Output Of Instrument Research Articles

Sampling procedure for small-scale heterogeneities (crossbedding) for reservoir modelling

Sampling permeability from individual laminae in crossbedded rocks is very well possible by making use of a so-called probe permeameter. The methodology and calculation of permeabilities from the output of this instrument are fairly well-established. However, what is hardly established is a sampling strategy that guarantees adequate representation of permeability contrast between laminae. Especially so, because finer foreset and bottomset are difficult to sample, yet their permeabilities are critical to fluid flow through a crossbed. Therefore we propose to systematically sample laminae. To this end we suggest a sampling strategy that is adapted to the heterogeneity under study, namely to the thickness of the finer foreset.

Adenosine A2A receptor antagonism reverses the effects of dopamine receptor antagonism on instrumental output and effort-related choice in the rat: implications for studies of psychomotor slowing

Organisms frequently make effort-related decisions based upon assessments of motivational value and response costs. Energy-related dysfunctions such as psychomotor slowing and apathy are critically involved in some clinical syndromes. Dopamine (DA), particularly in the nucleus accumbens, regulates effort-related processes. Dopamine antagonism and accumbens dopamine depletions cause rats performing on choice tasks to reallocate their behavior away from food-reinforced tasks that have high response requirements. There is evidence of a functional interaction between DA and adenosine A(2A) receptors in the neostriatum and nucleus accumbens. The present experiments were conducted to determine if adenosine A(2A) receptor antagonism could reverse the effects of dopamine receptor antagonism on instrumental behavior and effort-related choice. The adenosine A(2A) receptor antagonist MSX-3 was investigated for its ability to reverse the effects of the dopamine receptor antagonist haloperidol (0.1 mg/kg) on fixed ratio 5 instrumental lever-pressing and on response allocation using a concurrent lever-pressing/chow-feeding choice task. Haloperidol significantly suppressed fixed ratio 5 responding, and with rats responding on the concurrent choice task, it altered choice behavior, significantly reducing lever-pressing for food and increasing chow intake. Injections of MSX-3 (0.5-2.0 mg/kg) produced a dose-related attenuation of the effects of 0.1 mg/kg haloperidol on both tasks. The high dose of MSX-3, when administered in the absence of haloperidol, did not significantly affect responding on either task. Adenosine and dopamine systems interact to regulate instrumental behavior and effort-related processes, which may have implications for the treatment of psychiatric symptoms such as psychomotor slowing or anergia.

Ship-borne electromagnetic induction Sounding of Sea-ice thickness in the Southern Sea of Okhotsk

AbstractRecent observations have revealed that dynamical thickening is dominant in the growth process of Sea ice in the Southern Sea of Okhotsk. That indicates the importance of understanding the nature of thick deformed ice in this area. The objective of the present paper is to establish a Ship-based method for observing the thickness of deformed ice with reasonable accuracy. Since February 2003, one of the authors has engaged in the core Sampling using a Small basket from the icebreaker Soya. Based on these results, we developed a new model which expressed the internal Structure of pack ice in the Southern Sea of Okhotsk, as a one-dimensional multilayered Structure. Since 2004, the electromagnetic (EM) inductive Sounding of Sea-ice thickness has been conducted on board Soya. By combining the model and theoretical calculations, a new algorithm was developed for transforming the output of the EM inductive instrument to ice + Snow thickness (total thickness). Comparison with total thickness by drillhole observations Showed fair agreement. The probability density functions of total thickness in 2004 and 2005 Showed Some difference, which reflected the difference of fractions of thick deformed ice.

