Intestinal Infections In Children Research Articles

The structure of the incidence of acute intestinal infections in children of the Southern Aral Sea region and bioimmune correction of intestinal microbiocenosis in shigellosis

BACKGROUND: The microbiome of the gastrointestinal tract ensures colonization resistance of the intestinal epithelium, produces enzymes, and participates in nutrient metabolism. Changes in its composition lead to pathological conditions of the intestines.AIM: To determine the structure of the incidence of acute intestinal infections in children living in the Southern Aral Sea region and to characterize the effect of bioimmune correction of changes in the intestinal microbiome in children with shigellosis.
 MATERIAL AND METHODS: In the period from 06.07.2020 to 05.10.2020, 179 children with intestinal infections aged 2 to 7 years living in an environmentally unfavorable zone of Southern Uzbekistan were examined. The children were divided into two groups: the first (32 children) received basic therapy (pathogenetic therapy, antibiotic therapy, diet), the second (11 children) received basic therapy with bioimmune correction with bifidobacteria bifidum (bifidumbacterin PL) and thymus peptides of sheep embryos and newborn lambs (immunomodulin). To characterize the microbiome, the material was screened on differential diagnostic media, identifying obligate, facultative and opportunistic microflora. To assess the statistical significance of differences between data groups, the Student's t test was used, taking p ≤0.05 as a significant level.
 RESULTS: Shigellosis was diagnosed in 43 sick children (24% of those examined), escherichiosis was diagnosed in 34 (19%), salmonellosis was diagnosed in 30 (16.3%), and diarrhea of other bacterial etiology was diagnosed in 23 (13%) patients. In all variants, changes in the intestinal microbiome were detected. Etiotropic therapy led to an improvement in the general condition of patients, but did not affect dysbiotic changes in the intestines and did not contribute to the restoration of the microbiome. Bioimmune correction of dysbiosis in shigellosis in 11 patients using preparations of bifidobacteria bifidum and fetal thymic peptides led to the restoration of intestinal microflora to normal values: the number of lactose-negative E. coli significantly decreased by more than 5 orders of magnitude (p=0.037), fungi of the genus Candida (p=0.030) and enterococci (p=0.019) by 3 orders of magnitude, and staphylococci by 2 orders of magnitude (p=0.048).
 CONCLUSION: The use of preparations of bifidobacteria bifidum and fetal thymus peptides as bioimmunocorrectors is a promising therapeutic strategy for shigellosis in children.

Pediatrician Tactics In The Treatment Of Acute Gastroenteritis In Children

The high frequency of acute intestinal infections in children, most of which occur in young patients, determines the need to develop modern recommendations for their diagnosis and treatment. This article provides data on the etiology of intestinal infections, as well as the results of research by domestic and European scientists regarding the effectiveness of treatment of acute gastroenteritis, including information on the use of sorbents, probiotics, antiemetic and antibacterial drugs.

The effectiveness of the use of synbiotics in the complex therapy of acute intestinal infections in children

Relevance. Acute intestinal infections in children retain a high value in the structure of child morbidity and mortality, which necessitates the search for means and methods for their active treatment and improvement of prognosis.
 Aim: to determine the effectiveness of the use of synbiotics in the complex therapy of acute intestinal infections in children at the outpatient stage.
 Materials and methods. Fifty 6–17 years children with mild or moderate acute intestinal infections were examined. The patients were divided into the main group (30 children) and the control group (20 children), the groups were comparable. Patients from the main group, along with pathogenetic therapy, received a combination of Lacticaseibacillus paracasei DG I-1572 DSM 34154 
 (L. casei DG) and fructooligosaccharides (FOS), and children from the control group received only pathogenetic and symptomatic treatment. Clinical symptoms were evaluated over following up included temperature, frequency and, nature of stool, presence and severity of dyspeptic manifestations, nausea, frequency of vomiting, presence and severity of abdominal pain syndrome. Statistical data processing was carried out using statistical analysis Statistica v. 13.0 (StatSoft Inc., USA).
 Results. The combined use of L. casei DG and FOS in the pathogenetic therapy of acute intestinal infections reduces the time of relief of clinical manifestations. The severity of abdominal pain syndrome regresses significantly faster when using this synbiotic. Norma­lization of the frequency and nature of stool occurs significantly faster with the simultaneous appointment of pathogenetic therapy and the synbiotic. The combination of L. casei DG and FOS has demonstrated a high safety profile, side effects have not been reported.
 Conclusion. It is advisable to prescribe the combination of L. casei DG and FOS from the first day of acute intestinal infections alongside with pathogenetic and symptomatic therapy to achieve a clinical effect more quickly.

