Intensity Interference Research Articles

Photonics Scanning Pentaprism System for the Integrated Inspection of Large-Aperture Telescopes.

To improve their spatial resolution and detection capabilities, future ground-based optical telescopes will have a size of 30 m, and the aperture of space telescopes will be increased to 10 m. Such large optical systems necessitate the development of large integrated testing equipment. In this study, spectrum and system alignment measurements and wavefront quality checking were performed using the sub-aperture detection method and a fiber-connected Photonics Scanning Pentaprism (PSP). First, the system was aligned using an optical truss, ensuring that the optical axis was properly positioned. Second, using a sub-aperture light beam though the entrance pupil, light spots were formed on the focal plane and transmitted to the spectrometer via fibers to obtain the corresponding spectral components. Then, by taking measurements at different system positions, a full-aperture spectrum response could be reached. Lastly, by photon-integrated interference on the focal plane, intensity interference fringes could be projected at the entrance pupil of the system. And the wavefront quality of the system could be verified by observing the fringe deformation. The measurement accuracy of the optical axis of the system is better than 2 mrad. The spectral measurement accuracy was better than 5%, and the wavefront measurement accuracy surpassed 0.1 wavelengths (1 wavelength = 633 nm). This study effectively enhanced the detection and in situ calibration capabilities of large telescope systems, ensuring that the performance requirements can be met in the design of future telescopes.

Study on Cortisol Sensing Principle Based on Fluorophore and Aptamer Competitive Assay on Polymer Optical Fiber

In this study, we present a polymer optical fiber fluorophore/aptamer competitive assay-based cortisol sensing principle. We developed a low-cost, two-fiber perpendicular design for fluorophore-based sensing with less input light interference and high output signal intensity. The design is suitable for narrow stokes shift fluorophores. We have demonstrated the cortisol sensing principle based on the competition between tagged and normal cortisol. To date, the sensing design has exhibited a slow response, and we identified possible modifications for improvement. Our estimation shows that with miniaturization and a modified sensor assay compartment design, a less than one-hour response time can be achieved. The reported sensing principle and low-cost new design will be helpful for the future development of fluorophore-based fiber optic aptasensors that can potentially be used in a wet environment for online sensing.

Impact of antidepressant medication on the analgetic effect of repetitive transcranial magnetic stimulation treatment of neuropathic pain. Preliminary findings from a registry study.

Repetitive transcranial magnetic stimulation (rTMS) has been found to be effective in chronic neuropathic pain conditions. However, information about the combined effects of rTMS and antidepressant treatment is scarce. We studied the outcome of rTMS and concurrent antidepressant treatment in patients with neuropathic pain. In this retrospective, real-world study, 34 patients with neuropathic pain, who were considered resistant or not benefitting from conventional treatment, received rTMS treatment between 2017 and 2020. Pain-related factors were measured using the Numerical Rating Scale (NRS), Global Impression of Change (GIC), and Beck Depression Inventory. A decrease in pain intensity and pain interference assessed with NRS was observed after 10 treatment sessions in 16 patients. The impression of change was positive in 20 patients. Half of the patients (n=17) used antidepressant medication, while half (n=17) did not. A concurrent use of antidepressants with therapeutic rTMS was significantly linked with less pain intensity relief when compared with the nonuse of antidepressants (p=0.019). The impression of change was significantly in favor of the antidepressant nonuser group (p=0.002). No group differences in pain interference were found between the groups. Therapeutic rTMS for neuropathic pain is plausibly sensitive to interference with antidepressant medication. The exact mechanism of our findings remains to be elucidated; confirmatory studies are warranted.

Baseline Factors Associated with Pain Intensity, Pain Catastrophizing, and Pain Interference in Intensive Interdisciplinary Pain Treatment for Youth.

