In the on-orbit application of photogrammetry, constraints on thermal control resources or aging of thermal control equipment will trigger increased fluctuations in the camera operating environment temperature. Consequently, the parameters of the camera imaging model vary, such that the measurement accuracy is reduced. Accordingly, the accurate prediction of the camera imaging parameters (e.g., Camera Interior Parameters (CIP) and Lens Distortion Parameters (LDP)) at variable temperatures takes on critical significance.First, a novel method, termed as Virtual Multi-station Camera Calibration (VMCC), is proposed to calibrate the CIP and LDP with each frame at variable temperatures. Second, the Variational Mode Decomposition method combined with the Northern Goshawk Optimizer (NGO-VMD) is employed to decompose the camera imaging parameter signals obtained from VMCC, yielding the n Intrinsic Mode Functions (IMFs) contained in the respective parameter signal. Third, the Generalized Regression Neural Network combined with the Dung Beetle Optimizer (DBO-GRNN) is employed, such that the smoothness parameter q of the GRNN is iteratively optimized based on the camera imaging parameter prediction error. Lastly, the CIP and the LDP are accurately predicted at different temperatures in accordance with the temperature data from multiple parts of the camera.Based on this study, a reliable dataset of camera imaging parameter responses at variable temperatures can be generated for the on-orbit photogrammetry system. Furthermore, the prediction accuracy and immense application potential of neural network modeling methods are demonstrated in camera parameter prediction.