In the context of global changes, the deepening of multilateral strategic cooperation between Russia and China has become an important area of demonstrating the universal value and fundamental importance of comprehensive cooperation between countries in a new era. The challenges of our time associated with protracted regional conflicts, changing paradigms of international communication, management dilemmas, a lack of strategic mutual trust, and changes in the perception of the role of each country necessitate joint efforts by states to mitigate them. It is emphasized that the SCO and BRICS mechanisms can be used for this purpose, with some adjustments. On the one hand, it is important to harmonize the management focus and functional boundaries of the SCO, to use the complementary strengths and innovative potential of the countries in the activities of the association. On the other hand, it is necessary to enhance the environmental sustainability of states and the strength of their cooperation within BRICS, to standardize the various requirements of participants and ensure the merger of their interests, to explore opportunities for cooperation based on the Sino-Russian experience and use them to develop a strategy of multilateral interaction aimed at conducting constructive reforms and establishing a multipolar international order on an equitable basis.