Background: More could be known about baseline factors related to desirable Intensive Interdisciplinary Pain Treatment (IIPT) outcomes. This study examined how baseline characteristics (age, gender, child pain catastrophizing (PCS-C), pain interference, pain intensity, anxiety, depression, paediatric health-related quality of life (PedsQLTM), and parent catastrophizing (PCS-P)) were associated with discharge and 3-month follow-up scores of PCS-C, pain intensity, and pain interference. Methods: PCS-C, pain intensity, and pain interference T-scores were acquired in 45 IIPT patients aged 12-18 at intake (baseline), discharge, and 3-month follow-up. Using available and imputed data, linear mixed models were developed to explore associations between PCS-C, pain intensity, and pain interference aggregated scores at discharge and follow-up with baseline demographics and a priori selected baseline measures of pain, depression, anxiety, and PCS-C/P. Results: PCS-C and pain interference scores decreased over time compared to baseline. Pain intensity did not change significantly. Baseline PCS-C, pain interference, anxiety, depression, and PedsQLTM were associated with discharge/follow-up PCS-C (available and imputed data) and pain interference scores (available data). Only baseline pain intensity was significantly associated with itself at discharge/follow-up. Conclusions: Participants who completed the IIPT program presented with reduced PCS-C and pain interference over time. Interventions that target pre-treatment anxiety and depression may optimize IIPT outcomes.

A music-with-movement exercise programme for community-dwelling older adults suffering from chronic pain: A pilot randomized controlled trial.

This study developed, implemented and tested the effectiveness of a music-with-movement exercise programme in improving the pain situations of older adults with chronic pain. A pilot randomized controlled trial. This was a pilot randomized controlled trial. The intervention was an 8-week music-with-movement exercise (MMEP) programme for older adults with chronic pain recruited in elders' community centres. The control group received the usual care and a pain management pamphlet. Outcome variables were pain intensity, pain self-efficacy and pain interference, depression and loneliness. Seventy-one participants joined this study. Pain intensity was significantly reduced between the experimental group compared to the control group. The experimental group participants reported significant improvements in pain self-efficiency, pain interference and reduced loneliness and depressive symptoms. However, no significant difference was observed between groups.

Simulation study of an x-ray sub-picosecond resolution detection system based on time-domain amplification.

This study proposes what we believe to be a novel x-ray detection system that achieves a temporal resolution of 930fs with photorefractive and four-wave mixing effects. The system comprises two parts: a signal-conversion system and signal-acquisition system. The signal-conversion system is based on the photorefractive effect, which converts x-ray evolution into the variation of infrared interference intensity. The signal-conversion sensor consists of ultra-fast response LT-GaAs and a high-resolution interference cavity, achieving a resolution of 767fs. The signal-acquisition system consists of a time-domain amplification system based on four-wave mixing and a high-resolution signal-recording system with a resolution of 21ps, providing a temporal resolution of 525fs.

Hormonal changes in veterans with Gulf War Illness

AimsGulf War Illness (GWI) is a multi-system condition of complex etiology and pathophysiology without specific treatment. There is an overlap between the symptoms of GWI and endocrinopathies. This study aimed to identify hormonal alterations in 1990–91 Gulf War (GW) veterans and the relationship between GWI and hormonal dysregulation. Main methodsData from 81 GW veterans (54 with GWI and 27 controls without GWI) was analyzed in a cross-sectional, case-control observational study. Participants completed multiple questionnaires, neuropsychiatric assessments, and a comprehensive set of hormone assays including a glucagon stimulation test (GST) for adult growth hormone deficiency (AGHD) and a high-dose adrenocorticotropic hormone (ACTH) stimulation test for adrenal insufficiency. Key findingsThe GWI group had lower quality of life and greater severity of all symptoms compared to controls. Pain intensity and pain-related interference with general activity were also higher in the GWI group. AGHD was observed in 18 of 51 veterans with GWI (35.3 %) and 2 of 26 veterans without GWI (7.7 %) (p = 0.012 for interaction). Veterans with GWI also exhibited reduced insulin-like growth factor 1 (IGF-1) levels and IGF-1 Z-scores compared to controls. One participant with GWI met the criteria for adrenal insufficiency. No significant changes were observed in other hormonal axes. SignificanceThe frequency of AGHD was significantly higher in veterans with GWI compared to controls. Recombinant human growth hormone replacement therapy (GHRT) may become a breakthrough therapeutic option for this subgroup. A large clinical trial is needed to evaluate the efficacy of GHRT in patients with GWI and AGHD.

