Intravenous Bags Research Articles

Use of a two-bag fluid administration protocol in the treatment of paediatric diabetic ketoacidosis: A retrospective review

ABSTRACT Objectives The ‘two-bag method’ for the treatment of diabetic ketoacidosis (DKA) uses two intravenous fluid bags, only one of which contains 10% dextrose. The bags are run concurrently with rates adjusted according to a rate change table to allow the relative amount of dextrose administered to be adjusted over time, without the need for bag replacements. The Children’s Hospital at London Health Sciences Centre (CHLHSC) two-bag protocol is a simplified version of that used by other centres. The objective of this study was to ensure implementation of the CHLHSC two-bag protocol continues to provide safe and effective treatment of paediatric DKA and decreases resource utilization. Methods This retrospective chart review compared treatment pre- and post-protocol implementation. Results A total of 22 admissions were included. No significant differences in efficacy or safety outcomes were found between the protocol groups. There was no statistically significant difference between the two and one-bag protocols in time to normalization of serum bicarbonate (13.80 ± 7.68 versus 15.01 ± 7.53 h, P = 0.714), blood glucose correction (8.75 ± 4.86 versus 11.85 ± 4.92 h, P = 0.152), and critical care unit length of stay (24.26 ± 9.94 versus 32.30 ± 13.36, P = 0.399). The nursing staff appeared to appropriately implement the rate change table, but the chart documentation was poor. Conclusions The CHLHSC simplified two-bag protocol provides a safe and effective alternative to the one-bag protocol for DKA correction in paediatric patients and may also result in decreased resource utilization.

An automated dispensing cabinet alert influences anesthesia provider medication preparation in a remifentanil waste reduction initiative

Study ObjectiveTo decrease the occurrence of remifentanil waste of 1 mg or more (1 full vial) by 25 % in our surgical division while maintaining satisfaction of 60 % of providers by using a remifentanil mixing workflow. DesignA time series–design quality improvement initiative targeted preventable remifentanil waste. A period of active interventions, followed by a pause and reinstatement of a system intervention, was used to validate its effectiveness. SettingAn academic medical center in the US with 1219 inpatient beds, performing 144,418 surgical cases in 2019 and 127,341 surgical cases in 2020, in 148 operating rooms. InterventionsIndividual- and system-level interventions provided education on the issues of preventable waste, access to a remifentanil dose calculator, and an automated dispensing cabinet (ADC) alert to halt wasteful practice. MeasurementsPreventable remifentanil waste was identified as disposing of intravenous infusion bags containing 1 mg or more or 1 full vial or more of unused medication. Data were retrieved from ADC reports. A preimplementation and postimplementation survey of anesthesia providers assessed workflow attitudes, perceptions, and satisfaction surrounding remifentanil mixing. Main ResultsPreventable remifentanil waste (≥1 mg or ≥ 1 full vial) decreased significantly from 22.0 % of cases using remifentanil at baseline to 16.7 % of cases using remifentanil (odds ratio, 0.71; 95 % CI, 0.60–0.84; P < .001) during the final data collection. Individual-level interventions of education, remifentanil dose calculator, and practice champions did not significantly affect waste while unpaired from the system intervention of the ADC alert. ConclusionsThe implementation of an ADC alert reduced preventable remifentanil waste among anesthesia providers.

Biodegradable Alternatives to Plastic in Medical Equipment: Current State, Challenges, and the Future

The use of plastic products or components in medical equipment and supplies results in challenges in terms of environmental sustainability and waste management for disposable, non-recyclable, and non-biodegradable materials. Medical plastic waste includes items ranging from syringes, tubing, intravenous (IV) bags, packaging, and more. Developing biodegradable replacements to petroleum-based plastics in medical equipment has not yet become an urgent priority, but it is an important endeavor. Examining alternatives involves several key themes, including material selection, testing, validation, and regulatory approval. To date, research includes studies on biodegradable polymers, composite materials, surface modifications, bacterial cellulose, three-dimensional (3D) printing with biodegradable materials, clinical trials and testing, collaboration with industry, regulatory considerations, sustainable packaging for medical devices, and life cycle analysis. The incorporation of bio-based and biodegradable plastics in the healthcare industry holds immense potential for reducing the environmental impact of medical plastic waste. The literature suggests that researchers and industry professionals are actively working towards finding sustainable alternatives that meet the stringent requirements of the medical industry. This paper reviews the efforts made so far to develop biodegradable and sustainable alternatives to plastic in medical equipment using a meta-analysis of resources, which include relevant papers published in English until June 2024. A total of 116 documents were found and screened by three reviewers for relevance. The literature reviewed indicated that various medical uses require plastics due to their unique properties, such as having strength and flexibility; being lightweight; and being able to prevent bacterial contamination. Among the alternatives, polycaprolactone (PCL), polylactic-co-glycolic acid (PLGA), starch-based acid, and polybutyric acid (PBS) have demonstrated favourable outcomes in terms of biocompatibility, safety, and efficacy. Additionally, a set of approaches to overcome these barriers and strategies is discussed alongside potential future solutions. This review aims to catalyze discussions and actions toward a more environmentally sustainable future in the medical industry by providing a comprehensive analysis of the current state, challenges, and prospects of this domain.

