International Standards Research Articles

Compliance of Haditha Dam in Iraq to the International Standards for Surveillance and Monitoring

Dams are mega structures that retain huge volumes of water and their safety is important to national security, economy, and public interest. In this study, the types of regular measurements with their recorded value for Haditha Dam were checked for compliance with the standard international surveillance and monitoring procedures such as the procedures of the International Commission on Large Dams (ICOLD), the United States Bureau of Reclamation (USBR)and other to ensure safe dam operation and to avoid the scenario of the Derna Dam break, in Libya that occurred in September 2023. The result shows that the highest recorded settlement was found at station 41 on the left side of the dam body exceeding the design criteria (219 mm) by about 51 %, the frequency of measurement does not comply with the required international standards. There are 7 cells of pore pressure that exceeded the design criteria and the greatest percentage of exceedance was 21.57 % was found at pore pressure number 995. For piezometer reading, the percentage exceedance was 9.1% and it was found on the left side at piezometers number 58-8. The highest percentage of movement 62 % was found at join meter device number D18. The recorded seepage rate through the dam was found within the permitted limits. The visual inspection followed at Haditha Dam was not according to the standard required inspection.

Clove oil additives in vegetable oil: an assessment of fuel properties

Vegetable oil, obtained from plants such as coconut or Jatropha curcas, serves as a valuable renewable energy source. Nonetheless, it presents certain limitations in comparison to diesel fuels, namely, low volatility and high viscosity. One straightforward approach to overcome these limitations is the addition of high-volatility oil and low-viscosity oil. In this study, we incorporated 10% clove oil into coconut oil and Jatropha curcas oil. Fuel properties, including density, viscosity, flash point, and heating value, were measured in accordance with international standards. Additionally, Thermogravimetric Analysis (TGA) testing was performed to detect decomposition during the heating process. The findings indicated that the addition of clove oil increases density (from 0.922 g/ml to 0.934 g/ml), while other properties decrease, such as viscosity (from 30.12 cst to 27.7 cst), flash point (from 286°C to 182°C), and heating value (from 37.1 MJ/kg to 35.8 MJ/kg). TGA demonstrated that the inclusion of clove oil resulted in increased decomposition within the temperature range of 200°C–400°C, suggesting that clove oil falls into the category of medium-volatile oils. Although the addition of clove oil were able to modify the fuel properties of vegetable oil, it did not align with the characteristics of conventional diesel fuel and necessitates further modification for practical implementation

Enhancing equipment qualification testing facility for nuclear power plants: Achieving rapid temperature and pressure increase during design basis events

The present study focuses on the development of an equipment qualification (EQ) testing facility for Class 1E equipment in nuclear power plants (NPPs), emphasizing the need to ensure safety functions under design basis events (DBEs). The Republic of Korea (ROK) has implemented international safety standards to support large NPP projects, necessitating the development of domestic EQ testing facilities to reduce the dependence on foreign facilities. To address this need, herein, a specialized facility capable of simulating harsh DBE conditions that may occur in NPPs in ROK was constructed. Through exhaustive research, target temperature and pressure profiles were developed for pressurized water reactors, and a superheated steam injection technique was devised for rapid temperature and pressure changes. The present study contributes to the advancement of domestic EQ testing capabilities, achieving up to 230 °C and 700 kPa within 30 s.

Agricultural-Derived organochlorine pesticide residues impact on macroinvertebrate community in an Afrotropical Stream

