Enhancement Of Intensity Research Articles

Fluorescence tunable carbon dots for in vitro nuclear dynamics and gastrointestinal imaging in live zebrafish and their in vivo toxicity evaluation by cardio-craniofacial disfunction assessment.

Sub-cellular organelle anomalies are frequently observed in diseases such as cancer. Early and precise diagnosis of these alterations can be crucial for patient outcomes. However, current diagnostic tools using conventional organic dyes or metal quantum dots face limitations, including poor biocompatibility, stringent storage conditions, limited solubility in aqueous media, and slow staining speeds. These challenges underscore the need for safer, more effective diagnostic and therapeutic solutions. In these aspects, we have developed highly photostable, biocompatible, water-dispersible carbon dots (TNCDs) with an average size of 5.5 nm using tartaric acid and ethylenediamine via a hydrothermal route. The synthesized TNCDs have shown bright blue fluorescence under the irradiation of UV-light at an excitation wavelength of 365 nm. They exhibit a quantum yield (QY) of 25.1% with maximum emission at 390 nm. A nice tri-exponential fitting of the decay curve with characteristic lifetimes of 1.52 ns, 3.05 ns and 6.11 ns for TNCDs was obtained. In vitro studies demonstrated that TNCDs have high biocompatibility (20 μg ml-1) with almost 100% cell viability and excellent nucleus targeting and staining capabilities with low background interference (with 10-12 times enhancement in fluorescence intensity). Additionally, if tagged with photosensitizers or radionuclides, TNCDs can serve as therapeutic agents in photodynamic therapy against cancer cells. Importantly, TNCDs exhibited negligible toxicity in developing zebrafish even at high concentrations (up to 400 mg L-1) as investigated by cardio and craniofacial disfunction assessment. Live organism imaging revealed that TNCDs produced aggregation-induced strong and specific green fluorescence in the gut of zebrafish larvae even at low concentrations, indicating their potential for nucleus staining and gut-specific optical imaging (at 50 mg L-1). Thus, our TNCDs represent a robust nanoplatform for cellular and whole-organism fluorescence imaging, offering both diagnostic and therapeutic potential.

A Transient Photoelectric Spiking Neuron Based on a Highly Robust MgO Composite Threshold Switching Memristor for Selective UV Perception

AbstractThe biological photoreceptors in the retina convert light information into spikes, inspiring the emergence of artificial photoelectric spiking neurons. However, due to the lack of biocompatible and biodegradable characteristics, artificial photoelectric spiking neurons based on threshold switching (TS) devices are not available for bio‐integrated optical medical diagnostics and neuromorphic computing. Here, an artificial photoelectric spiking neuron integrated with a physically transient memristor and photodetector for UV perception is proposed. The transient memristor with a MgO:Mg resistive layer implemented by the co‐sputtering process of MgO and Mg targets shows highly robust TS performance, while the ZnO‐based transient photodetector can selectively detect UV light at power densities below 10 mW cm−2. More interestingly, the frequency of the firing spikes generated by artificial photoelectric spiking neuron increases with the enhancement of UV light intensity. In addition, the recognition accuracy of UV information extracted from the surrounding environment reaches ≈99.8% by spiking neural network consisting of photoelectric spiking neuron when the object that blended into the background are not easily detected. This work demonstrates that the functions of the biological photoreceptors may be truly mimicked by artificial photoelectric spiking neuron with transiency, expanding its application in optical disease diagnosis and implantable visual neuromorphic computing.

Coupling mechanisms of plasmon resonance and Bi3+ emission in YAG: Bi, Ce, Yb epitaxial films at low temperatures

This paper is devoted to the investigation of the plasmonic effect of metal nanoparticles (NPs) formed on the surface of the YAG: Bi, Ce, Yb phosphors in a temperature range between 4 and 300 K. Combination of a thin conversion layer with silver plasmonic nanostructures leads to increase of sensitizer absorption and emission efficiency. Enhancement of Bi3+ luminescence in YAG epitaxial films with Ag NPs was observed upon cooling the samples below 200 K. High enhancement factors were associated with closely matching the maximum of plasmon extinction and Bi3+ emission bands. The maximum value of enhancement factor near 170% at 4 K was obtained. It is shown that temperature decrease causes an increase in the EM field intensity around the NPs, the probability of spontaneous recombination, the penetration depth of the localized surface plasmon resonances (LSPR) into the substrate, and the adjustment of the position of the LSPR. Simultaneous action of all these factors leads to Bi3+ emission intensity enhancement. Comparative analysis of the Finite-Difference Time-Domain (FDTD) simulation data vs. experimental results of the temperature behavior of plasmon absorption spectra, luminescence spectra of Bi3+ ions, and their decay kinetics confirms the correctness of the proposed mechanisms.