Recycling potential of medical plastic waste

Medical plastic waste threatens the environment and human health if not properly handled and disposed of. This study used field visits, multi-criteria decision analysis, material testing, and data analysis to assess the feasibility of recycling medical plastic waste. The study identified medical plastic products (syringes, intravenous bags, and infusion sets) with high recyclability potential and proposed targeted recommendations for improving waste management practices. Medical plastic waste generation rates in kg/bed/day were 0.486 and 0.428. 55 kg/day and 5 kg/day of recyclable medical plastic waste are generated at KATH and KNUST hospitals, respectively. The contextual relevance of this research extends beyond the Ghanaian healthcare system, with implications for waste management practices in low and middle-income countries by contributing to the advancement of sustainable waste management practices.

SECURE FLOW - “A Life Saving Intravenous Drip System”

Intravenous (IV) therapy is a common medical procedure that involves the delivery of fluids, medications, or nutrients directly into a vein. Intravenous drips are often used in hospitals and clinics to treat a variety of conditions, including dehydration, sepsis, and chemotherapy. Traditionally, Intravenous drips are controlled manually by healthcare professionals or nurses. In recent years, there has been growing interest in the development of automated Intravenous drip systems. These systems can help to improve the accuracy, efficiency, and safety of Intravenous therapy. The system “Secure flow” is proposed to use solenoid valve to control the flow of fluid, and the load cell is used to measure the weight of the Intravenous bag. If the weight of the Intravenous bag decreases below a certain threshold, the solenoid valve is activated to stop the flow of fluid and also sends an alert notification to the registered number. It also has a potentiometer which can be used to adjust the preset value of the liquid in the solenoid to flow through the patient’s body. Overall, this system has the potential to improve the safety, efficiency, and accuracy of Intravenous therapy. This system can be a valuable tool for hospitals and clinics that are looking to improve the quality of care that they provide to their patients.

Development of a multilayer film for the first US Food and Drug Administration cleared aseptically-produced intravenous solution bags with a short history of key medical device milestones

Flexible intravenous solution containers (IV bags) were introduced to the marketplace in the early 1970s. These new containers were designed to replace glass IV bottles and were quickly adopted widely for delivering medical solutions to patients throughout the world. The 40 years during which commercially available IV solutions in glass bottles were used, the healthcare industry grew dramatically with better patient outcomes while also reducing operational costs. These early developments then led to the rapid expansion of new medical devices that have been further developed to improve healthcare and reduce overall costs of the products and devices. It is not an exaggeration to suggest that the medical device industry was founded on the development of the flexible poly (vinyl chloride) (PVC) plastic IV tubing and bag. After the IV bag product lines grew to serve many markets, a new unmet need was discovered for an aseptically produced premixed drug container. This article will review how a new film was developed and used to produce the required aseptically made IV premixed drug product. It was, after the Food and Drug Administration (FDA) gave “clearance to market”, a ground-breaking product, never before thought possible for the highly FDA-regulated and controlled industry.

An assessment of exposed syringe inner walls as a route of exposure from hazardous drugs.

