Choice Of Instruments Research Articles

Quantitative Endogenous Polyamine Analysis via Capillary Electrophoresis/Mass Spectrometry: Characterization and Practical Considerations.

Commonly used analytical techniques for polyamine analysis, including derivatization and mixed-mode liquid chromatography (LC), have inherent disadvantages. Capillary electrophoresis (CE) is uniquely suited to analyze small, highly charged molecules because analytes are separated on the basis of their electrophoretic mobility, not polarity or association with a stationary phase. Microfluidic CE-mass spectrometry (mCE-MS) is a relatively recent addition to commercially available CE offerings that streamlines traditional CE-MS interfacing and has the potential to improve upon classic CE challenges to robustness and reproducibility. MS instrument choice and scanning parameters are strongly influenced by a need for high acquisition rate to adequately sample CE peaks. Alternatively, isotachophoresis on loading can be intentionally avoided to produce sufficiently wide peaks. The mCE platform utilized here performed very well in many metrics; a limit of detection (LOD) as low as 0.25ng/mL was achieved for spermidine, and endogenous spermidine was easily detected in blood with this method. Both of these are challenging tasks for any separation technique and demonstrate a strong use case for the platform. During experimentation, various idiosyncrasies in the commercial CE-MS interface resulted in extensive chip-to-chip variability in both peak shape and LOD, complicating the application to robust absolute quantitation. Practical guidance for similar analyses is provided.

INTEGRATING CLIMATE POLICY OBJECTIVES INTO MUNICIPAL LAND POLICIES: From conceptualization to empirical evidence from Finland

AbstractUrban development ties in closely with climate change mitigation and adaptation. However, little is known about how climate policy objectives are incorporated into municipal land policies. Addressing this knowledge gap, we draw from the literature on policy integration and policy design to propose a framework for conceptualizing the ways in which policy objectives driven by climate concerns are incorporated into land policy. This framework incorporates three dimensions: 1) the alignment and prioritization of climate policy objectives in land policy; 2) the concreteness of the final integrated policy design; and 3) the commitment to promoting the objectives set through choices of policy instruments. We apply this framework to explore the level of integration in 30 highly populated municipalities in Finland. We identify three levels of climate policy objective integration within this sample, with only three municipalities demonstrating high integration. Our findings suggest that raising the level of climate policy integration into land policy may require institutional support.

Cognitive functioning in people with psychotic experiences: a systematic review and meta-analysis study.

Earlier research suggested that psychotic experiences (PEs), the extended-psychosis phenotype, are associated with cognitive impairment. Recent studies, however, revealed more mixed findings, and patterns and magnitude of cognitive deficits in PEs remain uncertain. We aimed to systematically review and quantitatively synthesize estimates of cognitive functioning covering a wide array of domains in individuals with versus without PEs. We systematically searched four databases from inception to 6 July 2023. We generated pooled effect size (Hedges'g) using random-effects models. Subgroup analyses and meta-regression examining the moderating effect of sex, age at PE assessment, study design, cognitive task, and PE assessment instrument on cognitive functioning were performed when applicable. The study was registered with PROSPERO (CRD42023442528). Twenty-seven and six studies were included for meta-analysis of cognitive functioning comparing individuals with versus without PEs (n = 82,561; 10,251 individuals with PEs) and individuals with high-level versus low-level PEs (n = 8062; 813 individuals with high-level PEs), respectively. Individuals with PEs exhibited worse cognitive performance in general cognition (Hedges'g = -0.10 [95%CI = -0.18 to -0.02]), verbal fluency (Hedges'g = -0.05 [95%CI = -0.10 to -0.00]), visual memory (Hedges'g = -0.21 [95%CI = -0.38 to -0.03]), and working memory (Hedges'g = -0.16 [95%CI = -0.28 to -0.04]). Meta-regression revealed that general cognition associated with PEs was related to younger age (z = 3.37, p = 0.001), male sex (z = -2.59, p = 0.010), and cognitive assessment before PE assessment (z = -2.15, p = 0.031), whereas working memory in individuals with PEs was associated with concurrent cognitive and PE assessment (z = 6.19, p < 0.001). We failed to find moderating effect of the choice of PE assessment instrument or cognitive task on cognitive functioning in PEs. Additional analysis showed no significant difference in the performance of any cognitive domains between individuals with high-level versus low-level PEs. Limitations included studies primarily derived from Western countries, no social-cognitive domains, and varied PE measurement. In sum, PEs are associated with milder and more circumscribed cognitive impairment relative to psychotic disorders. Future research is required to clarify differential cognitive trajectories between individuals with transient PEs and persistent/recurrent-PEs.

