Investigation Committee Research Articles

532 nm Sub Pulsed Laser for Treating Melasma in Latin American Patients, Series of Cases

<i>Objective</i>: To analyze a series of cases treated with a 532 nm Sub Pulsed laser treatment for Melasma in Latin American Patients with Fitzpatrick type IV. <i>Background</i>: Melasma is a common, acquired, symmetrical hypermelanosis that presents as light to dark brown macules on the face usually over the forehead and malar areas that negatively impact patient’s quality of life. Many laser treatments have been described without any consensus, however, targeting the vascular component has been gaining popularity daily but the adverse reactions such as transient post inflammatory hyperpigmentation or atrophic scars have been described for treating the superficial and deep vessels. We propose a new laser range in order to treat Melasma. <i>Methods</i>: This is an observational study with 20 patients, Fitzpatrick type IV diagnosed with facial melasma that were treated with one to two sessions of a Sub Pulsed 532 nm Laser with an interval of 11 to 30 days. Dermoscopy was performed in the patients before the laser in order to show the presence of multiple vessels and pigmentation in the patients, before and after pictures were taken with Quantificare Lifeviz to show the results after the laser without any other topical or oral treatment. This Study was reviewed and approved by the Ethics and Investigation Committee of Dermalaser KPW in Lima, Peru, adhering to the highest ethical standards and following the principles Outlined in the Helsinsky Declaration. Informed Consent was obtained from all participants, who also provided written authorization for the publication of the study results and accompanying images. <i>Results</i>: In this series of cases the Modified MASI Score describes an average of 90.9% improvement in Melasma severity after the laser sessions. The pictures taken with Quantificare Lifeviz in order to asses the vascular, pigmentary and basal pictures show significant improvement. No PIH (Post inflammatory Hyperpigmentation) or major adverse reaction were described in this study.

Evaluation of Safety and Efficacy of Cell Therapy Based on Osteoblasts Derived from Umbilical Cord Mesenchymal Stem Cells for Osteonecrosis of the Femoral Head: Study Protocol for a Single-Center, Open-Label, Phase I Clinical Trial.

Although mesenchymal stem cells (MSCs) insertion has gained recent attention as a joint-preserving procedure, no study has conducted direct intralesional implantation of human umbilical cord-derived MSCs (hUCMSCs) in patients with ONFH. This is a protocol for a phase 1 clinical trial designed to assess the safety and exploratory efficacy of human umbilical cord-derived osteoblasts (hUC-Os), osteogenic differentiation-induced cells from hUCMSCs, in patients with early-stage ONFH. Nine patients with Association Research Circulation Osseous (ARCO) stage 1 or 2 will be assigned to a low-dose (1 × 107 hUC-O cells, n = 3), medium-dose (2 × 107 cells, n = 3), and high-dose group (4 × 107 cells, n = 3) in the order of their arrival at the facility, and, depending on the occurrence of dose-limiting toxicity, up to 18 patients can be enrolled by applying the 3 + 3 escalation method. We will perform hUC-O (CF-M801) transplantation combined with core decompression and follow-up for 12 weeks according to the study protocol. Safety will be determined through adverse event assessment, laboratory tests including a panel reactive antibody test, vital sign assessment, physical examination, and electrocardiogram. Efficacy will be explored through the change in pain visual analog scale, Harris hip score, Western Ontario and McMaster Universities Osteoarthritis Index, ARCO stage, and also size and location of necrotic lesion according to Japanese Investigation Committee classification before and after the procedure. Joint preservation is important, particularly in younger, active patients with ONFH. Confirmation of the safety and efficacy of hUC-Os will lead to a further strategy to preserve joints for those suffering from ONFH and improve our current knowledge of cell therapy.

