Intravenous Laser Research Articles

The combined use of kinesio- and laser therapy in the regional hemodynamic disorders correction in dilated cardiomyopathy

Efficacy evaluation of the combined use of kinesio- and laser therapy for the correction of regional hemodynamics in patients with DCM against the background of maintenance drug therapy. 100 patients with DCM were examined. All patients received differential maintenance drug therapy (beta-blockers, ACE inhibitors, with intolerance to the latter - angiotensin II receptor blockers, aldosterone receptor antagonists, diuretics, cardiac glycosides, antiarrhythmic drugs). Patients were divided into 2 groups at least 3 months after the selection of drug therapy. Intravenous laser blood irradiation (ILBI) and the selection of unloading therapeutic exercises were performed for patients of the main group during therapy. Patients in the control group received only drug therapy. The main research method was venous occlusion plethysmography. It was used to assess regional hemodynamics with the determination of recirculating blood flow (Qr) and regional vascular resistance (Rr) at rest, venous tone (Vt), reserve blood flow (QH) and regional vascular resistance (RH) against a functional stress test. Data obtained in the dynamic observation process (after 1, 3, 6, 9 and 12 months) in the main group indicate a significant increase in Qr and QH, a decrease in Rr and RH, Vt. Significant positive dynamics in the control group was not observed. The regional hemodynamics indices after 9 and 12 months of observation significantly worsened. Thus, according to venous-occlusal plethysmography, the use of unloading therapeutic exercises in combination with ILBI against the background of rationally selected differentiated drug therapy in patients with DCM significantly improves the regional hemodynamics. The developed symptomatic therapy methods can be applied in the practice of cardiologists, general practitioners, therapeutists, rehabilitation physicians to optimize the treatment of patients with DCM.

The use of physical factors in the postoperative period with destructive appendicitis in children: the current state of the problem

Acute appendicitis is the most common childhood surgical disease. With the use of laparoscopic appendectomy for destructive appendicitis in children, the number of postoperative complications significantly decreased. However, in recent years there has been no tendency towards their further decline. The use of non-drug exposure, which has both local and systemic anti-inflammatory effects, can lead to further improvement in the treatment results of the most severe forms of the disease. As a result of a literature review, it was found that there is very little information about the use of physical factors in the postoperative period with destructive appendicitis in children. The effectiveness of the physical factors of systemic exposure (intravenous laser irradiation of blood, the use of ozone) was noted, but currently there are no recommendations on the application of local exposure physiotherapy techniques. Thus, the study of the effectiveness of the use of physical factors in the postoperative period with destructive appendicitis in children at the present stage remains relevant.

The effectiveness of combined laser therapy in patients with trophic leg ulcer and chronic venous insufficiency

Development and scientific justification for the low-intensity laser radiation of different wavelengths combined use in patients with trophic leg ulcers and chronic venous insufficiency (CVI). 102 patients with trophic leg ulcers and CVI were examined. They were divided into 3 equal groups using simple randomization. Patients in the control group received only traditional conservative therapy; comparison group - traditional conservative therapy and an intravenous laser blood irradiation (ILBI) (λ - 635 nm); the main group - traditional conservative therapy and different wavelengths laser therapy (LT) course. A more significant improvement in the clinical condition occurred under the influence of the course application of combined different wavelengths laser therapy in patients with trophic venous leg ulcers. Compared to patients who received traditional conservative therapy and in combination with ILBI 635 nm, the speed of reparative regeneration of trophic ulcers increased, the time for cleansing trophic ulcers from devitalized tissues was reduced. Computer capillaroscopy data showed that the positive effect of laser exposure on all parts of the microcirculation underlies its therapeutic efficacy.

Therapeutic potential of intranasal photobiomodulation therapy for neurological and neuropsychiatric disorders: a narrative review.

