Abstract
Background and Objectives Chronic hypertension causes structural and functional changes in the heart, ultimately leading to heart failure (HF), which further increases mortality. The aim of the present study was to examine the effect of intermittent aerobic exercise on the serum level of Apelin-17 and factors related to blood pressure in patients with HF. Subjects and Methods In this quasi-experimental study, 20 men with HF were selected based on the inclusion criteria and were randomly divided into exercise and control groups. The exercise program included interval aerobic training exercise that involved three sessions per week continued for eight weeks. Fasting blood samples and physiological variables were measured 48 hours before and after the intervention. Results After eight weeks of training, there was a significant increase in the levels of Apelin-17 (P = 0.039), Ang I (P = 0.005) and FMD (P = 0.008). A significant decrease in the levels of Ang II (P < 0.001) and SBP (P < 0.001) was observed, but no significant difference was found in the values of ACE-2 (P = 0.234) and DBP (P = 0.363). Conclusion According to the results, it can be stated that one of the adaptations of exercise that improves blood flow and lowers blood pressure in patients with HF is increasing the level of Apelin-17 in these patients.
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