Foreign bodies in the gastrointestinal tract in children: algorithm of management and choice of instruments for endoscopic removal

BACKGROUND: A foreign body (FB) in the gastrointestinal tract (GIT) may require either emergent removal or careful observation till its natural coming out. The effectiveness of endoscopic procedure (EP) in pediatrics depends on adequate medical knowledge and medical equipment. Not uncommon, endoscopists and surgeons from adult medical centers remove FB in children. Over the past decades, EP in the GIT has become the safest and most successful technique for FB diagnosis and removal. Up to now, there is no algorithm for managing and removing FB in children, or it does not always meet needs in clinical practice. To assess and choose the most optimal endoscopic equipment and instrumental accessories regarding child’s age, FB type and its harmful effects is still an important issue. AIM: To improve a management algorithm and selection of optimal equipment to ensure timely diagnostics and successful endoscopic removal of FBs from GIT in children. METHODS: A retrospective three-center analysis of children’s medical histories with suspected FBs in GIT from 2017 to 2020. The following parameters were analysed: clinical, X-ray and endoscopic diagnostic techniques depending on patient's age, FB location, its type and radiopacity, time before its removal, as well as type and effectiveness of endoscopic instrument, duration of endoscopic procedure, its effectiveness and complications, if any. RESULTS: 1173 children were taken in the study (boys n=676, girls n=497,) average age 3.5±3.3, (0–17 y.o.). FB diagnosis was confirmed in 1008 (100%) patients; endoscopy was performed in 756 (75%) cases; endoscopic removal — in 751 out of 756 cases. Surgeries were made to three children with giant trichobezoars and to two children with magnet objects which were complicated by perforation in one case and by intestinal obstruction in the other one. The performed retrospective analysis of children’s medical histories with suspected GIT FBs allowed to modify the algorithm of multidisciplinary approach to the management and endoscopic removal of swallowed objects. Examination by an ENT specialist and a pediatric surgeon was mandatory at the reception department. The pediatric surgeon formulated indications for X-ray examination in two projections. The confirmed fact of FB swallowing and X-ray findings could be indicators for CT scanning. After FB presence has been confirmed, the patient is jointly consulted by a pediatric surgeon, anesthesiologist and endoscopist so as to determine indications and time interval for removing a swallowed object endoscopically. Endoscopic instruments — net, rat tooth, forceps, loop and basket — turned out to be the most universal ones for removing four FB types, with the best average time of the procedure. There were no complications related to FB endoscopic removal. CONCLUSION: The proposed algorithm modification in child’s management and removal of GIT FB, the optimal choice of endoscopic equipment and manipulation accessories depending on patient’s age, FB location, type and its harm are key points to its successful and effective FB removal in children.

Classification of Quality Management Methods and Tools in a Functional Approach

Theoretical background: The evolution of the instrumentation of quality management makes the list of methods and tools constantly open and inexhaustible. The problems of dividing and classifying quality management instruments are very often discussed in the literature. The need to have a variety of methods and tools is due to the fact that the development of modern competitive strategies, affecting the strengthening of market position, the need for rapid decision-making, as well as progress, mainly in the field of information technology and continuous changes in markets, pose qualitatively new challenges to managers. Purpose of the article: The purpose of this article is to present selected quality management instrumentation by process group. Research methods: In this article, literature review was the starting point for empirical research. Finally, a set of fifty new and classic quality management methods and tools in relation to their main functions was analysed. Based on this, data tables were generated. Main findings: In a large collection of methods, tools and solutions, new concepts appear that are multi-disciplinary and require interdisciplinary knowledge. The choice of appropriate quality instruments is determined by the specificity of the organization and many other variables. The correct use of quality management instruments contributes to solving problems at the management and executive levels of production enterprises, while enriching knowledge about processes.

