Integrative Medicine Research Articles

Patients Experience Improvements in Pain and Quality of Life When Treated at a Physician Led Integrative Medicine Clinic at a Large Air Force Military Treatment Facility

ObjectiveA large percentage of military treatment facilities (MTFs) offer at least one type of complementary medicine and 80% of patients surveyed felt that integrative therapies should be routinely offered at all MTFs. We are the first to offer the breadth of modalities outlined below in a dedicated MTF Integrative Medicine Clinic (IMC). The purpose of this study was to determine whether the basket of services offered at our IMC improved patient pain and quality of life. Design and SettingPatient outcomes over a three-year period were retrospectively evaluated from a single cohort. Patients referred to the IMC for chronic pain at the MTF recorded pain scores using the Defense and Veterans Pain Rating Scale (DVPRS) and completed the Dallas Pain Questionnaire (DPQ), a 16-item visual analog quality of life questionnaire, at each visit. They also completed a non-validated quality of life question on discharge from the clinic. Modalities used include microcurrent therapies, extracorporeal shockwave therapy, medical Acupuncture, myofascial release techniques, low-level laser therapy, and the AllCore360. Results761 patients were seen from August 2019 to October 2022 in over 3,280 clinic visits. On average per visit, DVPRS scores were reduced from 4.4 to 1.5 (MD 2.9; 95%CI, 2.7-3.1). Total DPQ scores were reduced by 16.5% (MD 27.7; 95%CI 22.7-32.7). On discharge from the clinic 81% of patients reported their quality of life was either “a lot better” or “somewhat better.” ConclusionsIf implemented, we believe comparable clinics across the Department of Defense can replicate these improvements in patient-oriented outcomes.

Oncology researchers’ and clinicians’ perceptions of complementary, alternative, and integrative medicine: an international, cross-sectional survey

BackgroundComplementary, alternative, and integrative medicine (CAIM) has become an increasingly popular supportive therapy option for patients with cancer. The objective of this study was to investigate how researchers and clinicians in the oncology field perceive CAIM.MethodsWe conducted an online, anonymous, cross-sectional survey for researchers and clinicians who have published their work in oncology journals that are indexed in MEDLINE. The link to the survey was sent to 47, 991 researchers and clinicians whose contact information was extracted from their publications. The survey included various multiple-choice questions, and one open-ended question at the end to allow for any additional comments.Results751 respondents completed the survey, and they mostly identified themselves as researchers (n = 329, 45.13%), or as both researchers and clinicians (n = 332, 45.45%) in the field of oncology. Over half of the respondents perceive mind–body therapies (n = 354, 54.97%) to be the most promising CAIM category with regards to the prevention, treatment, and/or management of diseases related to oncology, and many respondents agreed that most CAIM therapies are safe (n = 218, 37.39%), and that clinicians should receive training on CAIM therapies via formal (n = 225, 38.59%) and supplemental education (n = 290, 49.83%). However, many respondents were unsure when asked if most CAIM therapies are effective (n = 202, 34.77%).ConclusionsThe findings from this study demonstrated great current interest in the use of CAIM in oncology. This information can serve as a foundation for conducting additional research and creating customized educational materials for researchers and clinicians in oncology.

The Use of Complementary and Integrative Medicine in Combination With Pharmacological Antiemetics to Address Chemotherapy-Induced Nausea and Vomiting in Pediatric Oncology: A Scoping Review.

Background: Chemotherapy is a common treatment in childhood cancer but causes significant side effects, among the most notable being nausea and vomiting, known as chemotherapy-induced nausea and vomiting (CINV). Pharmacological antiemetics and complementary and integrative medicine (CIM) have been studied separately to manage CINV, but a gap exists in understanding their use together. We aimed to investigate the potential multimodal effects of CIM and pharmacological antiemetics on CINV in pediatric oncology patients undergoing chemotherapy. Method: Systematic searches were conducted in four databases to identify studies evaluating the efficacy of CIM in combination with pharmacological antiemetics in patients ages 0-21 with cancer undergoing chemotherapy. Relevant data were extracted from each study and evaluated. Results: Eighteen sources examining CIM therapies in three distinct categories (herbal, physical, and psychological) were identified. Three of four herbal interventions yielded significant results, all of which implemented oral ginger. Physical interventions included manual and wristband acupressure, auricular acupuncture, and needle and laser acupuncture. Significant results were found in only four of these 10 studies. Among psychological interventions, two of four yielded significant results. Discussion: There is no clear evidence of benefit from CIM therapies in addition to pharmacological antiemetics to better control CINV. However, this review provides support and direction for future research to examine potential effects. Complementary therapies generally have little potential for harm, are relatively low cost, and low burden. Therefore, if there is a perceived benefit for patients and families, complementary and integrative therapies should be considered.