The Efficacy of Hypnotic Analgesic Suggestions in Chronic Nociplastic Pain: A Randomized Controlled Trial

ABSTRACT This blinded study evaluated the relative efficacy of three hypnosis sessions in 60 patients with chronic nociplastic pain allocated randomly to one of two conditions: hypnosis with analgesic suggestions, or hypnosis with nonspecific suggestions. Pain intensity, pain quality, and pain interference as outcome measures were assessed before and after treatment. A mixed-design analysis of the variance model showed no significant differences between groups. According to the adjusted model, large effect size improvements in pain intensity and pain quality emerged for both conditions but were only meaningful for patients not taking pain medications. Analgesic suggestions may not play a primary role in beneficial outcomes of hypnosis at the beginning of chronic pain management since both interventions demonstrated similar positive effects. Future studies should investigate the efficacy of the hypnosis components over longer treatment periods.

Psychological Factors and Pain Medication Use in Adolescents with Chronic Pain.

The purpose of this study was to examine (1) the associations between anxiety, depressive symptoms, and pain catastrophizing with pain medication use in adolescents with chronic pain; and (2) the extent to which these associations differed as a function of adolescents' sex. Cross-sectional data from 320 adolescents aged 12-18 years old with chronic pain were drawn from an epidemiological study on pediatric chronic pain conducted in Reus (Catalonia, Spain). Participants were asked to provide sociodemographic information and respond to measures assessing pain (location, frequency, intensity, and interference), pain medication use, anxiety, depressive symptoms, and pain catastrophizing. Point biserial correlations were conducted to examine univariate associations between the psychological variables and pain medication use. Hierarchical logistic regression analysis was used to examine these associations while controlling for demographic characteristics, pain intensity and pain interference. Anxiety, depressive symptoms, and pain catastrophizing were significantly associated with pain medication use in univariate analyses. Regression analysis identified pain catastrophizing as a unique independent predictor of pain medication use after controlling the effect of demographic variables (sex and age), pain intensity, and pain interference (OR = 1.1, p <0.05). No moderation effects of adolescents' sex on the associations between psychological factors and pain medication use was found. Adolescents with chronic pain with higher levels of pain catastrophizing use pain medications more often. Research to examine the impact of interventions targeting pain catastrophizing on pain medication use among adolescents with chronic pain would be an important next step.

Differential Mobility Spectrometry-Tandem Mass Spectrometry with Multiple Ion Monitoring Coupled with in Source-Collision Induced Dissociation: A New Strategy for the Quantitative Analysis of Pharmaceutical Polymer Excipients in Rat Plasma.

Polylactic acids (PLAs) are synthetic polymers composed of repeating lactic acid subunits. For their good biocompatibility, PLAs have been approved and widely applied as pharmaceutical excipients and scaffold materials. Liquid chromatography-tandem mass spectrometry is a powerful analytical tool not only for pharmaceutical ingredients but also for pharmaceutical excipients. However, the characterization of PLAs presents particular problems for mass spectrometry techniques. In addition to their high molecular weights and wide polydispersity, multiple charging and various adductions are intrinsic features of electrospray ionization. In the present study, a strategy combining of differential mobility spectrometry (DMS), multiple ion monitoring (MIM) and in-source collision-induced dissociation (in source-CID) has been developed and applied to the characterization and quantitation of PLAs in rat plasma. First, PLAs will be fragmented into characteristic fragment ions under high declustering potential in the ionization source. The specific fragment ions are then screened twice by quadrupoles to ensure a high signal intensity and low interference for mass spectrometry detection. Subsequently, DMS technique has been applied to further reduce the background noise. The appropriately chosen surrogate specific precursor ions could be utilized for the qualitative and quantitative analysis of PLAs, which provided results with the advantages of low endogenous interference, sufficient sensitivity and selectivity for bioassay. The linearity of the method was evaluated over the concentration range 3-100 μg/mL (r2 = 0.996) for PLA 20,000. The LC-DMS-MIM coupled with in source-CID strategy may contribute to the pharmaceutical studies of PLAs and the possible prospects of other pharmaceutical excipients.

