Intermittent Aerobic Exercise Research Articles

Regular Intermittent Aerobic Exercise Reduces Arterial Stiffness Associated with Postprandial Hyperglycemia in Middle-Aged and Older Individuals

Hardening of arterial walls associated with elevated postprandial blood glucose levels increases the risk of cardiovascular disease; however, the impact of intermittent aerobic training on reducing arterial stiffness is unknown. The aim of this study was to examine the chronic effects of intermittent aerobic exercise on arterial stiffness during hyperglycemia in middle-aged adults: 30 healthy middle-aged adults were randomly assigned to an 8-week intermittent aerobic training group (n = 15, jogging or running, 30 min/run, 3 times/week, 65% reserve heart rate) and a control group (n = 15, no training). Pulse wave velocity (PWV) of carotid-femoral (cf) and brachial-ankle (ba), heart rate, blood pressure, and blood glucose was measured before a 75 g oral glucose tolerance test (OGTT) and 30, 60, and 90 min after the test, before the exercise intervention, and 4 and 8 weeks after intervention. The baPWV and blood glucose levels before the intervention were elevated at 30, 60, and 90 min in both groups compared to levels before the 75 g OGTT (p < 0.01). The baPWV and blood glucose levels after 4 and 8 weeks of intervention were unchanged in the training group compared to that before the 75 g OGTT, but increased at 30, 60, and 90 min in the control group compared to that before the 75 g OGTT (p < 0.01). The baPWV and blood glucose levels at 30 and 60 min after the 75 g OGTT after 4 and 8 weeks of intervention were lower in the training group than in the control group (p < 0.01). These results indicate that intermittent aerobic exercise training may reduce the acute increase in arterial stiffness after hyperglycemia.

The Effect of Interval Training Exercise on the Serum Level of Apelin-17 and Vascular Blood Flow Improvement in Patients with Heart Failure

Background and Objectives Chronic hypertension causes structural and functional changes in the heart, ultimately leading to heart failure (HF), which further increases mortality. The aim of the present study was to examine the effect of intermittent aerobic exercise on the serum level of Apelin-17 and factors related to blood pressure in patients with HF. Subjects and Methods In this quasi-experimental study, 20 men with HF were selected based on the inclusion criteria and were randomly divided into exercise and control groups. The exercise program included interval aerobic training exercise that involved three sessions per week continued for eight weeks. Fasting blood samples and physiological variables were measured 48 hours before and after the intervention. Results After eight weeks of training, there was a significant increase in the levels of Apelin-17 (P = 0.039), Ang I (P = 0.005) and FMD (P = 0.008). A significant decrease in the levels of Ang II (P < 0.001) and SBP (P < 0.001) was observed, but no significant difference was found in the values of ACE-2 (P = 0.234) and DBP (P = 0.363). Conclusion According to the results, it can be stated that one of the adaptations of exercise that improves blood flow and lowers blood pressure in patients with HF is increasing the level of Apelin-17 in these patients.

Effect of high-intensity intermittent aerobic exercise on blood pressure, heart rate variability, and respiratory function in people with methamphetamine use disorder

Effect of high-intensity intermittent aerobic exercise on blood pressure, heart rate variability, and respiratory function in people with methamphetamine use disorder

WITHDRAWN: Effect of high-intensity intermittent aerobic exercise on blood pressure, heart rate variability, and respiratory function in people with methamphetamine use disorder

WITHDRAWN: Effect of high-intensity intermittent aerobic exercise on blood pressure, heart rate variability, and respiratory function in people with methamphetamine use disorder

Effect of 4 Weeks Preconditioning with High Intensity Interval Training and Moderate Intensity Continuous Training on Brain Levels of TNF-Α and TLR4 in Male Wistar Rats

