Intraday Variability Research Articles

Current and Future Estimates of Marginal Emission Factors for Indian Power Generation.

Emission factors from Indian electricity remain poorly characterized, despite known spatial and temporal variability. Limited publicly available emissions and generation data at sufficient detail make it difficult to understand the consequences of emissions to climate change and air pollution, potentially missing cost-effective policy designs for the world's third largest power grid. We use reduced-form and full-form power dispatch models to quantify current (2017-2018) and future (2030-2031) marginal CO2, SO2, NOX, and PM2.5 emission factors from Indian power generation. These marginal emissions represent emissions changes due to small changes in demand. For 2017-2018, spatial variability in marginal CO2 emission factors range 3 orders of magnitude across India's states. There is limited seasonal and intraday variability with coal generation likely to meet changes in demand more than half the time in more than half of the states. Assuming the Government of India approximate 2030 targets, the median marginal CO2 emission factor across states decreases by approximately a factor of 2, but emission factors still span 3 orders of magnitude across states. Under 2030-2031 assumptions there is greater seasonal and intraday variability by up to factors of two and four, respectively. Estimates provide emission factors to evaluate interventions such as electric vehicles, increased air conditioning, and energy efficiency.

Multicolor Optical Monitoring of the γ -Ray Emitting Narrow-line Seyfert 1 Galaxy PMN J0948+0022 from 2020 to 2021

In order to study the physical properties of the γ-ray emitting narrow-line Seyfert 1 (NLS1) galaxy population, photometric and spectral observations of the γ-ray emitting NLS1 PMN J0948+0022 were made with the Lijiang 2.4 m optical telescope of Yunnan Observatories, Chinese Academy of Sciences. Photometric data in the B and R bands were collected for 50 nights from 2020 January to 2021 December. During the observation epoch, the variability amplitudes are 73.67% in the B band and 79.96% in the R band. Intra-day variability is found in two observation nights, and the duty cycle value is 29% with variability amplitude > 12.9% in the R band, which support the presence of the relativistic jets in the target. The redder-when-brighter (RWB) chromatic trend (or steeper-when-brighter trend) appears on intra-day and long timescales. The RWB trend is dominated by the radiation of accretion disk and jet, and resembles those in flat spectrum radio quasars. When PMN J0948+0022 is brighter than 17.ͫ5 in the R band, there is no color change trend. By analyzing the spectral data of PMN J0948+0022, we obtained the black hole mass of M • = 1.61 × 107 M ⊙ and accretion rate of , and confirmed that PMN J0948+0022 is a super-Eddington accreting NLS1. The redshifts of reverberation mapped super-Eddington accreting active galactic nuclei can be expanded by PMN J0948+0022 up to above 0.5. Super-Eddington accreting NLS1 galaxies were chosen as a new type of cosmological candle in the literature. PMN J0948+0022 may be used as a target for the next step of reverberation mapping monitoring project of super-Eddington accreting massive black holes.

Diurnal variation on tear stability and correlation with tear cytokine concentration

PurposeTo investigate the effect of time of day on tear evaporation rate (TER) and tear break-up time, and its possible relationship with the concentration of inflammatory tear molecules (cytokines) in healthy subjects. MethodsParticipants with healthy ocular surfaces attended 3 visits, including the screening visit (V0), the 2nd visit (V1) and the 3rd visit (V2). There were 7-day intervals between visits. Participants with Dry Eye Disease (DED) were excluded by using appropriate clinical tests during V0. Clinical evaluation (TER and Non-Invasive Tear Break-Up Time (NITBUT)) and tear collection were performed during V1 and V2, between 9 and 10AM and 3-4PM. The relative humidity and temperature of the examination room were also measured. The tear fluid concentrations of 15 cytokines were measured by multiplex bead analysis. ResultsSeven men and 10 women (mean age ± S.D; 25.1 ± 6.63 years old) participated in the study. There were no differences in neither the TER and NITBUT outcomes, nor humidity and temperature among times or visits. Eleven out of the 15 cytokines measured were detectable in tear fluids in > 50% of the participants. In the tear levels, no significant (p > 0.05) inter- and/or intra-day differences were detected for EGF, fractalkine, IL-1RA, IL-1β and IP-10. However, significant inter-day differences were found in the tear levels of IL-10 (p = 0.027), IFN-γ (p = 0.035) and TNF-α(p = 0.04) and intra-day differences in the tear levels of IL-8/CXCL8 (p = 0.034) and MCP-1 (p = 0.002). A significant correlation between TER and IL1-β, IL-2, and Fractalkine (p = 0.03, p = 0.03 and p = 0.046, respectively) was found at V1. ConclusionsNITBUT and TER values had no significant variability over the course of a day (AM versus PM), or on different days in healthy participants when humidity and temperature were constant. However, some tear molecule levels did show inter- and intra-day variability, having an inconsistent and moderate correlation with TER diurnal variation.