French Legislation on Pre-Trial Investigation

Introduction. The article examines how the legal mechanism of preliminary investigation operates in France, taking into account the special approach of the French public authorities to its implementation, the importance of preliminary investigation in the criminal process of this state. And also, taking into account the fact that there is no institution of preliminary investigation in the Russian judicial system – such an investigation is carried out, according to domestic legislation, by investigators of the Investigative Committee of the Russian Federation – the procedural status of investigative judges of France, who belong to the judiciary on a permanent basis. Materials and methods. The research methods are a system of specially scientific and philosophical worldview approaches that provide an opportunity for an objective analysis of the topic. The research applied such methods as comparative law, historical law, formal law, structural and functional, as well as dialectical and materialistic Materials and methods. The research methods are a system of specially scientific and worldview approaches that provide an opportunity for an objective analysis of the topic. The research applied such methods as comparative law, historical law, formal law, structural and functional, as well as dialectical and materialistic. Special attention is paid to the problem of determining the role of the preliminary investigation in legal proceedings, the characteristics of its judicial status in the exercise of powers by the relevant attention is paid to the problem of determining the role of the preliminary investigation in legal proceedings, the characteristics of its judicial status in the exercise of powers by the relevant state authorities in science: the works of such scientists as M.V. Aleynikov, A.N. Volchanskaya, A.E. Vorobyov, B.Ya. Gavrilov, V.N. Galuzo, A.V. Grinenko have been published on this topic, L.V. Golovko, K.F. Gutsenko, S.A. Danilyan, I.S. Dikarev, A.Yu. Zotov, N.A. Kanafin, A.N. Konshakov, I.Ya. Foynitsky, M.Yu. Fisakov, etc.Research results. The purpose of this study is to conduct a comparative legal analysis of the preliminary investigation carried out by the relevant public authorities in France, with a comparative comparison of the role of the preliminary investigation carried out by public authorities in this State. In order to achieve this goal, special attention in this work will be paid to solving the following tasks: to identify the place of authority for the preliminary investigation in the activities of various law enforcement agencies; to investigate the features of the preliminary investigation at different stages of the development of France; to establish the features of its transformation; to analyze the real role of the preliminary investigation in France and characterize the authorities exercising authority to conduct it; to make a generalizing conclusion about whether it is advisable to make changes to the definition of the place of the preliminary investigation in the judicial proceedings of the Russian Federation, taking into account the legislative experience of France.Discussion and conclusion. After the Introduction, the article examines the very Concept of "preliminary investigation" and its national characteristics; The activities of judicial bodies conducting preliminary investigation; The procedure for conducting preliminary investigation; The end of the preliminary investigation; Instance control over the activities of the investigating judge. In conclusion, the authors of the article propose some theoretical generalizations on this topic and show the most outstanding distinctive features of French legislation on preliminary investigation in terms of methods of legal technique.

Tissue-Engineered Bone Regeneration for Medium-to-Large Osteonecrosis of the Femoral Head in the Weight-Bearing Portion: An Observational Study.

Stem cell therapy for the treatment of osteonecrosis of the femoral head (ONFH) showed promising outcomes. However, ONFH with a large lesion in the weight-bearing portion is a poor prognostic factor and still challenging issue to be solved. We aimed to evaluate the effect of tissue-engineered bone regeneration for this challenging condition to preserve the femoral head. A total of 7 patients (9 hips) with ONFH who received osteoblasts expanded ex vivo from bone marrow-derived mesenchymal stem cells (BMdMSCs) and calcium metaphosphate (CMP) as scaffolds from March 2002 to March 2004 were retrospectively reviewed. The median age was 27.0 years (interquartile range [IQR], 23.0-34.0 years), and the median follow-up period was 20.0 years (IQR, 11.0-20.0 years). After culture and expansion of stem cells, we performed core decompression with BMdMSC implantation at a median number of 10.1 ×107 (IQR, 9.9-10.9 ×107). To evaluate radiographic outcomes, the Association Research Circulation Osseous (ARCO) classifications, the Japanese Investigation Committee (JIC) classification, and modified Kerboul combined necrotic angle (mKCNA) were evaluated preoperatively and during follow-up. Clinical outcomes were evaluated by a visual analog scale (VAS) and Harris Hip Score (HHS). The preoperative stage of ONFH was ARCO 2 in 5 hips and ARCO 3a in 4 hips. The ARCO staging was maintained in 3 hips of ARCO 2 and 4 hips of ARCO 3a. Two hips of ARCO 2 with radiographic progression underwent total hip arthroplasty. According to mKCNA, 2 hips showed medium lesions, and 7 hips showed large lesions. The size of necrotic lesion was decreased in 4 hips (2 were ARCO 2 and 2 were ARCO 3a). There were no significant changes in JIC classification in all hips (type C1: 3 hips and type C2: 6 hips) (p = 0.655). Clinically, there were no significant changes in the VAS and HHS between preoperative and last follow-up (p = 0.072 and p = 0.635, respectively). Tissue engineering technique using osteoblasts expanded ex vivo from BMdMSC and CMP showed promising outcomes for the treatment of pre-collapsed and early-collapsed stage ONFH with medium-to-large size, mainly located in weight-bearing areas.