Introduction: Inflammation in the brain is known as neuroinflammation and increases TNF-α (Tumor necrosis factor alpha) secretion and activates the TLR4 (Toll-like receptor 4) pathway. The aim of this study was to evaluate the effect of 4 weeks preconditioning with high intensity intermittent training (HIIT) and moderate intensity training (MICT) on TNF-α and TLR4 levels in male Wistar rats.
 Methods: The current research was an experimental study.18 male Wistar rats were divided into three groups: high intensity intermittent training (6 heads), continuous moderate intensity training (6 heads) and the control group (6 heads). HIIT program included 6 stages of 2-minute activity with intensity of 85-90% VO2max and 5 stages of active rest for 2 minutes and MICT program with intensity of 65% VO2max with the same duration as HIIT for 4 weeks and 5 days per week was implemented. 48 hours after the last training session, rats were dissected and cortical tissues and layers of mice were extracted for TNF-α and TLR-4 using western blotting. Data analysis was performed using ANOVA test at a significance level of 0.05 With the help of SPSS version 16 software.
 Results: The results of the present study showed that TNF-α and TLR4 in the cortex and stratum cerebral areas after 4 weeks of high-intensity and moderate-intensity intermittent aerobic exercise did not change significantly compared to the control group (p≥0.05).
 Conclusion: According to these findings, it can be stated that exercise with high or moderate intensity cannot be an effective factor in increasing inflammatory markers in the brain.

The growing field of immunometabolism and exercise: Key findings in the last 5 years.

This perspective review highlights the impact of physical exercise on immunometabolic responses in the past 5 years. Understanding immunometabolism as a part of immunological research is essential. Furthermore, the roles of both acute and chronic effects of physical exercise on health, aging, and chronic diseases in immunometabolic changes should be elaborated. In immune cells, β2 adrenergic signaling stimulates the preferential mobilization of inflammatory phenotypes, such as CD16+ monocytes and CD8+ T cells, into the bloodstream after a physical exercise session. The mobilization of immune cells is closely related to the availability of energetic substrates for the cell and mechanisms associated with the uptake and oxidation of fatty acids and glucose. These cells, especially senescent T cells, are mobilized to the peripheral tissues and undergo apoptotic signaling, stimulating the creation of a "vacant space" where new cells will be matured and replaced in the circulation. This results in the upregulation of the expression and secretion of anti-inflammatory cytokines (IL-10 and IL-1ra), leading to increased regulatory immune cells that provide immunoregulatory properties. Thus, we suggest that a significant nutrient available to the cell will favor oxidative metabolism, augment ATP production, and consequently maintain the immune cells in their quiescent state, as well as promote rapid activation function. Therefore, based on the studies discussed in this perspective review, we highlight the importance of performing moderate-intensity continuous and high-intensity intermittent aerobic exercises, due to a higher magnitude of energetic demand and release of anti-inflammatory cytokines (IL-6 and IL-10).

Efficacy and Acceptability of Intermittent Aerobic Exercise on Polysomnography-Measured Sleep in People With Rheumatoid Arthritis With Self-Reported Sleep Disturbance: A Randomized Controlled Trial.

ObjectiveThis study's objective was to investigate the efficacy and acceptability of intermittent aerobic exercise training on sleep parameters, fatigue, pain, depressive symptoms, physical function, and cardiorespiratory fitness in people with rheumatoid arthritis (RA).MethodsThirty‐eight people with RA were assigned to intermittent aerobic exercise training (three sessions/week for 6 weeks; intervention group, n = 17) or usual care (control group, n = 21). The primary outcome was a change in polysomnography‐assessed sleep efficiency from baseline to the end of the intervention. Secondary outcomes were sleep quality (Pittsburgh Sleep Quality Index), fatigue (Bristol Rheumatoid Arthritis Fatigue Multi‐Dimensional Questionnaire), depression (Center for Epidemiological Studies‐Depression), and cardiorespiratory fitness (watt max test).ResultsNo between‐group differences were found in changes in polysomnography‐assessed sleep efficiency (0.04; 95% confidence interval [CI]: −0.02 to 0.09, P = 0.17). In the intervention group, sleep efficiency was improved significantly from baseline (0.84; 95% CI: 0.80‐0.88) compared with the end of the intervention (6 weeks) (0.88; 95% CI: 0.85‐0.92); however, there was no significant difference in the control group. Fatigue and depression measures were significantly lower in the intervention group than in the control group. Between‐group differences were overall fatigue (−16.1; 95% CI: −25.1 to −7.0, P = 0.001), physical fatigue (−5.0; 95% CI: −7.3 to −2.7, P = 0.0001), cognitive fatigue (−2.4; 95% CI: −4.2 to 0.6, P = 0.009), living with fatigue (−2.5; 95% CI: −4.5 to −0.5, P = 0.01), and depressive symptoms (−6.8; 95% CI: −12.4 to −1.1, P = 0.02).ConclusionThe intervention yielded no significantly better sleep efficiency compared with usual care. However, aspects of fatigue, including physical and cognitive fatigue, and depressive symptoms were significantly improved in the intervention group.

