Intensity Pattern Research Articles

Paraxial propagation characteristics of a controllable anomalous hollow vortex beam in free space

Propagation of a recently proposed controllable anomalous hollow vortex (CAHV) beam is investigated. Based on the integral formula of generalized Huygens–Fresnel diffraction, analytical expression for the CAHV beam through a paraxial ABCD optical system is derived. The factors that affect the intensity pattern are determined by the beam’s controllable parameters a, c x, c y, and the topological charge m. Results show that the Gaussian distribution features are controlled by parameter a, and the horizontal and vertical stretching deformations of the beam are adjusted by parameters c x and c y, respectively. For a controllable anomalous hollow (CAH) beam, when propagating in free space, it could initially maintain anomalous hollow property and the size of the spot increases with the increase of the propagation distance. Due to the CAHV beam carries the optical vortex, a dark hollow channel appears in the center of the beam during propagation, and the channel structure changes with the increase of topological charge. Additionally, the Poynting vector of CAHV beam proves the direction of energy flow corresponding to the intensity distribution. Results obtained in this paper could have potential applications in particle trapping and optical control.

AI driven analysis of MRI to measure health and disease progression in FSHD

Facioscapulohumeral muscular dystrophy (FSHD) affects roughly 1 in 7500 individuals. While at the population level there is a general pattern of affected muscles, there is substantial heterogeneity in muscle expression across- and within-patients. There can also be substantial variation in the pattern of fat and water signal intensity within a single muscle. While quantifying individual muscles across their full length using magnetic resonance imaging (MRI) represents the optimal approach to follow disease progression and evaluate therapeutic response, the ability to automate this process has been limited. The goal of this work was to develop and optimize an artificial intelligence-based image segmentation approach to comprehensively measure muscle volume, fat fraction, fat fraction distribution, and elevated short-tau inversion recovery signal in the musculature of patients with FSHD. Intra-rater, inter-rater, and scan-rescan analyses demonstrated that the developed methods are robust and precise. Representative cases and derived metrics of volume, cross-sectional area, and 3D pixel-maps demonstrate unique intramuscular patterns of disease. Future work focuses on leveraging these AI methods to include upper body output and aggregating individual muscle data across studies to determine best-fit models for characterizing progression and monitoring therapeutic modulation of MRI biomarkers.

Deracemization of sodium chlorate by hydrodynamic attrition of Taylor vortex flow

We investigated the deracemization of sodium chlorate in the unique hydrodynamic environment of Taylor vortex flow (TVF) in Couette-Taylor (CT) crystallizer. Our findings revealed a remarkable enhancement in the deracemization due to the effective hydrodynamic attrition of crystals, as compared to conventional mixing tank (MT) crystallizers utilizing the turbulent eddy flow (TEF). So, the deracemization of initial ee = 0 % in the CT crystallizer was significantly enhanced as increasing the rotation speed whereas the deracemization in the MT crystallizer occurred seldom with increase of agitation speed. Using the sparsely soluble solvent, it was demonstrated the TVF was much more effective for the hydrodynamic attrition of the crystals than the TEF. The deracemization depended not only on the flow intensity (viscous energy dissipation) but also the flow pattern. So, the TVF always produced the higher deracemization than the TEF at the same viscous energy dissipation. Also, the flow intensity and flow pattern significantly dictated the crystal agglomeration of homo-chiral (L-form and D-form) and hetero-chiral (L/D-form) forms during the deracemization. Our findings demonstrated the potential of the periodic TVF in the deracemization. The hydrodynamic attrition effect in the CT crystallizer provides a means to enhance enantiomeric purity and offers insights into the design of novel deracemization systems.

Time of week intensity estimation from partly interval censored data with applications to police patrol planning

Law enforcement agencies are tasked with crime prevention and crime reduction under limited resources. Having an accurate temporal estimate of the crime rate would be valuable to achieve such a goal. However, estimation is usually complicated by the interval censored nature of crime data. We cast the problem of intensity estimation as a Poisson regression using an EM algorithm to estimate the parameters. Two special penalties are added that provide smoothness over the time of day and day of week. This approach provides accurate intensity estimates and can also uncover day of week clusters that share the same intensity patterns. Both simulated and real crime data gathered from the city of Cincinnati and the city of Dallas are used to demonstrate the effectiveness of the proposed model.