This study evaluated the impact of pesticide application through agricultural activities in Chanchaga River, Nigeria, using macroinvertebrate data sets obtained for six months (September 2021–February 2022). Four (4) stations, characterized by various agricultural activities, were sampled along the river. Analysis of the water samples for organochlorine pesticide residues (OCP) using Gas Chromatography-Mass Spectrometry (GC/MS) at the peak of the two seasons revealed a high concentration of eleven isomers of organochlorine, which ranged from 0.01 to 0.81 μg/L, and a mean concentration that was above international drinking water standards set by the World Health Organization, the Federal Environmental Protection Agency, and the European Union. The mean concentration of detected OCP was recorded as DDT (0.72 μg/L), Dieldrin (0.59 μg/L), Paraquat (0.54 μg/L), Aldrin (0.49 μg/L), Metribuzin (0.48 μg/L), Butachlor (0.47 μg/L), Alachlor (0.28 μg/L), Atrazine (0.23 μg/L), Phenol (0.10 μg/L), Endrin (0.09 μg/L), and Benzene (0.08 μg/L). Atrazine, alachlor, metribuzin, aldrin, phenol, and endrin showed significant differences across the two seasons (p < 0.05), while dieldrin, butachlor, paraquat, benzene, and DDT showed no significant differences across the two seasons (p > 0.05). A total of 622 macroinvertebrate individuals from 19 species in 18 families from 8 orders were collected. More individuals were collected during the dry season (58.17 %) and the wet season (41.83 %). Canonical Correspondence Analysis (CCA) ordination revealed a strong relationship between species abundance and some organochlorine pesticide residues such as DDT, endrin, metribuzin, atrazine, benzene, and dieldrin. The response of macroinvertebrates to OCP indicates that Chanchaga River is a disturbed river, and the indicator organisms (Lestes sp., Coenagrion sp., Zyxomma sp., Appasus sp., Chironomus sp., Lymnaea natalensis, and Caridina nililotica) can also be used for further biomonitoring.

IsolateR: an R package for generating microbial libraries from Sanger sequencing data.

Sanger sequencing of taxonomic marker genes (e.g. 16S/18S/ITS/rpoB/cpn60) represents the leading method for identifying a wide range of microorganisms including bacteria, archaea, and fungi. However, the manual processing of sequence data and limitations associated with conventional BLAST searches impede the efficient generation of strain libraries essential for cataloging microbial diversity and discovering novel species. isolateR addresses these challenges by implementing a standardized and scalable three-step pipeline that includes: (1) automated batch processing of Sanger sequence files, (2) taxonomic classification via global alignment to type strain databases in accordance with the latest international nomenclature standards, and (3) straightforward creation of strain libraries and handling of clonal isolates, with the ability to set customizable sequence dereplication thresholds and combine data from multiple sequencing runs into a single library. The tool's user-friendly design also features interactive HTML outputs that simplify data exploration and analysis. Additionally, in silico benchmarking done on two comprehensive human gut genome catalogues (IMGG and Hadza hunter-gather populations) showcase the proficiency of isolateR in uncovering and cataloging the nuanced spectrum of microbial diversity, advocating for a more targeted and granular exploration within individual hosts to achieve the highest strain-level resolution possible when generating culture collections. isolateR is available at: https://github.com/bdaisley/isolateR.

A Suggested Accounting Framework to Apply Value Added Tax (VAT) in the State of Kuwait: An Empirical Study

Value Added Tax (VAT) has been widely adopted globally as a consumption tax, but its implementation can vary significantly across countries. This study aims to develop a suggested accounting framework for applying VAT in the State of Kuwait, considering its unique economic and legal environment. Through an empirical analysis of current VAT practices in Kuwait, the study identifies challenges and gaps in the existing framework. The proposed framework outlines clear guidelines for VAT registration, invoicing, tax calculations, and reporting, ensuring compliance with both domestic regulations and international VAT standards. By addressing the identified issues and providing a comprehensive accounting framework, this research seeks to enhance VAT administration, improve tax revenue collection, and facilitate business operations in Kuwait. Keywords: Value Added Tax (VAT), Kuwait, accounting framework, empirical study, tax compliance, tax administration.

The effect of temperature, pressure, and grind size on Total Dissolved Solids (TDS) and extraction yield of semi-automatic espresso machines

The number of coffee shops in Indonesia has grown from 1,083 stalls in 2016 to over 2,937 booths in 2019, representing a threefold growth. Coffee shop establishments must provide two essential kinds of equipment: espresso machines, which use pressure, and filter machines, which employ infusion. The issue lies in the exorbitant cost and immense power requirements of semi-automatic and automated espresso machines, which necessitate the use of a manual espresso machine for commercial operations. The equipment can generate satisfactory espresso but encounters several challenges; specifically, the espresso generated is characterized by inconsistency, constantly varying in quality. This might arise due to the erratic nature of the manufacturing process. The two objectives of this study are: (1) to design an economically efficient semi-automatic espresso machine capable of producing products that meet the international quality standards set by the Specialty Coffee Association (SCA standard) and (2) to investigate the impact of critical factors such as pressure, temperature, and grind size, on the consistent quality of the resulting coffee (measured by Total Dissolved Solids (TDS) and extraction yield (EXT)). The research employs the Research and Development (RD) methodology. The research findings indicate that the optimal levels of Total Dissolved Solids (TDS) and extraction yield (EXT) may be attained by using a pressure setting of 8 bars, a temperature of 90ºC, and a grind size of 3.2 on the scale. The technique for optimizing the response resulted in Total Dissolved Solids (TDS) levels of 10.03% and extraction yield (EXT) values of 19.56%. The results have been deemed acceptable based on the criteria set by the global standards of Specialty Coffee Association (SCA).