Диагностическая ценность шкалы Кларка для прогнозирования этиологии кишечных инфекций у детей

Цель исследования. Оценить диагностическую ценность шкалы Кларка (ШК) как раннего предиктора этиологии заболевания у детей с острыми кишечными инфекциями (ОКИ). Материалы и методы. Проведено ретроспективное исследование 1207 детей, госпитализированных с ОКИ различной этиологии, в возрасте от 12 месяцев до 17 лет. Были проанализированы баллы по ШК, абсолютное число нейтрофилов (АЧН) и уровень С-реактивного белка (СРБ). Пациенты были разделены на группы с неспецифическими, вирусными и бактериальными ОКИ в зависимости от возбудителей, обнаруженных с помощью теста мультиплексной полимеразной цепной реакции (ПЦР). Результаты. Пациенты в бактериальной группе имели значительно более высокие значения СРБ и баллы ШК по сравнению с пациентами в вирусной группе и значительно более высокие баллы ШК по сравнению с пациентами в неспецифической группе (P<0,05). Пациенты в вирусной группе имели значительно более высокие баллы ШК, чем в неспецифической группе (P<0,05). Логистический регрессионный анализ показал, что ШК была наиболее эффективным диагностическим инструментом для прогнозирования типа возбудителя (P<0,05). Площадь под кривой рабочих характеристик приемника для ШК была значительно больше, чем для АЧН и СРБ (P<0,05). При пороговом значении 10 по ШК может быть достигнута приемлемая диагностическая точность для различения бактериальных и вирусных патогенов при ОКИ. Заключение. ШК можно считать полезным и надежным инфекционным маркером детского гастроэнтерита. ШК может быть хорошим ранним предиктором типа возбудителя, позволяющим разработать план лечения до того, как будут доступны результаты посева кала или ПЦР-теста. Purpose of the study. To evaluate the diagnostic value of the Clarke scale (SC) as an early predictor of the etiology of the disease in children with acute intestinal infections (AII). Materials and methods. A retrospective study of 1207 children hospitalized with AEI of various etiologies aged from 12 months to 17 years was carried out. SC scores, absolute neutrophil count (ANC) and C-reactive protein (CRP) levels were analyzed. Patients were divided into non-specific, viral and bacterial groups depending on the pathogens detected using the multiplex polymerase chain reaction (PCR) test. Results. Patients in the bacterial group had significantly higher CRP values and SK scores compared to patients in the viral group and significantly higher SK scores compared to patients in the nonspecific group (P<0.05). Patients in the viral group had significantly higher SK scores than those in the nonspecific group (P<0.05). Logistic regression analysis showed that SC was the most effective diagnostic tool for predicting pathogen type (P<0.05). The area under the receiver performance curve for SC was significantly larger than for ANC and CRP (P<0.05). At a cut-off value of 10 on the QQ scale, acceptable diagnostic accuracy can be achieved to distinguish between bacterial and viral pathogens in AII. Conclusion. SK can be considered a useful and reliable infectious marker of childhood gastroenteritis. SK may be a good early predictor of pathogen type, allowing a treatment plan to be developed before stool culture or PCR test results are available.

Halting vaccine-derived poliovirus circulation: the novel type 2 oral vaccine might not be enough

Halting vaccine-derived poliovirus circulation: the novel type 2 oral vaccine might not be enough

Poliovirus antibodies following two rounds of campaigns with a type 2 novel oral poliovirus vaccine in Liberia: a clustered, population-based seroprevalence survey