The effect of the Japanese Investigation Committee classification on hip joint survival after core decompression therapy in pre-collapsed avascular necrosis of the femoral head

Aim: This study aimed to determine the failure rate of pre-collapse avascular necrosis (AVN) of the femoral head treated with core decompression (CD) and risk factors affecting the progression of the disease in patients by using an easily applicable staging system. . Material and Methods: A total of 174 hips from 134 patients diagnosed with precollapse AVN and treated with CD were retrospectively examined. Each hip was classified using the Japanese Investigation Committee (JIC) classification. The endpoint for joint survival following treatment was defined as the occurrence of total hip arthroplasty (THA). The risk analysis on joint survival of various independent variables (treatment type, age, gender, etiology) and the frequency of THA 2 and 5 years after treatment was calculated. Results: The mean age of the patients was 44.0 ± 15.0 years, with the majority being male (71.8%). THA was performed in 28.7% of treated hips within two years and 40.2% within five years. The frequency of THA application within two years was 2% for type A, 8% for type B, 40% for type C1 and 50% for type C2. Age (p=0.033), type C1 (p=0.028) and type C2 (p

Миграционная политика и актуальность ее реформирования в современной России

In the first quarter of the XXI century, a difficult situation with migration policy is developing in Russia. This idea was especially worrisome at the XII St. Petersburg International Legal Forum in May 2024. During his speech, the Chairman of the Investigative Committee of the Russian Federation (IC RF), Professor A.I. Bastrykin, repeatedly returned to the issues of legal regulation of migration. This article is devoted to the development of the system of legal regulation of migration relations in the Russian Federation at the present stage in the light of the emergence of new challenges and criminogenic threats. In order to overcome the diverse political and legal problems in the field of regulation of migration relations, the authors propose current directions for reforming the sphere of public relations under consideration.

МЕЖДУНАРОДНАЯ НАУЧНО-ПРАКТИЧЕСКАЯ КОНФЕРЕНЦИЯ «АКТУАЛЬНЫЕ ПРОБЛЕМЫ УГОЛОВНО-ИСПОЛНИТЕЛЬНОГО ПРАВА И ИСПОЛНЕНИЯ НАКАЗАНИЙ» ПАМЯТИ ПРОФЕССОРОВ Н. А. СТРУЧКОВА И М. П. МЕЛЕНТЬЕВА ПО ВОПРОСАМ РЕСОЦИАЛИЗАЦИИ ЛИЦ, ОСВОБОЖДЕННЫХ ИЗ УЧРЕЖДЕНИЙ УГОЛОВНО-ИСПОЛНИТЕЛЬНОЙ СИСТЕМЫ (12 АПРЕЛЯ 2024 ГОДА)

On April 12, 2024, an international scientific and practical conference «Actual problems of penal enforcement law and execution of punishments» was held in Nizhny Novgorod in memory of Professors N. A. Struchkov and M. P. Melentyev with a thematic meeting «Resocialization of persons released from institutions of the penal enforcement system: the role of the Investigative Committee of Russia, the Federal Penitentiary Service of Russia and other subjects crime prevention». The co-organizers of this event, in addition to the Department of Penal Enforcement Law and the organization of educational work with convicts of the Academy of the Federal Penitentiary Service of Russia, were the St. Petersburg Academy of the Investigative Committee of the Russian Federation, as well as the Union of Criminologists and Criminologists. The conference was the first of its kind and identified areas for further improvement of the theory, legislation and practice of implementing the institute of probation and execution of sentences, including the re-socialization of persons released from institutions of the penal enforcement system, as well as correctional and preventive measures against them.

АНТИЭКСТРЕМИСТСКОЕ УГОЛОВНОЕ ПРАВО: ВОПРОСЫ ТЕОРИИ И ПРАКТИКИ: ИНТЕРВЬЮ С ДИРЕКТОРОМ НИЖЕГОРОДСКОГО ФИЛИАЛА САНКТ-ПЕТЕРБУРГСКОЙ АКАДЕМИИ СЛЕДСТВЕННОГО КОМИТЕТА РОССИЙСКОЙ ФЕДЕРАЦИИ АЛЕКСЕЕМ ВЛАДИМИРОВИЧЕМ ПЕТРЯНИНЫМ

Interview with the Director of the Nizhny Novgorod branch of the St. Petersburg Academy of the Investigative Committee of the Russian Federation A. V. Petrjanin’

Risk assessment for femoral head collapse in osteonecrosis utilizing MRI-derived large lesion ratio: a retrospective cohort study