Emerging therapies in Ewing sarcoma.

There is an unmet need to improve outcomes for patients for Ewing sarcoma, a rare, aggressive sarcoma with a peak incidence in adolescents and young adults (AYA). Current therapy at diagnosis involves multiagent chemotherapy and local therapy, but despite intensification of treatment, those with metastases at diagnosis and recurrent disease have poor outcomes. Improved understanding of Ewing sarcoma biology has identified novel targets with promising activity in Ewing sarcoma patients, including tyrosine kinase inhibitors that are now undergoing evaluation as combination and maintenance therapy. Other emerging therapies include those that target the EWSR1::FLI1 fusion oncoprotein, and act on DNA damage, cell cycle and apoptotic pathways. Immunotherapeutic approaches, particularly CAR-T-cell therapy directed at GD2, also hold promise. Recent collaborative clinical trials that have defined an international standard of care for patients with newly diagnosed Ewing sarcoma and novel platform studies with adaptive designs offer unique opportunities to investigate these therapies inclusive of all ages. Close international collaboration between clinicians and biologists will allow us to prioritize promising emerging therapies and develop biomarkers to facilitate their incorporation into standard of care and more rapidly translate into benefit for Ewing sarcoma patients.

Introducing Indigenist Critical Policy Analysis: A rights‐based approach to analysing public policies and processes

AbstractInstitutional racism within Australia, grounded in the country's settler‐colonial structure, has sidelined Indigenous interests in public policymaking since federation. In an attempt to redress this, the United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP) was endorsed by the Australian government in 2009. UNDRIP is an authoritative international standard that could inform the ways that governments engage with Indigenous peoples and protect their rights. This paper introduces Indigenist Critical Policy Analysis (ICPA). While mainstream policy evaluation assesses whether policies and processes have met the governments stated objectives, ICPA assesses whether they uphold or violate Indigenous rights. ICPA involves reviewing policy documents against the key principles and specific Articles of UNDRIP. Presenting a worked example of ICPA, the NSW Regional Health Strategic Plan 2022–2032 is assessed against the five phases: (1) Orientation; (2) Close examination; (3) Determination; (4) Strengthening practice; and (5) Indigenous final word. This analysis finds that the Strategic Plan is poorly aligned with UNDRIP. Specifically, there is little evidence that Indigenous values influenced or held any authority in the process. ICPA offers a practical approach to analysing policy for compatibility with Indigenous rights under international law that could be used by Indigenous organisations and policymakers.

Factors Affecting Implementation of Joint Commission International Standards in Egyptian Hospitals: A comparative study between two private hospitals in Egypt.

Factors Affecting Implementation of Joint Commission International Standards in Egyptian Hospitals: A comparative study between two private hospitals in Egypt.

The Positive Impact of Social Responsibility (SR) Strategy on the Performance of SMSEs and Entrepreneurs in the North East Region of Nigeria

This study, empirical assessment of the effects of social responsibility (SR) strategy on the performance of SMSE’s and possible improvement on entrepreneurs in the north east region of Nigeria was undertaken and found that social responsibility has made an impact on the operation, economic growth and survival of SMSE’s sub-sector in Yobe State of Nigeria. The study was built in SMSE’s sector of the region, the “Thermo Fisher’s 4i Values” (Integrity, Intensity, Innovation and Involvement) it made up the sector in questions a great interaction with customers, suppliers and partners, communities and each other. These four values are foundational to our SR approach (Thermo Fisher scientific, 2020). Incognizance of the importance of SMSE, this study has expanded the body of knowledge in respect to social responsibility of small and micro enterprises. Specifically, the study worked out means in which SMSE sector be encouraged profitably. Only few of SMSE’s do participate and recognized the activities of SR. The study also recognized that financial institutions like banks, individual financer and government are attracted to few SMSE that participated in SR (Basariya, Al Kake, 2019). The study realized that “Social Responsibility (SR) has become a fundamental way of defining the role of business in society” (Itziar &amp; Josep, 2011). Other prominent writers in this context believe that, the needs of current and future generations cannot be met unless there is respect for natural systems and international standards protecting core social and environmental values. It is increasingly recognized the critical role of business sector. As a part of society, it is in business’ interest to contribute to addressing common problems. Strategically speaking, the study has captured that business can only flourish when the communities and ecosystems in which they operate are healthy (Marylyn, Caroline &amp; Sheena, 2011., Judy &amp; Victoria, 2011., Cameron, 2011., Tobias &amp; Frank, 2011., Min-Dong, 2011, &amp;Babafemi, 2015).