Comparing EQ-5D-5L, PROPr, SF-6D and TTO utilities in patients with chronic skin diseases.

We aim to compare the measurement properties of three indirect (EQ-5D-5L, PROPr, SF-6D) and one direct (time trade-off, TTO) utility assessment methods in patients with chronic skin diseases. 120 patients with physician-diagnosed chronic skin diseases (psoriasis 39%, atopic dermatitis 27%, acne 19%) completed a cross-sectional survey. Respondents completed the EQ-5D-5L, PROMIS-29+2 and SF-36v1 questionnaires and a 10-year TTO task for own current health. Utilities were computed using the US value sets. Ceiling, convergent and known-group validity were compared across the utilities derived with these four methods. Known-groups were defined based on general, physical and mental health. The agreement between utilities was assessed using intraclass correlation coefficients (ICC). Mean utilities for the EQ-5D-5L, PROPr, SF-6D and TTO were 0.79, 0.47, 0.76 and 0.89. In corresponding order, the ceiling was 28%, 0%, 2% and 65%. The SF-6D showed excellent agreement with the EQ-5D-5L (ICC = 0.770). PROPr demonstrated poor agreement with the EQ-5D-5L (ICC = 0.381) and fair with SF-6D utilities (ICC = 0.445). TTO utilities showed poor agreement with indirectly assessed utilities (ICC = 0.058-0.242). The EQ-5D-5L better discriminated between known groups of general and physical health, while the SF-6D and PROPr outperformed the EQ-5D-5L for mental health problems. There is a great variability in utilities across the four methods in patients with chronic skin conditions. The EQ-5D-5L, despite its higher ceiling, appears to be the most efficient in discriminating between patient groups for physical health aspects. Our findings inform the choice of instrument for quality-adjusted life year calculations in cost-utility analyses.

Monetary policy transmission dynamics: evidence from Indian financial markets

ABSTRACT Our study employs a non-recursive Structural Vector Autoregressive Model (SVAR) to examine to how monetary policy signals transmit across the money, treasury bills, bonds, forex, and the stock market in India and in the process unravel the relative efficacy of various monetary policy signalling instruments on these financial market variables. This exercise is conducted for two distinct monetary policy regimes -Multiple Indicator Regime and Flexible Inflation Targeting Regime. Our results indicate that the transmission of monetary policy differs not only across various segments of the financial markets, but is also sensitive to the choice of monetary policy instruments used by the Reserve Bank of India (RBI) under different regimes. In a bid to heighten the efficacy of monetary policy signals it is hence suggestive that developing economies with high inflation should move towards an inflation targeting regime.

Perioperative outcomes using computer navigation in primary total shoulder arthroplasty

IntroductionThe utilization of computer navigation to improve glenoid component placement in primary total shoulder arthroplasty (TSA) is becoming increasingly prevalent. However, there is a paucity of literature examining the perioperative outcomes and cost of this technology compared to standard instrumentation. The purpose of this study was to compare the perioperative complications and healthcare utilization between computer navigation and standard instrumentation in primary TSA. MethodsThe Nationwide Readmissions Database was queried from 2016 to 2020 to identify patients who underwent elective primary TSA. Patients who underwent TSA with computer navigation (n = 752) were propensity score matched in a 1:3 proportion to patients who underwent TSA with standard instrumentation (n = 2256) for age, sex, smoking status, alcohol abuse, hypertension, diabetes mellitus, congestive heart failure, obesity, peripheral vascular disease, chronic kidney disease, chronic liver disease, and chronic lung disease. Bivariate statistical analyses were performed to compare preoperative demographic and comorbidity data, postoperative complications, and hospital utilization metrics between the 2 groups. Chi-square and student t-tests identified differences in categorical and continuous variables, respectively. ResultsPatients undergoing TSA with computer navigation exhibited lower rates of revision within 180 days (P < .001) and lower rates of certain postoperative medical and surgical complications, including acute renal failure (P = .006), urinary tract infection (P = .015), acute respiratory distress syndrome (P = .045), surgical site infection (P = .022), dislocation (P = .012), and prosthetic loosening (P = .032). Computer navigation patients had a higher cost of initial admission (P < .001) but were less likely to have extended hospital stays (P = .047), less likely to be discharged with home healthcare (P < .001), and more likely to be discharged routinely (P < .001). ConclusionTSA with computer navigation was associated with lower revision rates and reduced postoperative complications. Although greater initial costs were observed, decreased extended hospital stays and more routine discharges show promise for long-term cost efficiency. These findings underscore the advantages of computer navigation in TSA and should be considered by orthopedic surgeons when evaluating choice of instrumentation.