PurposeThis study aimed to developed a novel and practical method to quantify the involvement of lesion in osteonecrosis of the femoral head (ONFH). We hypothesized that the new metric large lesion ratio (LLR) had promising prognostic value.MethodsA total of 131 hips with non-traumatic ONFH were included in this retrospective study. Patient aged 18–60 with MRI-confirmed diagnosis, and a minimum of 2-year follow-up or radiographic collapse progression during follow-up were included. Patients with prior hip surgery, incomplete data or advanced ONFH at baseline (femoral head collapse > 2 mm or osteoarthritis) were excluded. Involvement of necrotic lesion was evaluated by calculating LLR. The differences of LLR between collapse progression and non-progression groups were investigated, and the differences among different scanning parameters groups were also examined. Prognostic value of LLR was examined by multivariate regression analysis. Receiver operating characteristic curves (ROC) were constructed and areas under the curve (AUC) were compared.ResultsThe median of LLR was 66.67% in the collapse progression group, which was significantly higher compared with 25.00% in the non-progression group (P < 0.001). Subgroups analysis showed that LLR were significantly higher in the collapse progression group of Japanese Investigation Committee type C1 (P < 0.001)and C2 (P = 0.002). Multivariate regression showed that LLR were independently correlated with collapse progression (OR, 1.46 [95% CI, 1.24–1.78]; P < 0.001). ROC analysis showed that the AUC for LLR was 0.84, outperforming the 0.74 AUC OF the JIC classification.ConclusionLLR could served as a efficient tool to assess the risk of collapse progression and guide the selection of treatment strategy.

Factors influencing the survival status of the hip joint in post-collapse femoral head necrosis

BackgroundDespite hip function typically deteriorating in the post-collapse stage of osteonecrosis of the femoral head (ONFH), some patients can still demonstrate long-term favorable hip function, a state termed “survival with collapse”. This study aims to identify the characteristics of patients suitable for “survival with collapse” in cases of ONFH.MethodsThis cross-sectional study included 65 patients (87 hips) diagnosed with post-collapse ONFH for ≥ 3 years (average 9.1 years, range 3–23 years). Hip function was assessed using the Harris Hip Score (HHS). Demographic, clinical, and radiographic data were compared between the favorable group (HHS > 80) and the poor group (HHS ≤ 80). Independent protective factors for hip function were identified by multivariate analysis and receiver operating characteristic (ROC) curve analysis was further applied to evaluate these factors’ diagnostic efficacy.ResultsThe favorable and poor groups included 46 and 41 hips, respectively. Significant differences were found in body mass index (BMI), Association Research Circulation Osseous (ARCO) stage, collapse degree, Japanese Investigation Committee (JIC) classification, necrotic size, and hip subluxation between the two groups (p < 0.05). Multivariate logistic regression identified collapse < 3 mm(OR:14.49, 95%CI: 3.52–59.68, p < 0.001), JIC types B (OR: 11.08, 95% CI: 1.07-115.12, p < 0.05) and C1(OR: 5.18, 95% CI: 1.47–18.20, p < 0.05) as independent protective factors for hip function, while BMI (OR: 0.76, 95% CI: 0.59–0.97, p = 0.029) was an independent risk factor. ROC curve analysis demonstrated that both collapse degree (AUC = 0.798, sensitivity = 91.3%, specificity = 68.3%, p < 0.0001) and JIC classification (AUC = 0.787, sensitivity = 80.4%, specificity = 73.2%, p < 0.0001) had satisfactory diagnostic value for hip function. Combining JIC classification and collapse degree (AUC = 0.868, sensitivity = 76.1%, specificity = 85.4%, p < 0.0001) significantly enhanced diagnostic efficacy compared to using either alone (p < 0.05).ConclusionIn ONFH, femoral head collapse does not necessarily determine a poor prognosis. Patients with mild collapse (< 3 mm) and preserved anterolateral wall are more likely to retain satisfactory hip function, making them candidates for “survival with collapse.”

The «face» of modern juvenile delinquency: the results of a sociological study of the activities of the investigative departments of the Investigative Committee of the Russian Federation

The «face» of modern juvenile delinquency: the results of a sociological study of the activities of the investigative departments of the Investigative Committee of the Russian Federation

Spherical varus rotational osteotomy of the femur using a navigation system as extra-articular surgery for extensive osteonecrosis of femoral head: a case control study

BackgroundCurved varus osteotomy (CVO) is an effective femoral head-preserving surgical procedure for osteonecrosis of the femoral head (ONFH) classified as type B or C1 according to the Japanese Investigation Committee (JIC) classification; it reportedly provides better postoperative outcomes than transtrochanteric rotational osteotomy (TRO). We have developed a new procedure called spherical varus rotational osteotomy (SVRO) in which osteotomy of the femur into a spherical shape is followed by varus and anterior rotation using navigation to increase indications and improve postoperative outcomes.MethodsNine joints of eight patients who underwent SVRO and could be followed up for > 1 year were included in the study. Disease types determined preoperatively according to the JIC classification were type C1 for four joints and type C2 for five joints. Preoperative disease JIC classification stages were 3a for eight joints and 1 for one joint. SVRO was performed using OrthoMap® 3D Navigation software, and the following variables were measured: surgery time, intraoperative blood loss, difference between preoperative and postoperative angles of anteversion, postoperative lower limb length discrepancy, and postoperative intact area occupancy. The Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) was used for clinical evaluation. Visual Analog Scale and JHEQ scores were evaluated preoperatively and at the final follow-up.ResultsThe measurement results were as follows: surgery time, 130 min; blood loss, 200 ml; angle of varus, 20°; angle of anterior rotation, 30°; preoperative angle of anteversion, 15°; postoperative angle of anteversion, 22°; lower limb shortening, 11 mm; preoperative intact area occupancy, 0%; and postoperative intact area occupancy, 74.2%. There were no cases of progression in the postoperative stages or re-collapse.ConclusionSVRO allows for the repositioning of the exterior and posterior intact areas, providing a broader intact region postoperatively. This technique is particularly beneficial for young patients with ONFH and extensive necrosis and is a less invasive alternative to TRO. This procedure has been shown to be effective in achieving favorable outcomes in patients with extensive necrosis who would have otherwise required rotational osteotomy, depending on the necrosis location. Further longitudinal studies are necessary to validate these findings and establish long-term benefits.