The Tornado Archive: Compiling and Visualizing a Worldwide, Digitized Tornado Database

Abstract Given inconsistencies in reporting methods and general lack of documentation, the creation of a unified tornado database across the world has been an elusive target for severe weather climatology purposes and historical interest. Previous online tornado documentation has also often been inconsistent or is now defunct. Many individual countries or continents maintain tornado information through either government-sponsored or independent organizations. The Tornado Archive was developed to create a first-of-its-kind digitized synthesis of worldwide tornado documentation, using the most complete sources of information available for regions known to be tornadically active. Spatial and temporal trends in tornado occurrence and reporting can be visualized through an interactive user interface with a variety of filtering methods and environmental reanalysis datasets, such as the fifth major global reanalysis produced by ECMWF (ERA5). The additional data introduced using Thomas Grazulis’ Significant Tornadoes may be beneficial for tornado climatology studies over the United States. The Tornado Archive is also intended to be a collaborative exercise, with clear data attribution and open avenues for augmentation, and the creation of a common data model to store the tornado information will assist in maintaining and updating the database. In this work, we document the methods necessary for creating the Tornado Archive database, provide broader climatological analysis of spatiotemporal patterns in tornado occurrence, and outline potential use cases for the data. We also highlight its key limitations and emphasize the need for further international standardization of tornado documentation.

Impact of a Regional Pediatric Hematology/Oncology Fellowship Program in Guatemala.

This study aimed to describe and assess the regional experience of a pediatric hematology/oncology fellowship program based in Guatemala. The Unidad Nacional de Oncología Pediátrica (UNOP) in Guatemala City, Guatemala, is the only hospital in Central America dedicated exclusively to childhood and adolescent cancer. To address the regional need for specialists, a fellowship program in pediatric hematology/oncology was launched in 2003. The UNOP fellowship program comprises 3 years of training. Although the program is based at UNOP, it also includes rotations locally and internationally to enhance clinical exposure. The curriculum is based on international standards to cover clinical expertise, research, professionalism, communication, and health advocacy. Trainees are selected according to country or facility-level need for pediatric hematologists/oncologists, with a plan for them to be hired immediately after completing their training. Forty physicians from 10 countries in Latin America have completed training. In addition, there are currently 13 fellows from five countries in training. Of the graduates, 39 (98%) are now practicing in pediatric hematology/oncology in Latin America. Moreover, many of them have leadership positions within their institutions and participate in research, advocacy, and policy making. Graduates from the UNOP program contribute to institutions by providing care for an increasing number of patients with pediatric cancer. The UNOP program is the first pediatric hematology/oncology fellowship program in the world to be accredited by Accreditation Council for Graduate Medical Education-International, an international body accrediting clinical training programs. The UNOP program has trained specialists to increase the available care for children with cancer in Latin America. This regional approach to specialist training can maximize resources and serve as a model for other programs and regions.

Compliance Level of Adopting and Approving Harmonised National Standards in Information Sciences: Current State and Prospects