Patient and public involvement and engagement in the ASCEND PLUS trial: reflections from the design of a streamlined and decentralised clinical trial

IntroductionASCEND PLUS is a randomised controlled trial assessing the effects of oral semaglutide on the primary prevention of cardiovascular events in around 20,000 individuals with type 2 diabetes in the UK. The trial’s innovative design includes a decentralised direct-to-participant invitation, recruitment, and follow-up model, relying on self-completion of online forms or telephone or video calls with research nurses, with no physical sites. Extensive patient and public involvement and engagement (PPIE) was essential to the design and conduct of ASCEND PLUS.AimTo report the process and conduct of PPIE activity in ASCEND PLUS, evaluate effects on trial design, reflect critically on successes and aspects that could have been improved, and identify themes and learning relevant to implementation of PPIE in future trials.MethodsPPIE activity was coordinated centrally and included six PPIE focus groups and creation of an ASCEND PLUS public advisory group (PAG) during the design phase. Recruitment to these groups was carefully considered to ensure diversity and inclusion, largely consisting of adults living with type 2 diabetes from across the UK. Two members of the PAG also joined the trial Steering Committee. Steering Committee meetings, focus groups, and PAG meetings were conducted online, with two hybrid workshops to discuss PPIE activity and aspects of the trial.ResultsPPIE activity was critical to shaping the design and conduct of ASCEND PLUS. Key examples included supporting choice for participants to either complete the screening/consent process independently online, or during a telephone or video call interview with a research nurse. A concise ‘initial information leaflet’ was developed to be sent with the initial invitations, with the ‘full’ information leaflet sent later to those interested in joining the trial. The PAG reviewed the content and format of participant- and public-facing materials, including written documents, online screening forms, animated videos, and the trial website, to aid clarity and accessibility, and provided input into the choice of instruments to assess quality of life.ConclusionsPPIE is integral in ASCEND PLUS and will continue throughout the trial. This involvement has been critical to optimising the trial design, successfully obtaining regulatory and ethical approval, and conducting the trial.

Summary of Evidence on the Impact of Mindfulness Training on Anxiety Levels of Pregnant Women