Modern Means of Evidence before Administrative Investigation Committees under Jordanian Legislation: A Comparative Study

This study sought to identify the foremost modern methods of evidence employed before the Administrative Investigation Committee for detecting disciplinary misconduct. In conformity with Article 146/B/2 of Civil Service Bylaw No. 9 of 2020, the legislative framework in Jordan has primarily centered on establishing conventional rules governing the presentation of evidence. It is a well-established tenet that the burden of proof rests with the administration, necessitating a comprehensive demonstration of the evidential basis underpinning their misconduct allegations. Therefore, it is the responsibility of the administration to provide indisputable evidence in cases where employees are accused of disciplinary infractions. Simultaneously, employees have to present evidence that contradicts these allegations. Investigative committees are tasked with examining the necessary evidence to establish the accuracy of these claims. The study found a significant gap in the legislative framework pertaining to modern methods of evidence within the Jordanian civil service Bylaw. While these methods are acknowledged in general legal provisions, this recognition is considered insufficient due to variations among different employment systems. Therefore, this study recommends explicitly incorporating modern evidence presentation methods into legislation to align with ongoing scientific and technological progress and facilitate their widespread adoption. Consequently, there is a need to revise legislative regulations governing employment systems and include the methods at the core of this investigation. This study addresses the ambiguity in Jordan's legal framework related to validating allegations against public employees before administrative investigators using an analytical and comparative approach, juxtaposing the legal provisions of Jordan and Egypt in this context.

P-568 Correlation of ploidy analysis in two types of zygotes with 3 pronuclei (3PN) observed: same size 3PNs and one micronucleus 3PNs

Abstract Study question Do all zygotes with three observed pronuclei have an actual triploid chromosomal complement? Summary answer Not all zygotes with 3 pronuclei observed are triploid, most of embryos with two even pronuclei and one smaller micronucleus are diploid. What is known already In the in vitro fertilization (IVF) setting, normal oocyte fertilisation is commonly confirmed 16–19 hours after conventional insemination or intracytoplasmic sperm injection (ICSI) with the appearance of two pronuclei (2PN). The presence three pronuclei (3PN) shows an abnormal oocyte fertilization. The incidence of 3PN zygotes in IVF is between 5.0%- 8.1% in conventional insemination and between 2.0%- 6.2% in ICSI. 3PN fertilized embryos are commonly discarded due to the suspected increased risk of a triploid chromosomal complement. However, no definitive genetic evidence has been obtained to show that all 3PN zygotes are chromosomally abnormal. Study design, size, duration An Ethics Committee for Investigation accredited this prospective observational study performed in a private centre between June 2023 and January 2024. 120 3PN zygotes from 113 cycles were cultivated until blastocyst stage. 46 were biopsied to clarify ploidy and euploidy status. 3PNs were divided into 2 groups based on the size of their pronuclei: Micro Triploid (MT) (smallest pronucleus &amp;lt;70% of the diameter of the largest pronucleus) and Pure Triploid (PT) (smallest &amp;gt;70% of the largest). Participants/materials, setting, methods Patients with 1 or more 3PN embryo were offered to participate, culturing and assessing their 3PNs. If 3PNs reached blastocyst stage, they were biopsied and analysed using Next-Generation Sequencing strategy with Single Nucleotide Polymorphisms technology without the need for parental samples, to assess ploidy and aneuploidy status. Measures of the pronuclei size were taken to sort the 3PNs in both groups. Comparisons between these groups regarding blastocyst rates, ploidy status and aneuploidy rates were assessed. Main results and the role of chance 120 3PNs zygotes were identified in 1054 cycles, representing 1.9% of all fertilized embryos. The blastocyst rate (BR) for overall 3PNs was 38.3%, while the BR for 2PNs on those 113 cycles was 58.3%, showing significant differences (p &amp;lt; 0.001). 3PN zygotes were classified into the MT and PT groups described above. The MT group had 40.4% BR, and the PT group had 37.0% BR. No significant differences were found. Of the 46 biopsied embryos, 37 were informative (80.4%), 17 for the MT group and 20 for the PT group. The diploidy rate for the overall 3PNs was 37.8% (n = 14). The MT group had 82.4% (n = 14) of diploidy rate, while the PT group had 0% diploid rate (n = 0), showing significant differences between them. (p &amp;lt; 0.001). The overall euploidy rate for 3PN zygotes was 28.6% (n = 12) (36.2 mean age), which was similar to the euploidy rate (30.3%) for our overall 2PNs biopsied during 2023 (38.2 mean age). No differences found. Out of the 14 diploid 3PNs, 28.6% (n = 4) were euploid, showing no differences with our 2023 euploidy rate. Two diploid 3PNs were mosaic, resulting in a total of 6 embryos that could potentially be transferred. Limitations, reasons for caution This study is limited by the number of triploid embryos recruited. As blastocyst rate for 3PNs population is lower than observed in the 2PN population the number of biopsied embryos is reduced. Euploidy rates for 3PNs and 2PNs are very similar, but the mean age differs by 2 years. Wider implications of the findings It is very important to distinguish between both types of 3PNs observed: PT are not worthy to keep and analyse, while MT embryos are very likely to be diploid, and it is worthwhile to culture and analyse them. Patients with few embryos available in particular could benefit from this study. Trial registration number not applicable

