroid nodules in females (28.6%) was higher than that of males (20.1%). The detection rate increased with age (6.4% at group 6-, 10.9% at 12-, 12.0% at 18-, 24.4% at 40-, and 38.8% at 65-); with the highest in urban area (29.8%), followed by suburbs (23.3%) and in rural area it showed the least (20.3%). Urinary iodine level was found lower among the population who had been detected with thyroid nodules (160.36 µg/L) than those among the undetected population (182.00 µg/L). Hangzhou appeared to be an area where the environmental was iodine deficient. Iodized salt was the major source of iodine intake. The iodine status among the general population seemed to be safe and suitable, but the iodine level for pregnant women was not sufficient. There was still no evidence indicating that the universal salt iodization policy in Hangzhou was associated with the prevalence of thyroid nodules.

Nutritional status of iodine in pregnant women in Catalonia (Spain): study on hygiene-dietetic habits and iodine in urine

BackgroundIt is a priority to achieve an adequate nutritional status of iodine during pregnancy since iodine deficiency in this population may have repercussions on the mother during both gestation and post partum as well as on the foetus, the neonate and the child at different ages. According to the WHO, iodine deficiency is the most frequent cause of mental retardation and irrreversible cerebral lesions around the world. However, few studies have been published on the nutritional status of iodine in the pregnant population within the Primary Care setting, a health care level which plays an essential role in the education and control of pregnant women. Therefore, the aim of the present study is: 1.- To know the hygiene-dietetic habits related to the intake of foods rich in iodine and smoking during pregnancy. 2.- To determine the prevalence of iodine deficiency and the factors associated with its appearance during pregnancy.Methods/designWe will perform a cluster randomised, controlled, multicentre trial. Randomisation unit: Primary Care Team. Study population: 898 pregnant women over the age of 17 years attending consultation to a midwife during the first trimester of pregnancy in the participating primary care centres. Outcome measures: consumption of iodine-rich foods and iodine deficiency. Points of assessment: each trimester of the gestation. Intervention: group education during the first trimester of gestation on healthy hygiene-dietetic habits and the importance of an adequate iodine nutritional status. Statistical analysis: descriptive analysis of all variables will be performed as well as multilevel logistic regression. All analyses will be done carried out on an intention to treat basis and will be fitted for potential confounding factors and variables of clinical importance.DiscussionEvidence of generalised iodine deficiency during pregnancy could lead to the promotion of interventions of prevention such as how to improve and intensify health care educational programmes for pregnant women.Trial RegistrationClinicalTrials.gov: NCT01301768

Iodine sources and iodine levels in pregnant women from an area without known iodine deficiency

An adequate iodine intake during pregnancy is essential for normal development of the foetus. The World Health Organization (WHO) recommends that the median urinary iodine concentration (UIC) in a population of pregnant women should range between 150 and 249 microg/l. The aim of this study was to evaluate iodine status and to examine the main sources of iodine in pregnant women from an apparently iodine-sufficient area. Six hundred pregnant women in the third trimester completed a food frequency questionnaire, and iodine was measured in urine samples. Urinary iodine concentrations were described in the whole population and in subgroups according to their frequency of intake of milk, fish, eggs, bread and iodized salt, as iodine supplements. The median UIC was 104 microg/l (n = 600), however, the median was higher among women who had a high milk intake (117 microg/l), used iodized salt (117 microg/l) or who were supplemented with iodine (141 microg/l). Women receiving iodine supplementation who also consumed more than one cup of milk per day had median UIC higher than 150 microg/l. In multivariate models, women with moderate and high milk intake had lower risk of having UIC below 150 microg/l [OR (95% CI): 0.42 (0.22-0.82) and 0.29 (0.15-0.55) respectively], after adjustment for potential confounders. On the basis of WHO criteria, the iodine status of pregnant women was inadequate in this area. Milk was the most important dietary source of iodine, and iodine supplementation was also an important source of iodine, although not enough to reach the current recommendations.

Dietary Iodine in Pregnant Women from the Boston, Massachusetts Area

Dietary Iodine in Pregnant Women from the Boston, Massachusetts Area

Déficit de yodo y función tiroidea en una población de mujeres embarazadas sanas

Studies from Spain suggest that the intake of iodine in pregnant women is below nutritional requirements. This study was designed to determine iodine intake and its relation with thyroid volume during pregnancy in women from southeast Spain. A total of 520 healthy pregnant women were studied during the full three trimesters of their pregnancy. A control group was composed of 373 non-pregnant women. The following variables were measured: TSH, FT3, FT4, thyroglobulin, antiperoxidase antibodies, urinary iodine levels, and thyroid volume. Median urinary iodine levels were below 100 g/l in the controls and the pregnant women during their first trimester. These levels rose progressively and significantly over the second and third trimesters. Thyroid volume increased during the second and third trimesters compared with the first. TSH levels were lower during the first trimester compared to controls, and increased significantly during the third trimester. FT4 levels fell significantly during the third trimester. There was a significant negative correlation between TSH levels and thyroid volume (r = 0.22; p = 0.005). Iodine intake in pregnant women in Malaga is low. The results suggest a deficit in thyroid function secondary to iodine deficiency, which is worsened as pregnancy advances. The data support the convenience of systematic administration of an iodine supplement in healthy pregnant women.