Characterizing and Mitigating Intraday Variability: Reconstructing Source Structure in Accreting Black Holes with mm-VLBI

The extraordinary physical resolution afforded by the Event Horizon Telescope has opened a window onto the astrophysical phenomena unfolding on horizon scales in two known black holes, M87* and Sgr A*. However, with this leap in resolution has come a new set of practical complications. Sgr A* exhibits intraday variability that violates the assumptions underlying Earth aperture synthesis, limiting traditional image reconstruction methods to short timescales and data sets with very sparse (u, v) coverage. We present a new set of tools to detect and mitigate this variability. We develop a data-driven, model-agnostic procedure to detect and characterize the spatial structure of intraday variability. This method is calibrated against a large set of mock data sets, producing an empirical estimator of the spatial power spectrum of the brightness fluctuations. We present a novel Bayesian noise modeling algorithm that simultaneously reconstructs an average image and statistical measure of the fluctuations about it using a parameterized form for the excess variance in the complex visibilities not otherwise explained by the statistical errors. These methods are validated using a variety of simulated data, including general relativistic magnetohydrodynamic simulations appropriate for Sgr A* and M87*. We find that the reconstructed source structure and variability are robust to changes in the underlying image model. We apply these methods to the 2017 EHT observations of M87*, finding evidence for variability across the EHT observing campaign. The variability mitigation strategies presented are widely applicable to very long baseline interferometry observations of variable sources generally, for which they provide a data-informed averaging procedure and natural characterization of inter-epoch image consistency.

First Sagittarius A* Event Horizon Telescope Results. III. Imaging of the Galactic Center Supermassive Black Hole

We present the first event-horizon-scale images and spatiotemporal analysis of Sgr A* taken with the Event Horizon Telescope in 2017 April at a wavelength of 1.3 mm. Imaging of Sgr A* has been conducted through surveys over a wide range of imaging assumptions using the classical CLEAN algorithm, regularized maximum likelihood methods, and a Bayesian posterior sampling method. Different prescriptions have been used to account for scattering effects by the interstellar medium toward the Galactic center. Mitigation of the rapid intraday variability that characterizes Sgr A* has been carried out through the addition of a “variability noise budget” in the observed visibilities, facilitating the reconstruction of static full-track images. Our static reconstructions of Sgr A* can be clustered into four representative morphologies that correspond to ring images with three different azimuthal brightness distributions and a small cluster that contains diverse nonring morphologies. Based on our extensive analysis of the effects of sparse (u, v)-coverage, source variability, and interstellar scattering, as well as studies of simulated visibility data, we conclude that the Event Horizon Telescope Sgr A* data show compelling evidence for an image that is dominated by a bright ring of emission with a ring diameter of ∼50 μas, consistent with the expected “shadow” of a 4 × 106 M ⊙ black hole in the Galactic center located at a distance of 8 kpc.

The annual cycle in scintillation time-scale of PMN J1726+0639

ABSTRACT We discovered rapid intra-day variability in radio source PMN J1726+0639 at GHz frequencies, during a survey to search for such variability with the Australia Telescope Compact Array. Follow-up observations were conducted over 2 yr and revealed a clear, repeating annual cycle in the rate, or characteristic time-scale, of variability, showing that the observed variations can be attributed to scintillations from interstellar plasma inhomogeneities. The strong annual cycle includes an apparent ‘standstill’ in April and another in September. We fit kinematic models to the data, allowing for finite anisotropy in the scintillation pattern. The cycle implies a very high degree of anisotropy, with an axial ratio of at least 13:1, and the fit is consistent with a purely one-dimensional scintillation pattern. The position angle of the anisotropy, and the transverse velocity component are tightly constrained. The parameters are inconsistent with expectations from a previously proposed model of scattering associated with plasma filaments radially oriented around hot stars. We note that evidence for a foreground interstellar cloud causing anomalous Ca ii absorption towards the nearby star Rasalhague (α Oph) has been previously reported, and we speculate that the interstellar scintillation of PMN J1726+0639 might be associated with this nearby cloud.