Exercise-induced modulation of monocytes in breast cancer survivors

BackgroundExercise training reduces inflammation in breast cancer survivors; however, the mechanism is not fully understood. ObjectivesThe effects of acute and chronic exercise on monocyte toll-like receptor (TLR2 and 4) expression and intracellular cytokine production were examined in sedentary breast cancer survivors. MethodsEleven women with stage I, II, or III breast cancer within one year of treatment completion performed an acute, intermittent aerobic exercise trial. Blood samples were obtained before, immediately, and 1 h after a 45-min acute exercise trial that was performed before and after 16 weeks of combined aerobic and resistance. LPS-stimulated intracellular IL-1ß, TNF, and IL-6 production, and TLR2 and TLR4 expression were evaluated in CD14+CD16- and CD14+CD16+ monocytes using flow cytometry. ResultsExercise training decreased IL-1ß+CD14+CD16- proportion (24.6%, p=0.016), IL-1ß+CD14+CD16- mean fluorescence intensity (MFI) (−9989, p=0.014), IL-1ß+CD14+CD16+ MFI (−11101, p=0.02), and IL-6+CD14+CD16- proportion (16.9%, P=0.04). TLR2 and TLR4 expression did not change following exercise training but decreased 1 h after acute exercise in CD14+CD16- (−63, p=0.002) and CD14+CD16+ (−18, p=0.006) monocytes, respectively. Immediately after the acute exercise, both monocyte subgroup cell concentration increased, with CD14+CD16+ concentrations being decreased at 1 h post without changes in intracellular cytokine production. ConclusionsExercise training reduced monocyte intracellular pro-inflammatory cytokine production, especially IL-1ß, although these markers did not change acutely. While acute exercise downregulated the expression of TLR2 and TLR4 on monocytes, this was not sustained over the course of training. These results suggest that the anti-inflammatory effect of combined aerobic and resistance exercise training in breast cancer survivors may be, in part, due to reducing resting monocyte pro-inflammatory cytokine production.

