Combinative therapy of microsurgery and radiotherapy for intracranial chondrosarcoma

Abstract

Objective To explore the diagnosis and outcome, after eombinative therapy of microsurgery and radiotherapy for intracranial chondrosarcoma. Method We retrospectively reviewed 8 patients diagnosed as intracranial chondrosarcoma and treated by microsurgery from 2000 to 2007. All of the 8 patients underwent surgical resection of tuners as the initial treatment and the pathological subtypes of tumors were also detected. Their clinical manifestations and outcomes after the treatment of combination of microsurgery and radiotherapy were analyzed in order to evaluate the therapeutic significance. Results According to the histopathological standard,5 cases were of the classical subtypes,2 cases were of mesenchymal subtypes, 1 case was of the myxoid subtype. The total resection and sub-total resection was achieved in 5 and 2 intracranial chondrosarcoma cases, respeetively. Partial tumor resection was obtained in one case. All patients were followed up from about 6 months to 3 yearn. In the 5 cases with total tumor resection,2 cases suffered from tumor recurrence at about the 9th and 12th months after the operation. The 2 cases survived well after taking radiotherapy. One case died at the 24th month after operation because of tumor recurrence at about 18 months without radiotherapy. The left 2 cases survived well because of the preventative radiotherapy after operation. 2 of the 3 cases with partial tumor resection also survived well because of the early radiotherapy after operation. One case lost. Conclusions The outcome of intracranial chondrosarcoma is fine after the combinative therapy of micrnsurgery and radiotherapy although it is malignant. Key words: Chondrosarcoma; Microsurgery; Radiosurgery; Combi-native therapy