Background: Mental health during pregnancy is a global health problem, the percentage of pregnant women with antenatal anxiety or mood disorders ranges from 15% and 25%, with generalized anxiety disorder as the most common factor in the illness. Most of the research findings show a relationship between mothers’ psychological distress and poor prognosis for either the mother or the infant. Low well-being during pregnancy has significant adverse impacts on both mother and infant. Therefore, it is important to focus on antenatal anxiety and psychological stress in pregnant women. Mindfulness training, defined as an intentional and non-judgmental awareness of experience in the present moment, it is the most common intervention for antenatal education. Although the impact of positive thinking interventions on antenatal maternal well-being has been increasingly examined, the results still have not been systematically evaluated. Aim: This paper aims to systematically evaluate the effects of positive thinking interventions on evidence of antenatal anxiety in pregnant women and current research methods with a population of pregnant women by evaluating five studies of Randomized Controlled Trials (RCTs) using the CASP checklist tool. Summarize the implications of the evaluation results for future studies, and finally provide practical insights and research recommendations. Methods: Firstly, the research topic is identified: patient/problem: pregnancy anxiety; intervention: intervention in positive thinking; comparison: usual care. A complete internet-based search of five databases was conducted through Academic Search Complete, Medical Line, CINAHL, Health Source: Nursing/Academic Edition and Google Scholar to identify randomized controlled trials assessing positive thinking training versus postnatal depression controls. To select higher quality and relevant articles, the author rechecked titles and abstracts exclusion criteria and manually searched five peer-reviewed RCT articles from the last five years by further evaluating reference lists, while focusing on assessing interventions, measurement scale outcomes, study sample results, strengths and limitations. Secondly, randomized controlled trials were assessed using the CASP Randomized Controlled Trial Criteria Checklist. This version has now been updated to the 2020 Access Guide. Results: This paper provides a specific review of five RCT studies by using the CASP assessment tool, and concludes that positive thinking training shows potential benefits in terms of prenatal depression, anxiety and negative affect levels. From a comparison of the five intervention modalities of the positive thinking intervention, Mindfulness-integrated Cognitive Behavior Therapy (MICBT) had the broadest range of interventions and the most comprehensive curriculum. Most of the studies had small sample sizes of participants and an increase in sample size and longer follow-up time through comparative analysis would be beneficial to generalizability, therefore a sample size of 50 people on average between the intervention and control groups was chosen as appropriate, with a follow-up time of at least one month and three months. Also, the presence of potential bias was mentioned in these studies, by comparing randomized classification methods it was found that the smaller the base difference present through computer allocation and single-blind allocation, the less systematic bias there was. The choice of measurement instruments did not conflict with the sample size, the cultural background of the population and the findings. However, positive effects on anxiety and stress during pregnancy were less consistent with the assessment tool for the intervention group. Self-report instruments are highly sensitive and idiosyncratic, coupled with the tendency of participants to interact with researchers to produce bias. Therefore, when selecting a measurement tool, the best approach is to combine a self-report instrument with a researcher’s assessment. The literature highlights the increased interest in this area in recent years. Coupled with the prevalence of methodological issues and variation between studies, the current review is timely and necessary to determine intervention effects and best practice for future research. Findings: Mindfulness training is a useful intervention for improving anxiety and stress during pregnancy, but future research recommendations must follow robust methodological criteria with expanded sample sizes and longer follow-ups to examine the effects of positive thinking interventions during pregnancy.

Identifying and explaining policy preferences in Swiss water management

Policy preferences are a key element in understanding the policy process. In this article, we conceptualise policy preferences as latent constructs, which can be identified in an inductive way, based on actors’ choice of policy instruments and organisational structures. To inductively identify policy preferences, we take an approach based on principal component analysis, informed by theory on preference formation. Using water supply in Switzerland as a case study, we propose an approach based on policy preference spaces to identify preferences based on clusters of choices. Our results show the presence of three distinct policy preferences: 1) local management with regional support, 2) local autonomy, and 3) strong regional management with local financing autonomy. We investigate the factors affecting the formation of these policy preferences through a regression analysis. Our results indicate that preference formation is affected by actor types and, to a lesser degree, by goal priority. In this way, the article makes two distinct contributions to the field. The first is a methodological contribution, through its proposition for measuring and operationalising policy preferences; and the second is a theoretical contribution, in demonstrating how policy preferences are influenced by actor types and goal priority it highlights the context-dependent nature of policy preferences.

BAGURAU SALUANG DENDANG IN THE PERFORMANCE LAPIAK GURAU IN THE MINANGKABAU COMMUNITY IN TANAH DATAR DISTRICT: CONTINUITY CHANGE AND FUNCTION

