Internet Databases Research Articles

Induced abortion in Africa: A systematic review and meta-analysis.

One of the main factors contributing to maternal morbidity and mortality is induced abortion. The WHO estimates that over 44 million induced abortions take place annually around the world. The majority of these abortions-about 50%-are unsafe, significantly increasing maternal morbidity and contributing to 13% of maternal deaths. Thus, this review aimed to estimate the pooled prevalence of induced abortion and its associated factors in Africa. To find literature on the prevalence of induced abortion and its associated factors, a thorough search of the internet databases such as PubMed/MEDLINE, African Journals Online, and Google Scholar was conducted. The data were extracted using a structured method of data collection. Software called STATA 14 was used to do the analysis. funnel plot and Egger regression test were used to evaluate potential publication bias. I2 statistics and Cochrane's Q were used to measure the heterogeneity at a p-value < 0.05. 976 studies were found through a thorough search of electronic databases. Finally, 46 full-text abstract papers were included in this study. The estimated pooled prevalence of induced abortion was 16% (95% CI: 13%-19%). According to the sub-group analysis, most studies were conducted in Ethiopia, and the pooled prevalence was 19% (95% CI: 10%-30%). Similarly, the subgroup analysis by year of study showed that the prevalence of induced abortion was 39% (95% CI: 17%-64%) among studies conducted in 2019. The results of this study thus imply that the pooled prevalence of induced abortion is higher than that of earlier studies that were published in some nations. the data from this study are needed to support reproductive and adolescent health programmers and policymakers and to formulate recommendations for future clinical practice and guidelines.

Systematic review of COVID-19 vaccine acceptance and hesitancy: global perspectives and implications.

The acceptance rate towards COVID-19 vaccination among the global population could be higher due to the need for more education or awareness of prevention strategies to control the COVID-19 outbreak. Thus, there is a dire need to reduce the population’s reluctance towards COVID-19 vaccination across the globe, which will ultimately lead to the implementation of prevention and control strategies against the COVID-19 virus and improving health outcomes across the globe. The following study intends to conduct a systematic review of the literature to evaluate the relationship between COVID-19 vaccination and the current trends related to COVID-19 vaccination faced by the global population. The methodology employed in this study primarily focused on assessing secondary data by conducting a systematic literature review. Internet and electronic databases were used to select research articles to obtain secondary sources. Six articles were selected from ScienceDirect and Google Scholar for a systematic literature review. The keywords used for the selection of articles were “COVID-19,” “Global trends,” Reluctance, “and “vaccination.” The selected articles that were most suitable for the topic consisted of global trends related to COVID-19 vaccination. Six articles relevant to the topic were selected and reviewed. The selected articles showed data collection results from different research journals. The findings of the six research articles depicted common themes, such as each vaccine having a different level of access attitude towards the regional existence, which primarily depends on the variability to determine the vaccine’s effectiveness. Further studies are required to evaluate the factors and strategies that help healthcare organizations and governments reduce the reluctance to use the COVID-19 vaccine among populations worldwide.

Using Internet Databases to Advance Health Equity, Population Health, and Workforce Planning

Using Internet Databases to Advance Health Equity, Population Health, and Workforce Planning

Detecting epinephrine auto-injector shortages in Finland 2016-2022: Log-data analysis of online information seeking.