The application of photobiomodulation therapy (PBMT) for neuronal stimulation is studied in different animal models and in humans, and has shown to improve cerebral metabolic activity and blood flow, and provide neuroprotection via anti-inflammatory and antioxidant pathways. Recently, intranasal PBMT (i-PBMT) has become an attractive and potential method for the treatment of brain conditions. Herein, we provide a summary of different intranasal light delivery approaches including a nostril-based portable method and implanted deep-nasal methods for the effective systemic or direct irradiation of the brain. Nostril-based i-PBMT devices are available, using either lasers or light emitting diodes (LEDs), and can be applied either alone or in combination to transcranial devices (the latter applied directly to the scalp) to treat a wide range of brain conditions such as mild cognitive impairment, Alzheimer's disease, Parkinson's disease, cerebrovascular diseases, depression and anxiety as well as insomnia. Evidence shows that nostril-based i-PBMT improves blood rheology and cerebral blood flow, so that, without needing to puncture blood vessels, i-PBMT may have equivalent results to a peripheral intravenous laser irradiation procedure. Up to now, no studies were conducted to implant PBMT light sources deep within the nose in a clinical setting, but simulation studies suggest that deep-nasal PBMT via cribriform plate and sphenoid sinus might be an effective method to deliver light to the ventromedial part of the prefrontal and orbitofrontal cortex. Home-based i-PBMT, using inexpensive LED applicators, has potential as a novel approach for neurorehabilitation; comparative studies also testing sham, and transcranial PBMT are warranted.

THE USE OF INTRAVENOUS LASER BLOOD IRRADIATION IN THE TREATMENT OF PATIENTS WITH BEHCET’S SYNDROME

The results of a microbiological and PCR survey of patients with Behcet’s disease, as well as the results of intravenous laser irradiation of the blood (ILIB) are presented. According to the authors, the clinical picture of the disease was represented by the presence of single and multiple repeatedly recurring erosive and ulcerative defects in the area of the oral mucosa (cheek area and lateral surface of the tongue) and/or external genitalia. 4 patients noted soreness in the area of rashes, in 2 rashes were accompanied by a rise in temperature and the symptoms of malaise, weakness. Signs of catarrhal conjunctivitis and uveitis were present in 3 patients, while there was no reduction in visual acuity in the course of the disease. 3 patients had pain in large joints without visible changes on the radiograph and an increase in ESR up to 18-24 mm/h. As a result of the complex therapy with antibacterial, antiprotozoal, antiviral, antifungal therapy depending on the detected pathogen, as well as procedures of ILIB, the resorption of the infiltration zone was noted on the 10-11th day of treatment. Ulcerative elements began to epithelize. Erythema, feelings of burning and pain were absent.

Intravenous laser wavelength radiation effect on LCAT, PON1, catalase, and FRAP in diabetic rats.

The main purpose of this study is to evaluate the effect of intravenous irradiation of different low-level laser wavelengths on the activity of lecithin-cholesterol acyltransferase (LCAT), paraoxonase (PON1), catalase, and ferricreducing ability of plasma (FRAP) in diabetic rats. First, diabetes was induced in rats using streptozotocin (STZ). Enzymes' activity was measured in the blood samples and compared before and after intravenous laser blood irradiation. We used four continuous-wave lasers-IR (λ = 808nm), Red (λ = 638nm), Green (λ = 532nm), and Blue (λ = 450nm)-to compare the wavelength's effect on different enzymes' activity. Laser power was fixed at 0.01mW and laser energy was changed by 2-, 4-, 6-, and 8-min time of radiations.The enzymes' activity of blood samples was measured 2, 6, and 24h after radiation. The results show an increase in the activity of different enzymes when compare with diabetic non-radiated samples. More importantly, with a constant laser energy, the enzymes' activity increased with decreasing laser wavelength. It is important to note that with a constant laser energy, as the wavelength decreases, the photon energy increases and the number of photons decrease, while the enzyme's activity elevation increases. As a result, we can conclude that in intravenous low-level laser therapy, photon energy is more important than the number of photons even if their product, energy, is kept constant.

Effect of low-intensity laser radiation on hemostasis in patients with chronic obstructive pulmonary disease

Objective. The study presents results of the low-intensity intravenous (IV) laser radiation effect on some indicators of the hemostasis system and respiratory function of 83 patients with a chronic lung disease (COPD), stable phase, II-III (after GOLD scale), including 51 men and 32 women. The average COPD duration was 9.6±4.4 years.
 Materials and methods. All patients with COPD were randomly divided into 2 groups - comparison (30 people) and main (53 people). The control group consisted of 20 practically healthy people, matched by sex and age. Patients in the control group received only standard drug therapy with IGCC/DBA combination (budesonide/formoterol, salmeterol/fluticasone propionate inhalation at a therapeutic dose corresponding to the COPD clinical symptoms severity).
 Result and Discussion. In addition to the basic treatment, the main group received a course of intravenous lowintensity laser radiation. As established before the treatment initiation, patients with COPD experienced a decrease in FEV1, Tiffno index, SaO2.
 Conclusion. The respiratory function disruption was accompanied by a significant activation of plasma hemostasis ( prothrombin time shortening, thrombin time, activated partial thromboplastin time) and a significant increase in platelet aggregation (increase in the aggregation degree, aggregation rate, decrease in the aggregation time). At the same time, in patients with COPD, a significant decrease in anticoagulant activity was observed before treatment, particularly antithrombin III decrease when compared with the control group (p <0.05) and CRP (main group: 0.86±0.02; control group: 0.85±0.02). The introduction of low-intensity laser radiation into the patients complex with COPD led to the these parameters normalization.
 Bangladesh Journal of Medical Science Vol.18(3) 2019 p.586-592