Which Actigraphy Dimensions Predict Longitudinal Outcomes in Bipolar Disorders?

Bipolar disorder (BD) is characterized by recurrent mood episodes. It is increasingly suggested that disturbances in sleep–wake cycles and/or circadian rhythms could represent valuable predictors of recurrence, but few studies have addressed this question. Euthymic individuals with BD (n = 69) undertook 3 weeks of actigraphy recording and were then followed up for a median duration of 3.5 years. Principal component analyses were used to identify core dimensions of sleep quantity/variability and circadian rhythmicity. Associations between clinical variables and actigraphy dimensions and time to first recurrence were explored using survival analyses, and then using area under the curve (AUC) analyses (early vs. late recurrence). Most participants (64%) experienced a recurrence during follow-up (median survival time: 18 months). After adjusting for potential confounding factors, an actigraphy dimension comprising amplitude and variability/stability of circadian rhythms was a significant predictor of time to recurrence (p = 0.009). The AUC for correct classification of early vs. late recurrence subgroups was only 0.64 for clinical predictors, but combining these variables with objectively measured intra-day variability improved the AUC to 0.82 (p = 0.04). Actigraphy estimates of circadian rhythms, particularly variability/stability and amplitude, may represent valid predictive markers of future BD recurrences and could be putative targets for future psychosocial interventions.

Diabetes mellitus type 2: the relationship of baseline clinical, laboratory and echocardiographic parameters with long-term major adverse cardiovascular events

Background : Type 2 diabetes mellitus (T2DM) increases the risk of developing cardiovascular disease. The search for factors interrelated with the development of major adverse cardiovascular events (MACE) in patients with T2DM over a long period of observation is urgent. Aim : To reveal the relationship of clinical, laboratory and echocardiographic parameters with the development of long-term MACE in T2DM. Materials and methods : 94 patients with T2DM (mean age — 55,3 ± 5,5 years, 65% of women) without manifestations of moderate and severe chronic heart failure (CHF), impaired renal function, severe somatic pathology underwent a ­complete clinical and laboratory examination. Echocardiography and 6-minute walk test (6mwt) were performed. The plasma level of the N-terminal propeptide of natriuretic hormone B-type (NT-proBNP) was determined. The variability of fasting blood glucose and intraday glycemic variability were measured by calculating the standard deviation (SD) and the coefficient of variation (CV) of at least 3 blood glucose values for 3 days. Analysis of MACE (death from any cause, myocardial infarction, stroke, decompensation of CHF, myocardial revascularization for emergency indications) was performed after 8,8 ± 0,72 years ( n=88 ). Patients with T2DM were divided into 2 groups — without MACE (group 1, n=54) and with MACE (group 2, n=34). The search for predictors of long-term MACE in T2DM was carried out using the method of logistic regression. Results : Initially, group 2 differed from group 1 in a longer duration of T2DM, a higher incidence of stable coronary heart disease (55,9% vs 27,8%, p = 0,008), a higher presence of albuminuria>30 mg/day (66,7% vs 37,3% , p=0,008), a higher presence of initial symptoms of CHF (67,8% vs 21,8%, p=0,001), greater fasting glucose variability (SD 2,07 mmol/l vs 1,2 mmol/l, p=0,003), greater intraday glucose variability (SD 2,3 mmol/l vs 1,6 mmol/l, p=0,001, CV 28,2% vs 18,8%, p=0,001), higher levels of NT-proBNP (46,9 pg/ml vs 24,2 pg/ml, p=0,012), larger left atrial size (4,4 cm vs 4,1 cm, p=0,039), shorter 6mwt distance. The logistic regression method revealed the parameters that are most interconnected with long-term MACE in T2DM: intraday glycemic CV (p=0,0012), left atrial size (p=0,02) and initial manifestations of CHF (p=0,03). Conclusion : The development of long-term MACE in T2DM is associated with an increase in gl ycemic variability, an increase in NT-proBNP level, an increase in the left atrial size, and a decrease in exercise tolerance. According to logistic regression data, the most significant indicators associated with adverse outcomes are an increase in intraday glycemic CV, an increase in the left atrial size, and the presence of initial symptoms of CHF.