Medicine shortages prevail as a worldwide problem causing life-threatening situations for adults and children. Epinephrine auto-injectors are used for serious allergic reactions called anaphylaxis, and alternative auto-injectors are not always available in pharmacies. Healthcare professionals in Finland use the dedicated internet source, Physician's Database (PD), when seeking medical information in practice, while Health Library (HL) provides health information for citizens (S1 Data). The objectives were to assess whether (1) professionals' searches for epinephrine auto-injectors and (2) citizens' anaphylaxis article openings relate to epinephrine shortages in Finland. Monthly log data on epinephrine auto-injectors (EpiPen®, Jext®, Emerade®) from PD and on openings of anaphylaxis articles from HL were collected during 2016-2022. Professionals' searches of seven auto-injectors and citizens' openings of four anaphylaxis articles were compared to information on epinephrine shortages reported by Finnish Medicines Agency. Professionals' auto-injector prescriptions provided by Social Insurance Institution were also assessed. Total searches in EpiPen® (N = 111,740), Jext® (N = 25,631), and Emerade® (N = 18,329) could be analyzed during 2016-2022. EpiPen® only could visually show seasonal patterns during summertime, peaking vigorously in the summer of 2018 when the major EpiPen® shortage appeared worldwide. Anaphylaxis articles equaled 2,030,855 openings altogether. Openings of one anaphylaxis article ("Bites and Stings") peaked during summertime, while another article ("Anaphylactic Reaction") peaked only once (three-fold increase) at the end of 2020 when COVID-19 vaccinations started, and auto-injector prescriptions were lowest. Fifty EpiPen®, one Jext®, and twelve Emerade® shortages were reported. Almost a two-fold increase in peaks of auto-injector prescriptions was found during summertime. This study shows that (1) epinephrine shortages related to professionals' searching for auto-injectors, and (2) citizens' information seeking on anaphylaxis related to summertime and shortages with lesser prescriptions. Therefore, the dedicated internet databases aimed at professionals and citizens could be used as additional information sources to detect anaphylactic reactions and auto-injector shortages.

The effect of topical saliva application as a factor to accelerate wound healing: A review article

Background: Saliva is one part of the oral environment that has an important role in maintaining oral tissues. Saliva is also able to stimulate wound healing. When compared to wounds on the skin, the mucosa in the oral cavity tends to heal faster. Saliva is believed to be one of the main factors contributing to this comparison. Objective: This paper aims to determine the effectiveness of saliva as a factor that accelerates wound healing on topically applied skin. Methods: A source search of various journals found on internet databases was conducted to obtain relevant information related to this study. Discussion: Various biological substances contained in saliva, one of which functions in wound healing. The content of histatin and growth factors in saliva is influential in accelerating the wound healing process with the best reconstruction results. Conclusion: Saliva is effective in accelerating wound healing and can stimulate skin wound closure and has the potential to become a new therapy for treating open skin wounds.

Machine Learning Models and Technologies for Evidence-Based Telehealth and Smart Care: A Review

Background: Over the past few years, clinical studies have utilized machine learning in telehealth and smart care for disease management, self-management, and managing health issues like pulmonary diseases, heart failure, diabetes screening, and intraoperative risks. However, a systematic review of machine learning’s use in evidence-based telehealth and smart care is lacking, as evidence-based practice aims to eliminate biases and subjective opinions. Methods: The author conducted a mixed methods review to explore machine learning applications in evidence-based telehealth and smart care. A systematic search of the literature was performed during 16 June 2023–27 June 2023 in Google Scholar, PubMed, and the clinical registry platform ClinicalTrials.gov. The author included articles in the review if they were implemented by evidence-based health informatics and concerned with telehealth and smart care technologies. Results: The author identifies 18 key studies (17 clinical trials) from 175 citations found in internet databases and categorizes them using problem-specific groupings, medical/health domains, machine learning models, algorithms, and techniques. Conclusions: Machine learning combined with the application of evidence-based practices in healthcare can enhance telehealth and smart care strategies by improving quality of personalized care, early detection of health-related problems, patient quality of life, patient-physician communication, resource efficiency and cost-effectiveness. However, this requires interdisciplinary expertise and collaboration among stakeholders, including clinicians, informaticians, and policymakers. Therefore, further research using clinicall studies, systematic reviews, analyses, and meta-analyses is required to fully exploit the potential of machine learning in this area.

A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment.

