ABSTRACT The South Diyur exploration block of nearly 38,000 sq km is located in the Farafra Oasis region in the Western Desert of Egypt. It is a frontier exploration area, the nearest well being Ammonite-1, a dry hole drilled by Conoco in 1979 immediately outside the southwestern corner of the block. The South Diyur Block is located on the probable northeast extension of the Kufra Basin in southeast Libya. Although prolific reserves of oil and gas occur in Paleozoic basins in North Africa and throughout the Middle East, to date, the targets for petroleum exploration in the northern Western Desert have been in Jurassic and Cretaceous rocks. The regional structural surface features in the South Diyur Block are the NE-trending Bahariya and Farafra anticlines interpreted as a deeply eroded and inverted Late Cretaceous structure on the southern extension of the Syrian Arc system. The oldest exposed rocks are a Cretaceous sequence of sublittoral sediments (the Campanian Wadi Hennis Formation) in the core of the anticline. The interpretation of the subsurface is based on 1,175 line-km of reprocessed 1970s-vintage 2-D seismic. Four sequence boundaries have been identified from the seismic data. SB-1 correlates with the Jurassic/Cretaceous boundary in Ammonite-1. SB-2 is regionally correlated with the Late Devonian to Early Carboniferous Hercynian unconformity that overlies deeply eroded and truncated Paleozoic sequences and possibly marks the regionally extensive Late Paleozoic basin inversion. SB-3 near the base of the interpreted Silurian sequence coincides with the ‘hot shale’ petroleum source rock that is present throughout North Africa and the Middle East. SB-4 is interpreted as a major unconformity at the top of an Upper Proterozoic sedimentary section that was misinterpreted as the Precambrian acoustic basement in Ammonite-1. Five seismic sequences relate to the seismic boundaries. SS-1, from the surface to SB-1 is characterized by subparallel seismic stratification and is composed mainly of sandstone with shale interbeds in Ammonite-1. SS-2, bounded by SB-1 and SB-2, is distinguished by parallel to subparallel seismic stratification. In Ammonite-1, the sequence of interbedded sandstone and shale is fresh-water bearing and lacking in top seals, thus reducing its prospectivity. The underlying SS-3 (SB-2 to SB-3) directly underlies the Hercynian unconformity and is characterized by semi-transparent seismic facies that may correspond to a thick Silurian shale sequence. SS-4 (SB-3 to SB-4) of probable Cambrian–Ordovician age has parallel seismic stratification. Deep channels are interpreted as evidence of a Late Ordovician–Early Silurian glacial phase that is present throughout North Africa and the Middle East. SS-5 (below SB-4) is marked by partial subparallel seismic stratification and block faulting. It probably belongs to the Late Proterozoic (Pan-African) phase of block faulting and pull-apart basins. Similar seismic geometries and facies occur in the Kufra Basin in southeast Libya and in many parts of the Arabian Plate, including the prolific petroleum systems of Oman. Exploration plays in the South Diyur Block are a combination of Paleozoic structural and stratigraphic traps associated with prospective fairways, and possible stratigraphic traps in the Late Ordovician–Early Silurian glacial channels. In addition, the interpreted Late Proterozoic sequences (SS-5) warrant further evaluation. In order to identify future exploration plays and drill targets, additional 2-D seismic (4,490 line-km), aeromagnetic and airborne gravity surveys will be integrated with the present seismic data and drilling results from Ammonite-1. This will allow a proper assessment of the magnetic basement, basin configuration and prospective fairways.