Acoustic Output as Measured by Mechanical and Thermal Indices During Routine Obstetric Ultrasound Examinations

The purpose of this study was to quantify the acoustic output of clinical ultrasound instruments, as expressed by the thermal index (TI) and mechanical index (MI), during routine obstetric examinations. A prospective, observational study was conducted. Sonographers were unaware of the data being sought. Data were collected regarding duration of the examination and specific duration spent at each MI and TI. A total of 11 first-trimester, 14 second-trimester, and 12 third-trimester examinations were evaluated. The mean duration of the first-trimester examination was 8.9 minutes. The mean MI was 0.73 (range, 0.3-1.3), and the mean TI was 0.34 (0.1-1.7). The mean duration of the second-trimester examination was 31.8 minutes. The mean MI was 1.04 (0.5-1.5), and the mean TI was 0.28 (0.1-2.4). The mean duration of the third-trimester examination was 16.3 minutes. The mean MI was 1.06 (0.2-1.5), and the mean TI was 0.32 (0.1-2.4). Statistical significance existed across trimesters with regard to examination durations and MI (P < .001). However, no statistical significance existed in the TI across trimesters. During the third trimester, 3.5% of the examinations had a TI of greater than 1.0. Of these, 2.4% were between 1.0 and 1.49 and 1.1% were greater than 1.5. These changes (of TI > or = 1) were brief (mean +/- SD, 0.17 +/- 0.08 minutes) and were observed during the short periods of color Doppler imaging. Output levels during routine obstetric ultrasound examinations, as expressed by the MI and TI, are generally low. However, higher output levels, particularly TI levels of greater than 1.5, can be achieved, although they account for only a very small proportion of examination time.

Acoustic output as measured by mechanical and thermal indices during routine second trimester obstetrical ultrasound

Diagnostic ultrasound (DUS) has the potential to have bioeffects on living tissues. The Thermal Index (TI), expresses the potential for temperature rise at the ultrasound's focal point. The Mechanical Index (MI) indicates the potential for DUS to induce inertial cavitation in tissues. The present study was aimed at evaluating the acoustic output of clinical ultrasound instruments during second trimester exams and comparing acoustic output between B-mode and Doppler examinations.

Effects of Music Training on the Child's Brain and Cognitive Development

Research has revealed structural and functional differences in the brains of adult instrumental musicians compared to those of matched nonmusician controls, with intensity/duration of instrumental training and practice being important predictors of these differences. Nevertheless, the differential contributions of nature and nurture to these differences are not yet clear. The musician-nonmusician comparison is an ideal model for examining whether and, if so, where such functional and structural brain plasticity occurs, because musicians acquire and continuously practice a variety of complex motor, auditory, and multimodal skills (e.g., translating visually perceived musical symbols into motor commands while simultaneously monitoring instrumental output and receiving multisensory feedback). Research has also demonstrated that music training in children results in long-term enhancement of visual-spatial, verbal, and mathematical performance. However, the underlying neural bases of such enhancements and whether the intensity and duration of instrumental training or other factors, such as extracurricular activities, attention, motivation, or instructional methods can contribute to or predict these enhancements are yet unknown. Here we report the initial results from our studies examining the brain and cognitive effects of instrumental music training on young children in a longitudinal study and a cross-sectional comparison in older children. Further, we present a comparison of the results in these children's studies with observations from our cross-sectional studies with adults.

The relationship of seat backrest angle and neck injury in low-velocity rear impacts

Car-rear-impact-induced cervical spine injuries present a serious burden on society and, in response, seats offering enhanced protection have been introduced. Seats are evaluated for neck protection performance but only at one specific backrest angle, whereas in the real world this varies greatly owing to the variation in occupant physique. Changing the backrest angle modifies the seat geometry and thereby the nature of its interaction with the occupant. Low-velocity rear-impact tests on a BioRID II anthropomorphic test dummy (ATD) have shown that changes in backrest angle have a significant proportionate effect on dummy kinematics. A close correlation was found between changes in backrest angle and the responses of neck injury predictors such as lower neck loading and lower neck shear but not for the neck injury criterion NICmax. Torso ramping was evident, however, with negligible effect in low-velocity impacts. The backrest angle ranged from 20° to 30° whereas the BioRID II spine was adapted to a range from 20° to 26.5°. Nevertheless, in general, instrumentation outputs correlated well, indicating that this ATD could be used for evaluating seats over a 20–30° range rather than solely at 25° as required by current approval test specifications.

