The COVID-19 pandemic has subjected international relations to a severe stress test - at the level of both individual states and multilateral associations. Among the obvious challenges are the economic crisis, the crisis of global governance, the growth of protectionist and isolationist sentiments, the growing military confrontation along the US-China axis. The article focuses on two important areas of integration of the Greater Eurasia project - in the field of defense and security and in the economic sphere in the context of the pandemic. The first part of the article examines the challenges associated with the defense and security sector of Greater Eurasia, using the example of military cooperation between China and Russia. It is concluded that by 2016, an «average» level of military interaction had been achieved in Russian-Chinese relations, which opens up opportunities for further integration. However, given that relations between the two great powers are built on the basis of respect for national interests and sovereign equality, further military integration of Russia and China is being questioned. It is noted that in the face of growing contradictions between the PRC and the United States, the pandemic contributed to a more self-confident and assertive behavior of Beijing in the foreign arena. The second part of the article examines the economic and geographical dimension of the integration of Greater Eurasia on the example of relations between the Russian Federation and the PRC in the trade and economic sphere. It is indicated that the absence of an agreement on an additional reduction in oil production between Saudi Arabia, Russia and other OPEC+ countries and the corresponding collapse of oil prices have a significant impact on the development of economic integration in Greater Eurasia. Scenarios for the further economic development of this regional international community after the pandemic are proposed.