Thermal Atomic Compass Based on Radially Polarized Beam

AbstractThe relationship between the magnetic field direction and the spatial intensity distribution of a radially polarized light passing through a polarized thermal atom ensemble is investigated, which is intuitively presented in a polarization selection absorption effect of thermal atoms. The radially polarized light has a spatial axisymmetric polarization structure, which is set as the probe beam. If the direction of the applied magnetic field is transformed, the absorption of the alignment atomic system to special polarization components of the probe light is changed, resulting in a different absorption ratio. This allows the 3D vector direction of the magnetic field to be inferred by using only the absorption ratio and the projection coefficient of the transmission intensity pattern. Based on this, this work provides a compass based on a thermal atom system, demonstrating a new method for measuring the magnetic field direction in space.

Soliton groups and extreme wave occurrence in simulated directional sea waves

The evolution of nonlinear wave groups that can be associated with long-lived soliton-type structures is analyzed, based on the data of numerical simulation of irregular deep-water gravity waves with spectra typical to the ocean and different directional spreading. A procedure of the windowed Inverse Scattering Transform, which reveals wave sequences related to envelope solitons of the nonlinear Schrödinger equation, is proposed and applied to the simulated two-dimensional surfaces. The soliton content of waves with different directional spreading is studied in order to estimate its dynamical role, including characteristic lifetimes. Statistical features of the solitonic part of the water surface are analyzed and compared with the wave field on average. It is shown that intense wave patterns that persist for tens of wave periods can emerge in stochastic fields of relatively long-crested waves. They correspond to regions of locally enhanced on average waves with reduced kurtosis. This eventually leads to realization of locally extreme wave conditions compared to the general background. Although intense soliton-like groups may be detected in short-crested irregular waves as well, they possess much shorter lateral sizes, quickly disperse, and do not influence the local statistical wave properties.

Limitations in human auditory spectral analysis at high frequencies.

Humans are adept at identifying spectral patterns, such as vowels, in different rooms, at different sound levels, or produced by different talkers. How this feat is achieved remains poorly understood. Two psychoacoustic analogs of spectral pattern recognition are spectral profile analysis and spectrotemporal ripple direction discrimination. This study tested whether pattern-recognition abilities observed previously at low frequencies are also observed at extended high frequencies. At low frequencies (center frequency ∼500 Hz), listeners were able to achieve accurate profile-analysis thresholds, consistent with prior literature. However, at extended high frequencies (center frequency ∼10 kHz), listeners' profile-analysis thresholds were either unmeasurable or could not be distinguished from performance based on overall loudness cues. A similar pattern of results was observed with spectral ripple discrimination, where performance was again considerably better at low than at high frequencies. Collectively, these results suggest a severe deficit in listeners' ability to analyze patterns of intensity across frequency in the extended high-frequency region that cannot be accounted for by cochlear frequency selectivity. One interpretation is that the auditory system is not optimized to analyze such fine-grained across-frequency profiles at extended high frequencies, as they are not typically informative for everyday sounds.

Shining light on diurnal variation of non‐photochemical quenching: Impact of gradual light intensity patterns on short‐term NPQ over a day

AbstractMaximal sunlight intensity varies diurnally due to the earth's rotation. Whether this slow diurnal pattern influences the photoprotective capacity of plants throughout the day is unknown. We investigated diurnal variation in NPQ, along with NPQ capacity, induction, and relaxation kinetics after transitions to high light, in tomato plants grown under diurnal parabolic (DP) or constant (DC) light intensity regimes. DP light intensity peaked at midday (470 μmol m‐2 s‐1) while DC stayed constant at 300 μmol m‐2 s‐1 at a similar 12‐hour photoperiod and daily light integral. NPQs were higher in the morning and afternoon at lower light intensities in DP compared to DC, except shortly after dawn. NPQ capacity increased from midday to the end of the day, with higher values in DP than in DC. At high light ΦPSII did not vary throughout the day, while ΦNPQ varied consistently with NPQ capacity. Reduced ΦNO suggested less susceptibility to photodamage at the end of the day. NPQ induction was faster at midday than at the start of the day and in DC than in DP, with overshoot occurring in the morning and midday but not at the end of the day. NPQ relaxation was faster in DP than in DC. The xanthophyll de‐epoxidation state and reduced demand for photochemistry could not explain the observed diurnal variations in photoprotective capacity. In conclusion, this study showed diurnal variation in regulated photoprotective capacity at moderate growth light intensity, which was not explained by instantaneous light intensity or increasing photoinhibition over the day and was influenced by acclimation to constant light intensity.