Natural compounds hold promise in the search for cancer therapies due to their unique chemical structures and combinations that may effectively combat cancer while minimizing toxicity and side effects compared to conventional treatments. Silibinin, a natural lignan, has been found to possess strong anti-cancer activity against several types of human cancers based on emerging research. This study aims to provide an overview of the therapeutic potential of silibinin in the treatment and prevention of cancers. A comprehensive search was conducted using various internet databases such as PubMed, Google Scholar, and ScienceDirect to identify relevant research papers. Silibinin has been shown to exhibit anticancer activity against several types of cancers, including liver, lungs, breast, prostate, colorectal, skin, and bladder cancers. Its multifaceted mechanisms of action contribute to its therapeutic effects. Silibinin exerts antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, and anti-angiogenic activities, making it a promising candidate for cancer therapy. One of the key mechanisms underlying the anticancer effects of silibinin is its ability to modulate multiple signaling pathways involved in cancer development and progression. It can inhibit the activation of various oncogenic pathways, including PI3K/Akt, NF-κB, Wnt/β-catenin, and MAPK pathways, thereby suppressing cancer cell proliferation, inducing cell cycle arrest, and promoting apoptosis. Silibinin possesses great potential as an effective treatment agent for cancer. The multifaceted mechanisms of action, favorable safety profile, and potential synergistic effects of silibinin with conventional therapies make it an attractive candidate for further investigation and development as a cancer treatment. However, more extensive clinical studies are necessary to fully establish the efficacy, optimal dosage, and long-term effects of silibinin in cancer treatment.

Insights and future prospects of traditional Chinese medicine in the treatment of functional dyspepsia

BackgroundFunctional dyspepsia (FD) is a prevalent and challenging gastrointestinal disorder. Conventional medicine often faces limitations in providing effective treatment for FD, thus indicating the need to explore alternative approaches. Traditional Chinese medicine (TCM), which is rooted in ancient Chinese traditions and has evolved over thousands of years, offers a holistic approach to well-being. TCM incorporates herbal remedies, acupuncture, and other therapies while shaping the future of complementary and alternative medicine. PurposeTo review the existing literature on the current status and future prospects of using TCM to treat FD. MethodsWe extensively searched the PubMed, Google Scholar, Embase, an China National Knowledge Internet databases from inception to May 31, 2023 to identify relevant literature. We also searched the reference lists of the included articles. ResultsClinical evidence-based research has explored the efficacy of TCM in treating FD. Recent research has illuminated the multifaceted mechanisms through which TCM interventions affect FD. TCM is a promising alternative, as it emphasizes a holistic approach and holds potential advantages in addressing the complex nature of FD. ConclusionsThe integration of TCM and Western medicine offers a comprehensive approach to understanding and managing FD by bridging traditional wisdom with modern scientific understanding. This paper highlights the practical implications of this integration, the challenges to be addressed, and the potential for international collaboration to further elucidate the efficacy of TCM. However, continued research and dialog are needed to advance the modern development of TCM and to improve the quality of life of FD patients.

Toward human-like automated vehicles: Review and perspectives on behavioural decision making and intelligent motion planning

Abstract Rapid advancements in automated vehicles (AVs) technology have transformed the measurability, controllability, and unpredictability of transportation systems. Evaluating driving risk and effectively managing driving behaviours is critical. AVs should be enabled to identify, analyse, evaluate, and devise effective countermeasures for driving risk by autonomously learning from human driving experiences. This learning will enhance the interactive decision-making capabilities and achieve driving behaviours that reflect human-like logic. The primary challenge lies in integrating human-like logic and driving risk constraints based on behavioural decision-making outcomes. This integration is crucial to align the AVs' cognitive levels—movement, comprehension, memory, and inference—more closely with human driving necessities, habits, and styles. Such alignment holds the potential to improve the prediction and planning of future actions and facilitate the development of motion planning schemes geared towards minimizing driving risk. We performed a comprehensive review of AVs' behavioural decision-making and intelligent motion planning research from 2000 to 2023 from four key perspectives—driving risk, human-like logic, behavioural decision-making and motion planning. Based on the Web of Science and China National Knowledge Internet database, the results of our review indicate that significant progress has been made in AVs behavioural decision-making and intelligent motion planning over time. When AVs and human-driven vehicles coexist, greater incorporation of human-like logic is required. Guided by these findings, we delineate future development directions and propose a research paradigm for human-like logic and a research framework for human-like logic-driven behavioural decision-making and intelligent motion planning of AVs.