The aim of the article is to study the level of acceptance and approval, to reveal the status and outline the prospects for harmonising national standards in accordance with international normative documents in the field of information sciences, library, publishing and archival studies. Reresearch methods. The offered research grounds on a set of general scientific methods. In the course of studying the professional literature of scientific articles for the set goal and solving the tasks, the methods of analysis and synthesis, generalisation and systematisation, the method of grouping national standards according to the code designations of the National Standard 004: 2020 of the “Ukrainian Classifier of Regulatory Documents” are used, which make it possible to draw conclusions about the methods and the level of accepted and approved harmonised standards in information sciences. The scientific novelty of the article consists in revealing the level of adopting and approving harmonised national standards in information, library, publishing and archival studies in accordance with international regulatory documents, which ensures a high-quality level of development of standardisation in Ukraine. Main conclusions. The first adopted and approved national standards in information, library, publishing and archival studies as harmonised with international norms, requirements, rules and regulatory provisions according to the degree of compliance are mostly identical or modified, some of them are not equivalent to international regulatory documents. During the last decade the Ukrainian information community development the degree of adoption and harmonisation of national standards in relation to international normative documents has increased to 100 %, which makes it possible to improve information support, optimise the fund of normative documents, scientific and terminological base, analytical and synthetic processing of scientific and technical information, documentary, informational, library, publishing and archival studies. As a rule, harmonisation and implementation of international standards in the information sphere is a priority task for ensuring a qualitatively new level of standardisation development in Ukraine.

An ecological reorientation of the Codex Alimentarius Commission could help transform food systems.

The Codex Alimentarius Commission (Codex) has a substantial influence over the structure and operation of food systems by setting international standards that affect the composition, structure and labelling of food. Despite the dual mandates of Codex to protect public health and ensure fair practices in food trade, food systems are increasingly unhealthy and unsustainable. An ecological reorientation of the decision-making elements that influence how Codex sets food standards-particularly mandates, governance and risk assessment-could help transform food systems towards the UN Sustainable Development Goals.

RISKS OF INJURY AND HEALTH DAMAGE WHEN USING BLACKSMITH EQUIPMENT

The article identifies the need to analyze the risks of injury and health damage when using blacksmith equipment which is due to the implementation of the latest technologies for the successful economic development of the country, the introduction of a risk-oriented approach, as well as the implementation of international standards in all sectors of the economy. It was noted that international standards are based on the use of a risk-oriented approach in solving issues of safety and occupational health of employees. Therefore, this requires the implementation of new approaches and the formation of new relationships in particularly dangerous areas of production. The general state of occupational injuries and deaths of workers in Ukraine for the period starting from 2022 to 2024 (four months of the current year) is given. The given data indicate an increase in the number of accidents at work which is further complicated by the war. These data indicate an increase in injuries at work which is a bad indicator and the need to implement modern risk-oriented technologies in the metallurgical industry. Analyzing the situation in the metallurgical industry where blacksmith equipment is widely used it should be noted that the main causes of injury and death of workers are organizational. This proves that the risk management system at enterprises is imperfect and needs to be improved and brought into line with international standards. Scientific approaches to determining the risks of injury and damage to the health of workers (operators) when using blacksmith equipment are considered. It is shown that modern technologies of metal processing by forging as one of the methods of pressure processing, use more and more robotic complexes which have risks associated with the organization of work in the conditions of the probability of physical impact of their individual elements and substances on workers. The dangerous and harmful factors that accompany the work of operators when using the MKP10 forging manipulator are given. The operation of the MKP10 manipulator is considered as an example. Tables and diagrams of the manipulator are made in accordance with the DSTU ISO 12100:2016 standard. The calculation of the risk indicator of the MKP10 manipulator was also performed which showed that the risk is average in terms of its damage and probability indicators. This leads to the need to apply risk management to control such risk and reduce it to acceptably small values.