إثبات المخالفات التأديبية اثناء التحقيق الإداري على ضوء نظام الخدمة المدنية الأردني رقم 9 لسنة 2020 (دراسة مقارنة)

Objectives: this study sheds light on disciplinary evidence and defines its features to ascertain if an employee has committed a disciplinary offence while carrying out his job duties. It demonstrates how the Administrative Investigation Committee can establish the burden of proof. Research Problem: the adequacy of organising special rules of evidence before the Administrative Investigation Committee to detect behavioural violations. The Jordanian legislator addressed these rules in Article 146/b/2 of the Jordanian Civil Service Law No. 9 of 2020. However, these rules are not integrated, as it is assumed that the administration has complete evidence of claims of behavioural violations. It does not have the right to accuse the employee of deviating from his job mandate without evidence. The employee is also entitled to present evidence refuting such claims. Thus, it falls to investigation committees to search for the necessary evidence to clarify the truth. Methods: this study adopts a descriptive and analytical approach that compares the Jordanian, Egyptian and Emirati legislation concerning the rules of evidence. Results and Conclusions: the paper concludes by with the following results such as: Jordanian Civil Service Law fails to organise the means of evidence and administrative papers, as the legislator did not explicitly grant the Administrative Investigation Committee the authority to review documents related to the violation. In contrast, they were expressly formulated in the Egyptian and Emirati legislations. As well as, the Jordanian legislator did not deal with the method of inspection before the administrative investigation committee in the Civil Service Law, unlike the Egyptian legislator who regulated that method in the law and provided instructions to the Administrative Prosecution. Such was also the case for the UAE federal legislator within the framework of the executive regulations of the human resources law in the federal government. يهدف هذ البحث لتسليط الضوء على الأدلة التأديبية وتحديد ملامحها لمعرفة فيما إذا كان الفعل الواقع من الموظف أثناء قيامه بممارسة واجباته الوظيفية يدخل ضمن إطار المخالفة التأديبية من عدمه، ومعرفة كيفية وضع عبء الإثبات من قبل لجنة التحقيق الإداري، والوقوف عليها للخروج بتوصيات في غاية الأهمية للمشرع الأردني. وركز هذا البحث على موضوع في غاية الأهمية وهو الوقوف على مدى كفاية تنظيم قواعد خاصة بالإثبات أمام لجنة التحقيق الإداري للكشف عن المخالفات المسلكية، فقد تناول المشرع الأردني هذه القواعد وفقاً للمادة 146/ب/2 من نظام الخدمة المدنية الأردني رقم 9 لسنة 2020، إلا أنها غير متكاملة، فمن المفترض أن يكون لدى الإدارة دليل إثبات كامل على ما تدعي بوجود هذه الواقعة، وليس لها اتهام الموظف بالخروج عن مسلك وظيفته دون وجود ما يدل على موقفها، كما يحق للموظف تقديم ما ينفي ويدحض كل ما هو منسوب اليه، ويقع على عاتق لجان التحقيق عبء الوصول للأدلة اللازمة لاستجلاء الحقيقة، وقد بيّنت الدراسة عدم اهتمام المشرع الأردني للقواعد التي تتناول الأدلة الإثباتية في المخالفات التأديبية، إذ تناول بعضها دون بعض، ولذلك تكمن الاشكالية في وجود نقص في التشريع الأردني لتنظيم الإثبات للكشف عن المخالفة الواقعة من الموظف العام. وعليه نوصي بالعمل على تعديل المنظومة التشريعية من خلال إضافة نصوص قانونية تتعلق بأحكام وطرق الإثبات واجراءاتها من الناحية التفصيلية. واعتمد هذا البحث على مناهج عدة منها؛ المنهج التحليلي لتحليل النصوص التشريعية ومضمون الأحكام القضائية والآراء الفقهية ذات العلاقة، كما استخدم البحث المنهج المقارن، حيث تناول الموضوعات المطروحة في هذا البحث ضمن إطار مقارن بين الأردن ومصر والامارات في ضوء الأحكام القانونية المتعلقة بهذا الموضوع للوقوف على نقاط القوة والضعف، والوصول إلى أهم النتائج والتوصيات.