Validation of the PEG Scale in Spanish (PEG-S) Among Adults Receiving Care for Pain in US Primary Care

This study sought to evaluate the psychometric properties of a Spanish version of the PEG scale (PEG-S, whose items assess Pain intensity and pain interference with Enjoyment of life and General activity) in a sample of Spanish-speaking adults receiving care for pain at primary care clinics in the Northwestern United States. We evaluated the PEG-S’s 1) internal consistency, 2) convergent validity, and 3) discriminant validity. All participants (n = 200, mean age = 52 years [SD = 15], 76% women, mean PEG-S score = 5.7 [SD = 2.5]) identified as having Hispanic or Latino ethnicity, and detailed ethnic origin was predominantly Mexican or Chicano (70%). The PEG-S’s internal consistency (Cronbach’s alpha, .82) was good. Correlations between the PEG-S scale scores and established measures of pain intensity and interference ranged from .68 to .79, supporting the measure's convergent validity. The correlation between the PEG-S scale score and the Patient Health Questionnaire-9 (r = .53) was weaker than those between the PEG-S scale and measures of pain intensity and interference, supporting the measure's discriminant validity. The findings support reliability and validity of the PEG-S for assessing a composite score of pain intensity and interference among Spanish-speaking adults. PerspectiveWe present evidence supporting the reliability and validity of the PEG scale in Spanish (PEG-S) in a sample of adults receiving pain care at primary care clinics in the Northwestern United States. This 3-item composite measure of pain intensity and interference can help clinicians and researchers assess pain among Spanish-speaking adults.

All-optical nonvolatile optical modulator for in-fiber operation

Abstract The control of information is a defining feature of the information age, and the optical modulator likewise has a crucial role in optical networks. The transmission, processing, and storage of data have demanded low energy consumption and high speed for photonic systems, promoting the development of electro-optic modulators to all-optical modulators. Although these all-optical modulation methods eliminate the photoelectric conversion, the disadvantage of volatile materials requiring continuous power supply when processing and retaining data in new materials-based devices increase energy consumption. We propose a Ge2Sb2Te5 (GST) integrated all-optical, nonvolatile optical modulator for in-fiber operation. The pulse-induced GST phase transition changes the reflectivity of the fiber end face, and this difference affects the result of the interference, achieving a modulation of output light intensity in interference spectra. The experimental results reveal that the device has obtained 13 dB interference intensity contrast in the telecommunications bands, and its response to a pump pulse is around 100 ns. Furthermore, we demonstrated the operation of the device as a scalar multiplication unit and a logic operation unit. The signal can be transmitted, processed, and stored in the fiber without photoelectric conversion. With the benefits of the switching power consumption of less than 100 nJ and the nonvolatile nature of GST, the device will be more energy-efficient in synchronous processing and storing. This in-fiber operating modulator lays the foundation for developing all-optical devices and networks.

Cross-cultural adaptation and psychometric properties of Spanish Child Pain Anxiety Symptoms Scale