ANALYSIS OF RISK MANAGEMENT TERMINOLOGY IN EMPLOYEE HEALTH AND SAFETY MANAGEMENT SYSTEMS

An analysis of the main provisions and terms in accordance with domestic and international standards in the field of occupational health and safety of employees (hereinafter referred to as OSH) and risk management was carried out in order to avoid different interpretations in the draft Law on Occupational Safety and Health of Employees. To achieve this goal, the continuous sampling method, the descriptive method, the method of analyzing dictionary definitions, the method of word formation analysis, and the comparative method of component analysis were used. The study was conducted in four stages: analysis of the literature on occupational safety and health protection of workers; selection of terms for analysis; analysis of approaches to defining the concepts of "term", "terminology", analysis of lexical-semantic and structural features of terms; formation of general conclusions and prospects for further research. The justification of the change in the definitions of the main terms in OSH was carried out. It is proposed to present OSH at work as a part of the overall management system of the employer's activities, which is aimed at creating safe working conditions for employees and preserving their health by managing occupational risks. We recommend adding the concept of accident to the terms in the draft Law of Ukraine on occupational safety and health of workers, since the Procedure for Investigations and The Civil Protection Code of Ukraine defines the specified term. It is proposed to define occupational risk as a combination of the probability of occurrence of a work-related hazardous event(s) or exposure(s) and the severity of injury and health impairment that may be caused by this event(s) or exposure(s); occupational risk assessment as a process of comparing the results of occupational risk analysis with risk criteria to determine whether the occupational risk and/or its magnitude is acceptable (acceptable); occupational risk management is preventive and protective measures that reduce and/or modify (change) occupational risk to an acceptable (acceptable) level. The justification of the semantic load of the most used terms in the field of occupational safety and health protection of workers: risk, risk management, acceptable risk, dangerous event, incident was carried out for their qualitative use in the draft Law on Occupational Safety and Health of Workers. Recommendations for the description of terms and definitions for the draft Law of Ukraine on occupational safety and health of workers have been developed.

Trends and Developments in Contemporary Zakat Administration

Zakat is a third pillar of Islam and has been considered as the mainstay of Islamic economics. It comes at the center of the five pillars of Islam, which some scholars interpret as providing balance between ibadat (worship) and muamalat (day to day human transactions). Historically it provides solutions to economic problems of the Muslims society. However, its application is reduced to individual levels with limited impact in many parts of the world. In the recent times, there is revival of the institution of zakat. Thus, the paper examines the contemporary developments on zakat particularly its potential and applications in Muslim countries and communities. The methodology adopted is content analysis with critical review of the literature. Secondary data were sourced from reports covering 2014 to 2020. The data was specifically analyzed based on the trends and potentials of zakat in Asia, Sub-Saharan Africa, North Africa and the Russian Federation. The paper finds that, zakat in many Muslim jurisdictions has the potential of alleviating poverty and drastically reducing income inequality based on international standards. The implication of the study is that Muslim countries and communities should revive zakat and apply it in their mainstream economic system to solve their socio-economic problems.

An overview of the historical development and current vision of academic education

The academic side of education has always been the ultimate point regarding purpose, structuring, and reflecting education to society from past to present. Naturally, the definition of the university and its contribution to society should not be ignored. Historically speaking, universities are institutions where inquisitive minds are trained. Therefore, it is necessary to research the quality of their impact on society. This article aims to draw attention to the fact that the educational disciplines of today’s universities need to be questioned more loudly, as the demand for higher education and the increase in quality do not go parallel. In this article, the stages of academic education from its historical beginnings to the present have been evaluated by scanning the literature. Thus, it is aimed to make the readers question themselves about whether the situation of academic education from the beginning to the present is positive progress or just a change. Therefore, the study focused on discussing the quality of education at universities rather than comparing articles with each other. Articles focused on the main idea of the research were downloaded, examined, and indexed according to the path of academic education in history. The optimal approach should be to evaluate each university according to its own social, geographical, and cultural environment, as well as international standards. Easier access to information is of no importance without a mind that questions the accuracy and validity of the information. The ultimate point that an academic education can reach should be measured by the contribution to society of the people who have attained that education.

International Legal Approaches to the Issue of Admissibility of the Use of Genomic Technologies in Medicine

The purpose of the paper is to determine the main international standards and positions of international intergovernmental and non-governmental organizations regarding the use of genomic technologies in medicine, which are reflected in their documents. At the universal level, there is no international treaty containing uniform rules in this area, but there are many documents of international organizations (such as WHO, UNESCO) that set out the relevant standards. At the regional level, the experience of the Council of Europe in the field of legal regulation of genomic medicine plays a significant role. National approaches to the legal regulation of genomic medicine vary. In such conditions, the practice of international non-governmental organizations in the field of biomedicine and genetic technologies plays a significant role. They set standards and represent the positions of the biomedical community.Based on the analysis of international acts, it can be concluded that the general position of the international biomedical community is that genome editing technologies can be widely used for therapeutic and scientific purposes, provided that there is no criterion for transmitting genes to descendants. Genome editing should be carried out in accordance with international professional and ethical standards, including the principles of benefit over harm and informed consent. Discussions about the admissibility of hereditary genome editing continue. The prevailing approach of international organizations is that there are currently no reasonable standards for the safety and effectiveness of this technology, while research itself is encouraged.