Land-sea contrast of vertical structure of precipitation over Sumatra revealed by GPM DPR observations

This study examines the land-sea contrast in the vertical structure of precipitation over Sumatra and its surrounding ocean using eight years (2014–2021) of dual-frequency precipitation radar (DPR) data from the Global Precipitation Measurement (GPM) mission. The study area is segmented into Ocean, Coast I (west coast), Land I (west of Barisan Mountains), Land II (east of Barisan Mountains), and Coast II (east coast). The effective reflectivity factor (Ze), rainfall rate (R), and two raindrop size distribution (DSD) parameters, namely the mass-weighted mean diameter (Dm) and the normalized intercept (Nw), were analyzed. Stratiform and deep convective rainfall were the most frequent types in Coast I, followed by Ocean, Land I, Land II, and Coast II. In contrast, shallow convective rainfall was the most common type in Ocean, followed by Coast I, Land I, Land II, and Coast II. The average rain top height (RTH) was found to be higher in Land II and Coast II than in Ocean, Coast I, and Land I, in accordance with the surface rainfall intensity pattern previously reported by other studies. Furthermore, the data on heavy ice precipitation demonstrated an increase from the ocean to the coast and land, with a significant number of instances observed in Land I, Land II, and Coast II, in addition to Coast I. This contrast in heavy ice precipitation and RTH influences DSD. The land-sea contrast of DSD is more pronounced for deep convective rains. Deep convective exhibited a lower frequency of large raindrops over the ocean than over the coast and land, as reflected in the Dm profile. Conversely, raindrop concentration, particularly small drops, was higher at sea. The percentage of Dm > 2 mm at sea was approximately 2%, rising to 4–6% in Land II and Coast II. The land-sea contrast in the vertical structure of precipitation over Sumatra exhibited apparent diurnal variation. Larger Dm and smaller Nw were observed over Land I and Coast I, particularly in the afternoon and evening, correlating with peak rainfall. This pattern aligns with heavy ice precipitation profiles, vertical relative humidity (RH), and wind profiles. This study highlights the complexities and potential discrepancies between vertical precipitation profiles and surface precipitation data, underscoring the nuanced nature of land-sea precipitation migration.

Acoustic spin-controlled orbital rotations in double spiral acoustic beams

Similar to optical spin-orbit interactions (SOIs), acoustic SOIs are anticipated to offer fresh perspectives and capabilities for acoustic manipulation beyond conventional scalar degrees of freedom. However, the acoustic extrinsic SOIs caused by particular properties of the medium were seldom explored. Here, the acoustic extrinsic SOI is observed in a double spiral acoustic beam (DSAB), as evidenced by the rotation of the spatial intensity pattern along the propagation axis. The interaction of the acoustic plane wave with the well-designed artificial flat structure generates two non-paraxial focused acoustic vortices (NFAVs) with different spin angular momentums. The coaxial coupling between them leads to acoustic spin-controlled orbital rotation (SOR). Theoretical formulations, supported by numerical simulations and experimental results, are provided to demonstrate the validity of acoustic SOR. Our work provides new perspectives and capabilities for understanding sound processing, and may open an avenue for the development of spin-orbit acoustics.

Generation of dual bi-power-exponents helico-conical beams employing spin-isolated geometric metasurface.

Unlike traditional optical vortex (OV), helico-conical optical beams (HCOBs) carry orbital angular momentum (OAM) related to the beam's radius and exhibit a helical intensity pattern, drawing widespread attention in fields such as optical communication and optical tweezers. In this study, we introduce two independent power-exponents into the HCOB configuration and employ spin-isolated geometric phase metasurfaces to simultaneously generate dual bi-power-exponent helico-conical beams (BPE-HCBs). This innovative approach allows unprecedented control over the beams' shape and intensity using only simple linearly polarized (LP) incident light, facilitating the transformation from dual helical structures to multi-ring hollow beams and vector vortex beams (VVBs) patterns. Our research not only simplifies the design process of metasurfaces but also demonstrates their significant capabilities in generating and manipulating complex OAM beam patterns, paving the way for innovative designs in integrated optical systems.

