As our fast-paced complex world advances through this century, coping with the huge challenges of today and facing even bigger ones in the future, there is an increasing concern about the need to provide for massive amounts of clean efficient and affordable power, addressing a difficult equation between security of supply, energy equity and environmental sustainability.In a more than ever electricity-driven energy-intense global world, full of huge environmental, socio-political and economic issues, every country, irrespectively of size, location, current political system or starting point, has ambitions to prosper and grow. In this context, some nations ambition to build strong large and modern power infrastructures almost from scratch while others face the imperative requirement to replace their “end of life” ageing and technically obsolete energy generation facilities. This reality, couple with the goals to combat climate change and improve national energy security and diversity, has brought nuclear power back as a top priority of the energy policy agenda.Nuclear new build seems today a very much reinvigorated option. But developing any large and complex multi-billion infrastructure is never an easy task, and even less it is for nuclear. Designing, promoting, licensing and building new nuclear power stations is without any doubt even more complex, controversial and risky option than any other large energy project. In the complex world we live in today, where a myriad of socio-political, legal, regulatory and financial considerations overshadow the intrinsic technical and engineering complexities a new nuclear power station has on its own, nothing should be taken for granted. If there is not a meticulously designed plan behind, ready to address the numerous types and levels of issues needed to be solved on these projects, from conception to final delivery, the chances nuclear new build projects will attract the right attention and finance at the right time would shrink.This paper tries to help in the task of definitely making nuclear new build a more robust and credible option to bet on and invest in. It presents a comprehensive model to evaluate, plan and manage a successful delivery for any new nuclear power project. It offers a practical, multidisciplinary and structured framework, which may be used by developers and key decision-makers in their attempt to identify, assess, prioritize, plan and manage in an integrative way all the main issues and topics around new build. Addressing the multiple dimensions and layers of complexity of these project/s with a more comprehensive, integrative and holistic eye, should be of significant assistance at the different stages of the process, from conceptualization to development and materialization, improving their value-propositions and ultimately the prospects of becoming a real success.The paper addresses and tries to give answer to the following questions:May the different goals and contexts in which nuclear new build can take place significantly influence or modify the way a project should be conceived, organised and executed? How might different set of tools apply?What does success mean? How can it be measured? Is it possible, sensible and useful to pursue an integrative and broadly-acceptable definition of Project’s success? should project’s success concept only refer to execution-related parameters such us time, cost and performance or be stretched by addressing all key stakeholders’ concerns within a whole asset life-cycle perspective? What are the critical factors and enabling conditions necessary for a nuclear new build project to thrive through the different development stages? How to identify, assess and address the main risk and blockers of the Project?How to develop an integrated project management and decision-making framework which helps to move the project forward in a well-orchestrated, smooth and steady manner? Which are the main milestones in this journey? Who are the main actors and how should they best interact and work together?Which are the main levers to improve the project’s prospects and make it more appealing for both the investment community and the general public? How to manage the journey from scepticism, hesitation and denial to approval, embrace and enthusiasm about the idea of new nuclear?How lessons coming from the past or more recent building experiences can be incorporated in the delivery of a new nuclear power stations?