In the 1950s and 1960s, most electronics hobbyists learned the trade by building radios. Francisco Bezanilla went a step further: he made his own television. Bezanilla grew up in Santiago, Chile, and when Chile hosted the World Cup in 1962, the country broadcast soccer games around the globe from new transmitters installed on the campuses of the national universities. Television sets were extremely rare, so Bezanilla and a friend decided to build their own. “We even had to design the coils of the intermediate frequency amplifiers,” he says. “There was a table full of electronics and a little oscilloscope tube for a screen.” Bezanilla's parents dreamed of watching Brazil's Pele perform his magic, in flickering green and black if necessary. Unfortunately, the “television” was completed shortly after the World Cup's final games. Later, Bezanilla's parents sent their son to Argentina to buy commercial parts, out of which he fashioned a new set that they used for many years. Bezanilla, whose intimate knowledge of electronic hardware was acquired during his childhood, is now a biophysicist whose advanced experiments on neurons and ion channels earned his election to the National Academy of Sciences in 2006.In addition to his work on ion channel gating, Bezanilla is a pathfinder in the use of fluorescent labeling techniques for studying dynamic rearrangement in channel proteins, and codiscoverer of gating current in sodium channels. Francisco Bezanilla In his Inaugural Article, published in this issue of PNAS (1), Bezanilla reports on ion channels. Although Bezanilla concedes that his research on the molecular basis of voltage sensing does not have direct application in any one particular area, it is fundamentally important to many fields. “It is the basis of the nerve impulse, the heart beating, brain activity,” he says. “Even enzymes are activated by voltage.” Certain genetic abnormalities affect voltage sensing, such as the “long QT syndrome,” a sometimes-fatal heart condition characterized by arrhythmias and associated with exercise or excitement. “People exercising can suddenly drop dead because there is a problem with the repolarization of the action potential of the heart,” he says. His research could lead to the development of new drugs to treat long QT syndrome and related conditions. Bezanilla recognizes that his expertise with electronics has been key to his research success and wishes that young scientists today had a deeper understanding of the instruments they employ. “Today, people doing patch clamping just buy the system with a computer and everything. They run the program. But they have very little idea what is going on behind the scenes.” This is a problem, he says, because the complex equipment can generate artifacts that a novice might think represent an experimental result. To ground his own graduate students in the basics, Bezanilla, along with Julio Vergara, initiated a special course in electronics at the University of California, Los Angeles (UCLA, Los Angeles, CA), that he and Vergara taught for a quarter of a century and is still offered today. “If you look at the history of physiology,” Bezanilla says, “every big advance came after somebody invented some new equipment.” He knows of what he speaks; his first major discovery occurred after he designed and built a device to measure ion channel gating currents superior to any on the market at the time.
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