The research is based on the features of the influence of interethnic relations on the development of cross-border cooperation. It is noted that, provided effective ethno-national policies are implemented, multi-ethnic border regions have the advantage that national communities facilitate cross-border cooperation, and they often act as intermediaries in inter-regional relations. It has been proven that interethnic relations have a significant impact on the development of cross-border cooperation, in particular the importance of local authorities and national governments, which have a significant role to play in the issues of inter-ethnic relations in the region. It is argued that in the development of cross-border cooperation, greater emphasis should be placed on programs and projects aimed at improving the coexistence and development of national minorities in the border regions where they are most often living compactly, in particular representatives of national minorities; as a factor of European integration. For the successful development of cross-border cooperation, it is important to understand the needs and interests of the ethnic communities of a particular region, and to take into account historical, cultural factors. It is noted that the integration model is effective in the development of cross-border cooperation, since it enables different ethnic groups and national minorities to maintain their national identity, as well as to participate in regional and inter-state cooperation. Each interethnic community in Europe has its own peculiarities, and therefore the general list of recommendations included in the European Charter does not list the granting of large permits to municipal regions. However, these documents formed the basis for cross-border cooperation in European regions, and the provisions contained therein strengthened activities in this field. An important fact is that most inter-ethnic cooperation activities are within the structures of the European Union. The most common term is "territorial cooperation" or "cross-border cooperation", which are understood as different types of cooperation programs. These programs support the promotion and implementation of joint projects of an international nature throughout the European Union and its neighbors. A specific form of cross-border cooperation is Euroregional. Its characteristic feature is the institutionalization of cross-border cooperation structures. These structures may be: interethnic associations, councils, secretariats, committees, working groups, etc. Euroregional cooperation is carried out within the Euroregion. The Euroregion can be seen as a formal structure of cooperation, adopted on the basis of agreements between interethnic local and regional authorities in order to deepen economic and social cooperation. It is emphasized that the European experience of using the opportunities of cooperation with national minorities in multiethnic regions is of great importance for Ukraine, in particular, the work of the Council of Europe, the EU Strategy for the Danube Region (EUSDR), the Association of European Border Regions, which receive considerable attention, is useful. national minorities in the development of cross-border cooperation. European experience demonstrates that, with proper organization of state policy and historical experience, the involvement of ethnic groups in cross-border cooperation can have a positive impact. Interethnic cooperation promotes political stability and reduces tensions in border areas, and has a positive impact on economic cooperation, development of education, science and culture. It is proved that cross-border cooperation must take into account the nature of ethno-political relations in the border regions, promote the provision of conditions for the development of ethno-cultural characteristics of national minorities and develop mechanisms of interethnic interaction, cooperation of local authorities and public organizations of national minorities.