The prevention of cardio-vascular diseases in workers of enterprises of mining industry

The leading increasing of cardiovascular pathology in miner workers dictates necessity of development of effective methods of prevention. The article presents the results of application of intravenous blood laser irradiation in miner workers with cardiovascular pathology. The evaluation of condition of cardio-vascular system was carried out to detect mine workers with high cardio-vascular risk. To this group of mine workers course of preventive procedures was prescribed. The course included common medicinal treatment and intravenous laser therapy. The application of intravenous blood laser irradiation promoted normalization of indicators of Holter monitoring of electrocardiogram, day monitoring of arterial pressure, lipid profile and hemostasis system. The anti-arrhythmic, anti-hypertensive, anti-atherogenic and anti-aggregative effects of complex therapy using intravenous blood laser irradiation in mine workers with high cardiovascular risk with its subsequent decrease as a result of treatment.

Estimation of the influence of photobiomodulation on the endothelial function in patients with arterial hypertension under the conditions of hyperuricemia

Introduction. In 2015, the global prevalence of hypertension in the world was estimated at 1.13 billion. The European Association for the Treatment of Hypertension (ESH) updated its recommendations in 2018 and officially added to the already existing risk factors of hypertension hyperuricemia. In patients with comorbidity of hyperuricemia and hypertension, endothelial dysfunction is observed. The aim of the study is to establish correlation between uric acid level and pulse wave velocity, Tei index, endothelium-dependent vasodilation of the brachial artery and evaluate the effect of photobiomodulation on endothelial dysfunction in patients with hypertension. Materials and methods. The study included 102 patients with hypertension: 48 without hyperuricemia (group 1) and 54 with comorbidity of hypertension and hyperuricemia (group 2). Groups 1A and 2A received antihypertensive therapy. Groups 1B and 2B — antihypertensive therapy with a course of intravenous laser therapy with a wavelength of 635 nm, course 10 procedures. Endothelium-dependent vasodilation of the brachial artery was determined by a breakdown with reactive hyperemia. Tei index was calculated during echocardiography. The pulse wave velocity was measured with a SonoScape S6 Pro. Results. Antihypertensive therapy in group 1A reduced the rate of the pulse wave by 7.8 %. Antihypertensive therapy and intravenous laser therapy in Group 1 reduced uric acid by 5.7 %, pulse rate by 12.2 %, Tei index by 9.5 %, increased endothelium dependent vasodilation of the brachial artery by 19.1 % (p < 0,05). Antihypertensive therapy in Group 2A reduced uric acid by 4.7 %, pulse rate by 8.5 % and increased endothelium-dependent brachial artery vasodilation by 31.7 %. Combined use of antihypertensive therapy and intravenous laser therapy in group 2B reduced uric acid by 19.2 %, pulse wave speed by 21.9 %, Tei index by 29.0 %, increased endothelium- dependent vasodilation of the brachial artery by 97.7 % < 0.05). A correlation was established between uric acid level and endothelium dependent vasodilation of the brachial artery r = - 0.62 (p < 0.001) and between uric acid level and pulse wave velocity r = + 0.68, uric acid level and systolic blood pressure (day ) r = + 0.48 (p < 0.001), uric acid level and Tei index r = + 0.47 (p < 0.05). Conclusion. Given the established negative correlation between the mean strength between uric acid level and endothelium-dependent vasodilation of the brachial artery, it is appropriate to use in clinical practice a combination of antihypertensive therapy with intravenous laser therapy, which significantly reduces the level of uterine fibrillation hypertension and in patients with comorbidity of hypertension and hyperuricemia.