The data center construction of the Xinjiang Astronomical Observatory based on virtual observatory standards

As part of the Chinese National Astronomical Data Center, the Xinjiang Astronomical Observatory Data Center is built based on the virtual observatory standards. The data resources mainly include the pulsar dataset, the molecular spectral lines dataset, the intra-day variability source dataset generated by the Nanshan 25 m radio telescope, and the Nanshan 1 m wide-field telescope dataset, published through about a dozen data services, including a Table Access Protocol (TAP) endpoint. Some of these data services are registered with the International Virtual Observatory Alliance. Users can use standard virtual observatory tools, browsers, and scripts to retrieve all the metadata information in the data center and to realize simple data analysis, processing, and visualization operations.

Characterizing Fixational Eye Motion Variance Over Time as Recorded by the Tracking Scanning Laser Ophthalmoscope.

PurposeThe purpose of this study was to characterize the benign biological variance of fixational microsaccades in a control population using a tracking scanning laser ophthalmoscope (TSLO), accounting for machine accuracy and precision, to determine ideal testing conditions to detect pathologic change in fixational eye motion (FEM).MethodsWe quantified the accuracy and precision of the TSLO, analyzing measurements made by three operators on a model eye. Repeated, 10-second retinal motion traces were then recorded in 17 controls, 3 times a day (morning, afternoon, and evening), on 3 separate days. Microsaccade metrics (MMs) of frequency, average amplitude, peak velocity, and peak acceleration were extracted. Trace to trace, interday, and intraday variability were calculated across all subjects.ResultsIntra-operator and machine variation contributed minimally to total variation, with only 0.007% and 0.14% contribution for frequency and amplitude respectively. Bias was detected, with lower accuracy for higher amplitudes. Participants had an average (SD) microsaccade frequency of 0.84 Hz (0.52 Hz), amplitude of 0.32 degrees (0.11 degrees), peak velocity of 43.68 degrees/s (14.02 degrees/s), and peak acceleration of 13,920.04 degrees/s2 (4,186.84 degrees/s2). The first trace recorded within a session significantly differed from the second two in both microsaccade acceleration and velocity (P < 0.05), and frequency was 0.098 Hz higher in the evenings (P < 0.05). There was no MM difference between days and no evidence of a session-level learning effect (P > 0.05).ConclusionsThe TSLO is both accurate and precise. However, biological inter- and intra-individual variance is present. Trace to trace variability and time of day should be accounted for to optimize detection of pathologic change.

Simultaneous quantitative analysis of seven steroid hormones in human saliva: A novel method based on O-ethylhydroxylamine hydrochloride as derivatization reagent.

Saliva has been widely accepted as a more convenient alternative to serum or plasma in the field of clinical diagnosis. However, the detection of trace components in saliva has been a bottleneck problem. The aim of this work was to develop a highly sensitive and reliable method for simultaneously determining the trace steroid hormones including some with poor ionization efficiency in human saliva by liquid chromatography/tandem mass spectrometry (LC/MS). Saliva was deproteinated by acetonitrile containing mixed isotope internal standards and extracted with methyl tert-butyl ether. The extraction solution was dried under a stream of nitrogen and the residue was derivatized using 50 mM O-ethylhydroxylamine hydrochloride in 80% methanol/water solution (v/v). The processed sample was determined by LC/MS in multiple reaction monitoring (MRM) mode. The method was successfully established for the simultaneous quantification of seven steroid hormones in human saliva and showed excellent specificity and sensitivity. The limits of quantification (LOQs) of all steroid hormones were below 5pg/mL, in particular, the LOQ of progesterone was as low as 0.15 pg/mL. The linear correlation coefficients (r) were greater than 0.9990 in the range of 2-200 pg/mL for T, DHEA, A4, P4, P5, and 17OHP4 and in the range of 5-500 pg/mL for 17OHP5. The intra-day and inter-day variability ranged from 1.86% to 7.83% and 1.95% to 10.4%, respectively. The recovery of the method ranged from 86.9% to 111.1% for all steroid hormones using three spiked concentrations. A novel LC/MS/MS method was developed for the simultaneous quantification of seven kinds of trace steroid hormones in human saliva. The results of the methodological study showed that the method exhibited excellent sensitivity and reliability for the evaluation of free steroid hormones in the human body. It is believed that this method could provide useful information of steroid hormone metabolism for auxiliary diagnosis of some endocrine disorders.