Maintaining safe working environments for health care personnel, especially for those who regularly handle hazardous drugs (HDs), is of utmost importance. Studies have shown that when closed system transfer devices (CSTDs) are used with standard open barrel syringes, cyclophosphamide (CP), a commonly used HD, is transferred to the syringe plunger during compounding or administration processes. This contamination can then be transferred to the work environment, endangering workers. The purpose of this study was to quantify HD contamination of the inner surface of standard open barrel syringes and to compare contamination levels between three commonly used HDs: 5-fluorouracil (5-FU), CP, and ifosfamide (IF). Each HD was transferred from a vial to an intravenous (IV) bag using a standard open barrel syringe and Becton, Dickinson and Company (BD) PhaSealTM CSTD connectors. Samples were taken from the inner surface of each of the syringe barrels to measure the amount of HD contamination. Each drug was tested 15 times and compared to a positive control. Significant amounts of each drug were transferred to the inner surfaces of the syringes. The average amounts of each drug measured were: 5-FU, 1327.7 ng (standard deviation [SD] = 873.6 ng); CP, 1074.8 ng (SD = 481.6 ng); and IF, 1700.0 ng (SD = 1098.1 ng). There was no statistically significant difference between the three drugs (p = 0.14). This study underscores the presence of HD contamination on standard open barrel syringe inner surfaces after transfer of drug from vial to syringe to IV bag. Such contamination could be spread in the working environment and expose health care workers to harm.

Impact of NaCl on Monoclonal Antibody Aggregation Induced by Agitation.

Monoclonal antibodies (mAbs) are a successful class of therapeutics, but their development can be challenging due to the risk of degradation that could happen during manufacturing, storage, and clinical use. One of the common causes of degradation is agitation stress from transportation and clinical handling, which increases interfacial stresses to mAbs. For example, the preparation of the dose solution prior to administration often requires diluting therapeutic mAbs in intravenous (IV) infusion bags containing normal saline, which can substantially reduce the level of protective surfactant and increase the level of salt in mAb solutions. Then the interfacial stress in the subsequent transportation of IV bags can cause mAb aggregation or even particle formation. To better understand the complex interplay between dilution, interfacial stress, and salt, we studied the impact of sodium chloride (NaCl) on the aggregation of two mAbs under agitation stress. We found that the presence of NaCl accelerates the aggregation of both mAbs, but the aggregation mechanism, morphology, and reversibility are very different. Our results clearly highlight the impact of salt on mAb stability at the clinical in-use condition. We believe this study further increases our understanding of protein aggregation mediated by interfacial stresses and brings valuable insights to support development of mAb formulations for patients.

Physicochemical and biological stability of diluted vedolizumab in intravenous infusion bags

IntroductionIntravenous vedolizumab is a widely used monoclonal antibody for outpatients with inflammatory bowel disease. Drug preparation is performed on the day of administration, but is time consuming, causing unnecessary in-hospital...

IOT IV Bag Monitoring and Termination System

Abstract: This paper introduces an innovative IoT-based Intravenous (IV) Bag Monitoring and Termination System designed to address critical challenges in traditional IV therapy. The proposed system leverages advanced sensors and connectivity to monitor IV bag parameters in real-time, ensuring accurate and timely administration of medical fluids. The system comprises a network of smart sensors integrated into IV bags, capable of continuously measuring fluid volume, infusion rate, and temperature. These parameters are wirelessly transmitted to a centralized control unit, providing healthcare professionals with comprehensive and up-to-the-minute data. The IoT IV Bag Monitoring and Termination System offers an intelligent alert mechanism to notify healthcare providers of any deviations from prescribed values, facilitating proactive intervention and minimizing the risk of complications. This ensures patient safety by preventing over-infusion or under-infusion scenarios. The proposed system not only improves the precision of IV therapy but also streamlines healthcare workflows, reducing the burden on medical staff and enhancing overall patient care.

ADVANCEMENTS IN HEALTHCARE THROUGH DESIGN AND DEVELOPMENT OF AN INTELLIGENT INTRAVENOUS BAG MONITORING AND ALERT SYSTEM

The Intelligent Intravenous Bag Monitoring and Alert System is a device designed for nighttime patient monitoring, allowing nurses to focus on other duties and prevent air bubbles from entering the patient's bloodstream. The device uses an S-type load cell to measure IV bag contents, and the Blynk app to display readings on a smartphone. The device's CPU, a NodeMCU, operates on a voltage range of 5V to 12V. The device's goal is to monitor the current IV content level, which can be checked using a smartphone and the LCD display. This innovative solution is particularly useful for intravenous (IV) treatment, which allows patients to receive fluids, medications, and nutrients directly into their veins. The device's effectiveness is further enhanced by the Blynk app.

Transportation of mAb Dosing Solution in Intravenous Bag: Impact of Manual, Vehicle, and Pneumatic Tube System Transportation Methods on Product Quality.