The application of instrumental physiotherapy for the treatment of the patients with erectile dysfunction

This article presents information on the application of apparatus physiotherapy for the treatment of the patients with erectile dysfunction. The authors report the results of the analysis of scholarly research designed to confirm the effectiveness of the physiotherapeutic methods applied for the treatment of the patients presenting with this pathology. Special attention is given to the mechanisms underlying the influence of the procedure with the use of local negative pressure-LOD therapy and shock wave therapy on the main pathogenetic components of erectile dysfunction. In addition, the article provides information about the effectiveness of the modern combined physiotherapeutic techniques including sinusoidal modulated current (SMT) electrophoresis of vasoactive substances and vibromagnetic-laser therapy in the combination with the general purpose methods as exemplified by intravenous laser irradiation. Based on the evidence presented in the article, the authors arrive at the conclusion about the prospects for further research on the development of new physiotherapeutic modalities and their introduction in the practical treatment of the patients with erectile dysfunction.

Influence of linear intravenous energy density on the success of intravenous laser ablation for treatment of chronic venous insufficiency.

BackgroundIt is relevant to elucidate the influence that mean linear endovenous energy density (LEED) has on the success of endovenous laser ablation treatment for chronic venous insufficiency, in order to reduce the method’s adverse effects.ObjectivesTo evaluate the influence of mean LEED on the prevalence of saphenous closure 30 days after the laser ablation procedure.Methods153 lower limbs from 118 patients seen at a tertiary hospital and treated for chronic venous insufficiency with endovenous 1470 nm laser ablation under local anesthesia were evaluated. The mean LEED used to treat patients was calculated to determine whether greater than average LEED was required for treatment success.ResultsA significant difference (p = 0.021) in saphenofemoral junction closure was associated with mean LEED used above the knee. Conversely, there was no significant difference in the thigh segment.ConclusionsLinear intravenous energy density greater than the mean of 70.57 J/cm was associated with a higher rate of closure at the saphenofemoral junction. However, density did not have an influence on the result for the thigh segment, showing that an energy density exceeding 70.57 J/cm tends not to be required for treatment of this segment.

Intravenous Laser Wavelength Irradiation Effect on Interleukins: IL-1α, IL-1β, IL6 in Diabetic Rats.

The main purpose of this investigation in Low-Level Laser Therapy (LLLT) on diabetic rats is laser wavelength effect on interleukins: IL-1α, IL-1β, IL6. At first, diabetes was induced in Wistar rats by streptozotocin (STZ) injection. Then, by intravenous laser therapy, the rats were irradiated by four continuous wave lasers: IR (λ = 808 nm), Red (λ = 638 nm), Green (λ = 532 nm) and Blue (λ= 450 nm) to compare the related laser wavelength effect on different interleukins. The inflammatory parameters were measured 2,6 and 24 hours after laser therapy from blood samples and plotted for different laser wavelengths. The results show a decrease in all the above parameters by different laser irradiation in comparison to non-radiated diabetic control ones. More importantly with constant laser energy as the laser wavelength decreases, it affects more efficiently on lowering the above parameters. we can conclude from our data on diabetic rats that in intravenous LLLT, with constant laser energy, shorter wavelengths like Blue (λ= 450 nm) is more effective than longer wavelengths such as Red (λ = 638 nm) and IR (λ = 808 nm) lasers to lower the level of interleukins toward non-diabetic ones.

Интраоперационные инновационные технологии и внутривенное лазерное облучение крови в комплексном лечении при двустороннем деструктивном лекарственно-устойчивом туберкулезе легких

Интраоперационные инновационные технологии и внутривенное лазерное облучение крови в комплексном лечении при двустороннем деструктивном лекарственно-устойчивом туберкулезе легких