A comparison of two laser-based methods for determination of burn scar perfusion: Laser Doppler versus laser speckle imaging

Laser Doppler perfusion imaging (LDI) is an established technique for early assessment of burn depth to help determine a course of treatment. Laser speckle perfusion imaging (LSPI) is an alternative laser based, non-invasive perfusion monitoring technique that offers rapid and high resolution images of tissue. We have evaluated the ability of the LSPI instrument in determining and monitoring burn scar perfusion over time and compared it with the LDI instrument as a standard. Methods: Ten patients with hypertrophic burn scars (time since injury: 1–8 months) were recruited. Burn scars were scanned with both instruments (LSPI and LDI) monthly over a period of 11 months. Clinical grading of the burn scars was assessed on every scan date using the Vancouver burn scar scale. Results: Comparison of the perfusion values determined by each instrument shows a strong positive correlation, r 2 = 0.86 ( n = 63). Each instrument's output also correlated significantly with the clinical grading of the scar, indicating the expected decrease in perfusion as the clinical condition of the scars improved with time. Significance: The new LSPI instrument compared favorably with the established LDI instrument, yielding similar results. The considerably faster scan time and higher resolution of the LSPI method provides a distinct clinical advantage, both in terms of patient comfort and for reliably matching perfusion characteristics to their associated anatomical features. The fast temporal response of the LSPI instrument could be used to monitor near real-time responses to mechanical or pharmacological interventions to study dynamic vascular changes to burn damaged tissues.

SCUBA: The Self-Contained Unified Bass Augmenter

The Self-Contained Unified Bass Augmenter (SCUBA) is a new augmentative OSC (Open Sound Control) controller for the tuba. SCUBA allows new expressive possibilities by adding onboard continuous and discrete sensors to provide user-controlled parametric data for the processing of the instruments natural sound in Pd. SCUBA endows acoustic instruments with parametric control of virtual instruments and provides a means of integrating the output of a virtual instrument with the natural sound of the tuba. The user sends controller data from the augmented tuba interface to the virtual instrument via FSRs (Force-Sensitive Resistors) and buttons mounted on the existing instrument interface. An AVRMini microcontroller converts raw sensor data to OSC (Open Sound Control) messages, which are mapped in Pd to control virtual instrument parameters. Virtual instrument output is integrated into the solo instrument interface via satellite speakers mounted in the bell; this allows for mixing of the instruments natural sound with that of the virtual instrument to create the impression of a single instrument. This integration is the goal of the SCUBA project: by providing a flexible but unified control interface and acoustic output, traditional acoustic instrument interfaces can be augmented and paired with virtual musical instruments. [We would like to thank Michael Gurevich, Max Matthews, Bill Verplank, Pascal Stang, and classmates from Music 250 (Fall 04) for assistance in the realization of this project.]

Evaluation of Serum Protein Profiling by Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Detection of Prostate Cancer: I. Assessment of Platform Reproducibility

Protein expression profiling for differences indicative of early cancer has promise for improving diagnostics. This report describes the first stage of a National Cancer Institute/Early Detection Research Network-sponsored multiinstitutional evaluation and validation of this approach for detection of prostate cancer. Two sequential experimental phases were conducted to establish interlaboratory calibration and standardization of the surface-enhanced laser desorption (SELDI) instrumental and assay platform output. We first established whether the output from multiple calibrated Protein Biosystem II SELDI-ionization time-of-flight mass spectrometry (TOF-MS) instruments demonstrated acceptable interlaboratory reproducibility. This was determined by measuring mass accuracy, resolution, signal-to-noise ratio, and normalized intensity of three m/z "peaks" present in a standard pooled serum sample. We next evaluated the ability of the calibrated and standardized instrumentation to accurately differentiate between selected cases of prostate cancer and control by use of an algorithm developed from data derived from a single site 2 years earlier. When the described standard operating procedures were established at all laboratory sites, the across-laboratory measurements revealed a CV for mass accuracy of 0.1%, signal-to-noise ratio of approximately 40%, and normalized intensity of 15-36% for the three pooled serum peaks. This was comparable to the intralaboratory measurements of the same peaks. The instrument systems were then challenged with sera from a selected group of 14 cases and 14 controls. The classification agreement between each site and the established decision algorithm were examined by use of both raw peak intensity boosting and ranked peak intensity boosting. All six sites achieved perfect blinded classification for all samples when boosted alignment of raw intensities was used. Four of six sites achieved perfect blinded classification with ranked intensities, with one site passing the criteria of 26 of 28 correct and one site failing with 19 of 28 correct. These results demonstrate that "between-laboratory" reproducibility of SELDI-TOF-MS serum profiling approaches that of "within-laboratory" reproducibility as determined by measuring discrete m/z peaks over time and across laboratories.