Role of Complement-dependent Cytotoxicity Crossmatch and HLA Typing in Solid Organ Transplant.

Solid organ transplantation is a life-saving medical operation that has progressed greatly because of developments in diagnostic tools and histocompatibility tests. Crossmatching for complement-dependent cytotoxicity (CDC) and human leukocyte antigen (HLA) typing are two important methods for checking graft compatibility and reducing the risk of graft rejection. HLA typing and CDC crossmatching are critical in kidney, heart, lung, liver, pancreas, intestine, and multi-organ transplantation. A systematic literature search was conducted on the internet, using PubMed, Scopus, and Google Scholar databases, to identify peer-reviewed publications about solid organ transplants, HLA typing, and CDC crossmatching. Recent advances in HLA typing have allowed for high-resolution evaluation, epitope matching, and personalized therapy methods. Genomic profiling, next-generation sequencing, and artificial intelligence have improved HLA typing precision, resulting in better patient outcomes. Artificial intelligence (AI) driven virtual crossmatching and predictive algorithms have eliminated the requirement for physical crossmatching in the context of CDC crossmatching, boosting organ allocation and transplant efficiency. This review elaborates on the importance of HLA typing and CDC crossmatching in solid organ transplantation.

Retracted: An English Online Homework Tutoring System Supported by Internet Database

Retracted: An English Online Homework Tutoring System Supported by Internet Database

Evaluation of Publishing Status of Doctoral Theses of Faculty of Medicine Department of Anatomy in Scientific Journals

Aim: The aim of this study was to evaluate the publication status of doctoral theses conducted by the anatomy departments of medical faculties in scientific journals.&#x0D; Material and Method: In this descriptive, cross-sectional study, data were obtained retrospectively from the internet database of the National Thesis Center in the High Education Board (YÖK). A total of 148 doctoral dissertations published between 2009-2019 in the anatomy department of medical faculty were included in the study.&#x0D; Results: Of the 148 theses, 82 (55.4%) were published in a journal and 66 (44.6%) were unpublished. Of the published theses, 53 (35.8%) were published in SCI/SCI-E, 3 (2%) in TÜBİTAK/Ulakbim TR index and 26 (17.6%) in other international indexes (p=.0001).&#x0D; Conclusion: It was observed that the publication rate of doctoral dissertations in the anatomy department of medical faculty in Türkiye and the rate of publication as articles in journals in SCI/SCI-E were quite high.

Approval status of essential therapeutic drugs for systemic sclerosis versus that of drugs for rheumatoid arthritis

Objective: Systemic sclerosis, a rare disease characterized by chronic multisystem fibrosis, requires lifelong management, necessitating enough insurance coverage for the patient. Official drug approval is the first step to ensuring that the drug is covered by insurance. In this study, we investigated the approval status of essential therapeutic drugs for systemic sclerosis across eight countries and compared it with that of drugs for rheumatoid arthritis. Methods: The essential therapeutic drug lists for systemic sclerosis and rheumatoid arthritis were taken from the guidelines of the American College of Rheumatology and the European Alliance of Associations for Rheumatology. Official drug approval status for the selected drugs was confirmed by searching representative Internet databases from eight countries: the United States, the United Kingdom, Germany, France, Italy, Switzerland, Japan, and the Republic of Korea. Results: A total of 21 and 16 drugs were selected for systemic sclerosis and rheumatoid arthritis, respectively. The drug approval rates of the 21 drugs for systemic sclerosis varied among countries. Most drugs used to treat pulmonary arterial hypertension, which were developed recently and are expensive, are approved by most countries; however, most older drugs—which are still essential for management of Raynaud’s phenomenon, digital ulcers, interstitial lung disease, and skin fibrosis—are not approved by most countries. By contrast, almost all of the 16 drugs used to treat rheumatoid arthritis, whether old or new, are approved by most countries. Conclusion: Approval rates for drugs used to treat systemic sclerosis, a rare disease, are much lower than those for drugs used to treat rheumatoid arthritis. Thus, approval rates of essential therapeutic drugs for systemic sclerosis need to improve, which will benefit patients by increasing the number of drugs covered by insurance.