THE IMPACT OF ENVIRONMENTAL FACTORS OF AN INDUSTRIAL CITY ON THE FORMATION OF A DERMATOLOGICAL MORBIDITY OF CHILDREN

Introduction. High anthropogenic load in the industrialized regions poses a threat to the health of children. Atopic dermatitis (AD) takes one of the leading places in the overall structure of allergic diseases. The purpose of the study was to substantiate preventive measures aimed at reducing the incidence of atopic dermatitis among children living in the territory of the industrially developed region and to evaluate their effectiveness. Material and methods. the analysis of the state of the environment and the incidence of allergodermatosis in children residing in the Mytishchi district of the Moscow region. Two groups of patients aged from 14 to 17 years (70) were selected to develop measures for the prevention of atopic dermatitis. The first group received intravenous laser irradiation of blood (ILRB) and traditional therapy, the second - only traditional treatment. Laboratory studies included indices of immune and antioxidant status. Results. The unfavorable trend in the prevalence of allergic skin diseases in children is presented: allergic dermatoses make up 44.5% (AD - 36.8%, eczema - 7.7%). The increase in severe and moderate forms of AD by 7% and 15% was noted. In this region statistically significant correlations between indices of the air pollution, drinking water, technogenic loading and level of the morbidity rate of skin, including (AD)(r=0,73-0,84) are revealed. Application of the ILRB in children with atopic dermatitis had a positive impact on the state of cellular immunity: the number of CD3+and CD8+ lymphocytes increased by 1.2-1.4 times, the level of IL-10 and IL-4 decreased by 1.5 times; humoral immunity (the number of patients with a positive effect on indices of IgA, IgM, IgE, CIC, was more than 80%); antioxidant status (MDA decreased by 1.3 times, the activity of serum catalase increased by 1.2 times). In general, there was an improvement in the clinical course of the skin damage process, an increase in terms of remission. During the six-month following-up of patients included in the study, in the ILRB group, only 20% had an exacerbation of the disease compared to 68% of the group receiving traditional treatment.

Aspects of Diagnosis and Treatment of Retinoblastoma in Mongolia

Objectives: To describe the clinical characteristics and the treatment outcome of retinoblastoma in Mongolian children. Methods: Data of all children diagnosed with retinoblastoma at the National Center for Maternal and Child Health of Mongolia from 1987 to January 2017 were reviewed retrospectively. The ICRB classifi cation was used. Survival characteristics of the cohort were analyzed. Results: Retinoblastoma was diagnosed in 100 eyes of 79 children during the study period. Median age of diagnosis was 23.2±5.8 months. There were no differences in sex ratio and 21 cases (27%) were bilateral. Fifty-two patients (66%) were from rural areas. The more frequent clinical presentations were leukocoria in 64 (81%) patients, unilateral mydriasis 35 (45%) and strabismus in 34 (44 %) patients. Sixty-nine (87.3%) patients were diagnosed with Classifi cation D or worse when presented to us. Due to late diagnosis in the majority of cases, unilateral and bilateral enucleations were performed in 58 (58%) eyes and 26 (26%) eyes respectively; exenteration was done in 3 (3%) eyes, intravenous chemotherapy was done (11%) eyes and laser surgery was done (4%) eyes. After the mean follow up of 10 years, 67 (84.8%) patients were alive, 5 (6.3%) patients died and in 7 (8.8%) patients their vital status was unknown. The mean follow-up period was 144.1±16.3 (95% CI 122.6-165.5) months (range, 15-365months). In 5 cases in which immunohistochemistry analysis was performed, neuron-specifi c enolase (NSE), Ki-67 protein (Ki-67), B-cell lymphoma 2 (Bcl-2) positive cells were found in all of 5 (100%) cases and Rb protein was detected in 3 (60%) cases. Conclusion: The implementation of International Classifi cation of Retinoblastoma, systemic intravenous chemotherapy and laser treatment for retinoblastoma, shows favorable outcome in the treatment of retinoblastoma and further prognosis.

Effectiveness of low level laser therapy for treating male infertility.

In half of the cases, the infertility of the couple is due to the disorder of the male fertility. The leading factors that cause male infertility are urogenital infections, disorders of the immune system, testicular and prostate pathology, as well as endocrine disorders.Low level laser therapy (LLLT) is a very effective physical therapy method, used in many areas of medicine, including obstetrics and gynaecology, andrology and urology; and it is recommended as an integral part of the complex treatment of infertility.The literature review showed that LLLT is beneficial in treating male infertility. Laser can significantly improve the survival, motility and speed of movement of spermatozoa. Laser therapy of patients with prostatitis and vesiculitis can eliminate infiltrative-exudative changes, improve reproductive and copulatory functions. Local illumination of red (635 nm) and infrared (904 nm) spectra should be combined with intravenous laser blood illumination (ILBI) of red (635 nm) and ultraviolet (UV) (365 nm) spectra.

СOMPARATIVE EFFICACY OF TRANSCRANIAL ELECTROSTIMULATION AND INTRAVENOUS LASER BLOOD IRRADIATION IN TREATMENT OF CHRONIC DIFFUSE LIVER DISEASES

The article presents the results of an evaluation of the comparative efficacy of treatment for 198 patients with chronic diffuse liver diseases, which show that transcranial electrostimulation is generally comparable in effectiveness with the method of intravenous laser irradiation of blood, differing in non-invasiveness and lower cost.