간헐적 유산소 운동 중재가 폐경 여성의 노화관련 인자, 생활습관병 위험 인자 및 신체구성에 미치는 영향

이 연구는 폐경 여성을 대상으로 12주 간헐적 유산소 운동 중재가 노화관련 인자(DHEAs, melatonin), 생활습관병 위험 인자(TG, TC, HDL-C, LDL-C) 및 신체구성(체중, 체지방률, BMI) 변화를 살펴 보위하여 간헐적 유산소 운동 집단(13명)과 통제집단(12명)으로 집단을 구성하였고, 자료처리는 SPSS ver. 20.0을 이용하여 집단 간 차이검증은 독립 t검정, 집단 내 차이 검증은 대응 t검정을 실시하였다. 노화관련 인자에서 DHEAs는 집단 내 비교에서 운동집단이 유의한 증가를 보였다(p<.05). melatonin은 집단 내 비교에서 운동집단이 통계적으로 유의한 증가를 보였고(p<.01), 집단 간 비교에서 운동집단이 유의한 증가를 보였다(p<.05). 생활습관병 위험인자에서 TG는 집단 내 비교에서 운동집단이 유의한 감소를 보였고(p<.05), 집단 간 비교에서 운동집단이 유의한 감소를 보였다(p<.01). LDL-C은 집단 내 비교에서 운동집단이 유의한 감소를 보였고(p<.01), 집단 간 비교에서 운동집단이 유의한 감소를 보였다(p<.05). 신체구성에서 체중(kg)은 집단 내 비교에서 운동집단이 유의한 감소를 보였고(p<.01), 집단 간 비교에서 운동집단이 유의한 감소를 보였다(p<.001). 체지방률은 집단 내 비교에서 운동집단이 유의한 감소를 보였고(p<.05), 집단 간 비교에서 운동집단이 유의한 감소를 보였다(p<.01). 따라서 간헐적 유산소 운동 중재가 폐경 여성을 대상으로 노화관련 인자, 생활습관병 관련 인자 및 신체구성에 긍정적인 영향을 미치는 것으로 판단된다.

Changes in Some Inflammatory Indices in Men with Heart Failure after Eight Weeks of Continuous and Intermittent Aerobic Exercise

Changes in Some Inflammatory Indices in Men with Heart Failure after Eight Weeks of Continuous and Intermittent Aerobic Exercise

Virtual training leads to physical, cognitive and neural benefits in healthy adults

Physical activity, such as high-intensity intermittent aerobic exercise (HIE), can improve executive functions. Although performing strength or aerobic training might be problematic or not feasible for someone. An experimental situation where there is no actual movement, but the body shows physiological reactions, is during the illusion through immersive virtual reality (IVR). We aimed to demonstrate whether a virtual HIE-based intervention (vHIE) performed exclusively by the own virtual body has physical, cognitive, and neural benefits on the real body. 45 healthy young adults (cross-over design) experienced HIE training in IVR (i.e., the virtual body performed eight sets of 30 s of running followed by 30 s of slow walking, while the subject is completely still) in two random-ordered conditions (administered in two sessions one week apart): the virtual body is displayed in first-person perspective (1PP) or third-person perspective (3PP). During the vHIE, we recorded the heart rate and subjective questionnaires to confirm the effectiveness of the illusion; before and after vHIE, we measured cortical hemodynamic changes in the participants’ left dorsolateral prefrontal cortex (lDLPFC) using the fNIRS device during the Stroop task to test our main hypothesis. Preliminary, we confirmed that the illusion was effective: during the vHIE in 1PP, subjects’ heart rate increased coherently with the virtual movements, and they reported subjective feelings of ownership and agency. Primarily, subjects were faster in executing the Stroop task after the vHIE in 1PP; also, the lDLPFC activity increased coherently. Clinically, these results might be exploited to train cognition and body simultaneously. Theoretically, we proved that the sense of body ownership and agency can affect other parameters, even in the absence of actual movements.

Comparison between the effects of continuous and intermittent aerobic exercise on biomarkers of creatine metabolism and oxidative-antioxidant balance in female athletes

Comparison between the effects of continuous and intermittent aerobic exercise on biomarkers of creatine metabolism and oxidative-antioxidant balance in female athletes

Effect of one Bout Continuous Versus Intermittent Aerobic Exercise on Plasma Levels of Intercellular Adhesion Molecules 1 and Vascular Cell Adhesion Molecules 1 in Patients with Coronary Heart Disease