Novel oral poliovirus vaccine type 2 (nOPV2) was administered in Liberia in response to an outbreak of circulating vaccine-derived poliovirus type 2 (cVDPV2) in 2021. We conducted a serological survey of polio antibodies after two national campaigns with nOPV2. This clustered, cross-sectional, population-based seroprevalence survey was conducted in children aged 0-59 months, more than 4 weeks after the second nOPV2 vaccination round. We used a clustered sampling method in four geographical regions of Liberia, followed by a simple random sampling of households. One eligible child was randomly selected per household. Dried blood spot specimens were taken and vaccination history was recorded. The antibody titres against all three poliovirus serotypes were assessed using standard microneutralisation assays done at the US Centers for Disease Control and Prevention in Atlanta, GA, USA. Analysable data were obtained from 436 (87%) of 500 enrolled participants. Of these, 371 (85%) children were reported via parental recall to have received two nOPV2 doses, 43 (10%) received one dose, and 22 (5%) received no doses. The seroprevalence against type 2 poliovirus was 38·3% (95% CI 33·7-43·0; 167 of 436 participants). No significant difference was observed between type 2 seroprevalence in children aged 6 months or older who were reported to have received two doses of nOPV2 (42·1%, 95% CI 36·8-47·5; 144 of 342), one dose (28·0%, 12·1-49·4; seven of 25), or no doses (37·5%, 8·5-75·5; three of eight; p=0·39). The seroprevalence against type 1 was 59·6% (54·9-64·3; 260 of 436), and the seroprevalence against type 3 was 53·0% (48·2-57·7; 231 of 436). Unexpectedly, the data showed low type 2 seroprevalence after two reported doses of nOPV2. This finding is probably affected by the lower oral poliovirus vaccine immunogenicity previously demonstrated in resource-limited settings, with high prevalence of chronic intestinal infections in children and other factors discussed herein. Our results provide the first assessment of nOPV2 performance in outbreak response in the African region. WHO and Rotary International.

THE PROBLEM OF INCIDENCE OF ACUTE INTESTINAL INFECTIONS IN CHILDREN DURING WARTIME IN UKRAINE

The relevance of this pathology today is due to the increased incidence of acute intestinal infections in children. The purpose of our work was the analysis of modern views on the diagnosis and treatment of acute intestinal infections in children during the wartime period in Ukraine. Materials and methods: the data of the scientific literature were analyzed using the bibliosemantic method of research and a clinical case of the medical history was proposed, which caused some difficulties for the doctors at the initial stage. Research results and their discussion. The range of possible human etiological agents continues to expand as previously unknown viruses are isolated. The diseases caused by them are less studied, since their detection was carried out mainly in the framework of scientific research. The most frequent pathogens of intestinal infections are rotaviruses, enteroviruses, adenoviruses, and coronaviruses. Episodes of acute diarrheal diseases in European countries in children under 3 years of age were noted up to 2 times a year, but in countries with limited resources or military operations, on average, up to 6 times a year (in particular, in Ukraine by 2022). The war led to an increase in viral etiology and an increase in the share of children with secondary bacterial complications, and accordingly, the share of the use of antibacterial agents increased. The most common nosology of the gastrointestinal tract was acute gastroenterocolitis, which was characterized by any combination of diarrhea, fever, vomiting, and abdominal pain. Diarrhea is the second leading cause of child mortality in the world, especially in countries where there are military conflicts or a low social standard of living. The authors give an example of a clinical case of a girl, born in 2018, who was treated in the children's infectious disease department in the summer of 2022. and referred to persons forcibly resettled due to military operations.
 Isolation and identification of the causative agent usually takes at least 48 hours, and therefore the possibility of choosing a therapy decreases. Virological research in routine practice is rarely available due to the high cost of research. Therefore, it should be noted that there is immunoprophylaxis, in particular, of rotavirus infection. In the world, since 2006, vaccination has been introduced in more than 100 countries, which made it possible to significantly reduce the level of morbidity among children under 2 years of age. Two vaccines against rotavirus are registered in Ukraine. The first - is used in 2 doses at the age of 6 to 24 weeks, and the second - at the age of 6 to 32 weeks. Protection against severe rotavirus gastroenteritis is approximately 90-95%. But in our country, this vaccination is not yet included in the calendar of mandatory vaccinations. The authors give an example of a clinical case of a girl who was treated in the children's infectious disease department of the 1st Medical Center of Poltava in the summer of 2022.
 Conclusion. Thus, acute intestinal infections in childhood are a complex pathological process. Treatment should be timely, complex and justified from the etiopathogenetic point of view.

Prophylactic Measures in the Field of the Prevention of Intestinal Infections in Children and Adults

The article discusses the features of prophylactic measures in the field of preventing the development of intestinal infections in children and adults. The author notes that taking proper measures on time in this area will reduce the dynamics of the spread of such diseases, as well as the number of cases of intestinal infections among people. The prevention measures which are considered in this work should be implemented in organizations, educational institutions and public places. This will reduce the cost of the consequences of the spread of various intestinal infections and preserve the health of adults and children, since the consequences of intestinal diseases can be significant for a person and cause the development of various systemic diseases of the gastrointestinal tract.