X-ray intraday variability and power spectral density profiles of the blazar 3C 273 with XMM–Newton during 2000–2021

ABSTRACT We present X-ray intraday variability and power spectral density (PSD) analyses of the longest 23 pointed XMM–Newton observations of the blazar 3C 273 that were taken during 2000–2021. These good time intervals contain between 5 and 24.6 h of data. Variability has been estimated in three energy bands: 0.2–2 keV (soft), 2–10 keV (hard), and 0.2–10 keV (total). 9 of the 23 observations exhibited some variability, though no major variations exceeding 5 per cent were detected. Typical time-scales for variability were ∼1 ks. For those variable light curves, we find that a power-law model provides good fits to each PSD, with most of the slopes between −1.7 and −2.8. Although no variations of hardness ratio (HR) could be measured in any individual observation, an anticorrelation in flux and HR is found in long term data that indicates a harder when brighter trend. Our flux and spectral analyses indicate that both particle acceleration and synchrotron cooling processes make an important contribution to the emission from this blazar.

Intraday Optical Multiband Observation of BL Lacertae

Abstract We observed BL Lac in the B, V, R, and I bands with an 85 cm telescope on nine nights from 2019 September 18 to 2019 December 6. More than 2300 data points were collected. All intraday light curves were examined for variations by using the most reliable power-enhanced F-test and the ANOVA test, and intraday variability was found on five nights. Thanks to our high precision and high temporal resolution data, two key discoveries were made in the following analyses. (1) In addition to the strong bluer-when-brighter behavior on most nights, we observed a color reversal that is rarely found in BL Lac objects. This indicates that there are two different energy distributions of injected electrons on this night. (2) The object traced clockwise loops on the color–magnitude diagrams on one night. These are the first intraday spectral hysteresis loops reported in the optical bands in this object, suggesting interband time lags. We estimated the interband lags by using the ZDCF, ICCF, and JAVELIN, and found the variations in the V and R band lagged that in the B band by about 16 and 18 minutes, respectively. Such optical time lags are expected if the acceleration timescale is much shorter than the cooling timescale.

Complications of Diabetes and Metrics of Glycemic Management Derived From Continuous Glucose Monitoring.

ContextAlthough glycated hemoglobin A1c is currently the best parameter used clinically to assess risk for the development of diabetes complications, it does not provide insight into short-term fluctuations in glucose levels. This review summarizes the relationship between continuous glucose monitoring (CGM)-derived metrics of glycemic variability and diabetes-related complications.Evidence AcquisitionPubMed and Embase databases were searched from January 1, 2010 to August 22, 2020, using the terms type 1 diabetes, type 2 diabetes, diabetes-related microvascular and macrovascular complications, and measures of glycaemic variability. Exclusion criteria were studies that did not use CGM and studies involving participants who were not diabetic, acutely unwell (post stroke, post surgery), pregnant, or using insulin pumps.Evidence SynthesisA total of 1636 records were identified, and 1602 were excluded, leaving 34 publications in the final review. Of the 20 852 total participants, 663 had type 1 diabetes (T1D) and 19 909 had type 2 diabetes (T2D). Glycemic variability and low time in range (TIR) showed associations with all studied microvascular and macrovascular complications of diabetes. Notably, higher TIR was associated with reduced risk of albuminuria, retinopathy, cardiovascular disease mortality, all-cause mortality, and abnormal carotid intima-media thickness. Peripheral neuropathy was predominantly associated with standard deviation of blood glucose levels (SD) and mean amplitude of glycemic excursions (MAGE).ConclusionThe evidence supports the association between diabetes complications and CGM-derived measures of intraday glycemic variability. TIR emerged as the most consistent measure, supporting its emerging role in clinical practice. More longitudinal studies and trials are required to confirm these associations, particularly for T1D, for which there are limited data.