IntroductionPain anxiety is a psychological component that can regulate and modulate the experience of pain in children and adolescents. It can also have an impact on the outcomes of surgical procedures, chronic pain management and psychological interventions. The aim of our study was to translate the Child Pain Anxiety Symptoms Scale (CPASS) into Spanish and assess the psychometric properties of the Spanish version. Patients and methodsFirst, the CPASS was translated according to international guidelines. Secondly, to assess the psychometric properties of the translated version, we conducted an analysis in a paediatric sample. A total of 160 children, 49.37% female, with a mean age of 14.5 years (SD, 2.3; range, 8−18 years) completed pain catastrophising, health-related quality of life, pain interference and pain intensity scales. We assessed the following psychometric properties: construct validity (exploratory and confirmatory factor analysis), internal consistency, floor and ceiling effects and convergent validity (correlation of CPASS to the other completed questionnaires completed and with objective aspects of the health history). ResultsIn the exploratory factor analysis, the final 18-item version (having excluded items 18 and 19) of the CPASS was the best fit, with all items included in the hypothetical construct and exhibiting optimal factor loadings. The confirmatory factor analysis showed that the final 18-item, 4-factor model was adequate for the scale structure. We did not detect any floor or ceiling effects in the final version. Lastly, the results confirmed that the Spanish version has good internal consistency (Cronbach α, 0.88) and an adequate convergent validity. ConclusionThe Spanish CPASS exhibits good psychometric proprieties and it can be used to assess pain anxiety in the paediatric population.

Sleep disturbances are associated with pain intensity and pain-related functional interference in patients experiencing orofacial pain.

Sleep and pain have a reciprocal relationship, interacting with psychosocial aspects including depression, anxiety, somatization and significant stressful events. The aim of this study was to assess patients with oro-facial pain (OFP) and related sleep disturbances and determine the strongest psychosocial correlates. A cross-sectional study of anonymized data of consecutive patients with OFP {January 2019 and February 2020} were analysed. Diagnostic and Axis-II data were integrated to assess the relationship between sleep disturbances, measured using Chronic Pain Sleep Inventory, and demographic factors, clinical comorbidities, recent stressful events, pain severity and pain- and psychological-related function. Five out of six patients with OFP were presented with pain-related sleep disturbances. Sleep problems were enhanced in patients with primary oro-facial headache compared with other OFP conditions. However, once the level of pain intensity and interference was accounted for, primary headache, was not a significant correlate of pain-related sleep disturbances. Multivariate analysis revealed (average) pain severity and pain interference were both significantly associated with sleep problems. There were also significant independent associations of sleep problems with somatization levels and reported experience of recent stressful events. Identifying sleep problems as a part of OFP management may be beneficial and could result in better management outcomes.

Quantitative phase-amplitude surface determination in reflection differential interference contrast profilometry.

An approach for measuring the surface profile of the samples with reflection variations using the Nomarski differential interference method is presented. The system is analyzed with Jones's matrices tool, and polarization effects of a non-polarizing beam splitter are taken into account. Equations are also developed to allow the determination of the surface profile from interference intensity when the sample reflectively is not uniform. The validity and accuracy of the measurement are verified by measuring the adhered silicon cantilever on a substrate with high reflectivity. This method is expected to be a valuable tool to inspect elements of micromechanics and microsystems.

Interactive music therapy for chronic pain management in people with advanced cancer: A mechanistic study.