Uses and recommendations of Traditional, Complementary and Integrative Medicine in Brazil

Background and purposeThe growing interest in preventive health practices, either as a complement or substitute for conventional treatments, is currently notable. Particularly noteworthy are Traditional, Complementary and Integrative Medicine (TCIM) therapies, with a prevalence of usage varying globally. Therefore, this study aimed to analyze the factors associated with the prevalence of usage and recommendation of TCIM therapies in Brazil. Material and methodsIt is a cross-sectional study using secondary data from the National Health Survey. A total of 279,141 participants were evaluated, predominantly females, individuals of mixed race, single, and with a high school or higher education. To describe the data, absolute and relative frequencies were used and prevalence ratios and their respective confidence intervals (95 %CI) calculated. ResultsThe prevalence of TCIM therapies was 4.74 %. The usage of these practices was more common among females, individuals over 60 years old, and white individuals, while it was less prevalent among those without a partner. The Southern and Northern regions of Brazil showed a higher prevalence of TCIM. Medicinal plants were the most used TCIM, followed by acupuncture. In the prescription by healthcare professionals, work-related musculoskeletal disorders were the most common indication. ConclusionThis article provides insights into the usage and prescription profile of TCIM in Brazil, essential for guiding health policies and integrating these practices into the healthcare system.

Integrative medicine in oncology: redefining the standard of care.

Integrative medicine in oncology: redefining the standard of care.

Teaching integrative and complementary medicine in health undergraduate courses: systematic review

Background: Health undergraduate courses have their curricula focused on conventional medicine. Integrative and Complementary Practice also known as Complementary and Alternative Medicine (CAM) have been included in this worldwide scenario motivated by the growing need for new care possibilities that value Traditional Medicines and the individual-centered view. This work aims to analyze published evidence about CAM in health teaching around the world. Methods: This is a systematic review about the teaching of CAM on fifteen different undergraduate health courses, published between 2010 and 2020, in Portuguese and English, indexed in the Pubmed and VHL databases. The descriptors were “complementary and alternative medicine teaching” or its variations and the name of fifteen undergraduate health courses. The methodological quality was assessed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations and Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria. Results: The initial search identified 351 articles. After exclusion criteria, 22 articles were read to identify the courses that offers CAM, the modalities and the effects of including CAM in health courses. Different modalities were found and varies according to the country and health course, as well as they are offered as elective format. The contact with integrative medicine at undergraduate increases the interest, confidence and level of knowledge. In students’ opinions, the professional who adds CAM in their training tends to take full care of patients. Conclusions: There is a clear need to include integrative medicine in all undergraduate health courses curriculum to provide safe and complete information about integrative medicine.

Assessment of knowledge, attitude, and use of complementary and integrative medicine among health-major students in Western Pennsylvania and their implications on ethics education

Assessment of knowledge, attitude, and use of complementary and integrative medicine among health-major students in Western Pennsylvania and their implications on ethics education

An international, cross-sectional survey of psychiatry researchers and clinicians: perceptions of complementary, alternative, and integrative medicine.

Psychiatry is a branch of medicine that focuses on mental, behavioral and emotional well-being. Complementary, alternative, and integrative medicine has been an increasingly popular choice for patients with psychiatric disorders, therefore our study aimed to explore the perceptions of psychiatry researchers and clinicians on the use of CAIM. We conducted an online, anonymous, cross-sectional survey for researchers and clinicians who have published their work in psychiatry medical journals that are indexed in MEDLINE. 42,667 researchers and clinicians were sent the link to the survey after extraction of their email addresses from their respective publications. Respondents were asked numerous multiple-choice questions regarding their perceptions on various CAIM therapies, followed by an open-ended question where they could include any additional thoughts. The survey was completed by 987 respondents, with a majority identifying as a researcher (n=447, 46.51%), or as both a researcher and a clinician (n=368, 38.29%) within the field of psychiatry. Most respondents (n=629, 78.04%) perceived mind-body therapies such as meditation, biofeedback, hypnosis, and yoga to be the most promising CAIM therapy for the prevention, treatment, and management of psychiatric diseases. Many participants said that they agree (n=285, 38.14%) that most CAIM therapies in general are safe, however, many disagree that CAIM therapies are effective (n=245, 32.93%). Respondents indicated that there is value to conducting research on CAIM therapies (n=356, 47.91%), and that there should be more funding allocated to researching these therapies (n=265, 35.71%). Respondents were also in agreement that clinicians should receive training on CAIM therapies through formal education (n=295, 39.76%) or supplementary education (n=380, 51.28%). The findings from this study showed that there is great interest and potential in researching CAIM within the field of psychiatry. This information can be used as a basis for further research and to develop tailored educational resources for researchers and clinicians in psychiatry.

