Addressing patient adherence is a key element in ensuring positive health outcomes and improving health-related quality of life for patients with atopic and immunologic disorders. Understanding the complex etiologies of patient non-adherence and identifying real-world solutions is important for clinicians, patients, and systems to design and effect change. This review serves as a key resource for defining key issues related to patient non-adherence and outlines solutions, resources, knowledge gaps, and advocacy areas across five domains: healthcare access, financial considerations, socio-environmental factors, health literacy, and psychosocial factors. To allow for more easily digestible and usable content, we describe solutions based on three macro-levels of focus: patient, clinician, and system. This review and interactive toolkit serve as an educational resource and call to action to improve equitable distribution of resources, institutional policies, patient-centered care, and practice guidelines for improving health outcomes for all patients with atopic and immunologic disorders.