The Bagurau Saluang Dendang performance referred to in this research is the Bagurau Saluang Dendang performance at the Lapiak Gurau event, literally meaning 'joking on a mat', which usually occurs in many coffee shops in Tanah Datar Regency. This show is an entertainment show. This thesis aims to analyse the changes that occur in the Lapiak Gurau Saluang Dendang (TLGSD) tradition performance today. This performance is usually performed at night, from 20.00 WIB until dawn. The accompanying instrument for singing in this performance is usually only the saluang musical instrument. Meanwhile, the singers are only men. This is because traditional rules prohibit the participation of women in bagurau art. In the early 2000s, changes began to occur. In fact, nowadays, TLGSD performances are held from 22.00 WIB until just before dawn. The cast in TLGSD currently numbers ten people, with details: one saluang player, one keyboard player, one Janang, four singing children, and three singing parents. Changes in the mindset of the Minangkabau people in the last three or four decades have had an impact on the orientation of TLGSD performances. The changes in question predominantly occurred in aspects of the procedures for performing lapiak gurau, including traditional norms for female singers, the choice of ensemble format used as accompaniment to the song, and the text of the pantun. The method used in this research is a qualitative-descriptive method using an ethnographic perspective. The results of this research show that the tradition of lapiak gurau saluang dendang has undergone changes: (i) the choice of instruments to accompany the dang that is popular with audiences is now more modern; (ii) the majority of singers currently in demand as singers are women; (iii) weakening the role of the ninik mamak as traditional elders who are supposed to protect the dignity of Minangkabau women. However, TLGSD is now contributing to increasing the financial income of stall owners.

Use of HugoTM RAS in General Surgery: The First 70 Cases at a German Centre and a Systematic Review of the Literature.

Introduction: The versatile open modular design of the newly introduced robotic platform HugoTM RAS is expected to allow its rapid spread in general surgery. However, the system is not yet approved for use in oesophageal and HPB-surgery and is not licensed worldwide. The aim of this work was to review the current spectrum of general surgical procedures that may be feasibly and safely performed with Hugo. Methods: We retrospectively reviewed our own series and performed a systematic review of all the published reports of general surgical procedures performed with this system in the literature. Results: Seventy patients underwent general surgery with Hugo at our institution, and another 99 patients were reported in the literature. The most common procedures were colorectal (n = 55); cholecystectomy (n = 44); repair of groin, ventral and hiatal hernias (n = 34); upper GI (n = 28); adrenalectomy (n = 6); and spleen cyst deroofing (n = 2). No device-related complications were reported. Arm collisions and technical problems were rare. The docking and console times improved in all series. The port positions and robotic arm configurations varied among authors and depended on the surgical indication, patient characteristics and surgeon's preference. Conclusions: A wide spectrum of general surgical procedures has been safely and effectively performed with the Hugo RAS, even by robotically inexperienced teams with a limited choice of instruments. Technical improvements to the system and the introduction of robotic energy devices may help Hugo evolve to a vital alternative to established robotic systems.

Pulmonary Vein Morphology in Patients Undergoing Catheter Ablation of Atrial Fibrillation.

Variations in the anatomy of pulmonary veins can influence selection of approaches of atrial fibrillation catheter ablation. Therefore, preprocedural evaluation and knowledge of pulmonary veins anatomy is crucial for proper mapping and the successful ablation of atrial fibrillation. The aim of this observational study was to assess CT angiography scans and perform detailed analysis of pulmonary veins morphology in patients scheduled for catheter ablation of atrial fibrillation. CT angiography was performed in 771 individuals (223 females, 548 males, mean age 58.4 ± 10.7years). Pulmonary veins anatomy was evaluated using 3D models. The patterns used for evaluation included typical anatomy with four separate pulmonary veins, a common left ostium, and various types of accessory veins either alone or in combination with common left ostia. An anatomical variant with common left ostium was observed as the most prevalent anatomy (44%). The typical variant was observed in 34.8% of patients. Accessory pulmonary veins were observed predominantly on the right side. The prevalence of anatomical variants did not differ between sexes with the exception of the unclassifiable category U (4.4% vs. 9%, p < 0.05). Our study shows that a considerable number of atypical anatomies is present in patients undergoing AF catheter ablation. This knowledge may influence the choice of instrumentation. The data could be possibly helpful also in development of new ablation techniques.

The Effect of Financial Literacy, Income, and Financial Behaviour on Gen-Z Investment Decisions in Bekasi Regency

Investment is now a hot topic among young people, especially among Gen-Z. This research focuses on the interest of Generation Z in Bekasi Regency towards investment and their choice of investment instruments. Through a qualitative approach using questionnaires and literature studies, it was found that Gen-Z's interest in investment is very high. The research conducted on 209 Gen-Z in Bekasi Regency aims to examine the impact of financial literacy, income, and financial behaviour on their interest in investing, as well as the investment instruments they choose. Gold emerged as their favourite investment instrument because it is easy to use and has a low risk of loss. The findings show the great potential of Gen-Z in managing finance and investment in Bekasi Regency.