Integrative therapeutics for ocular surface disorders.

Integrative medicine techniques are increasingly accepted into the treatment paradigm for many chronic disorders including eye disease. Over 71% of patients, including 67% of those with eye disorders, use some form of Integrative therapy. Physicians should be well versed in evidence-based therapies to know how to refer patients for the best complimentary care. We highlight the most effective integrative therapeutics from different complementary treatment paradigms to offer a framework for approaching therapy in patients with ocular surface disorders (OSDs). Lifestyle and behavioral modifications help a proportion of people with OSDs like dry eye disease and allergic conjunctivitis, which are interrelated disorders. Nutrition and supplementation can also play a role in addressing underlying inflammation and improving OSD symptoms. Acupuncture and traditional herbal medicine may also benefit some patients. New technologies offer innovative treatment pathways in the treatment of OSD but require referral to Ocular Surface Treatment Centers. Integrative treatment approach for OSD incorporates allopathic medicine, traditional remedies and lifestyle behavioral interventions, Ayurveda and herbal medicine, Nutritional Supplements, Homeopathy, Acupuncture and Chinese Medicine. New cutting-edge technologies offer breakthroughs in difficult to treat ocular surface cases. Collaboration between allergy or otolaryngology offices, complementary practitioners, as well as optometrists and ophthalmologists in Ocular Surface Treatment Centers can offer patients new avenues of treatment.

Expert consensus on quality control indicators for integrative medicine in ankylosing spondylitis (2023 version)

AbstractThe integrated treatment with Chinese and Western medicine plays an important role in the treatment of ankylosing spondylitis (AS), which can significantly relieve the patient's symptoms and improve quality of life. However, as a result of the lack of standardization of clinical management in some regions, the quality of AS treatment in China remains unoptimistic. In 2021, initiated by the Center for Integrative Medicine of China‐Japan Friendship Hospital, led by the traditional Chinese medicine department of rheumatology of China‐Japan Friendship Hospital, relying on the rheumatology branch of the Beijing Association of the integrating of traditional and Western medicine, and using the Delphi method, an expert consensus on “Quality Control Indicators for Integrative Medicine in Ankylosing Spondylitis” was established (Beijing Association of the Integrating of Traditional and Western Medicine Standardization Expert Consensus Filing Number: 2021Z031A2). The consensus revision updates the 2021 version by adding four items, which will provide a reference for the quality control of integrated traditional Chinese and Western medicine for AS in China and help improve the current diagnosis and treatment status of AS.

Yoga in Pediatric Gastroenterology.

Pediatric use of yoga as an integrative medicine modality has increased in prevalence over the last several decades. In this article, we review the available evidence for yoga in pediatric gastrointestinal disorders. Evidence supports that in many pediatric disorders of gut brain interaction (DGBI), including irritable bowel syndrome, functional abdominal pain and functional dyspepsia, yoga decreases pain intensity and frequency and increases school attendance. Yoga has been shown to improve health-related quality of life and improve stress management as an effective adjunct to standard medical therapy in pediatric inflammatory bowel disease (IBD). Further studies are needed regarding optimal frequency, duration of practice and evaluation of the impact on IBD disease activity measures. Yoga may benefit pediatric gastroenterology patients with DGBIs and IBD through improving quality of life and reducing pain. Future yoga studies could investigate biomarkers and continued research will help integrate this modality into routine pediatric gastroenterology care.

A Survey of Utilization and Satisfaction of Korean Subfertility Treatment among Korean Women.