Day and Night, Night and Day: Associations of Sleep and Activity Variability and Mortality

Self-reported sleep duration has been repeatedly found to predict mortality. Actigraphy has recently been added to population-based studies to provide more accurate sleep measures. Actigraphy sleep duration has not consistently predicted mortality, but actigraphy measures of sleep disruption measures are generally found to be predictive of mortality for older adults. A few studies have more fully used actigraphy data and constructed variables to summarize 24-hour activity patterns, which have also predicted mortality. In this study, we use a nationally representative study of Americans aged 61 – 91 to examine the associations between mortality and actigraphy-derived measures of variability, for both sleep and 24-hour activity patterns. We use 72-hour wrist actigraphy data from a substudy of the 2010/11 round of the National Social Life, Health and Aging Project (NSHAP) linked to the National Death Index (NDI) to establish 5-year mortality. Sleep variability was represented by sleep fragmentation and the standard deviation of wake and bed times. Intraday variability and between day (interday) variability described the 24-hour activity patterns. Cox proportional hazards models were adjusted for sociodemographic confounders and average daytime activity. In general, more variability was associated with increased death hazard for all measures. Fragmentation (HR: 1.04, 95% CI: [1.01, 1.07], p = 0.01), standard deviation of bedtimes (HR: 1.16, 95% CI: [1.02, 1.31], p = 0.02), and intraday variability (HR: 1.19, 95% CI: [0.98, 1.43], p = 0.07) showed the strongest associations. This study suggests that both consistent sleep and 24-hour activity patterns are associated with better prospective health.

Optical Variability of a Newly Discovered Blazar Sample from the BZCAT Catalog

Abstract In an optical monitoring program to characterize the variability properties of blazars, we observed 10 sources from the Roma-BZCAT catalog for 26 nights in V and R bands during 2014 October to 2015 June with two telescopes located in India. The sample includes mainly newly discovered BL Lacertae objects (BL Lacs) for which the redshift of some sources is not yet known. We present the results of flux and color variations of the sample on intraday and short timescales obtained by using the power-enhanced F-test and the nested-ANOVA tests, along with their spectral behavior. We find significant intraday variability in the single flat-spectrum radio quasar in our sample, having an amplitude of variation ∼12%. Although a few of the BL Lacs showed probable variation in some nights, none of them passed the variability tests at 99.9% significance level. We find that 78% of the sample showed significant negative color–magnitude correlations, i.e., a redder-when-brighter spectral evolution. Those that do not show strong or clear chromatism predominantly exhibit a redder-when-brighter trend. Unlike on hourly timescales, the high-synchrotron-peaked blazars in the sample (BZGJ0656+4237, BZGJ0152+0147, and BZBJ1728+5013) show strong flux variation on timescales of days to months, where again we detect a decreasing trend of the spectral slope with brightness. We observe a global steepening of the optical spectrum with increasing flux on the intranight timescale for the entire blazar sample. The nonvariability in the BL Lacs in our sample might be caused by the distinct contribution from the disk as well as from other components in the studied energy range.

Association of childhood asthma with intra-day and inter-day temperature variability in Shanghai, China

