The recent boom in interval type-2 fuzzy sets has attracted many researchers to the fields of fuzzy numbers, algebraic expressions, and iterative methods. Interval type-2 fuzzy pentagonal polynomial (IT2 FPP) is one of the algebraic expressions that combine the knowledge of interval type-2 pentagonal fuzzy numbers and polynomial equations. Solving IT2 FPP in the absence of an iterative method is becoming a common encounter as the solution is often difficult, expensive, and inexact. This paper defines IT2 FPP and the iterative method Horner-Muller’s used to find the approximate solution of the IT2 FPP. The IT2 FPP is introduced by combining the generalization of interval type-2 pentagonal fuzzy numbers and fuzzy polynomials, whereas the Horner-Muller’s method is a combination of Horner’s method and Muller’s method. A numerical example is presented to illustrate the computational procedures for finding the approximate solution. The approximate solution is obtained after two iterations with zero error. A Comparative analysis is also presented to validate the consistency and efficiency of the proposed method compared to benchmark iterative methods.