Monoclonal antibody (mAb) products for intravenous (IV) administration generally require aseptic compounding with a commercial diluent within a pharmacy. The prepared dosing solution in the IV bag may be transported to the dosing location via manual, vehicular, pneumatic tube system (PTS), or a combination of these methods. In this study, the type and level of physical stresses associated with these three methods and their product quality impact for relatively sensitive and stable mAbs were assessed. Vibration was found to be the main stress associated with manual and vehicle transportation methods, although this was at a relatively low level (<1 GRMS/Root-Mean-Square Acceleration). Shock and drop events, at relatively low levels, were also observed with these methods. PTS transportation showed substantially more intense shock, vibration, and drop stresses and the measured levels were up to 91 G/force of acceleration or deceleration, 3.7 GRMS and 39 G, respectively. Using a foam padding insert for PTS transportation reduced the shock level considerably (91 G to 59 G). Transportation of mAb dosing solutions in IV bags via different methods including PTS transportation variables caused a small increase in the subvisible particle counts and there was no change in submicrometer particle distribution. No visible particles and no significant change to soluble aggregate levels were observed after transportation. Strategies such as removal of IV bag headspace prior to transport and in-line filtration poststress reduced the subvisible particles counts. All tested transportation conditions showed negligible impact on other product quality attributes tested. Removal of IV bag headspace prior to PTS transport prevented formation of micro air bubbles and foaming compared to the unaltered IV bag. This study shows examples where manual, vehicle, and PTS transport methods did not significantly impact product quality, and provides evidence that mAb products that are appropriately stabilized in the dosing solution (e.g., with a surfactant) can be transported via a PTS.

Evidence for the cardiodepressive effects of the plasticizer di-2-ethylhexyl phthalate.

Di-2-ethylhexyl phthalate (DEHP) is commonly used in the manufacturing of plastic materials, including intravenous bags, blood storage bags, and medical-grade tubing. DEHP can leach from plastic medical products, which can result in inadvertent patient exposure. DEHP concentrations were measured in red blood cell units stored between 7 and 42 days (17-119 μg/ml). Using these concentrations as a guide, Langendorff-perfused rat heart preparations were acutely exposed to DEHP. Sinus activity remained stable with lower doses of DEHP (25-50 μg/ml), but sinus rate declined by 43% and sinus node recovery time (SNRT) prolonged by 56.5% following 30-min exposure to 100 μg/ml DEHP. DEHP exposure also exerted a negative dromotropic response, as indicated by a 69.4% longer PR interval, 108.5% longer Wenckebach cycle length (WBCL), and increased incidence of atrioventricular (AV) uncoupling (60-min exposure). Pretreatment with doxycycline partially rescued the effects of DEHP on sinus activity, but did not ameliorate the effects on AV conduction. DEHP exposure also prolonged the ventricular action potential and effective refractory period, but had no measurable effect on intracellular calcium transient duration. Follow-up studies using human-induced pluripotent stem cell-derived cardiomyocytes confirmed that DEHP slows electrical conduction in a time (15 min-3 h) and dose-dependent manner (10-100 μg/ml). Previous studies have suggested that phthalate toxicity is specifically attributed to metabolites of DEHP, including mono-2-ethylhexylphthalate. This study demonstrates that DEHP exposure also contributes to cardiac dysfunction in a dose- and time-dependent manner. Future work is warranted to investigate the impact of DEHP (and its metabolites) on human health, with special consideration for clinical procedures that employ plastic materials.

Development of a generic approach for monitoring leachable compounds in hospital pharmacy-prepared prefilled plastic packaging by ultrahigh-performance liquid chromatography coupled to high-resolution mass spectrometry with postcolumn infusion