Soft Metalens for Broadband Ultrasonic Focusing through Aberration Layers

Aberration layers (AL) often present significant energy transmission barriers in microwave engineering, electromagnetic waves, and medical ultrasound. However, achieving broadband ultrasonic focusing through aberration layers like the human skull using conventional materials such as metals and elastomers has proven challenging. In this study, we introduce an inverse phase encoding method employing tunable soft metalens to penetrate heterogeneous aberration layers. Through the application of effective-medium theory, we determined the refractive index of micro-tungsten particles in silicone elastomer, closely aligning with experimental findings. The soft metalens allows for transmission across broadband frequencies (50 kHz to 0.4 MHz) through 3D-printed human skull models mimicking aberration layers. In ex vivo transcranial ultrasound tests, we observed a 9.3 dB intensity enhancement at the focal point compared to results obtained using an unfocused transducer. By integrating soft materials, metamaterials, and gradient refractive index, the soft metalens presents future opportunities for advancing next-generation soft devices in deep-brain stimulation, non-destructive evaluation, and high-resolution ultrasound imaging.

Biocompatible Ni(II) Complex as an Amyloid Sensor for Human PrP106-126 Fibrillar Aggregates

Introducing KRS-1, a biocompatible nickel(II) complex as a potent fluorescent probe for PrP106-126 fibrillar aggregates. KRS-1 shows a 15-fold enhancement in PL intensity and detects all stages of PrP106-126 aggregation....

Remarkable increase in electrochemiluminescence of isomeric bipyridine-based covalent organic frameworks via regulating the direction of imine linkage for sensing application.

Covalent organic frameworks (COFs) with highly ordered structures and predictable optoelectronic properties provide an ideal platform to investigate the electrochemiluminescence (ECL) performance based on organic materials by atomically varying the molecular construction. Herein, the effect of imine-bond orientation on the ECL performance of COFs is investigated. We report two COFs (NC-COFPy-Bpy and CN-COFPy-Bpy) with different orientations of imine bonds using pyrene donor units (D) and bipyridine acceptor motifs (A) monomers. The direction of the imine linkage (carbon of imine bonds as the D unit and nitrogen as the A unit) in NC-COFPy-Bpy oppose to the direction of donor and acceptor charge transfer between the molecular motifs. In contrast, CN-COFPy-Bpy is in the same direction (D-A type imine COFs). However, the NC-COFPy-Bpy demonstrates a superior ECL performance with 22.4-fold enhancement in ECL intensity compared to CN-COFPy-Bpy, due to the effective separation of the highest and lowest occupied molecular orbitals to facilitate intramolecular charge transfer (IRCT) for strong ECL. Moreover, the ECL intensity of NC-COFPy-Bpy remains higher stability than CN-COFPy-Bpy at low-excited positive potential with tri-n-propylamine (TPrA) as the coreactant. The experimental and modeling investigation indicate that the bimodal ECL patterns of NC-COFPy-Bpy were derived from the competitive oxidation mechanism of IRCT regulated: the co-reactant-mediated oxidation at lower potential and the direct oxidation at higher potential, but the CN-COFPy-Bpy only has a co-reactant pathway. Notably, the NC-COFPy-Bpy can be used to construct an ECL sensor for sensitive detection of doxorubicin (DOX). This research provides a protocol for the molecular design of COFs as ECL emitters with atomically regulated charge transfer direction in D-A systems.

Microbial Coadaptation Drives the Dynamic Stability of Microecology in Mainstream and Sidestream Anammox Systems Under Exposure of Progesterone