Meta-analysis of the efficacy of postoperative adjuvant chemotherapy for stage IB non-small cell lung cancer.

Many clinical trials have shown that postoperative adjuvant chemotherapy can provide a survival benefit for patients with stage IB non-small cell lung cancer. However, whether adjuvant chemotherapy should be routinely given after surgery remains controversial. Therefore, we performed a meta-analysis to investigate the efficacy of adjuvant chemotherapy versus surgery alone for stage IB non-small cell lung cancer (NSCLC). Relevant retrospective studies or randomized controlled trial comparing the efficacy of postoperative adjuvant chemotherapy versus observation on the survival outcomes of NSCLC patients up to October 30, 2023 were searched in PubMed, Web of Science, EMBASE, Cochrane Library, VIP database, Wanfang database, and China National Knowledge Internet database. Patient survival data, population characteristics, and other relevant information were extracted, and data were analyzed using Review Manager 5.4. The primary endpoints included overall survival, disease-free survival, and recurrence-free survival. A total of 13 randomized controlled trials or cohort studies including 19,442 patients were included. The results of the meta-analysis showed that postoperative adjuvant chemotherapy in patients with stage IB NSCLC had better overall survival (odds ratio [OR] = 1.25, 95% confidence interval [CI] 1.19-1.31, P < .00001) and disease-free survival or recurrence-free survival (OR = 1.57, 95% CI 1.3-1.9, P < .00001) compared with observation; and the 4-year survival rate of patients who received postoperative adjuvant chemotherapy was better than the observation group (OR = 1.52, 95% CI 1.05-2.18, P = .03); and the 8-year survival rate of patients receiving postoperative adjuvant chemotherapy (OR = 1.5, 95% CI 0.94-2.4, P = .09) was comparable to the observation group. Receiving postoperative adjuvant chemotherapy improved people's survival and prolonged disease-free survival and recurrence-free survival in patients with stage IB non-small cell lung cancer compared with surgery alone.

Revitalizing Key Conditions and Integrated Watershed Management to Mitigate Land Degradation and Sustain Water Availability for Agriculture in Semi-Arid Regions: A Case Study of Ethiopia

Land, the source of 97% of global food, remains threatened by progressive soil erosion-induced land degradation, such as, in the semi-arid regions. To address this problem, soil and water conservation interventions have been implemented in watersheds across Ethiopia. Despite witnessing successful and positive impacts in some watersheds, the broader promotion of watershed-based interventions faces obstacles. Soil and water deteriorations persist in many of the watersheds in Ethiopia, leading to water shortages and related challenges in sustaining agriculture. The objectives of this research are thus to i) identify the main challenges and constraints hindering the promotion of watershed-based interventions in Ethiopia, and ii) identify key conditions for revitalizing the Integrated Watershed Management (IWSM) approach to mitigate soil erosion-induced land degradation, rehabilitate and sustainably manage watershed resources. A systematic review of over 60 published articles, extracted from the internet database using various search engines such as Google Scholar, ScienceDirect, Academia.edu, and ResearchGate, was conducted. Additionally, valuable comments from 65 peer-reviewers worldwide were collected through the Qeios platform during a posting period for more than two months, and these comments were utilized to update the first preprint version of this article. Based on the review, identified challenges and limitations include poor institutional support, lack of participation, inadequate planning of soil and water conservation (SWC) technologies, absence of research and development linkages, and insufficient capacity building. To address these challenges and limitations, recommendations for revitalizing the integrated watershed management (IWSM) approach and key conditions are discussed. The identified key conditions for revitalizing watershed-based interventions in Ethiopia include: i) ensuring institutional support and community participation, ii) strengthening the watershed-based intervention, and iii) establishing a watershed-based platform for scientific tools, research-based innovation, and capacity building to sustain water availability for agriculture in Ethiopia, serving as an experience for other semi-arid regions.