e24119 Background: Chronic pain is one of the most feared symptoms in people with cancer. Although music therapy is frequently used for pain management in cancer care, there is a lack of knowledge of underlying mechanisms. Yet, it is well accepted that knowledge of mediators is essential for optimization of psychosocial treatment interventions. We conducted a multi-site randomized controlled trial to examine mediators hypothesized to account for the pain-reducing effects of interactive music therapy (IMT) in adults with advanced cancer. Methods: This study included adults with advanced cancer (stage III/IV) who had moderate to severe chronic pain caused by 1) locally advanced cancer that had extended to other organs/soft tissue or was impinging on/eroding the bone, 2) bone metastasis, or 3) soft tissue metastasis. We excluded adults with primary central nervous system (CNS) tumor, CNS metastatic disease, or hematologic malignancies. We randomized 92 participants to 6 individual IMT ( n = 45) or social attention control (SAC) ( n = 47) sessions. The mediators (anxiety, mood, pain-related self-efficacy and emotional support) and pain outcomes (pain intensity and pain interference) were measured at baseline, week 4, and week 6 using self-report measures. We included treatment expectancy, music reward, and adult playfulness as moderators. Follow-up interviews were conducted to examine congruence between the hypothesized mediation model and participants’ explanations of how IMT impacted their pain experience. Our target sample size was 100 to achieve 80% power to detect a medium effect at α = 0.05 and 28% attrition. We used ITT analyses and the mediation model per Preacher and Hayes to estimate the total and specific indirect effects of each hypothesized mediator individually. Interview transcripts were analyzed using thematic analysis. Results: Participants were 56±12 years old. Most were female (72%), white (44%) or Black (39%), and had stage IV cancer (75%). The most common types of cancer were breast (46%) and lung (13%). Self-efficacy was found to be a significant mediator for the effect of IMT on pain intensity (indirect effect ab = 0.79, 95% CI 0.01 to 1.82) and pain interference (indirect effect ab = 1.16, 95% CI 0.02 to 2.51), while anxiety, mood, and perceived support were not. The quantitative results were supported by the qualitative findings. None of the proposed moderators were found to be significant. However, we found that the mediating effect of pain-related self-efficacy on pain intensity and pain interference was significantly moderated by baseline pain interference. Conclusions: This study suggests that the impact of music therapy on chronic pain management is mediated through self-efficacy. This knowledge can help further optimize music therapy interventions for chronic pain management in people with advanced cancer by capitalizing on teaching music-based self-management techniques. Clinical trial information: NCT03432247 .

The impact of music therapy on opioid use in cancer survivors with chronic pain.

e24124 Background: Chronic pain and persistent opioid use are significant problems for many cancer survivors. Opioid tapering comes with major challenges. It is therefore recommended that cancer survivors learn non-pharmacological techniques to support opioid tapering. Methods: The purpose of this pilot study ( N = 26) was to examine the benefits of interactive music therapy (IMT) for opioid tapering in cancer survivors with chronic pain who are persistent opioid users. Those with a history of polysubstance abuse/substance use disorder or who were receiving maintenance methadone or suboxone were excluded. Participants were randomized to 10 weekly, individual IMT ( n = 14) or social attention control ( n = 12) sessions. We measured daily opioid use and chronic pain outcomes (pain interference, pain-related self-efficacy, and pain intensity) at baseline, post-intervention (week 10) and 3-month follow-up (FU). We also conducted semi-structured interviews to gain understanding of participants’ perspectives on the usefulness of IMT for opioid tapering. We modeled the pattern of mean daily opioid dose change over time using multilevel models. The cross-level interaction between time and treatment was used to determine the effect of treatment condition on the pattern of change in the target outcomes. We used restricted maximum likelihood to estimate model parameters and to test the significance of random effects. Given the small sample size, we relied on effect sizes for interpretation. Interview transcripts were analyzed using thematic analysis. Results: Participants were 58±13 years old. Most participants identified as female (58%), not Hispanic or Latino (92%), and white (58%) or Black (38%), and reported to have had breast (23%), cervical (8%), lung (8%), or melanoma skin cancer (8%). A total of 85% of participants said that they were quite to very motivated to taper their opioid use. About one third had had prior opioid tapering attempts and 31% stated that they had concerns related to opioid tapering. We found a large effect of IMT on mean daily opioid use at week 10 ( η2p = 0.36) and at 3-month FU ( η2p = 0.27). There was a medium effect of IMT on pain interference at week 10 ( η2p = 0.18) and a large effect at 3-month FU ( η2p = 0.30). For pain-related self-efficacy, we found a medium effect at week 10 ( η2p = 0.21) and small effect at 3-month FU ( η2p = 0.09). IMT resulted in a small treatment effect for pain intensity at week 10 and at 3-month FU (week 10: η2p = 0.05; 3 month: η2p = 0.09). The quantitative results were congruent with the qualitative findings as many IMT participants reported feeling more “in control” of their pain and being able to apply the music-based self-management strategies outside of the sessions to help with pain management and improve their functioning. Conclusions: These promising findings warrant further research on the effects of IMT on opioid tapering and chronic pain management in cancer survivors. Clinical trial information: NCT03782506 .