Актуальная роль этиотропной терапии при бактериальных кишечных инфекциях у детей

Актуальная роль этиотропной терапии при бактериальных кишечных инфекциях у детей

Features of CD4+ lymphocytes apoptosis in children with cryptosporidiosis

The aim of this study was to identify the features of CD4+ lymphocytes apoptosis in children with cryptosporidiosis. Feces for the detection of cryptosporidium and venous blood for the study of lymphocytes apoptosis were the material of the study. Mononuclear leukocytes were isolated from venous whole blood and cultured in a complete culture medium. Cells were incubated for 24 hours with inducers of the receptor (TNFα) and mitochondrial pathways of apoptosis (dexamethasone).Cryptosporidia have been found in 35% of acute intestinal infections in children. The number of lymphocytes with cytoflurimetric signs of apoptosis in the group of cryptosporidiosis-positive patients did not differ from that in patients without cryptosporidiosis (p=0.421). There were no intergroup differences in the number of CD4+ lymphocytes expressing the Fas receptor on their surface (p=0.462). In cultures incubated in the presence of dexamethasone, a decrease in the number of apoptotically altered CD4+ lymphocytes was registered only in the group of cryptosporidiosispositive patients (p=0.028).The study showed that in cryptosporidiosis, the sensitivity of CD4+ cells to the induction of the mitochondrial pathway of apoptosis changes in favor of slowing down this variant of cell death.

ОСТРЫЕ КИШЕЧНЫЕ ИНФЕКЦИИ У ДЕТЕЙ В ДОПАНДЕМИЧЕСКИЙ ПЕРИОД И В ПЕРИОД ПАНДЕМИИ COVID-19 В г. ЯКУТСКЕ

Humanity has faced an infection caused by a new strain of human coronavirus SARS-CoV-2. The infection is characterized by a variety of clinical symptoms with damage not only to the respiratory tract, but also to other organs and systems. Against the background of the pandemic of a new coronavirus infection, the widespread introduction of anti-epidemic measures has led to a change in the situation with other infectious diseases. The purpose of this work was to analyze the incidence of acute intestinal infections among children in the city of Yakutsk. Acute intestinal infections (AII) refer to diseases that are transmitted by the alimentary route. In the Russian Federation, from the very beginning of the epidemic manifestations of COVID-19, a course has been taken to implement the “advanced response” strategy, in accordance with which all anti-epidemic measures have been and are being carried out. The restrictive measures introduced as part of the fight against the spread of COVID-19 have had a beneficial effect on the epidemiological situation with many other infections. Many countries have implemented social distancing as a measure to “flatten the curve” of the ongoing epidemic. The results obtained by us coincide with the data obtained in other regions during similar studies. The decrease in the number of cases of most infectious diseases is a fact common to countries where anti-epidemic measures have been taken. We analyzed data on hospitalized patients with AII in the Children’s Clinical Infectious Diseases Hospital in Yakutsk for 2018, 2019, and 2020. We identified some features of the dynamics of the incidence of acute intestinal infections in children in the pre-pandemic period and in the first year of the COVID-19 pandemic. The introduction of anti-epidemic measures against the background of a new coronavirus infection led to a significant decrease in the incidence of infectious diseases in general and to a significant decrease in the number of acute intestinal infections in children.

Personalized symbionic therapy of campylobacteriosis protracted course in children