Introduction: Adhesion molecules play an important role in the pathogenesis of atherosclerosis and the type of training may affect the response to these indicators. Therefore, the purpose of the present study was to investigate the effect of a continuous versus interval aerobic training session on plasma levels of intercellular adhesion molecules 1 (ICAM-1) and vascular cell adhesion molecules 1 (VCAM-1) in patients with coronary artery disease.&#x0D; Methods: In this quasi-experimental study, 9 women with coronary artery disease participated in pre-test and two stages of post-test design (interval and continuous). Continuing training program included running or walking for 30 minutes with an intensity of 60% of maximum heart rate. Therefore, interval training included 30 minutes of walking or running with variable intensity between 50% and 80% peak heart rate. ICAM-1 and VCAM-1 serum levels were measured in scale of ng/ml by ELISA. Results were analyzed by SPSS Inc., Chicago, IL; version 24 and repeated measures test were used at a significant level of P≤0.05.&#x0D; Results: One session of continuous and interval training didn’t show significant differences in ICAM-1 and VCAM-1 serum levels. So that the ICAM-1 levels were obtained (233.6 ± 0.1) after continuous training and (230.4 ± 1) after interval training (P= 0.186). In addition, VCAM-1 levels were observed (163.3 ± 7.0) after continuous training and (194.8 ± 6.9) after interval training (P= 0.121).&#x0D; Conclusion: One session of training stimulates inflammatory pathways in coronary artery disease patients. Based on the results of this study, the effect of continuous aerobic training on the levels of adherent molecules cannot be determined certainty and more research is needed.&#x0D;

Assessing the effects of 6 weeks of intermittent aerobic exercise on aerobic capacity, muscle fatigability, and quality of life in diabetic burned patients: Randomized control study.

Both burn and diabetes mellitus (DM) cause functional and psychosocial disabilities. A low-cost and safe approach is greatly required to reduce these disabilities and the effects of aerobic exercise have generated varied evidence to date. The aim of the study was to explore the effects of 6 weeks of intermittent aerobic exercise (IAE) on aerobic capacity, muscle fatigability, and quality of life (QoL) in diabetic burned patients (DBPs). The study design was a prospective, single-blind, randomized controlled trial. Between March 2018 and July 2019 thirty-six (22 males and 16 females) diabetic burned patients were included in the study, their age ranged 35-55 years. They were clinically diagnosed with type 2 DM and total body surface area (TBSA) was 15-30%. The participants were randomly assigned to the IAE group (n = 18) and controls (n = 18). Aerobic capacity, muscle fatigability, and QoL were assessed initially and repeated after 6 weeks of intervention. Initial data demonstrated non-significant differences between the IAE and control groups (p > 0.05). Comparing pre- and post-intervention outcomes showed significant improvement of VO2max, muscle fatigability, QoL domains in the IAE group after 6 weeks intervention (p < 0.05) and non-significant changes in the control group (p > 0.05). The IAE group showed statistically significant improvement more than the control group in all outcome measures (p < 0.05). 6 weeks of intermittent aerobic exercise is an effective alternative modality to improve aerobic capacity, muscle fatigability, and QoL in DBPs. Adherence to intermittent aerobic exercise should be practicable into mainstream clinical intervention for those patients.

Effect of Intermittent High Intensity Aerobic Exercise on Exercise Endurance of Patients with Stroke Complicated with Coronary Heart Disease

Effect of Intermittent High Intensity Aerobic Exercise on Exercise Endurance of Patients with Stroke Complicated with Coronary Heart Disease

Virtual training leads to real acute physical, cognitive, and neural benefits on healthy adults: study protocol for a randomized controlled trial

