The effect of topical saliva application as a factor to accelerate wound healing: A review article

Abstract

Background: Saliva is one part of the oral environment that has an important role in maintaining oral tissues. Saliva is also able to stimulate wound healing. When compared to wounds on the skin, the mucosa in the oral cavity tends to heal faster. Saliva is believed to be one of the main factors contributing to this comparison. Objective: This paper aims to determine the effectiveness of saliva as a factor that accelerates wound healing on topically applied skin. Methods: A source search of various journals found on internet databases was conducted to obtain relevant information related to this study. Discussion: Various biological substances contained in saliva, one of which functions in wound healing. The content of histatin and growth factors in saliva is influential in accelerating the wound healing process with the best reconstruction results. Conclusion: Saliva is effective in accelerating wound healing and can stimulate skin wound closure and has the potential to become a new therapy for treating open skin wounds.