Microbial cooperation determines the efficacy of wastewater biological treatment, and the adaptability of microorganisms to environmental stresses varies. Recently, extensive use of hormones results in their inevitable discharge into aquatic environment. Therefore, mainstream and sidestream anammox reactors were constructed in this study to evaluate their removal performance of progesterone and nitrogen simultaneously, the adaptability of anammox consortia to progesterone stress and the corresponding regulation mechanism. Both anammox processes had the resilience to progesterone stress, with the average nitrogen removal efficiency exceeding 90%. At the same time, progesterone removal efficiency also exceeded 70%. In contrast, microbial community in the mainstream reactors was more susceptible to progesterone interference. The adaptation of anammox consortia mainly depended on microbial cooperation and molecular regulation. Initially, bacteria secreted more extracellular polymeric substances to detain progesterone. Biodegradation also contributed to mitigating the side effect of progesterone, which was demonstrated by the proliferation of potential degrading bacteria such as Bacillus salacetis, Bacillus wiedmannii and Rhodococcus erythropolis. In addition, the enhancement of microbial interaction intensity drove their cooperation to enhance adaptability and maintain stable performance. Combined with metagenomic and metatranscriptomic analyses, such microbial adaptability was enhanced through molecular regulations, including the energy redistribution for amino acid synthesis and alteration of key metabolic pathways. Related functional gene expressions and microbial interactions were, in turn, regulated by quorum sensing. This work verifies the feasibility of anammox process in hormone-containing wastewater treatment and provides a holistic understanding of molecular mechanism of microbial interaction and coadaptation to stress.

Poly(allylamine) and cysteine co-capped silver indium sulfide quantum dots with excellent photostability for specific Cd2+ and Zn2+ detection based on fluorescence enhancement

Metal chalcogenide quantum dots (MCQDs) have received tremendous attention in biomedical field for their fascinating optical properties and the admirable biomolecular modifiability. However, challenged by low stability and notorious biocompatibility, MCQDs make them limited for direct biomedical use. Herein, a novel designed and synthesized poly(allylamine) and cysteine co-capped silver indium sulfide quantum dots (PAA-Cys-AIS QDs) with excellent photostability is reported for the specific rapid detection of Cd2+ and Zn2+ ions. The obtained water-soluble PAA-Cys-AIS QDs emitted a stable orange fluorescence at 625 nm with an average size of 3.639 ± 1.006 nm. The unusual anti-photobleaching property of PAA-Cys-AIS QDs is demonstrated to be owing to the introducing of poly(allylamine) and cysteine, which uniquely increased the crystallinity and hydrodynamic size of the structure system. Unexpectedly, unlike most reported approaches for Cd2+ and Zn2+ detection based on the quenching fluorescence mechanism, the PAA-Cys-AIS QDs showed remarkable and rapid fluorescence enhancement after being exposed to Cd2+ and Zn2+ ions aqueous solutions. Notably, the detection limits of the new probe for Cd2+ and Zn2+ are 175 and 50 nM respectively. Complexation and metal ions doping mechanisms are proposed to be responsible for the enhancement of photoluminescence intensity based on the metal ions capture capacity coming from PAA-Cys-AIS QDs’ intrinsic defects and abundant surface amino functional groups. Moreover, the intracellular photostability and biocompatibility of PAA-Cys-AIS QDs are strong enough to prompt us to investigate the metal ions imaging applications in SH-SY5Y cells to further demonstrate the potential for real-live biomedical applications.

Trace level detection of Pb2+ ion using organic ligand as fluorescent-on probes in aqueous media.

In this study, an optical sensor, JA/(2,6-di((E)-benzylidene)cyclohexan-1-one), was synthesized and characterized using 1H NMR and FT-IR spectroscopy. The sensor exhibited high efficiency and selectivity in detecting Pb2+ ions, even in the presence of potential interfering ions such as Mn2+, Cu2+, Co2+, Cr3+, Ni2+, Ce3+, Hg2+, and Cd2+ in aqueous solutions. The interaction of JA with Pb2+ resulted in a significant enhancement of fluorescence intensity, suggesting the formation of a stable complex. A 2:1 binding ratio between JA and Pb2+ was confirmed through fluorometric analysis, absorption spectra, and theoretical calculations (DFT). The association constant for the complex was calculated to be 3×106M-2. The sensor demonstrated high sensitivity towards Pb2+ with a detection limit of 5×10-7M. Additionally, JA was successfully reused by applying EDTA to release Pb2+ from the sensor. Real sample analysis under optimized conditions of pH, time, and concentration of JA and Pb2+ further validated the practical applicability of the sensor.

The Impact of Silver Codoping on Tb3+ Luminescence in Lithium Tetraborate Glasses.