Strapdown at the Crossroads

Algorithms needed for processing raw strapdown inertial instrument outputs, long regarded as the exclusive province of experts, can be dramatically simplified for most applications. If extended coast durations are not required (because of repetitive updates), error propagation is also vastly simplified. After quantifying that coast duration in relation to gyro and accelerometer quality, this paper describes straightforward computational procedures capitalizing on modern processing capabilities. Conclusions are validated by description of results with measured data in the literature.

Near‐infrared Fourier transform surface‐enhanced Raman scattering spectroscopy of 1,4‐benzodiazepine drugs employing gold films over nanospheres

AbstractSERS spectra of eight benzodiazepine drugs were recorded with an FT‐NIR Raman spectrometer employing AuFONs (gold films over nanospheres) as SERS‐active substrates. A tentative assignment of the vibrational bands was made by comparison with the Raman spectra of crystalline reference samples and the results of density functional theory (DFT) calculations. It is concluded that the bands observed in the SERS spectra are almost exclusively due to vibrations located on rings a and b of the benzodiazepine moiety. The latter should be adsorbed with the molecular plane essentially orthogonal to the metal surface. However, different adsorption geometries are postulated for derivatives containing NH or NCH3 groups. It is demonstrated that a few hundred nanograms of analyte per well are sufficient to record spectra that allow identification and discrimination of the drugs. Such amounts can be collected at the output of an HPLC instrument employed for separating these drugs from blood serum. Copyright © 2004 John Wiley &amp; Sons, Ltd.

Utility of pedometers for assessing physical activity: construct validity.

Valid assessment of physical activity is necessary to fully understand this important health-related behaviour for research, surveillance, intervention and evaluation purposes. This article is the second in a companion set exploring the validity of pedometer-assessed physical activity. The previous article published in Sports Medicine dealt with convergent validity (i.e. the extent to which an instrument's output is associated with that of other instruments intended to measure the same exposure of interest). The present focus is on construct validity. Construct validity is the extent to which the measurement corresponds with other measures of theoretically-related parameters. Construct validity is typically evaluated by correlational analysis, that is, the magnitude of concordance between two measures (e.g. pedometer-determined steps/day and a theoretically-related parameter such as age, anthropometric measures and fitness). A systematic literature review produced 29 articles published since > or =1980 directly relevant to construct validity of pedometers in relation to age, anthropometric measures and fitness. Reported correlations were combined and a median r-value was computed. Overall, there was a weak inverse relationship (median r = -0.21) between age and pedometer-determined physical activity. A weak inverse relationship was also apparent with both body mass index and percentage overweight (median r = -0.27 and r = -0.22, respectively). Positive relationships regarding indicators of fitness ranged from weak to moderate depending on the fitness measure utilised: 6-minute walk test (median r = 0.69), timed treadmill test (median r = 0.41) and estimated maximum oxygen uptake (median r = 0.22). Studies are warranted to assess the relationship of pedometer-determined physical activity with other important health-related outcomes including blood pressure and physiological parameters such as blood glucose and lipid profiles. The aggregated evidence of convergent validity (presented in the previous companion article) and construct validity herein provides support for considering simple and inexpensive pedometers in both research and practice.