Kriterien für wirtschaftspolitische Maßnahmen zum Abbau kritischer Importabhängigkeiten

Abstract In this study, an analytical scheme is developed to operationalise the objective of strategic autonomy in a cost-effective way. This is highly relevant as the concept of strategic autonomy is fuzzy and can therefore easily be misinterpreted in a way that would lead to large government subsidies for inefficient purposes in a time of high public debts, low growth and many other public spending needs. The main criteria of the analytical scheme are the degree of critical import dependency on a specific product, the existence of production in the EU and a long-term comparative advantage for this product, as well as the possibility of diversified friend-shoring to secure the supply of this product. Based on a product-specific evaluation of these criteria, it can be determined whether or not government intervention is justified in order to achieve sufficient de-risking of critical import dependencies. This is illustrated using several examples, including raw materials, pharmaceuticals, electric vehicles, batteries for electric vehicles and solar modules. If government intervention is found to be justified, the choice of instrument should be based on the principle that the degree of intervention should be minimised, provided that de-risking objective is sufficiently achieved. Several instruments such as warehousing, incentives for firm-based de-risking, trade barriers and subsidies are discussed. Subsidies in general should be the last resort.

Tax Incentives for Economic Growth in the Russian Far East: Broad vs. Targeted Stimuli

The purpose of this study is to justify the choice of tax incentive policy instruments aimed at the economic development of the Russian Far East, which is facing acute demographic and environmental problems. To model the dynamics of the region’s real economic system, this study employed a mathematical model based on actual data from 2010 to 2021, covering economic, technological, and socio-ecological aspects. Using the versatile AnyLogic 8.0 platform for agent-based and system dynamics modeling, experiments on alternative tax incentive policy options involving both broad tax incentives and targeted economic development measures were conducted. Specifically, a 50% investment tax deduction for residents in special economic zones in the Russian Far East was implemented. The experimental results show that, despite comparable population dynamics, targeted stimulation of growth poles through public-private partnership programs outperforms broad tax incentives for economic entities in the Russian Far East. This is evident in higher economic growth rates in the region, particularly during the experimental period, except for 2040–2050, where adverse demographic trends constrain growth in both scenarios. The theoretical significance of the application of this method has shown that it allows us to obtain new significant results in the subject area of research due to the consideration of the complex interaction of factors of influence both at the micro- and macro-level, primarily behavioral factors that are fundamentally important for understanding the action of taxes. The practical implications of this study lie in defining the parameters of tax policy to target and stimulate growth poles in regions serving as hubs for generating and disseminating new technologies. The planned perspective is to encourage population growth and ensure sustained economic development in Russia’s Far East. It is advisable to explore comprehensive tax and budgetary regulations that simultaneously address economic, socio-demographic, and environmental issues in the region. Doi: 10.28991/ESJ-2024-08-03-021 Full Text: PDF

A powerful local government's optimal discretion in simple menu contract of monopoly regulation

We analyse the optimal discretion of a powerful local government (LG) in deciding the instrument choice and setting standards of simple menu contracts (composed of a fixed price and a cost reimbursement) of monopoly regulation. Between the two, a fixed-price contract entails more incentives for efficiency than a cost-reimbursement contract, but ensures more profits for the firm. Due to a preference bias towards the firm's benefits between governments, an incentive reward, offered by the federal government (FG) to the powerful LG with informational advantage of efficiency gain from the regulation, is considered to induce an efficient regulatory policy. We find that under the FG's delegation mechanism, upper-level government conflict leads to a compromised policy as an exchange payoff and additional informational rent to the LG for part of their information value. For the remaining information, the reward is rejected, and the LG has the discretionary power to set policy criteria for simple contracts. The results suggest that bureaucratic political issues still lead to an excessive tendency towards either a fixed price or cost reimbursement scheme, depending on the bias direction of the LG's preferences regarding the monopoly. However, the delegation mechanism of hierarchical bureaucracy can effectively alleviate the influence of policy distortions caused by political factors.