Spectroscopic properties of Tb-doped and Tb-Ag codoped lithium tetraborate (LTB) glasses with Li2B4O7 (or Li2O-2B2O3) composition are investigated and analysed using electron paramagnetic resonance (EPR), optical absorption, photoluminescence (PL) and photoluminescence excitation (PLE) spectra, PL decay kinetics and absolute quantum yield (QY) measurements. PL spectra of the investigated glasses show numerous narrow emission bands corresponding to the 5D4 → 7FJ (J = 6-0) and 5D3 → 7FJ (J = 5-3) transitions of Tb3+ (4f8) ions. The most intense PL band of Tb3+ ions at 541 nm (5D4 → 7F5 transition) is characterised by a lifetime slightly exceeding 2.6 ms. PL spectra of the Ag-containing glass show two broad weakly resolved emission bands in the violet-green spectral range attributed to Ag+ ions and nonplasmonic Ag nanoclusters. Decay kinetics of these bands are nonmonoexponential, characterised by an average lifetime in the microsecond range. A significant enhancement of the PL intensity and PL QY of Tb3+ ions was observed in Tb-Ag codoped LTB glass in comparison with Tb-doped LTB glass. The excitation energy transfer (EET) mechanisms from Ag+ ions and Ag nanoclusters to Tb3+ ions were explored.

Enhanced and directional fluorescence emission regulated by dual resonant surface modes

Fluorescence emission regulation is of great interest for its promising applications in various fields such as microscopy, chemical analysis, encryption, and sensing. Most studies focus on the regulation of the fluorescence emission process. However, the spectral separation of excitation and emission of fluorophores requires careful design of resonances to cover both emission and excitation wavelengths, which is a better choice to enhance fluorescence intensity. In this Letter, we engineer an efficient dielectric concentric ring grating on a dielectric multilayer film with two resonate modes to enhance the excitation and emission processes. By careful design of the structure, the two resonate modes occupy similar in-plane wave vector and overlap in the fluorescence area. Experimentally, fluorescence intensity enhancement about five times and the divergence of fluorescence into free space compressed to less than 5° are achieved. Our work provides what we believe to be a new strategy for the realization of high directional on-chip light emitter at room temperature.

Ultrasensitive infrared spectroscopy via vibrational modulation of plasmonic scattering from a nanocavity.

Most molecules and dielectric materials have characteristic bond vibrations or phonon modes in the mid-infrared regime. However, infrared absorption spectroscopy lacks the sensitivity for detecting trace analytes due to the low quantum efficiency of infrared sensors. Here, we report mid-infrared photothermal plasmonic scattering (MIP-PS) spectroscopy to push the infrared detection limit toward nearly a hundred molecules in a plasmonic nanocavity. The plasmon scattering from a nanoparticle-on-film cavity has extremely high sensitivity to the spacing defined by the analyte molecules inside the nanogap. Meanwhile, a 1000-fold infrared light intensity enhancement at the bond vibration frequency further boosts the interaction between mid-IR photons and analyte molecules. MIP-PS spectroscopic detection of nitrile or nitro group in ~130 molecules was demonstrated. This method heralds potential in ultrasensitive bond-selective biosensing and bioimaging.

Enhancement of Sm3+ Luminescence in Sol-Gel Silica Matrix: Effect of Ligands Phenyl Phosphinic Acid and Trioctylphosphine Oxide.

Sol-gel silica matrices singly doped with Sm3+ and co-doped with ligands phenyl phosphinic acid (PPIA) and trioctylphosphine oxide (TOPO) were fabricated and studied for their structural and spectroscopic behaviour. Structural studies were done by x-ray diffraction (XRD) and Fourier transform infra-red (FTIR) absorption analysis whereas spectroscopic behaviour was studied by ultraviolet - visible (UV-Vis) absorption, photoluminescence (PL) excitation, emission and time-correlated decay analyses. XRD studies exhibit the amorphous nature of the samples and FTIR studies corroborate the presence of the ligands in the silica matrix. UV-Vis absorption and PL studies show significant enhancement in the radiative parameters in ligand co-doped samples compared to singly doped Sm3+ sample. Judd Ofelt parameters estimated from the absorption spectra possess higher values compared to popular hosts; revealing higher asymmetry and covalency around the active Sm3+ ions. An enhancement in PL intensity by 50.38 times and yield by 52.57 times with the co-doping of the ligands PPIA and TOPO is reported. These enhancement in the radiative output in ligand co-doped samples is attributed to the modification of the silica network with the incorporation of the ligands, energy transfer from ligands to nearby Sm3+ ions as well as due to the shielding of Sm3+ ions from the OH quenchers in the silica matrix. The improved PL behaviour especially corresponding to 4G5∕2→6H9∕2 transitions occurring at 643nm suggests the potential of PPIA and TOPO co-doped Sm3+ silica matrix for diverge optical applications.