Designing Effective Low-Impact Developments for a Changing Climate: A HYDRUS-Based Vadose Zone Modeling Approach

Low-Impact Developments (LIDs), like green roofs and bioretention cells, are vital for managing stormwater and reducing pollution. Amidst climate change, assessing both current and future LID systems is crucial. This study utilizes variably saturated flow modeling with the HYDRUS software (version 4.17) to analyze ten locations in Ontario, Canada, focusing on Toronto. Historical and projected climate data are used in flow modeling to assess long-term impacts. Future predicted storms, representing extreme precipitation events, derived from a regional climate model, were also used in the flow modeling. This enabled a comprehensive evaluation of LID performance under an evolving climate. A robust methodology is developed to analyze LID designs, exploring parameters like water inflow volumes, peak intensity, time delays, runoff dynamics, and ponding patterns. The findings indicate potential declines in LID performance attributed to rising water volumes, resulting in notable changes in infiltration for green roofs (100%) and bioretention facilities (50%) compared to historical conditions. Future climate predicted storms indicate reduced peak reductions and shorter time delays for green roofs, posing risks of flooding and erosion. Anticipated extreme precipitation is projected to increase ponding depths in bioretention facilities, resulting in untreated stormwater overflow and prolonged ponding times exceeding baseline conditions by up to 13 h at numerous Ontario locations.

Arterial Spin-Labeling Perfusion Lightbulb Sign: An Imaging Biomarker of Pediatric Posterior Fossa Hemangioblastoma.

Hemangioblastoma is a rare vascular tumor that occurs within the central nervous system in children. Differentiating hemangioblastoma from other posterior fossa tumors can be challenging on imaging, and preoperative diagnosis can change the neurosurgical approach. We hypothesize that a "lightbulb sign" on the arterial spin-labeling (ASL) sequence (diffuse homogeneous intense hyperperfusion within the solid component of the tumor) will provide additional imaging finding to differentiate hemangioblastoma from other posterior fossa tumors. In this retrospective comparative observational study, we only included pathology-proved cases of hemangioblastoma, while the control group consisted of other randomly selected pathology-proved posterior fossa tumors from January 2022 to January 2024. Two blinded neuroradiologists analyzed all applicable MRI sequences, including ASL sequence if available. ASL was analyzed for the lightbulb sign. Disagreements between the radiologists were resolved by a third pediatric neuroradiologist. χ2 and Fisher exact test were used to analyze the data. Ninety-five patients were enrolled in the study; 57 (60%) were boys. The median age at diagnosis was 8 years old (interquartile range: 3-14). Of the enrolled patients, 8 had hemangioblastoma, and 87 had other posterior fossa tumors, including medulloblastoma (n = 31), pilocytic astrocytoma (n = 23), posterior fossa ependymoma type A (n = 16), and other tumors (n = 17). The comparison of hemangioblastoma versus nonhemangioblastoma showed that peripheral edema (P = .02) and T2-flow void (P = .02) favor hemangioblastoma, whereas reduced diffusion (low ADC) (P = .002) and ventricular system extension (P = .001) favor nonhemangioblastoma tumors. Forty-two cases also had ASL perfusion sequences. While high perfusion favors hemangioblastoma (P = .03), the lightbulb sign shows a complete distinction because all the ASL series of hemangioblastoma cases (n = 4) showed the lightbulb sign, whereas none of the nonhemangioblastoma cases (n = 38) showed the sign (P < .001). Lightbulb-like intense and homogeneous hyperperfusion patterns on ASL are helpful in diagnosing posterior fossa hemangioblastoma in children.

Factors behind the resilience of rural startups

Rural areas are characterized by sparse population, low population density, remoteness, and population aging, which can discourage startups and undermine their financial performance, as the theory of urban agglomeration economies suggests. However, many studies have shown that companies created in rural areas survive longer than those created in urban areas, which seems contradictory. This paper aims to identify the factors that explain this rural resilience. We analyzed all of the startups founded in Spain over 10 years. We used statistical matching methods to test for the effect of the location while controlling for founding conditions and environmental factors. Our study confirmed that few startups are created in rural areas and they grow less, but their survival rate is slightly higher than those established in urban areas. We found that high subsidies, low operating costs, high labor intensity, a slow but low-risk growth pattern, and other foundational conditions and external factors contribute to explaining rural resilience. Nonetheless, additional factors, including the traits of rural entrepreneurs and the lack of alternatives to bankruptcy, as proposed by the entrepreneurial opportunity theory, also matter.