Факторы, влияющие на выбор сберегательных и инвестиционных инструментов поколением Z: экспериментальное исследование с применением нейрооборудования

В работе исследуются факторы, влияющие на принятие решения о выборе сберегательных и инвестиционных инструментов поколением Z (студентов Экономического факультета МГУ), для которых характерна цифровая грамотность и доступность финансовых продуктов и услуг с раннего возраста. Данные собраны в ходе проведения лабораторного эксперимента с применением технологий айтрекинга и пульсометрии, а также опросов. На основе полученных данных построена серия эконометрических логит-моделей бинарного вида по выбору сберегательных / инвестиционных инструментов, и мультиноминального вида по выбору одного из финансовых инструментов (вклада, акций, инвестиционной или сберегательных копилок). Исследование показывает, что на выбор финансовых инструментов влияют как основные факторы (пол, уровень образования, финансовые предпочтения, наличие рекламы и финансовое содержание видеоролика, психофизиологические характеристики его восприятия — внимание и вовлеченность), так и дополнительные факторы (характеристики финансовой грамотности, информационные факторы выбора, опыт финансовой деятельности, прохождение дополнительных курсов и расчетно-финансовые компетенции). This paper investigates the factors infl uencing the decision- making process in the choice between saving and investment instruments by the generation Z (158 students of the Faculty of Economics of Moscow State University), which are characterized by digital literacy and access to the fi nancial products and services from an early age. Data was collected through a laboratory experiment using eye-tracking and heart rate monitor technologies, as well as surveys. Based on the collected data a series of econometric logit models was built, both binary (propensity to save or invest) and multinomial (choice of one of the fi nancial instruments — deposit, shares, investment or savings money box). The study shows that the choice of fi nancial instruments by generation Z is infl uenced by both primary factors (gender, education, fi nancial preferences, advertising and fi nancial content in the video, psycho- physiological characteristics— attention and engagement) and additional factors (fi nancial literacy, information of fi nancial choice, fi nancial experience, additional courses and computational &amp; fi nancial competencies). Keywords: generation Z, fi nancial decision- making, advertisement, fi nancial context, psycho- physiological indicators, savings, investments.

Comparing Oral Microbiota Changes after Pulpotomy/Pulpectomy in Pediatric Patients.

Pediatric dental procedures like pulpotomy and pulpectomy are commonly performed to treat pulp-related dental issues in primary teeth. The choice of instrumentation, such as traditional rotary instruments or laser technology, can impact the oral microbiota. This study aims to compare the changes in oral microbiota following pulpotomy/pulpectomy in pediatric patients treated with traditional rotary instruments versus laser technology. A total of 60 pediatric patients, aged 4-10 years, requiring pulpotomy or pulpectomy were randomly assigned to two groups: group A (traditional) and group B (laser). In group A, traditional rotary instruments were used for pulp removal, while in group B, a dental laser was utilized. Saliva and plaque samples were collected before the procedure (baseline), immediately after the procedure, and at the one-month follow-up. Microbial deoxyribonucleic acid (DNA) was extracted and analyzed using 16S ribosomal ribonucleic acid (rRNA) sequencing to assess changes in the oral microbiota. At baseline, both groups exhibited similar microbial diversity and composition. However, immediate post-procedure results showed a significant decrease in microbial diversity in both groups, with group B (laser) demonstrating a more pronounced reduction. At the one-month follow-up, group A (traditional) showed a partial recovery of microbial diversity, while group B (laser) continued to exhibit lower microbial diversity compared to baseline. Notably, group B (laser) displayed a shift in microbial composition with a decrease in pathogenic species and an increase in beneficial bacteria compared to group A. This study highlights that both traditional rotary instruments and laser technology have a significant impact on the oral microbiota of pediatric patients following pulpotomy/pulpectomy. While both methods initially reduce microbial diversity, laser treatment appears to have a more sustained effect, favoring the growth of beneficial bacteria over time. Further research is needed to assess the long-term clinical implications of these microbiota changes for the oral health of pediatric patients.