Raman intensity enhancement of Raman active and forbidden modes induced by naturally occurred hot spot at GaAs edge

Abstract Edge structures are ubiquitous in the processing and fabrication of various optoelectronic devices. Novel physical properties and enhanced light-matter interactions are anticipated to occur at crystal edges due to its broken spatial translational symmetry. However, the intensity of first-order Raman scattering at crystal edges has been rarely explored, although the mechanical stress and edge characteristics have been thoroughly studied by the Raman peak shift and the spectral features of the edge-related Raman modes. Here, by taking GaAs crystal with a well-defined edge as an example, we reveal the intensity enhancement of Raman-active modes and the emergence of Raman-forbidden modes under specific polarization Raman configurations at the edge. This is attributed to the presence of hot spot at the edge, due to the redistributed electromagnetic fields and electromagnetic wave propagations of incident laser and Raman signal near the edge, which are confirmed by the finite-difference time-domain simulations. Spatially-resolved Raman intensity of both Raman-active and Raman-forbidden modes near the edge is calculated based on the redistributed electromagnetic fields, which quantitatively reproduce the corresponding experimental result. These findings offer new insights into the intensity enhancement of Raman scattering at crystal edges and presents a new avenue to manipulate the light-matter interactions of crystal by manufacturing various types of edges and to characterize the edge structures in photonic and optoelectronic devices.

Surface plasmon enhanced auto-fluorescence and Raman spectroscopy for low-level detection of biological pathogens.

The current culture-based bacterial detection technique is time-consuming and requires an extended sample preparation methodology. We propose the potential of surface-enhanced Raman spectroscopy (SERS) and surface plasmon-enhanced auto-fluorescence spectroscopy (SPEAS) for the label-free identification and quantification of bacterial pathogens at low concentrations collecting its unique auto-fluorescence and Raman signatures utilising highly anisotropic three-dimensional nanostructures of silver nano dendrites (Ag-NDs). The SERS data facilitates qualitative bacterial identification using the spectral features coming from the bacterial cell wall compound, and the SPEAS data was utilised to gain unique auto-fluorescence spectra present on the bacterial cell wall with enhanced quantification. The enhancement of Raman and auto-fluorescence signals of Ag-NDs were first evaluated using rhodamine 6g (R6G) as a probe molecule that exhibits a significant enhancement of 106 and limit of detection (LOD) of 10-12 M for SERS and 15 fold intensity enhancement and LOD of 10-15 M for SPEAS measurements. Further, the SERS and SPEAS measurements of bacterial pathogens, such as Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), using the Ag-NDs were recorded, and the results exhibit high auto-fluorescence and Raman signal intensity for both the samples up to 100 cfu/ml for both modalities. The significant photon count and distinct emission range in SPEAS measurements of bacteria enables accurate quantification. Therefore, the comprehensive investigation of plasmonic enhancement of Ag-NDs for SPEAS and SERS techniques provides complementary information about molecules to enable accurate and quick identification and quantification of pathogens.

Structural investigation and red emission intensity enhancement in Sm3+/Eu3+-doped/co-doped KSrPO4 phosphors: effect of charge compensation

Structural investigation and red emission intensity enhancement in Sm3+/Eu3+-doped/co-doped KSrPO4 phosphors: effect of charge compensation

A-Site Ion Doping in Cs2AgBiBr6 Double Perovskite Films for Improved Optical and Photodetector Performance

Perovskite materials, as emerging semiconductors, have attracted significant attention for their exceptional optoelectronic properties, tunable bandgaps, ease of fabrication, and cost-effectiveness, making them promising candidates for next-generation optoelectronic devices. The all-inorganic perovskite Cs2AgBiBr6 distinguishes itself from other perovskite materials due to its remarkable optical absorption and emission properties, excellent stability, prolonged carrier recombination lifetime, and nontoxic characteristics. However, a deeper understanding of its unique luminescent properties and a further optimization of its structure and performance are still necessary. This study systematically investigates the optimization of Cs2AgBiBr6 double perovskite films through A-site Na+ doping. At an optimal Na+ doping concentration of 3.5% (Na0.07Cs1.93AgBiBr6), the film shows 1.4 times and 2.7 times enhancement in light absorption and photoluminescence intensity, compared to the undoped film. Low-temperature spectroscopy measurements indicate that Na0.07Cs1.93AgBiBr6 exhibits higher exciton binding energy and phonon energy. Based on Na0.07Cs1.93AgBiBr6, the photodetectors demonstrate significant performance improvements, with a high photocurrent response of 10−2 A, a photo-to-dark current ratio (PDCR) of 7.57 × 104, a responsivity (R) of 16.23 A/W, a detectivity (D*) of 2.92 × 1012 Jones, a linear dynamic range (LDR) of 98.75 dB, and a fast response time of 943 ms. This work provides a promising strategy for optimizing all-inorganic perovskite materials through doping and offers guidance for enhancing high-performance photodetectors.