Probabilistic fragility assessment of slopes considering uncertainty associated with temporal patterns of rainfall intensity

The temporal patterns of rainfall intensity, characterized by the variability of rainfall intensity over time during a single rainfall event, play a crucial role in landslide triggering and evolution. However, the influence of temporal patterns of rainfall intensity on the fragility and reliability assessment of slope instability has received limited attention. This study presents a novel methodology for probabilistic slope fragility assessment accounting for uncertainty associated with the temporal patterns of rainfall intensity. Hourly-scale random time series for the rainfall event are generated, considering uncertainties in temporal patterns of rainfall intensity, using the statistical concepts of skewness and kurtosis within the Pearson system of distributions. A time-dependent seepage-stability mechanical model coupling the finite element method and limit equilibrium method for the slope under hourly-scale rainfall time series is established. Slope fragility assessment under rainfall is conducted, accounting for uncertainties in temporal patterns of rainfall intensity based on Monte Carlo simulation. An illustrative example is provided, focusing on a hypothetical soil slope in the southeastern coastal area of China, susceptible to rainfall-induced landslides. The impact of skewness and kurtosis of rainfall time series on the slope failure probability and failure time are examined.

High prevalence and low intensity of Echinophthirius horridus infection in seals revealed by high effort sampling

Seal lice (Echinophthirius horridus) are bloodsucking ectoparasites of phocid seals and vectors of pathogens like the heartworm, Acanthocheilonema spirocauda. Grey and harbour seal populations are recovering in German waters and wildlife health surveillance is crucial for wildlife conservation. A new, high effort sampling protocol for seal lice was applied for grey and harbour seals along the German North- and Baltic Sea coast. Freshly dead seals were systematically sampled within a health monitoring of stranded seals over 12 months. Prevalence, intensity and distribution patterns of seal lice were analysed. 58% of harbour seals (n = 71) and 70% of grey seals (n = 10) were infected with seal lice. A majority of harbour seals displayed mild levels of infection, while three were moderately and two were severely infected. The head was the preferred predilection site, indicating that E. horridus prefers body areas with frequent access to atmospheric oxygen. Nits and different developmental stages were recorded in all age classes in grey and harbour seals in all seasons. For the first time, copulating specimens of E. horridus were recorded on a dead harbour seal, highlighting that E. horridus reproduces throughout the year on seals of all age classes in German waters.

High parasite prevalence in an ecosystem engineer correlated with both local- and landscape-level factors.

Spatial variation in parasitic infection may have many physical and biological drivers. Uncovering these drivers may be especially important for parasites of ecosystem engineers because the engineers are foundational to their communities. Oysters are an important coastal ecosystem engineer that have declined drastically worldwide, in part due to enhanced cases of lethal oyster diseases, such as Dermo and MSX, caused by the protozoan parasites Perkinsus marinus and Haplosporidium nelsoni, respectively. Besides water quality and hydrodynamics, there is little information on how other variables influence the prevalence and intensity of these pathogens in oysters across a regional scale. To examine drivers of spatial variation in these oyster parasites-including host size, local reef properties, and landscape properties-we sampled 24 reefs systematically spread along the coast of Georgia, USA. Across sites, we found universally high prevalence of oysters with at least one of these parasites (91.02% ± 8.89, mean ± SD). Not only are high levels of parasite prevalence potentially problematic for a pivotal ecosystem engineer, but also low spatial variability may limit the explanatory power of variables across a regional scale. Our statistical models explained between 18 and 42% of the variation in spatial patterns of prevalence and intensity of these microparasites. Interestingly, landscape context was a positive predictor of P. marinus, but a negative predictor of H. nelsoni. Overall, our findings suggest that factors driving parasite prevalence and intensity operate across multiple spatial scales, and the same factor can both facilitate and hinder different parasites within the same host species.

Hydrothermally deposited Sb2S3 absorber, and a Sb2S3/CdS solar cell with VOC approaching 800 mV

We report the hydrothermal deposition of Sb2S3 thin film on top of CdS buffer layer, and the fabrication of prototype photovoltaic devices utilizing spiro-OMeTAD as the hole transport layer. The as-deposited films were amorphous, which transformed to polycrystalline after thermal processing. The pristine films were annealed at different temperatures and showed effective recrystallization at 350 °C which resulted in larger grains, intense XRD patterns, and significantly improved device parameters. The obtained VOC of 795 mV is among the highest reported for a Sb2S3 based solar cell. Deep level transient spectroscopy studies detected an electron trap with activation energy 0.61 eV in the pristine annealed absorber, which became deeper (0.66 eV) upon Na incorporation. However, the capture cross-section decreased by an order of magnitude, and the trap density halved. The reduction in the capture cross-section and trap density for the Na-incorporated device coincides with the improved EQE response in the mid- and long-wavelength regions and a 9 % increase in device efficiency. The light intensity dependence of VOC clearly demonstrated that Na incorporation reduced the trap-assisted recombination and facilitated efficient charge transport in the device.