Low fertility is a critical social problem worldwide, and infertility has a prevalence of 15%. This cross-sectional study aimed to understand the factors affecting the usage and satisfaction of Korean medicine (KM) in subfertile women. An online survey was conducted from 3 November to 8 November 2021. The survey collected basic information, KM treatment experience, and satisfaction from women who experienced poor pregnancy. The t-test and chi-square test (χ2-test) were used to determine the overall characteristics of the subjects and factors affecting the utilization and satisfaction of KM treatment. Of the total of 29,465 people, 4922 read the survey email, and 601 responded. After excluding 51 respondents with questionable response patterns, 550 respondents were included in the final analysis. Of these, 43.1% (n = 237) had experience with conventional treatment, and 16.5% (n = 91) had received KM treatment. The group that received both KM treatment and CM treatment (n = 59, 24.9%) was significantly more prevalent than the group that received KM treatment alone (n = 32, 10.2%) (p = 0.00). Women who had given birth more than once or held a master's degree were significantly more willing to participate in the 'KM Support Project for Subfertility' program. Our findings suggest that subfertile patients prefer integrated treatment that combines KM and CM treatments. Further studies are needed to assess the status of integrative medicine treatment, satisfaction with each KM intervention, factors for low satisfaction, and patient requirements.

Swa-Anguli Pramana of Shira (Head) in Asthi-Sara-Purusha (Person Having Enriched Bone Tissue)

Ayurveda is an ancient Indian holistic medicine system focusing on promoting health by maintaining body balance. It is gaining relevance in today's integrative medicine landscape for treating chronic diseases. Key Ayurvedic concepts like Shira Pradesha, Maha Shira, and Asthi-Sara-Purusha contribute to individual health assessment. Methods: This review examines the applicability of Ayurvedic anthropometric methods, particularly Swa-Anguli Pramana, in current clinical practice. It includes discussions on validation studies and comparative analyses with modern techniques. Results: Swa-Anguli Pramana shows consistent personalized diagnostic potential across different demographic groups. Challenges exist regarding discrepancies with modern measurements and the need for standardization. Discussion: Integrating Ayurvedic measurements with modern metrics is likely to be valid and acceptable in contemporary healthcare. There is growing interest in traditional measurement methods for providing personal health information aligned with the holistic approach of Ayurveda. Conclusion: Ayurvedic anthropometric methods, especially Swa-Anguli Pramana, have potential for individualized health assessment. Standardization and validation are vital, and future research should focus on establishing a standardized integrative framework.

Integrative Korean medicine treatment for inpatients with osteoarthritis of the knee: An observational study.

The use of integrative Korean medicine treatment (IKMT) for patients with knee osteoarthritis (OA) has been reported previously; however, to date, no studies have investigated the long-term prognosis of these patients following IKMT for primary knee OA. We aimed to examine the long-term effects of IKMT in patients diagnosed with primary knee OA and receiving IKMT during hospitalization. This retrospective observational study, complemented by a follow-up survey, included patients with primary knee OA who received IKMT during hospitalization across 7 Korean medicine hospitals. The primary outcome was the Numerical Rating Scale knee-pain score, whereas the secondary outcomes were the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), EuroQol-5 dimension-5 level questionnaire (EQ-5D-5L), and Patient Global Impression of Change scores. Patients were evaluated at admission, discharge, and during follow-up. Of the 180 included patients, 81 responded to the survey. Compared with the corresponding values at admission, the Numerical Rating Scale score decreased by 2.44 (2.08-2.81) points at discharge and 1.89 (1.5-2.26) points at follow-up. Additionally, compared with their scores at admission, the WOMAC score decreased by 17.20 (13.68-20.71) points at discharge and 25.74 (22.22-29.26) points at follow-up, whereas the EuroQol-5 dimension-5 level questionnaire score improved by -0.15 (-0.18 to -0.12) points at discharge and -0.12 (-0.15 to -0.09) points at follow-up. The patients expressed high satisfaction with pharmacopuncture (65.4%), acupuncture (54.03%), physical therapy (35.8%), and herbal medicine (34.6%). Regarding Patient Global Impression of Change, 96.30% of the patients reported improvement. IKMT was effective in improving pain, functional disability, and quality of life in patients with primary knee OA. Its effects were maintained throughout the long-term follow-up period, and physical functions continuously improved.