Dynamic Modulation of Afterglow Emission in Polymeric Phosphors via Inverse Opal Photonic Structures.

Tuning the afterglow of polymeric phosphors is critical for advancing their use in optical data storage and display technologies. Despite advancements in polymer matrix design and dopant engineering, achieving dynamic control over afterglow intensity remains a significant challenge. In this study, a novel approach is introduced for dynamically tuning the afterglow of polymeric phosphors by integrating them into an inverse opal photonic structure. By precisely aligning the photonic stopband of the inverse opal structure with the afterglow band of the polymer film, a remarkable 15-fold enhancement in afterglow intensity is achieved. This enhancement is tunable, decreasing from 15 to 1.2 by infiltrating the photonic structure with media of varying refractive indices ranging from 1.00 (air) to 1.37 (ethyl acetate). The tunability arises from reducing the mismatch between the stopband and the afterglow band, as the weighted refractive index shifts between 1.15 and 1.40. Additionally, the inverse opal photonic structure induces angle-dependent structural colors in the Janus polymeric phosphors, modulated by the refractive index of the infiltrating media. This integration of dynamically tunable afterglow with angle-dependent structural coloration unlocks new potential for advanced optoelectronic applications.

Raman spectroscopy with a microfluidic device embedded with plasmonic metasurface.

Metasurfaces offer a powerful tool to realize label-free and highly sensitive Raman spectroscopy. Embedding metasurfaces into microfluidic channels is promising to establish a new characterizing platform for microfluids. In this Letter, we present a highly stable method for improving the Raman scattering intensity of biological microfluids by using a microfluidic chip embedded with a plasmonic metasurface. The embedded metasurface consists of a nanosphere array coated with a silver layer, where the diameter of the nanosphere is ∼100 nm. The Langmuir-Blodgett method and a chemical spraying method were adopted to prepare the nanosphere-array metasurface. In the case of red blood cell measurement, a giant enhancement of Raman spectra intensity is achieved with a metasurface compared to that without a metasurface. Moreover, a two-time enhancement of Raman spectra intensity is obtained with a metasurface under radially polarized beam illumination compared to linearly polarized beam illumination. Furthermore, a microfluidic device embedded with a plasmonic metasurface was applied to monitor the environmental variation of rat red blood cells. Peaks in the range from 2143 cm-1 to 2303 cm-1 arise with the addition of glucose and are still obviously distinguishable when the additive concentration is down to 10-3 M. This indicates high sensitivity to the concentration of glucose mixed with rat red blood cells, which could be further applied to monitor biological cell environments such as glucose concentration, pH, and sodium salt concentration.

Gradient Luminescence Enhancement in Organic Metal Halide Perovskites via the Suppression of [SbCln]3-n Unit Distortion.

Intrinsic stereochemical activity of the 5s2 electron configuration in Sb3+ leads to structural distortion within [SbCln]3-n units, which, while stabilizing the material, paradoxically diminishes luminescence intensity due to induced asymmetry. To address this issue, a strategy, which encompasses increasing the structural dimensions and introducing In3+ doping, was developed to mitigate the geometrical distortion in the [SbCln]3-n units within the metal-organic perovskite (DABCO)2Sb2Cl10·H2O and (DABCO)2SbCdCl9·2H2O (DABCO = triethylenediamine). This dimensional augmentation confines lattice distortion effectively, and the In3+ doping modifies the 5s2 electron configuration of Sb3+, thereby reducing the distortion at its origin. The unique suitability of indium-based halides as a matrix for Sb3+ doping is underscored by our approach, which capitalizes on their ability to regulate the electron configuration of Sb3+. This strategy has been validated through crystallographic data from single-crystal X-ray diffraction. By effectively reducing the adverse effects of geometric distortion, several hundred-fold enhancements in the luminescent intensity of the material have been achieved by our methodology, leading to potential applications in white-light LEDs. This advancement not only highlights the pivotal role of structural symmetry in the optical properties of materials but also exemplifies the power of material engineering to optimize the optical performance.