Prefilled plastic packaging is time- and cost-effective in hospital pharmacy because it prevents waste, preparation errors, dosage errors, microbial contamination and accidents. This packaging mostly includes prefilled syringes (PFS), intravenous (IV) bags and vials intended for long-term storage that can be used for immediate treatment. There is a rising availability in the market for prefilled drug products due to their practical approach. Leachable compounds could be evaluated in hospital pharmacy-prepared prefilled drug solutions. The Pharmacy Department at the Lausanne University Hospital has developed an innovative, highly sensitive, and generic method by postcolumn infusion based on ultrahigh-performance liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) for the analysis of plastic additives in hospital pharmacies. The postcolumn infusion solution was developed with 2% ammonium hydroxide in methanol on a representative set of 30 candidate compounds with different physical-chemical properties, such as log P and molecular structure, to represent the most important categories of additives. The LODs obtained for all compounds ranged from 0.03 to 7.91 ng/mL with linearity up to 250 ng/mL. Through this screening method, plastic additives can be rapidly identified due to the combined use of retention time, exact mass (including isotopic pattern) and MS/MS spectra. In addition, the users can screen for vast categories of plastic additives, including plasticizers, epoxy monomers, antioxidants, UV stabilizers, and others. The screening is facilitated by assessments of a complex in-house-built database for extractable and leachable trace assessment (DELTA), containing 205 compounds for unambiguous identification. Relative response factors were established for all analytes to obtain a semiquantitation of compounds. Moreover, the database also contains valuable estimative toxicology information, which was obtained through calculating their permissible dose exposure threshold; thus, estimative toxicology assessment can be performed for identified compounds in prefilled drug products. This method and the database were applied to a hospital pharmacy-prepared prefilled vancomycin syringe for paediatric use. Ultrasound-assisted dispersive liquid-liquid microextraction (UA-DLLME) was used to prepare the samples for leachable analysis. As a result, 17 plastic additives were formally identified, and their concentrations were estimated. A toxicology assessment was performed by comparing their concentrations with their theoretical PDE thresholds. In conclusion, the prefilled drug solution released a negligible amount of known leachables that appeared to be safe for use in neonates and children.

Deep learning-based monitoring technique for real-time intravenous medication bag status.

The online version contains supplementary material available at 10.1007/s13534-023-00292-w.

Just-in-time procedural training for pediatric emergency medicine trainees: A randomized educational interventional trial.

Pediatric requirements include procedural skills training such as peripheral intravenous (PIV) catheter placement and bag-mask ventilation (BMV). Clinical experiences may be limited and temporally remote from scheduled teaching. Just-in-time (JIT) training prior to utilization can promote skill development and mitigate learning decay. Our objective was to assess the impact of JIT training on pediatric residents' procedural performance, knowledge, and confidence with PIV placement and BMV. Residents received standardized baseline training in both PIV placement and BMV during scheduled educational programming. Between 3 and 6 months later, participants were randomized and received JIT training for either PIV placement or BMV. JIT training included a brief video and coached practice, totaling <5 min. Each participant was videotaped performing both procedures on skills trainers. Blinded investigators scored performance using skills checklists. Pre- and postintervention knowledge was assessed using multiple-choice and short-answer items, and confidence was reported using Likert scores. Seventy-two residents completed baseline training sessions: 36 were randomized to receive JIT training for PIV and 36 for BMV. Thirty-five residents in each cohort completed the curriculum. There were no significant differences between the cohorts with regard to demographics, baseline knowledge, or prior simulation experience. JIT training was associated with improved procedural performance for PIV (median 87% vs. 70%, p < 0.001) and for BMV (mean 83% vs. 57%, p < 0.001). Results remained significant after using regression models to adjust for differences in prior clinical experience. Improvements in knowledge or confidence were not associated with JIT training in either cohort. JIT training resulted in a significant improvement in resident procedural performance with PIV placement and BMV in a simulated environment. There were no differences in outcome with regard to knowledge or confidence. Future work might explore how the demonstrated benefit translates into the clinical setting.

How much do we throw away in the intensive care unit? An observational point prevalence study of Australian and New Zealand ICUs

ObjectiveDuring the current COVID pandemic, waste generation has been more evident with increased use of single use masks, gowns and other personal protective equipment. We aimed to understand the scale of waste generation, recycling rates and participation in Australian and New Zealand (ANZ) ICUs. DesignThis is a prospective cross-sectional point prevalence study, as part of the 2021 ANZICS Point Prevalence Program. Specific questions related to waste and sustainability practices were asked at the site and patient level. Setting and participantsANZ adult ICUs and their patients on the day of the study. Main outcome measuresAmount of single use items disposed of per shift, as well as the engagement of the site with sustainability and recycling practices. ResultsIn total, 712 patients (median number of patients per ICU = 17, IQR 11–30) from 51 ICUs across ANZ were included in our study; 55% of hospitals had a sustainability officer, and recycling paper (86%) and plastics (65%) were frequent, but metal recycling was limited (27%). Per patient bed space per 12-h shift there was recycling of less than 40% paper, glass, intravenous fluid bags, medication cups and metal instruments. A median of 10 gowns (IQR 3–19.5), 10 syringes (4.5–18) and gloves 30 (18–49) were disposed of per bed space, per 12-h shift. These numbers increased significantly when comparing patients with and without infection control precautions in place. ConclusionsIn ANZ ICUs, we found utilisation of common ICU consumables to be high and associated with low recycling rates. Interventions to abate resource utilisation and augment recycling are required to improve environmental sustainability in intensive care units.

