Background: In the case of a stenosis of the superior vena cava, the cerebrospinal venous circulation (CSVC) normally flows in the jugular and brachiocephalic veins and, through the upper intercostal veins and the mammary veins, it reaches the azygos and the inferior vena cava. Recent studies have shown that in the presence of a stenosis of the superior vena cava (SVC), venous blood can invert the direction of its flow and move towards the CSVC. To confirm this hypothesis, we describe the angiographic status of two patients with stenosis of the SVC. Methods: First case. A 67-year-old-woman undergoing reconstructive surgery for an ascending aortic aneurysm. The postoperative period, the patient presented a progressive appearance of an upper left anterior oedema with significant swelling of the neck suspecting a brachiocephalic vein stenosis. Second case. A 52-year-old-male with a collar of stokes oedema, turgor of the jugular veins, congestion of the face and conjunctiva and marked venous circle of the thorax. An echo-colordoppler examination revealed thrombosis of the SVC due to the placement of a central venous catheter with reflux into the right jugular vein. An injection of contrast into the right basilar vein confirmed that there was a stenosis of the SVC. Conclusion: Both patients underwent surgery and angiographic controls performed after stenosis removal showed normalization of the direction of blood flow from the cerebral venous loop to the superior vena cava. Patients with neurodegenerative diseases present alteration of the venous system, therefore a surgical correction could determine a possible clinical improvement.