Cmos microsystem for ac current measurement with galvanic isolation

In this paper, we present an integrated ac current sensor based on sensitivity-optimized horizontal Hall effect devices and a differential readout chain. This microsystem has been designed for 5-A rms nominal ac current measurement with 5-kV galvanic isolation and 0.5% accuracy after calibration from 250 mA to 5 A, over 1.5-kHz bandwidth, which allows up to 30th (25th) harmonic detection in 50-Hz (60-Hz) applications. This qualifies the current sensor microsystem for class 1 products according to international norms for energy meters (IEC44-1 and IEC1036). From the sensing element throughout the instrumental chain's output, the signal conditioning is exclusively performed by low-noise standard CMOS analog blocks. Moreover, the whole microsystem features a mixed-signal structure dedicated to auto-balancing.

A novel method for automatic genotyping of microsatellite markers based on parametric pattern recognition.

Genetic mapping of loci affecting complex phenotypes in human and other organisms is presently being conducted on a very large scale, using either microsatellite or single nucleotide polymorphism (SNP) markers and by partly automated methods. A critical step in this process is the conversion of the instrument output into genotypes, both a time-consuming and error prone procedure. Errors made during this calling of genotypes will dramatically reduce the ability to map the location of loci underlying a phenotype. Accurate methods for automatic genotype calling are therefore important. Here, we describe novel algorithms for automatic calling of microsatellite genotypes using parametric pattern recognition. The analysis of microsatellite data is complicated both by the occurrence of stutter bands, which arise from Taq polymerase misreading the number of repeats, and additional bands derived form the non-template dependent addition of a nucleotide to the 3' end of the PCR products. These problems, together with the fact that the lengths of two alleles in a heterozygous individual may differ by only two nucleotides, complicate the development of an automated process. The novel algorithms markedly reduce the need for manual editing and the frequency of miscalls, and compares very favourably with commercially available software for automatic microsatellite genotyping.

LOINC, a universal standard for identifying laboratory observations: a 5-year update.

The Logical Observation Identifier Names and Codes (LOINC) database provides a universal code system for reporting laboratory and other clinical observations. Its purpose is to identify observations in electronic messages such as Health Level Seven (HL7) observation messages, so that when hospitals, health maintenance organizations, pharmaceutical manufacturers, researchers, and public health departments receive such messages from multiple sources, they can automatically file the results in the right slots of their medical records, research, and/or public health systems. For each observation, the database includes a code (of which 25 000 are laboratory test observations), a long formal name, a "short" 30-character name, and synonyms. The database comes with a mapping program called Regenstrief LOINC Mapping Assistant (RELMA(TM)) to assist the mapping of local test codes to LOINC codes and to facilitate browsing of the LOINC results. Both LOINC and RELMA are available at no cost from http://www.regenstrief.org/loinc/. The LOINC medical database carries records for >30 000 different observations. LOINC codes are being used by large reference laboratories and federal agencies, e.g., the CDC and the Department of Veterans Affairs, and are part of the Health Insurance Portability and Accountability Act (HIPAA) attachment proposal. Internationally, they have been adopted in Switzerland, Hong Kong, Australia, and Canada, and by the German national standards organization, the Deutsches Instituts für Normung. Laboratories should include LOINC codes in their outbound HL7 messages so that clinical and research clients can easily integrate these results into their clinical and research repositories. Laboratories should also encourage instrument vendors to deliver LOINC codes in their instrument outputs and demand LOINC codes in HL7 messages they get from reference laboratories to avoid the need to lump so many referral tests under the "send out lab" code.