Physical therapy of psoriasis. The modern methodological approaches

This article describes the modern approaches to the application of physical factors for the treatment of various forms of psoriasis taking into consideration the severity of clinical manifestations and the phase of the disease, the extent of disturbances of the functional state of different organs. The principles of prescription of physiotherapeutictreatmnt are formulated taking account of the stages and forms of the disease. Special attention is paid to the high therapeutic effectiveness of ultraviolet irradiation of the skin including narrow-band UVВ (311 nm) as well as to photodynamic therapy (PUVA), intravenous laser irradiation of blood, and ozone therapy. Also considered is the spa and health resort-based treatment and peloid therapy at various stages of the pathological process. The application of the combined techniques is described with special reference to radon and hydrogen sulfide baths and microwave therapy in the patients presenting with psoriatic arthritis. Much attention is given to the effectiveness of the prescription of the spa and health resort-based treatment at the stationary and regressive stages of psoriasis. The pathogenetic mechanisms underlying the therapeutic action of the physical factors used for the treatment of patients suffering from psoriasis are discussed.

Effects of Intravenous Laser Irradiation of Blood on Pain, Function and Depression of Fibromyalgia Patients

Objective: Fibromyalgia, labeled for an illness of wide spreading pain, fatigue, restless sleep, gastrointestinal disturbances, and mood disorders, is a complex and heterogeneous disease. Novel and improved treatments would allow healthcare professionals to improve the conditions of patients with fibromyalgia. For instance, photo biomodulation is a new treatment that minimizes heavy usage of drugs and side effects. This study investigated the clinical effects of intravenous laser irradiation of blood on pain, sleep, mood disorders, and quality of life in patients with fibromyalgia.Methods: Fifteen patients diagnosed as having fibromyalgia based on the modified 2010 criteria of the American College of Rheumatology from an outpatient clinic were recruited. Before admission, all subjects were asked to submit visual analog scale (VAS), numbers of tender points, revised Fibromyalgia Impact Questionnaire (FIQR), revised Beck Depression Inventory (BDI) and Pittsburgh Sleep Quality Index (PSQI) according to their outcomes before/after drugs in a previous outpatient clinic. After admission, all participants received two courses of intravenous laser irradiation of blood, each course is composed of 10 intravenous laser irradiation of blood sessions, each session of the therapeutic duration lasted for 60 minutes. Two consecutive courses had a 7-day rest interval. The trial lasted for 4 weeks. Outcomes based on patient-reported symptoms of the aforementioned tests were evaluated on two separate occasions: baseline and within 24 hours after the last day of the protocol.Results: The drugs resulted in significant reduction in pain intensity only. However, the before/after comparisons of intravenous laser irradiation of blood showed a significant improvement in VAS (p=0.001), number of tender points (p=0.002), FIQR (p=0.001), BDI (p=0.003) and PSQI (p=0.01). We also noted significantly positive effects of ILIB compared with drugs in all tests.Conclusion: Intravenous laser irradiation of blood had a better effect on pain severity, sleep, mood disorder, and quality of life in patients with fibromyalgia. No unfavorable events were recorded; thus, intravenous laser irradiation of blood appears to be an effective treatment for patients with fibromyalgia.

Disorders of the Functional State of the Haemostatic System during Intraoperative and Postoperative Anesthesia and their Prevention

The purpose is to develop principles of intra-and postoperative preventive measures against thromboembolic complications in gynaecologic patients with haemostasis system defects. The methods of examining the haemostasis system status included the determination of the platelets level, platelets aggregation, activated partial thromboplastin time (APTT), plasma coagulation time, prothrombin time, international normalized ratio (INR), concentration of fibrinogen in plasma, antithrombin III activity, and D-dimer. A comprehensive analysis of the haemostasis and fibrinolysis system was carried out with the ARP-01 “Mednord” portable analyser of blood rheological properties. Obtained results were statistically processed with the SPSS v.20.0 software (Providence Software Solutions, Inc., USA) with Student's t-test and Mann-Whitney U-test. The comparison of dependent variables used the Wilcoxson W-test. The significance of differences in qualitative attributes was analysed during the frequency analysis with Fisher's exact test and the chi-squared test. The study suggests two differentiated approaches to the prescription of intravenous laser irradiation of blood, based on hemocoagulogram indicators that reflect the structural and chronometric properties of the formed clot.