The Central Bohemian Plutonic Complex (CBPC) consists of episodically emplaced plutons, the internal fabrics of which recorded tectonic evolution of a continental magmatic arc. The ~354–350 Ma calc-alkaline plutons were emplaced by multiple processes into the upper-crustal Tepla-Barrandian Unit, and their magmatic fabrics recorded increments of regional transpression. Multiple fabrics of the younger, ~346 Ma Blatna pluton recorded both regional transpression and the onset of exhumation of mid-crustal orogenic root (Moldanubian Unit). Continuous exhumation-related deformation during pluton cooling resulted in the development of a wide zone of sub-solidus deformation along the SE margin of the CBPC. Finally, syn-exhumation tabular durbachitic pluton of ultrapotassic composition was emplaced atop the intrusive sequence at ~343–340 Ma, and the ultrapotassic Tabor pluton intruded after exhumation of the orogenic root (~337 Ma). We suggest that the emplacement of plutons during regional transpression in the upper crust produced thermally softened domain which then accommodated the exhumation of the mid-crustal orogenic root, and that the complex nature of the Tepla-Barrandian/Moldanubian boundary is a result of regional transpression in the upper crust, the enhancement of regional deformation in overlapping structural aureoles, the subsequent exhumation of the orogenic root domain, and post-emplacement brittle faulting.