Review of Herbal Medicinal Plants Used in the Management of Cancers in the East Africa Region from 2019 to 2023.

In the East African region, herbal plants are essential in the treatment and control of cancer. Given the diverse ecological and cultural makeup of the regional states, it is likely that different ethnic groups will use the same or different plants for the same or different diseases. However, since 2019, this has not been compiled into a single study. The study aimed to compile and record the medicinal plants utilized in East Africa from April 2019 to June 2023 to treat various cancer types. The study examined 13 original studies that included ethnobotanical research conducted in East Africa. They were retrieved from several internet databases, including Google Scholar, Scopus, PubMed/Medline, Science Direct, and Research for Life. The study retrieved databases on plant families and species, plant parts used, preparation methods and routes of administration, and the country where the ethnobotanical field surveys were conducted. Graphs were produced using the GraphPad Prism 8.125 program (GraphPad Software, Inc., San Diego, CA). Tables and figures were used to present the data, which had been condensed into percentages and frequencies. A total of 105 different plant species from 45 different plant families were identified, including Asteraceae (14), Euphorbiaceae (12), Musaceae (8), and Apocynaceae (7). Uganda registered the highest proportion (46% of the medicinal plants used). The most commonly mentioned medicinal plant species in cancer management was Prunus africana. Herbs (32%), trees and shrubs (28%), and leaves (45%) constituted the majority of herbal remedies. Most herbal remedies were prepared by boiling (decoction) and taken orally (57%). East Africa is home to a wide variety of medicinal plant species that local populations and herbalists, or TMP, frequently use in the treatment of various types of cancer. The most frequently used families are Asteraceae and Euphorbiaceae, with the majority of species being found in Uganda. The most frequently utilized plant species is Prunus africana. Studies on the effectiveness of Prunus africana against other malignancies besides prostate cancer are required.

Meta-analysis of the effectiveness and safety of magnetic stimulation for chronic pelvic pain.

To systematically assess the effectiveness and safety of magnetic stimulation (MS) for treating chronic prostatitis (CP) and chronic pelvic pain syndrome (CPPS) through a meta-analysis. A comprehensive search of databases including PubMed, The Cochrane Library, EMbase, VIP, Web of Science, WanFang, China Biology Medicine disc (CBMdisc), and China National Knowledge Internet (CNKI) databases was conducted to retrieve randomized controlled trials (RCTs) on MS interventions for CPPS from inception to the present. The search employed keywords such as "MS", "CPPS", and "prostatitis". Data analysis was performed using RevMan 5.4 software, focusing on NIH-Chronic Prostatitis Symptom Index (NIH-CPSI), maximal urinary flow rate (Qmax), and international index of erectile function-5 (IIEF-5) score. Eight RCTs involving 636 patients were included. Our meta-analysis revealed that extracorporeal MS significantly reduced NIH-CPSI scores [MD = -6.65; 95% CI (-8.15, -5.15), P < 0.00001] and improved Qmax [MD = 2.98; 95% CI (1.36, 4.59), P = 0.0003] compared to the control group. Although a trend toward improved IIEF-5 scores was observed [MD = 0.81; 95% CI (-0.34, 1.95), P = 0.17], the results were not significant. MS is effective in alleviating clinical symptoms and enhancing Qmax in patients with CP/CPPS.