A simple and inexpensive method to monitor and minimize exposure from manipulation of cytotoxic drugs.

Pharmacy personnel that manipulate cytotoxic drugs are under continuous exposure risk. Therefore, training and strict adherence to recommended practices should always be promoted. The main objective of this study was to develop and apply a safe, effective and low-cost method for the training and assessment of the safe handling of cytotoxic drugs, using commercially available tonic water. To evaluate the potential of tonic water as a replacement marker for quinine hydrochloride, deliberate spills of 1 mL of four different tonic waters (one coloured and three non-coloured) were analysed under ultraviolet light (300-400 nm). The pigmented sample did not produce fluorescence under ultraviolet (UV) light. The three commercially available tonic waters that exhibited fluorescence were further analysed by UV/Vis spectrophotometry (300-500 nm). Afterwards, a protocol of simulated manipulation of cytotoxic drugs was developed and applied to 12 pharmacy technicians, that prepared 24 intravenous bags according to recommended routine procedures using tonic water. Participants responded to a brief questionnaire to evaluate the adequacy and applicability of the activity. Seven of the participants had spillages during manipulation, the majority of which recorded during manipulation with needles. All participants scored the tonic water manipulation simulation with 4 or 5 points for simplicity, efficiency and feasibility. The obtained results suggest that tonic water can be used to simulate the manipulation of cytotoxic drugs in training and assessment programs. By using this replacement marker for quinine hydrochloride, it is possible to perform a more cost-effective, yet equally effective, assessment.

IoT Intravenous Bag Monitoring and Alert System

The day-to-day monitoring of patients in a hospital is a challenging task under our existing medical care system. During Health Hazard times like Covid 19 physicians or nurses are too busy to keep track of every patient. This leads to numerous issues. Work relating to health should be completed correctly and accurately. Saline or intravenous (IV) fluid injections into patient veins are an example of this kind of activity in our hospitals. Inadequate drip system monitoring can result in issues like blood loss, fluid backflow, and other issues. We present a solution called the IoT Intravenous Bag Monitoring and Alert System in order to lessen the strain and resolve such a dire issue in the domain of an intravenous drip monitoring system. Healthcare workers found themselves overburdened at the height of the Covid-19 Epidemic due to the constant influx of new patients. Frontline staff members cannot directly monitor and care for every patient during such periods. A medical procedure called Intravenous treatment is used to inject nutrients, medicines, and fluids straight into a patient's vein. IV therapy is essential to aid a patient in recovering quickly because it is frequently used to rehydrate and supply nutrients. Nonetheless, IV drips require routine inspection and replacement. Depending on the patient and their condition, the fluid flow must also be measured. The Weight Sensor used by this IoT intravenous fluid monitoring system detects when the fluid level in the IV infusion bottle drops and broadcasts the information over IoT.

Analysis and Implementation of Intravenous Bag Monitoring System

The Intravenous Bag Monitoring System is based upon the "Internet of Things" with the use of new technology of Artificial Intelligence and it issues flu for the Hardware as well as the software any type of project we can create using this technology and with the use of new technology today's world are grown up to the never possible conditions are also possible through the AI system So, we are looking forward to our application is used for the hospital purpose including small Clinics and Big Hospitals we had studied on it for which type of problems faced by Nurses and doctors so as we are looking for this problem then we r generating and finding a solution on it that is “Intravenous Bag Monitoring System”. This application works on the IV Bags weight sensor through this sensor the load cell sense the weight of the IV Bag and through cloud computing that data goes to the cloud and the Blynk IOT application fetches the data from the cloud and it will display the Blynk IOT dashboard like how much liquid is available in the bottle and the new feature added in this application is that when the liquid is coming up to the 15% then the Buzzer get started on the particular Hardware Kit and as well as on the mobile also alert notification sending if any nurse was busy in her another work and she can’t use her mobile that time Buzzer get started while the liquid is below 15% and as per the bottle we can set the percentage as the Buzzer will get started.