IMG-22. ASL PERFUSION LIGHTBULB SIGN: A POTENTIAL PATHOGNOMONIC FEATURE OF PEDIATRIC POSTERIOR FOSSA HEMANGIOBLASTOMA

Abstract INTRODUCTION Hemangioblastoma is a rare vascular tumor which occurs within the central nervous system in children. Differentiating hemangioblastoma from other posterior fossa tumors can be challenging on imaging and preoperative diagnosis can change neurosurgical approach. We hypothesize a ‘lightbulb sign’ (diffuse homogenous intense hyperperfusion within solid component of tumor) will help differentiate hemangioblastoma from other posterior fossa tumors. METHODS In this retrospective case-control study, we only included pathology-proven cases of hemangioblastoma, while the control group consisted of other randomly selected pathology-proven posterior fossa tumors from January 2022 to January 2024. Two blinded neuroradiologists analyzed all applicable MRI sequences. Their perfusion analysis also included the “lightbulb sign” as an extra criterion. Disagreements between the radiologists were confirmed by a third pediatric neuroradiologist. Chi-square and Fisher’s exact test were used to analyze the data. RESULTS 95 patients were enrolled in the study, 57(60%) were male. The median age at diagnosis was 8 (IQR: 3-14). Out of the enrolled patients, 8 had hemangioblastoma, and 87 had other posterior fossa tumors, including medulloblastoma (n=31), pilocytic astrocytoma (n=23), posterior fossa ependymoma type A (n=16), and other tumors (n=17). The comparison of hemangioblastoma vs non-hemangioblastoma showed that peripheral edema (p=0.020, OR=1.8) and T2 flow void (p=0.021, OR=1.7) favors hemangioblastoma, whereas reduced diffusion (low ADC) (p=0.002, OR=2.3) and ventricular system extension (p=0.001, OR=2.4) favors non-hemangioblastoma tumors. 42 cases also had perfusion studies. While high perfusion favors hemangioblastoma (p=0.021, OR=2.9), the lightbulb sign shows a complete distinction since all the ASL series of hemangioblastoma cases (n=4) showed the lightbulb sign, whereas none of the non-hemangioblastoma cases (n=38) showed the sign (p&amp;lt;0.001). CONCLUSION Lightbulb-like intense and homogenous hyperperfusion pattern on ASL allows differentiation of hemangioblastoma from other posterior fossa tumors in children.

Spatial N-glycomics of the normal breast microenvironment reveals fucosylated and high-mannose N-glycan signatures related to BI-RADS density and ancestry.

Higher breast cancer mortality rates continue to disproportionally affect black women (BW) compared to white women (WW). This disparity is largely due to differences in tumor aggressiveness that can be related to distinct ancestry-associated breast tumor microenvironments (TMEs). Yet, characterization of the normal microenvironment (NME) in breast tissue and how they associate with breast cancer risk factors remains unknown. N-glycans, a glucose metabolism-linked post-translational modification, has not been characterized in normal breast tissue. We hypothesized that normal female breast tissue with distinct Breast Imaging and Reporting Data Systems (BI-RADS) categories have unique microenvironments based on N-glycan signatures that varies with genetic ancestries. Profiles of N-glycans were characterized in normal breast tissue from BW (n=20) and WW (n=20) at risk for breast cancer using matrix assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI). A total of 176 N-glycans (32 core-fucosylated and 144 noncore-fucosylated) were identified in the NME. We found that certain core-fucosylated, outer-arm fucosylated and high-mannose N-glycan structures had specific intensity patterns and histological distributions in the breast NME dependent on BI-RADS densities and ancestry. Normal breast tissue from BW, and not WW, with heterogeneously dense breast densities followed high-mannose patterns as seen in invasive ductal and lobular carcinomas. Lastly, lifestyles factors (e.g. age, menopausal status, Gail score, BMI, BI-RADS) differentially associated with fucosylated and high-mannose N-glycans based on ancestry. This study aims to decipher the molecular signatures in the breast NME from distinct ancestries towards improving the overall disparities in breast cancer burden.