Objective Through study the clinical characteristics,diagnosis,treatment and prognosis of intracranial chondrosarcoma,to improve the management of this disease. Methods The clinical data of 26 cases of intracranial chondrosarcoma confirmed by pathology from Nov.2004 to Sep.2011 were analyzed retrospectively,then the data of result were valued.Results 24 cases from skull base,1 case from supratentorial and 1 case from pineal region,they were all given operated.Of 26 cases,7 cases of totally resection,15 cases of sub - total resection and 4 cases of gross resection.Then the 12 cases were given radiotherapy.22 cases were followed up for 6 months to 89 months (mean 41 months),4 cases died,18 cases can recover daily life.Conclusions Intracranial chondrosarcoma are malignant tumors,and usually arise in skull base,surgery should be firstly performed,then the radiotherapy can be selected in some cases.The prognosis is related to the degree of resection and pathology.Most of cases can have a better outcome though the active therapy. Key words: Cranial base; Chondrosarcoma; Microsurgery; Prognosis; Pathology