Nucleus accumbens dopamine and work requirements on interval schedules

Considerable evidence indicates that nucleus accumbens dopamine (DA) is involved in the regulation of instrumental response output, and that interference with DA transmission disrupts the ability of rats to overcome work-related response costs. The present experiments were conducted to assess the effects of accumbens DA depletions on the performance of variable interval schedules, to determine if the intermittence of a schedule, in itself, is an important determinant of sensitivity to accumbens DA depletions. For this purpose, two variable interval 30 s lever pressing schedules were used, each with different response requirements added to the interval requirement. For one of the schedules, the animals were reinforced for the first response after the interval elapsed (tandem variable interval/fixed ratio 1: VI/FR1). On the other schedule an additional work requirement was attached by requiring the rats to make five responses after the interval in order to receive reinforcement (tandem variable interval/fixed ratio 5: VI/FR5). Attachment of the additional work requirement led to greater response rates during baseline training. After training, rats were injected with either ascorbate vehicle or 6-hydroxydopamine (6-OHDA) into the nucleus accumbens. The effects of DA depletion on responding were highly schedule-dependent. DA depletions had no significant effect on lever pressing under the condition with low response requirement (VI/FR1), but these depletions substantially disrupted responding on the schedule with the higher response requirement (VI/FR5). The disruption of responding on the schedule with the high response requirement showed recovery over the 4 weeks of post-surgical testing. In a second experiment, the effect of 6-OHDA on spontaneous locomotion in an open field was assessed. The DA-depleted animals had impairments in locomotion and rearing compared with the vehicle treated rats when tested 8 days after surgery, but not when tested 29 days after surgery, which demonstrates recovery of locomotor function after the accumbens DA depletions. The results of these experiments support the hypothesis that nucleus accumbens DA is involved in regulating behavioral activation. The lever pressing experiment indicates that depletions of DA in the accumbens interfere with the processes that enable rats to overcome behavioral constraints such as work-related response costs, and suggest that the intermittence of reinforcement per se is not the most critical factor in determining sensitivity to accumbens DA depletions.

Is functional gain really functional?

Is functional gain really functional?

A proposed polarity standard for multicomponent seismic data

This paper proposes a multicomponent acquisition and preprocessing polarity standard that will apply generally to the three Cartesian geophone components and the hydrophone or microphone components of a 2‐D or 3‐D multicomponent survey on land, at the sea bottom, acquired as a vertical seismic profile, vertical‐cable, or marine streamer survey. We use a four‐component ocean‐bottom data set for purposes of illustration and example. A primary objective is a consistent system of polarity specifications to facilitate consistent horizon correlation among multicomponent data sets and enable determination of correct reflectivity polarity.The basis of this standard is the current SEG polarity standard, first enunciated as a field‐recording standard for vertical geophone data and hydrophone streamer data. It is founded on a right‐handed coordinate system: z positive downward; x positive in the forward line direction in a 2‐D survey, or a specified direction in a 3‐D survey, usually that of the receiver‐cable lines; and y positive in the direction 90° clockwise from x. The polarities of these axes determine the polarity of ground motion in any component direction (e.g., downward ground motion recording as positive values on the vertical‐geophone trace). According also to this SEG standard, a pressure decrease is to be recorded as positive output on the hydrophone trace. We also recommend a cyclic indexing convention, [W, X, Y, Z] or [0, 1, 2, 3], to denote hydrophone or microphone (pressure), inline (radial) geophone, crossline (transverse) geophone, and vertical geophone, respectively.We distinguish among three kinds of polarity standard: acquisition, preprocessing, and final‐display standards. The acquisition standard (summarized in the preceding paragraph) relates instrument output solely to sense of ground motion (geophones) and of pressure change (hydrophones). Polarity considerations beyond this [involving, e.g., source type, wave type (P or S), direction of arrival, anisotropy, tap‐test adjustments, etc.] fall under preprocessing polarity standards. We largely defer any consideration of a display standard.

PLANCK: Systematic effects induced by periodic fluctuations of arbitrary shape

A fundamental requirement in the new generation of high resolution Cosmic Microwave Background imaging experiments is a strict control of systematic errors that must be kept at K level in the nal maps. Some of these errors are of celestial origin, while others will be generated by periodic fluctuations of the satellite environment. These environment instabilities will cause fluctuations in the measured signal output thus generating correlated eects in the reconstructed maps. In this paper we present an analytical study of the impact of periodic signal fluctuations on the measured sky maps produced by the Planck survey. In particular we show how it is possible to estimate analytically the damping factor of the peak-to-peak amplitude of the fluctuation at the instrument output after the projection in the nal maps.