Study on Compensation of Blood Oxygen Sensor’s Ambient Light Based on GA-BP Neural Network

In order to reduce the interference of ambient light on near-infrared blood oxygen sensors (used to measure oxygen saturation of human tissue or oxygen saturation of circulating blood during Extracorporeal membrane oxygenation treatment) and improve the measurement accuracy of a blood oxygen sensor, a compensation method of ambient light interference is proposed. This method does not need an ambient light sensor or an additional circuit. The interference intensity of ambient light is calculated by changing the light intensity value emitted by the LED in the sensor and combining the light intensity value received by the sensor. The Genetic Algorithms-Back Propagation(GA-BP) neural network is modeled, the detection light intensity value and the ambient light interference evaluation values are taken as the input characteristics, the blood gas analysis true value is taken as the expected output, and the network model is used for prediction. The results show that the accuracy of this method is higher than the traditional fitting results, and the error between the network prediction value and the true value of blood gas analysis is basically within 5%.

Waveguide invariant estimation based on correlation coefficient of tonal acoustic intensity interference fluctuation

The waveguide invariant is usually not extracted from the striation pattern of broadband continuous spectrum in the low frequency analysis and recording spectrum at low signal-to-noise ratio. In this paper, the correlation coefficient of multi-tonal acoustic intensity interference fluctuation is utilized to estimate waveguide invariant. Since the proportional relationship between the reference intensity interference fluctuation and the scaled intensity interference fluctuation is dependent on waveguide invariant, the waveguide invariant estimation can be done. Firstly, the tonal intensity interference fluctuation has been resampled in the new time domain under the radial and non-radial motion models respectively. Then, the similarity degree between the resampling reference tonal intensity interference fluctuation and the scaling tonal intensity interference fluctuation can be described by correlation coefficient, and the peak of correlation coefficient is corresponding to the true value. Finally, the numerical results and the experimental results prove the proposed method's effectiveness.

0853 Neighborhood disorder and pain: The mediating role of sleep

Abstract Introduction Neighborhood factors are related to poor sleep, and sleep problems are known to have a strong relationship with pain. The underlying mechanisms for this association remain unclear. The present study evaluated whether sleep duration, sleep quality, or global sleep quality mediated the relation between perceived Neighborhood Disorder (ND) and pain intensity or interference. The study also explored whether adjusting for depressive symptoms accounted for significant mediational pathways found in Aim 1. Methods Participants were drawn from Wave 4 (September 2013 to September 2017) of the Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) epidemiologic cohort study (n=1,071). Perceived ND was measured using the HANDLS Neighborhood Problems Scale, which assesses how often a particular neighborhood problem occurs. The Patient Reported Outcomes Measurement Information System Pain Intensity short form 3a was used to assess how much a person hurt in the past 7 days, and pain interference was measured by the bodily pain subdomain of the 12-item Short-Form Health Survey. The Pittsburgh Sleep Quality Index was used to assess sleep duration, subjective sleep quality, and global sleep quality. Results Results of the study revealed mediating effects of global sleep quality on the relation of perceived ND and pain intensity (indirect effect = .5527, SE =.1355, 95% CI [.2914, .8316]) and pain interference (indirect effect = .0579 (SE = .0143), 95% CI [.0312, .0876]) and also of subjective sleep quality on pain intensity (indirect effect = .5801, SE =.1337, 95% CI [.3206, .8468]) and pain interference (indirect effect = .0587 (SE =.0137), 95% CI [.0327, .0867]). Results revealed that mediating effects of sleep quality and global sleep on the relation of perceived ND and pain intensity and pain interference remained significant after adjustment for depressive symptoms. Conclusion These findings provide preliminary evidence to support the notion that select sleep dimensions, particularly sleep quality, is a pathway by which subjective neighborhood factors may impact pain intensity and pain interference. More research is needed to understand potential pathways underlying the perceived ND and pain relation. Support (if any) NIH Intramural Research Program Inter-laboratory proposal provided by the National Institute on Aging Intramural Research Program