The impact of five-dimensional operators, which might originate from compactification of extra dimensions, is investigated on SO(10) grand unification with Pati-Salam (PS) symmetry as the intermediate gauge group. When the PS group is left-right symmetric, the resulting equation for ${{sin}^{2}\ensuremath{\theta}}_{W}$ is noted to be independent of the parameter ($\ensuremath{\epsilon}$) of the nonrenormalizable Lagrangian, although the unification mass (${M}_{U}$) does depend upon it. In addition to solutions of the type obtained by Shafi and Wetterich, we find new predictions with a much larger grand-unification mass, consistent with a larger compactification scale. When parity and $\mathrm{SU}{(2)}_{R}$ breaking are decoupled, the equation for $\mathrm{ln}(\frac{{M}_{U}}{{M}_{W}})$ is independent of $\ensuremath{\epsilon}$, but ${{sin}^{2}\ensuremath{\theta}}_{W}$ does depend upon it. The most interesting predictions include observable $n\ensuremath{-}\overline{n}$ oscillations, rare kaon decays, and small neutrino masses, that are, however, measurable in the laboratory for ${\ensuremath{\nu}}_{\ensuremath{\mu}}$ and ${\ensuremath{\nu}}_{\ensuremath{\tau}}$, corresponding to the low intermediate scale ${M}_{C}\ensuremath{\sim}{10}^{5}\ensuremath{-}{10}^{6}$ GeV. In such cases ${M}_{U}$ is large and the solutions are consistent with a larger compactification scale.