Examining the Moderating Role of the Automated Trading System on the Financial Performance of the Ghana Stock Exchange

The study investigates the role of the automated trading system on stock market capitalization, liquidity, efficiency, returns and volatility on the Ghana stock exchange. The project solely focus on secondary data from the internet databases of the Ghana Stock Exchange (GSE), and Bank of Ghana (BOG). The data is evaluated using a multivariate regression approach and includes monthly time series data from 2000 to 2020 as well as the volume of stock traded before and after the exchange is automated. The study finds that market performance has an impact on the automated trading system, and it also finds that the amount of stock traded is positively impacted by the automated trading system, exchange rates, and interest rates. Once more, the study draws the conclusion which asserts the economic indicator variable of the nation are marked via erratic and significant fluctuations in conversion rates. According to the report, the exchange’s transaction guidelines need to alter in order to provide shareholders the knowledge and confidence to make trading decisions on their own, without the assistance of a licensed stockbroker.

Enterprise Resource Planning (ERP): Opportunities, Benefits and Implementation Challenges in Bangladesh

Enterprise Resource Planning (ERP) is a software system used by organizations to manage and integrate the core functions like manufacturing, finance, human resources, supply chain, and customer management of their business processes in a unified system which has been proved to be a vital instrument for improving operational efficiency, reducing manual work, enhancing data accuracy and thus facilitates timely and accurate decision-making which help an organization to adapt and craft an appropriate proactive response to evolving challenges and problems of today's changing market trends, rising customer expectations, and growing global competition. With this backdrop, the aim of this study is to know the status of available opportunities that create facilitating conditions for effective ERP implementation in Bangladesh and the resulting benefits of ERP implementation as well as the challenges of ERP implementation in Bangladeshi enterprises. This paper used secondary data sources that include browsing internet databases like Google scholar, emerald, web of science, and research gate to find research papers, articles, and study materials on ERP. The study reveals that supportive policies of government, increasing technological infrastructure, growing IT expertise, financial support from different financial institutions create major opportunities for ERP implementation in Bangladesh. Moreover, improved efficiency, centralized information systems, facilitating better decision-making, automatic process identified as the major benefits of adopting ERP and cost constraint, resource constraint, inadequate IT infrastructure, organizational resistance, customization challenges, vendor dependency are the prime challenges of implementing ERP system in Bangladeshi organizations. Finally, the paper proposes some suggestions to overcome the challenges.

Association between the triglyceride glucose index and depression: a meta-analysis.

Obesity and diabetes have been associated with depressive symptoms. The aim of this systematic review and meta-analysis was to evaluate the association between the triglyceride glucose index (TyG index) a novel indicator of insulin resistance (IR) and depression in the adult population. Relevant observational studies were acquired through comprehensive searches of the Medline, Web of Science, Embase, Wanfang, and China National Knowledge Internet databases. To account for heterogeneity, a random-effects model was employed to combine the findings. Additionally, multiple subgroup analyses were conducted to assess the impact of various study characteristics on the outcome. The meta-analysis comprised eight datasets from six cross-sectional studies, encompassing a total of 28,973 adults. The pooled findings suggested that subjects with a high TyG index, compared to those with a low TyG index, were associated with a higher prevalence of depression (odds ratio [OR]: 1.41, 95% confidence interval (CI): 1.28-1.56, p<0.001; I2=19%). Sensitivity analyses, by omitting one dataset at a time, showed consistent results (OR: 1.39-1.45, p<0.05). Further subgroup analyses showed consistent results in participants aged <50 years old and in those aged ≥50 years old, in men and in women, in studies with different cutoff values for the TyG index, and in studies with different methods for the diagnosis of depression (for each subgroup difference, p>0.05). A high TyG index may be associated with a higher prevalence of depression in the adult population.