Antimicrobial activity of curcuma longa and mimosa pudica: a comprehensive review

The active ingredient in turmeric, Curcuma longa, and the traditional medicinal plant, Mimosa pudica, have both been the subject of intensive research due to their wide range of therapeutic applications. The antibacterial, anti-inflammatory, and wound-healing qualities of Mimosa pudica have long been employed, whereas curcumin is well known for its anti-inflammatory, antioxidant, and anticancer benefits. The pharmacological advantages of these two naturally occurring substances are summarized in this article, which also discusses their possible synergistic effects, modes of action, and therapeutic uses. Our goal in examining the complimentary qualities of Mimosa pudica and curcumin is to present a through analysis that bolsters their application in integrative medicine and offers ideas for further research. Curcumin is known for its powerful anti-inflammatory, antioxidant, and anticancer properties. Its therapeutic success is related to its capacity to affect numerous cellular pathways, such as inhibiting NF-KB and activating AREs. These pathways play a vital role in reducing inflammation and oxidative stress, which contribute to chronic diseases like cancer, cardiovascular disease, and neurodegeneration. Curcumin's antibacterial characteristics make it a promising medicinal agent with broad-spectrum applications. Mimosa pudica, often known as the "sensitive plant" for its quick responsiveness to physical stimuli, has a long history in traditional medicine, especially in Ayurvedic and folk treatments. It is used for wound healing,anti-inflammatory, antibacterial, and anti-ulcer properties. The pharmacological actions of Mimosa pudica are primarily due to its rich composition of bioactive compounds, including alkaloids,flavonoids, tannins, and phenolic acids.These compounds collectively contribute to the plant's ability to modulate immune responses, promote tissue regeneration, and inhibit microbial growth.Curcumin and Mimosa pudica have complimentary mechanisms that can lead to synergistic effects. Curcumin modulates intracellular signaling pathways and transcription factors, while Mimosa pudica's bioactive ingredients also interact with extracellular targets and microbial cell walls, indicating a multimodal approach to illness management.

Challenges and solutions in developing an objective and structured clinical examination for complementary and integrative medicine: A mixed-method approach.

This study explores the challenges encountered by developers when creating objective and structured clinical examination (OSCE) modules specifically for Korean medicine (KM). The complexity of developing pattern identification (PI) items, due to the lack of standardized materials and ambiguity in KM, was a primary focus. A mixed-method approach was utilized, including a survey, importance-performance analysis, and focus group interviews. Seven developers participated, creating a total of 21 OSCE modules. The main difficulties identified were in developing PI items, selecting appropriate cases, crafting realistic examination situations, determining scoring criteria, setting up checklists, and writing scenarios. Challenges were categorized into "case," "examination situation," "postexamination notes," "checklist," "scenario," "format," and "PI." The importance-performance analysis revealed improvements in module development capabilities with each iteration. For the future development of efficient OSCE modules, standardization of KM diagnostic methods and PI is essential. The study highlights the need for social and academic efforts, as well as support from the KM education community and schools, to address these challenges and enhance the development process.

Herbal and Non-Herbal Dietary Supplements for Psychiatric Indications: Considerations in Liver Transplantation.

Traditional, complementary, and integrative medicine (TCIM) modalities are widely employed. However, TCIM, specifically herbal and non-herbal dietary supplements, can pose challenges in the context of organ transplantation. In this review, we discuss common supplements used for psychiatric purposes and highlight important considerations for candidates and recipients of liver transplants. Ashwagandha, kava kava, green tea extract, skullcap, turmeric, and valerian have known idiosyncratic hepatotoxic potential and may complicate the liver transplantation course. Multiple supplements reportedly carry a lower risk of hepatotoxicity, though evidence for widespread use in those at risk for or with hepatic impairment is limited. Psychiatrists caring for candidates and recipients of liver transplants must recognize that patients may find supplements helpful in alleviating psychiatric symptoms, despite an overall limited evidence base. Evaluating benefit versus risk ratios and reviewing drug-drug interactions is essential to promote transplant candidacy and mitigate the possibility of native or graft liver dysfunction.

Assessing the role and impact of research in clinical practice among acupuncturists in western countries: a multinational cross-sectional survey.

