The relevance of the work is stipulated by the need to develop a measurement toolkit of energy, environmental, social, and economic processes in the focus of interdisciplinary research. The aim of the research is to form an objective tool for measuring the state of regional systems, taking into account the interrelation of environmental, social, and economic processes. The methodological basis of the work is physical and economic indicators reflecting the interrelation of natural and economic processes. The main hypothesis put forward is that it is possible to build an integral index that objectively describes the model of competitively sustainable development of regions in the context of the interrelation of energy, environmental, social, economic processes. The results of the study have shown that the physical-economic (natural-physical) law operating in economic life, in the economy is the law of conservation of energy (power) flow, and the methodological basis for the construction of an integrated model of regional development should be the requirements arising from the law of conservation of energy (power) flow. The work is the result of theoretical, methodological, and applied research on systemic natural-scientific analysis of development management in socioeconomic systems considered in interaction with the environment. The results of the study contribute to the understanding of methodological possibilities of non-monetary measurement and on this basis the construction of a multilevel complex model in terms of natural-scientific indicators. The analysis of the results of application of the developed models allows to reveal conditions and limitations of energy, ecological, social, economic development of regions.