Campylobacteriosis is one of the most common bacterial intestinal infections with high risks of severe and prolonged infection in childhood. The growing incidence of campylobacteriosis, the variety of clinical forms of the disease, the difficulties of timely diagnosis of the infection against the background of a high level of resistance of the microorganism to a number of antibacterial drugs determine the need to optimize the rational tactics of treating this infectious disease. One of the possible ways to overcome these difficulties is to further expand the use of probiotics and autoprobiotics. Aim: to reveal the features of the influence of autoprobiotic and probiotic E. faecium strains on clinical and laboratory parameters in children with non-smooth forms of campylobacteriosis .. Materials and methods: In the period from 2018 to 2020. In DNCIB FMBA, a comprehensive single-center prospective dynamic open observational study of 34 children with an uneven course of campylobacteriosis was carried out. For therapeutic purposes, patients were prescribed an autoprobiotic (group A; n = 15) or a probiotic strain E. faecium (group P; n = 19). Clinical and laboratory parameters and indicators of the intestinal microbiocenosis composition were assessed by real-time PCR. Results: Studies of the effect of two different approaches to prescribing probiotic strains of enterococcus to children with a protracted course of campylobacteriosis - a conditionally “reference” industrial strain E. faecium L3 and autoprobiotic strains with a comparable frequency (88.9% and 93.3% of cases, respectively) revealed their significant positive impact on the course of protracted forms of campylobacteriosis, which was expressed by the disappearance of abdominal pain syndrome, normalization of the frequency and consistency of stools, relief of hemocolitis in the absence of undesirable side effects. Analysis of the dynamics of coprograms before and after taking autoprobiotics and probiotic E. faecium L3 also did not reveal significant differences: there was an equivalent positive dynamics in the form of improvement in most of the macroscopic and microscopic characteristics of the stool. The study of the composition of the intestinal microbiota showed that after the course of administration of autoprobiotic strains of E. faecium, there was a significant increase in the content of butyrate-producing indigenous representative - F. prausnitzii, which promotes the repair of the intestinal mucosa. The studies also showed that the course use of autoprobiotic strains of enterococcus contributed to a decrease in the frequency of convalescent release of campylobacter, which suggests a sanitizing effect of autoprobiotics and does not exclude a similar effect in relation to other bacterial pathogens of intestinal infections in children.

Клінічне значення простагландинів у формуванні варіантів перебігу бактеріальних кишкових інфекцій у дітей

У дітей раннього віку, хворих на бактеріальні кишкові інфекції, досліджені рівні простагландину Е та простагландину F2α у сироватці крові. Виявлено зв’язок між підвищенням показників у гострий період захворювання та варіантом його перебігу.

Острое повреждение почек как осложнение кишечных инфекций у детей (обзор литературы)

The article discusses one of the main complications in acute intestinal infections in children — acute kidney injury (AKI), which is often a life-threatening condition that occurs due to acute loss of kidney function. In the future, these patients may develop chronic kidney disease. The main pathogenetic aspects of this complication in children and the mechanisms of its development are analyzed; the frequency of occurrence is shown according to the data of different authors. Transient renal dysfunction occurs in 21.9–41.6% of children with acute intestinal infections. Hemolytic uremic syndrome is the leading cause of acute renal failure in children under 3 years of age. Aspects of the AKI diagnosis at the present stage are presented, including endogenous markers for assessing the glomerular filtration rate (GFR). The importance of early diagnosis of AKI is shown, and the need to introduce new standardized criteria for calculating GFR is substantiated.

Застосування азитроміцину в клінічній практиці

Азитроміцин є антибіотиком, який зазвичай призначається для лікування інфекцій верхніх і нижніх дихальних шляхів у дітей. Незважаючи на його високу популярність, останніми роками збільшились побоювання щодо зростаючої резистентності збудників респіраторних захворювань до цього препарату. Розглянуто фармакокінетику, спектр активності, проблему стійких бактерій і клінічні аспекти, а також рекомендації щодо застосування. Азитроміцин рекомендується як антибіотик вибору для емпіричної й селективної терапії основних бактеріальних збудників гострих кишкових інфекцій у дітей, для етіотропного лікування коклюшу, при хворобі Лайма та для тривалої імуномодулюючої терапії при муковісцидозі.

Место азитромицина при лечении инфекционных заболеваний у детей

Азитромицин остается одним из наиболее часто назначаемых антибиотиков в мире при лечении инфекций дыхательных путей, желудочно-кишечного тракта, урогенитального тракта и кожи. В последние годы отмечается рост резистентных к антибиотикам штаммов среди возбудителей инфекционных болезней. Азитромицин выгодно отличается от большинства антибиотиков многогранностью действия, которое, кроме антимикробной активности, включает противовоспалительный и иммуномодулирующий эффекты, что обеспечивает высокую клиническую эффективность препарата при лечении острых и хронических инфекций. В статье представлены данные международных рекомендаций по лечению инфекционной диареи различной этиологии, болезни Лайма, коклюша. Азитромицин рекомендуется в качестве препарата выбора для эмпирической и селективной терапии основных бактериальных кишечных инфекций у детей, для этиотропного лечения коклюша, болезни Лайма.