Evidence-informed practice is crucial to perform safe and efficient health interventions. In recent years, the evidence base of acupuncture continuously increased leading to the integration of acupuncture into clinical guidelines by various leading medical associations worldwide. At the same time, recent studies showed that licensed acupuncturists are rarely utilizing scientific research to inform their practice. This descriptive study using an online survey assessed the role of evidence-informed practice of acupuncturists in Austria, Germany, the United States of America, Australia, and New Zealand and aimed to determine critical factors relevant for promoting research literacy including demographical data, data about the clinical practice patterns, and the role and value of different information sources of traditional, complementary and integrative medicine (TCIM) practitioners. In total, 404 acupuncturists completed the online survey that included questions about demographic characteristics, the role and value of research in clinical practice, and details about the amount and type of continuing professional education. Univariate and multivariate analysis was used to determine significant predictors of the outcome variable "importance of research in clinical practice" (numerical rating scale, 0 to 100). The results showed that the majority of acupuncturists use certified courses as primary source of continuing professional education and value experts' opinions as the most reliable source of information. Multivariate analysis showed that the importance of research is dependent on the interest in research, an interdisciplinary learning environment, and positive experiences with research including if an acupuncture study ever changed the clinical practice of practitioners. Future educational programs should therefore focus on an interactive format aiming to promote skills to critically assess the value and practical use of research studies to improve the general practice of acupuncture.

Effectiveness and Safety of Pharmacopuncture on Inpatients with Tension Headache Caused by Traffic Accidents: A Pragmatic Randomized Controlled Trial.

Background: This study investigated the effectiveness and safety of pharmacopuncture for pain relief and functional improvement in patients with traffic accident (TA)-induced acute tension headaches. Methods: The study employed a parallel, single-centered, pragmatic, randomized controlled trial design. Eighty patients complaining of acute tension headaches were randomized into the integrative Korean medicine treatment (IKM treatment) group and the pharmacopuncture group on suboccipital muscles (suboccipital muscles pharmacopuncture + IKM treatment), with 40 participants assigned to each group. The patients in the pharmacopuncture group underwent pharmacopuncture as an add-on therapy, consisting of three sessions. Both groups were reassessed 2 months post-intervention. To assess the outcomes, the Numeric Rating Scale (NRS) for Headache, NRS for Neck Pain, Headache Disability Index, Headache Impact Test-6, EuroQol 5-Dimension, and Patient Global Impression of Change were used. Results: The improvement in the outcomes of the pharmacopuncture group was significantly greater than that of the comparison group on day 4 of hospitalization in terms of pain (difference in NRS of headache -2.59, 95% CI -3.06 to -2.12; NRS of Neck pain -1.05, 95% CI -1.50 to -0.59) and function (difference in HDI -24.78, 95% CI, -31.79 to -17.76; HIT-6 -6.13, 95% CI, -9.47 to -2.78). Additionally, in 2 months of follow-up, the recovery rate of headache was significantly higher in the pharmacopuncture group than in the comparison group. Conclusions: The pharmacopuncture group demonstrated superior outcomes in symptom improvement than the comparison group did, providing insights into novel and useful applications of pharmacopuncture in the clinical practice of Korean medicine.

Complementary and integrative medicine - Resolving situations of reduced remuneration for additional work under the SwissDRG system

Aim of the studyComplementary and integrative medicine (CIM) has been increasingly recognized as offering promising treatment adjunctions in various clinical settings, even amongst patients with serious, chronic, or recurrent illness. Today, only few tertiary care facilities in Switzerland offer dedicated CIM services for inpatients. The aim of the present study was to evaluate whether CIM services for complex medical conditions are adequately valued by the national inpatient SwissDRG reimbursement system. MethodsA simulation was performed by adding a specific code of the Swiss classification of interventions (CHOP) to the list of codes of each patient who received CIM therapies at the Lausanne University Hospital (CHUV) in 2021. This code is to be used when CIM services are provided. Hitherto, it was not entered due to a lack of specific documents justifying the resources used. The analysis focused on the impact of adding this CIM CHOP code on the Swiss Diagnosis Related Group (DRG) reimbursement. ResultsIn total, 275 patients received a CIM therapy in 2021. The addition of the CIM CHOP code 99.BC.12 (10–25 CIM sessions per stay) resulted in a simulated loss of income of CHF 766 630 for the hospital, while the net real result is already negative by more than CHF 6 million. The DRGs positively impacted by the addition of CIM CHOP code 99.BC.12 had a mean (SD) cost weight (CW) of 1.014 (0.620), while the DRGs negatively impacted had a mean (SD) CW of 3.97 (2.764) points. ConclusionIt is necessary to quickly react and improve the incentives contained in the grouping algorithm of the prospective payment system, whose effects can threaten the provision of adequate medical care to the patients despite suitable indications and potential for cost-savings.