반민특위조사기록에 나타난 정상참작 사유 연구

Special investigation committee of anti-national activities was launched on October 23, 1948 and was active for 343 days until August 31, 1949. We analyzed the extenuating circumstances seen during the special committee’s investigation. The main data is “the investigation records of Special investigation committee of anti-national activitiesvities” and it was examined with a focus on “Nonprosecution Case Records”, “Memoirs”, “Petitions” and “Witness Interrogation Reports”, which reveal extenuating circumstances. Various extenuating circumstances were reflected in the investigation, prosecution, and trial process of the special committee. In order to have their sentences reduced or exempted, the suspects requested that the circumstances be taken into consideration by submitting confessions and petitions and selecting witnesses favorable to the defendants. Since it was a complaint or statement made with the expectation that it would be advantageous to the suspect, the content was naturally perceived generally positively. If we classify the extenuating circumstances that appear in the special committee investigation records by content, they include that there was no choice but to cooperate; that it was not a pro-Japanese act as it was done for the sake of the nation; that it contributed to education, social work, and industrial development; and that it was a public achievement after liberation. It can be classified as having accumulated. Among the suspects, those from government offices claimed that there were extenuating circumstances in the process of performing their duties. Although they followed the policy of the Joseon Government-General, they had no choice but to do so and argued that they were not malicious in the process. Furthermore, there was also the logic that they passively resisted it by not actively carrying out it. It was also claimed that there were activities for the nation in the performance of duties. Those who served as elected local council members received positive evaluations in that they were elected. They also petitioned for extenuating circumstances, citing their contributions to educational activities and regional development. They also advocated participation in local movements such as the movement to publicize the electricity business. These matters were largely accepted by the prosecution department, and this can be confirmed in the reasons for suspension of prosecution in the nonprosecution case record.

Acetabular coverage exerts minimal influence on femoral head collapse and the necessity for surgical intervention in patients with osteonecrosis of femoral head

PurposeThe acetabular coverage in osteonecrosis of the femoral head (ONFH) affects the need for surgical intervention, and the collapse of the femoral head remains unclear. This study aimed to evaluate the relation between the acetabular coverage and the need for surgical treatment and femoral head collapse.MethodsThe study included 158 patients with 252 hips with glucocorticoid administration and idiopathic ONHF without osteoarthritis changes. The mean age at the first visit was 45.2 years, and the mean follow-up period was 92.2 months. All ONFH hips were subsequently divided into two groups: those needing surgical intervention and those without surgery. Additionally, it divided 167 initially non-collapsed hips into those that either later collapsed or not. Radiographic parameters with the centre-edge angle, acetabular roof obliquity, sharp angle, and necrotic location, following the guidelines of the Japanese Investigation Committee, were evaluated.ResultsThere were no significant differences in radiographic parameters between the 106 hips that underwent surgery and the 146 hips without surgery. Among the 167 hips without initial collapse, 91 eventually collapsed while 76 did not; their radiographic findings have no significant differences. The necrotic locations were significantly larger in hips requiring surgical intervention or femoral head collapse. Furthermore, 21.8% (55 out of 252 hips) had acetabular dysplasia, which did not significantly correlate with the necessity for surgical treatment or the incidence of femoral head collapse.ConclusionsAcetabular coverage has little effect on the necessity for surgical treatment and femoral head collapse in ONFH patients over a long-term follow-up.