ObjectivesShort-term temperature variability (TV) is associated with the exacerbation of asthma, but little is known about the relative effects of intra- and inter-day TV. We aimed to assess the relative impacts of intra- and inter-day TV on childhood asthma and to explore the modification effects by season. MethodsA quasi-Poisson generalized linear regression model combined with a distributed lag nonlinear model was adopted to evaluate the nonlinear and lagged effects of TV on childhood asthma in Shanghai from 2009 to 2017. Intra- and inter-day TV was measured with diurnal temperature range (DTR) and temperature changes between neighboring days (TCN), respectively. ResultsIncreased DTR was associated with the elevated relative risk (RR) of daily outpatient visits for childhood asthma (DOVCA) in both the whole year (RRlag0-14 for the 99th percentile: 1.264, 95% confidence interval (CI): 1.052, 1.518) and cold season (RRlag0-12 for the 99th percentile: 1.411, 95% CI: 1.053, 1.889). Higher TCN in the warm season was associated with the increased RR of DOVCA (RRlag0-14 for the 99th percentile: 2.964, 95% CI: 1.636, 5.373). The number and fraction of DOVCA attributed to an interquartile range (IQR) increase of TCN were higher than those attributed to DTR in both the whole year period and warm season. However, the number and fraction of DOVCA attributed to an IQR increase of DTR were greater than those attributed to TCN in the cold season. ConclusionsOur results provide novel evidence that both intra- and inter-day TV might be a trigger of childhood asthma. Higher DTR appeared to have greater impacts on childhood asthma in the cold season while an increase in TCN seemed to have bigger effects in the warm season.

Intra-day variability of BL Lacertae from 2016 to 2018

We monitored BL Lacertae in the B, V, R and I bands for 14 nights during the period of 2016–2018. The source showed significant intra-day variability on 12 nights. We performed color-magnitude analysis and found that the source exhibited bluer-when-brighter chromatism. This bluer-when-brighter behavior is at least partly caused by the larger variation amplitude at shorter wavelengths. The variations at different wavelengths are correlated well and show no inter-band time lag.

Evaluation of Orthostatic Reactions in Real-World Environments Using Wearable Sensors.

As global life expectancy is constantly rising, the early detection of age-related, neurodegenerative diseases, such as Parkinson's disease, is becoming increasingly important. Patients suffering from Parkinson's disease often show autonomic nervous system dysfunction which is why its examination is an important diagnostic tool. Measuring the response of the heart rate (variability) to postural transitions and thereby assessing the orthostatic reaction is a common indicator of autonomic nervous system functioning. However, since these measurements are commonly performed in a clinical environment, results can be impaired by the white coat effect. To reduce this influence as well as inter- and intra-day variations, our work aims to investigate the assessment of orthostatic reactions in free-living environments. We collected IMU and ECG data of seven healthy participants over four days and evaluated differences in orthostatic reactions between standardized tests at lab, at home, as well as unsupervised recordings during real-world conditions. Except for the first lab recording, we detected significant changes in heart rate due to postural transitions in all recording settings, with the strongest response occurring during standardized tests at home. Our findings show that real-world assessment of orthostatic reactions is possible and provides comparable results to supervised assessments in lab settings. Additionally, our results indicate high inter- and intra-day variability which motivates the continuous orthostatic reaction measurement over the span of multiple days. We are convinced that our presented approach provides a first step towards unobtrusive assessment of orthostatic reactions in real-world environments, which might enable a more reliable early detection of disorders of the autonomic nervous system.

Multiwavelength analysis and modeling of OJ 287 during 2017–2020

Context. The blazar OJ 287 has been proposed as binary black hole system based on its periodic optical outburst. Black hole binary systems are scarce among blazars with parsec scale jets, and hence this source is exciting to study Aims. The BL Lac OJ 287 is an interesting object for multiwavelength study due to its periodic outbursts. We analysed the optical, X-ray and γ-ray data of OJ 287 for the period of 2017–2020. There are several high states in optical–UV and X-ray frequencies during this period. Based on the observed variability in optical and X-ray frequencies, the entire period 2017–2020 is divided in five segments, in this paper referred as A, B, C, D, and E. A detailed temporal and spectral analysis is performed to understand the nature of the flaring activities of OJ 287. Methods. To understand the temporal variability in this source we studied the intraday and fractional variability for all the various states. In additon, fast variability time was also estimated in order to understand the nature of variability. Furthermore, the multiwavelength spectral energy distribution (SED) modeling was performed to know more about the physical processes responsible for the simultaneous broadband emission and the fast variability. Results. The Fermi-LAT observations show a moderate flux level of this source in γ-ray frequency throughout this period, though flux variability has been observed. The source has shown a strong flux variability in X-ray, optical, and UV during early 2017 and mid 2020 when the source was in very high state. A single-zone synchrotron self-Compton emission model is considered to model the SED, and this helps us to explore the nature of this BL Lac with binary supermassive black holes.