Азитромицин в современной педиатрической практике

Азитромицин в течение многих лет применяется в педиатрической практике для лечения широкого спектра заболеваний. В данном обзоре приводятся данные о фармакологических и фармакокинетических особенностях азитромицина. Рассмотрены опыт применения препарата при различных заболеваниях у детей и роль азитромицина с позиций доказательной медицины и со-временных международных рекомендаций. В частности, азитромицин рекомендуется как антибиотик выбора для эмпирической и селективной терапии острых кишечных инфекций у детей, вызванных основными бактериальными возбудителями, для этиотропного лечения коклюша, при болезни Лайма и для длительной терапии при муковисцидозе. Рекомендуется его применение в терапии инфекций дыхательных путей, вызванных атипичными возбудителями.

Rotavirus and adenovirus infections in children during COVID-19 outbreak in Hangzhou, China

BackgroundThis study aims to investigate the impact of protective measures and isolation on intestinal infection in children before and after COVID-19 outbreak in Hangzhou, China.MethodsData on outpatient visits, intestinal infection visits, and tests of adenovirus or rotavirus from electronic healthcare records were extracted in Children’s Hospital of Zhejiang University School of Medicine during the COVID-19 outbreak (January–December, 2020), and be compared with those in 2019 during the same period.ResultsWe found that pediatric outpatient visits, patients with intestinal infection and its proportion from January to December of 2020 were significantly less than that in the same period of 2019. Furthermore, the numbers of outpatient visits and patients with intestinal infection were the lowest in February and elevated slowly from March to December in 2020. We also found significantly decreased number of completed tests for intestinal viruses, positive cases of adenovirus and rotavirus, positive rate of rotavirus during January–December, 2020. The positive rates of adenovirus from March to September and December of 2020 were significantly lower than the levels of the same period in 2019. The positive rate of rotavirus and adenovirus in all age groups in 2020 is lower than the level of all age groups in 2019.ConclusionsThe outpatient visits and intestinal, rotavirus and adenovirus infections in children significantly decreased during COVID-19 outbreak. Adequate protective measures and isolation in children may help to prevent intestinal virus infections in children.

Intensive therapy emergency states in acute intestinal infections in children

Despite the successes achieved in the fight against many infectious diseases, the problem of diarrheal diseases in Uzbekistan, as well as throughout the world, continues to be relevant. The medical and social significance of the problem is de- termined not only by the significant spread of diseases, but also by the high fre- 150 quency of severe complicated forms of the disease, especially among young children. In addition, diarrheal diseases indirectly contribute to an increase in the incidence of other infections, as they lead to depletion and, as a result, to a decrease in the body's resistance. Despite the sufficiency of literature data on the study of diarrheal diseases and their treatment, many clinical and organizational aspects of the problem of acute intestinal infections, especially in young children, remain unresolved. Treatment of an emergency in acute intestinal infections (ACI) often reduces only to the elimination of various degrees of exsiccosis using oral and intravenous rehydration.

Choice of paediatric medical nutrition in intestinal infections

Acute intestinal infections are the most common cause of a diarrheal syndrome at an early age and represent a great challenge in paediatrics. Over one billion people suffer from acute infectious diarrhoea worldwide every year, of which 65–70% are children under 5 years of age. Along with pharmaceutical (etiotropic and pathogenetic) therapy, nutritional therapy is the most important part of the treatment of children suffering from acute intestinal infections, as the unbalanced and improperly selected nutrition may cause development of a long-lasting diarrheal syndrome resulting in a weight loss, lactase deficiency and some other unfavourable conditions. It is obvious that the issue of adequate nutrition becomes important in case of intestinal infections in children, as it should be easily digested and assimilated, replenishing energy and microbiocenotic losses. An early return to a normal nutrition ration helps reduce duration of the disease, speed up recovery in both functional and anatomical aspects. Today, there is a sufficiently large selection of products in the paediatric practice, which contribute, to one degree or another, to a balanced nutrition of children in the acute stage of the disease. Probiotic products hold a most unique position among these products. The article pays special attention to the baby foods produced by the Russian manufacturer, which is the leader in the Russian paediatric nutrition market and has been producing natural and healthy products for babies for about 30 years. The product line of this manufacturer includes a wide range of probiotic and functional products for patients of older age groups for the management of microbiota dysbiosis in acute intestinal infections.