BackgroundKeeping a certain level of physical activity has beneficial effects on the body itself but also, surprisingly, on cognition: specifically, physical high-intensity intermittent aerobic exercise (HIE) can show improvement on cognitive executive functions. Although, in some cases performing strength or aerobic training is problematic or not feasible. Immersive virtual reality (IVR) can induce the illusory feeling of ownership and agency over a moving virtual body, therefore showing comparable physiological reactions: for example, if an individual is sitting on a chair but his virtual body climbs a hill, the individual’s heart rate increases coherently, as if he is actually walking.In this study, we investigate whether this same illusion can show beneficial consequences on the body as well as on executive functions (using the color-word matching Stroop task) and on its neural substrates (using functional near-infrared spectroscopy [fNIRS]).MethodsIn a cross-over randomized controlled trial, 30 healthy young adults will experience HIE training in IVR (i.e. the virtual body will perform eight sets of 30 s of running followed by 30 s of slow walking, while the participant is completely still) according to two random-ordered conditions: during the experimental condition, the virtual body is displayed in first-person perspective (1PP), while in the control condition, the virtual body is displayed in third-person perspective (3PP). To confirm that individuals have the illusion of ownership and agency over the virtual body in 1PP (and not in 3PP), we will record the heart rate, in addition to subjective questionnaires. Before and after every IVR sessions (one week apart), we will measure cortical hemodynamic changes in the participants’ prefrontal cortex using the fNIRS device during the Stroop task’s execution.DiscussionFrom a theoretical perspective, we could prove that the sense of body ownership and agency can modulate physical and cognitive parameters, even in the absence of actual movements; from a clinical perspective, these results could be useful to train cognition and body simultaneously, in a completely safe environment.Trial registrationUniversity Hospital Medical Information Network Clinical Trial Registry, UMIN000034255. Registered on 1 October 2018.

Continuous versus intermittent aerobic exercise in the improvement of quality of life for women with polycystic ovary syndrome: A randomized controlled trial.

Polycystic ovary syndrome predisposes alterations which contribute to the reduction of quality of life. This randomized controlled clinical trial study was to evaluate the effect of two protocols of aerobic exercise on quality of life in women with polycystic ovary syndrome. Women were allocated to three groups: continuous aerobic training (n = 28), intermittent aerobic training (n = 29), and control group (no training; n = 30). Testosterone levels, body composition indices, and quality of life were assessed at baseline and after 16 weeks of intervention. Both protocols were effective to improve testosterone levels, anthropometric indices, and quality of life in polycystic ovary syndrome women. Thus, these protocols should be included in the clinical environment to improve clinical parameters psychological, biological and social health to this population.

Effect of Continuous vs Intermittent Aerobic Exercise on Glycemic Control in a Barbadian Population With Type 2 Diabetes

Effect of Continuous vs Intermittent Aerobic Exercise on Glycemic Control in a Barbadian Population With Type 2 Diabetes

비만중년남성의 기간별 간헐적 유산소운동 참여가 비만지표, 혈중 지질 및 피로관련인자에 미치는 영향

비만중년남성의 기간별 간헐적 유산소운동 참여가 비만지표, 혈중 지질 및 피로관련인자에 미치는 영향

Effects of combined supervised intermittent aerobic, muscle strength and home-based walking training programs on cardiorespiratory responses in women with breast cancer

The aim of this investigation was to study the effects of supervised combined intermittent aerobic, muscle strength and home-based walking training programs on cardiorespiratory fitness in women with breast cancer during adjuvant chemotherapy treatment. Thirty-two women with breast cancer undertaking adjuvant chemotherapy participated in the study (trained group n=20 and control group n=12). The trained group carried out 6weeks of supervised intermittent cycling aerobic, muscle strength and home-based walking training programs. The self-selected walking speed (WS), walking distance covered (WD), heart rate (rHR), blood lactate ([La]b) concentration and rating of perceived exertion (RPE) were assessed in the two groups during the 6-min walking test before and after the training period. Compared to controls, a significant increase in the WS (P<0.01) and the WD (P<0.01) accompanied by a significant decrease in resting rHR (P<0.01), exercising HR6' (P<0.01), [La]b (P<0.05), HR6'/WS (P<0.01) and [La]b/WS ratios (P<0.01) was reported in the trained group. However, a significant decrease both in WD (P<0.01) and WS (P<0.01) has been observed in the controls. No significant difference was observed in resting HR, exercising HR6', [La]b, HR6'/WS, and [La]b/WS ratios were observed in the control group. A significant improvement was observed for RPE in training group (P<0.05). However, no difference was shown in controls. Combined training based on intermittent aerobic exercise, muscle strength and walking improve cardiorespiratory responses and reduce the perception of fatigue in women with breast cancer.