NURS-15. THE ROLE OF THE ADVANCED PRACTICE PROVIDER AND NURSES IN CLINICAL TRIALS

Abstract BACKGROUND For many years clinical trials fell under the umbrella of medicine without much acknowledgement to the role of the nurse, both as advanced practice provider (APP) and staff nurse. Oncology continues to rank as one of the highest subspecialties when it comes to availability and participation in clinical trials. There remain multiple barriers to involvement including availability, lack of education, and medical mistrust. The specialized role and skill set of the APP and RN as part of the clinical trial team is important in overcoming these barriers. METHODS We distributed a survey to members of the Advanced Practice Provider and Nurse Investigator Committee (APPNIC), a group within the Pediatric Neuro-Oncology Consortium (PNOC), in order to identify themes, barriers to care, and opportunities for both the APP and RN within clinical trials. The use of a survey and interviews within our APPNIC cohort allowed us to collaborate on the nursing role, prioritize care in new and amended trials, and share unanticipated adverse effects and effective management. RESULTS APPs are actively involved with clinical trial enrollment, performance of diagnostic exams and procedures, education, and early recognition/management of adverse effects. There is also a growing theme of the APP as sub-investigator which provides value in facilitating consent, impacting accrual, determining eligibility, managing anticipated side effects. The role of the staff nurse in clinical trials is found to be vital in providing consistent communication/support, educating patients and families, and alleviating adherence and medical mistrust. CONCLUSION The APP and nurse have a specialized, relevant skill set, which when included as part of the multi-disciplinary team, has the ability to decrease barriers and increase overall delivery and safety of clinical trials. Our goal is to outline specific roles we feel should be standardized in the international arena for nursing involvement within clinical trials.

Panoramic heat map for spatial distribution of necrotic lesions.

In this study, we aimed to visualize the spatial distribution characteristics of femoral head necrosis using a novel measurement method. We retrospectively collected CT imaging data of 108 hips with non-traumatic osteonecrosis of the femoral head from 76 consecutive patients (mean age 34.3 years (SD 8.1), 56.58% male (n = 43)) in two clinical centres. The femoral head was divided into 288 standard units (based on the orientation of units within the femoral head, designated as N[Superior], S[Inferior], E[Anterior], and W[Posterior]) using a new measurement system called the longitude and latitude division system (LLDS). A computer-aided design (CAD) measurement tool was also developed to visualize the measurement of the spatial location of necrotic lesions in CT images. Two orthopaedic surgeons independently performed measurements, and the results were used to draw 2D and 3D heat maps of spatial distribution of necrotic lesions in the femoral head, and for statistical analysis. The results showed that the LLDS has high inter-rater reliability. As illustrated by the heat map, the distribution of Japanese Investigation Committee (JIC) classification type C necrotic lesions exhibited clustering characteristics, with the lesions being concentrated in the northern and eastern regions, forming a hot zone (90% probability) centred on the N4-N6E2, N3-N6E units of outer ring blocks. Statistical results showed that the distribution difference between type C2 and type C1 was most significant in the E1 and E2 units and, combined with the heat map, indicated that the spatial distribution differences at N3-N6E1 and N1-N3E2 units are crucial in understanding type C1 and C2 necrotic lesions. The LLDS can be used to accurately measure the spatial location of necrotic lesions and display their distribution characteristics.

Implantation of Culture-Expanded Bone Marrow Derived Mesenchymal Stromal Cells for Treatment of Osteonecrosis of the Femoral Head.

Although core decompression (CD) with stem cell for the treatment of osteonecrosis of the femoral head (ONFH) showed promising results in many reports, the efficacy remains uncertain. We aimed to evaluate the efficacy of CD with culture-expanded autologous bone marrow-derived mesenchymal stem cell (BM-MSC) implantation in early stage ONFH. A total of 18 patients (22 hips) with ONFH who underwent CD with culture-expanded BM-MSC implantation from September 2013 to July 2020 were retrospectively reviewed. The median age was 35.0years [interquartile range (IQR), 28.5-42.0], and the median follow-up period was 4.0years (IQR, 2.0-5.3). The median number of MSCs was 1.06 × 108. To evaluate radiographic and clinical outcomes, Association Research Circulation Osseous (ARCO) classifications, Japanese Investigation Committee classification, combined necrotic angle (CNA) visual analogue scale (VAS) and Harris Hip Score (HHS) were checked at each follow-up. The preoperative stage of ONFH was ARCO 2 in 14 hips and ARCO 3a in 8 hips. The ARCO staging was maintained in 7 hips in ARCO 2 and 4 hips in ARCO 3a. The radiographic failure rate of ARCO 2 and 3a was 14.3 and 50%, respectively. Furthermore, CNA decreased to more than 20° in 6 hips (four were ARCO 2 and two were ARCO 3a).There was no significant difference in the VAS and HHS (P = 0.052 and P = 0.535, respectively). Total hip arthroplasty was performed in 4 hips. CD with culture-expanded autologous BM-MSCs showed promising results for the treatment of early stage ONFH.