Instituto De Quimica Research Articles

Avaliação dos impactos ambientais dos tratamentos de resíduos de solventes no Instituto de Química da Universidade de São Paulo

As the result of research work and teaching, the Instituto de Quimica da Universidade de Sao Paulo generates 10,000L/year of used solvent mixtures. Although recovery is usually considered an attractive alternative to incineration, a fundamental question remained unanswered: how to ascertain and compare environmental impacts of distillation of a waste mixture of solvents or its disposal by incineration. To this end, after separation of the components of ten solvent mixtures by distillation, Ecosolvent® software was used to compare, for both alternative methods, the EI99 values for some parameters like mass balance, energy and water consumption, gaseous emissions and transportation to the incinerating facility. Results showed that for nine of such mixtures the EI99 parameters were lower for distillation than for incineration.

Running ahead of doping: analytical advances and challenges faced by modern laboratories ahead of Rio 2016.

Running ahead of doping: analytical advances and challenges faced by modern laboratories ahead of Rio 2016.

Um caso de contratendência: baixa evasão na licenciatura em química explicada pelas disposições e integrações

Resumo Este trabalho faz parte de um estudo de caso sobre uma instituição pela qual seus alunos apresentavam um forte sentimento de pertencimento e adesão, materializado em baixos índices de evasão. Trata-se da licenciatura em química do Instituto de Química (IQ) da Universidade Estadual Paulista (UNESP) de Araraquara, no interior do estado de São Paulo. Analisamos as trajetórias escolares e acadêmicas de 27 licenciandos em química, com base na Teoria da Integração do Estudante (TIE) de Vincent Tinto, quanto à integração social e acadêmica. Também utilizamos o conceito de disposição, apresentado inicialmente por Pierre Bourdieu e revisto por Bernard Lahire, para compreender essas integrações e explicar qualitativamente os baixos índices de evasão analisados quantitativamente. Adotamos a metodologia dos retratos sociológicos, também proposta por Lahire, para analisar as entrevistas dos licenciandos quanto a esses aspectos. Os retratos apontam para uma predominância de trajetos que conjugam uma integração social e acadêmica, favorecida por umencaixe das disposições anteriores atualizadas ou reforçadas na universidade. Ao investigar o caso de uma instituição específica, percebemos que as condições oferecidas pela universidade, que implícita ou explicitamente promovem a atualização de várias disposições dos licenciandos e são favoráveis à sua integração social e acadêmica, são fundamentais para explicar os baixos índices de evasão e tornam esse curso peculiar, principalmente pelas maneiras de criar vínculos com seus alunos.

Symposium 19: The contributions of the Department of Biochemistry/USP towards Biochemistry teaching

K-Education(Portuguese) Chair: V. Trindade Bayardo Torres; Clovis Wannmacher; Denise Macedo The contributions of the Department of Biochemistry/USP towards Biochemistry teaching. O ensino de Bioquimica nos ultimos 20 anos Bayardo B. Torres Departamento de Bioquimica, Instituto de Quimica, USP. Sao Paulo, Brazil. Among the contributions of the Department of Biochemistry/USP one must recall: 1. Winter school for graduate studentsThis course, now at the ninth edition, is intended for students in the final stage of their Masters or PhD in Biochemistry or related areas from any institution of higher education.Modern and important techniques are offered as possible support to help the student’s projects.2. Summer courses for undergraduate studentsThe Department offers every year, since 1999, complementary courses for undergraduate students to extend their knowledge in biochemical subjects not ordinarily treated in introductory courses. Some examples:Plant Molecular Biology, Biochemistry and Diseases, Biochemistry of Mind, Biochemistry of Ageing, Cancer Biochemistry, Nutrition and Sports, Biochemistry of Beauty, Biochemistry of the Envenomation Response, etc.3. Summer courses for high school teachers. Some examples:Biochemistry of Nutrition, DNA – Techniques and Applications, Biochemistry in the kitchen.4. Software developmentMany software for biochemistry teaching/learning were developed and are freely available at the Biblioteca Digital de Ciencias [http://www.bdc.ib.unicamp.br/bdc/index.php]. Some examples:Oxygen consumption by mitochondria, Muscle contraction, Electron transport chain and oxidative phosphorylation, Free radicals, Enzyme kinetics, cAMP signalization, Interactive study of protein structure, Leptin, Insulin and Obesity.5. A Biochemistry textbook.

New insights on algal products and bioprospection in Brazil: pharmaceutical, cosmetic and public health applications

This special issue provides the readers of the Revista Brasileira de Farmacognosia with access to selected peer-reviewed papers based on lectures presented at the “Third Workshop of RedeAlgas: Biodiversity, Biotechnology and Sustainable Applications”, held at Paty dos Alferes, RJ, Brazil, in July, 2011, and attended by academic scientists, professionals from industry and a signifi cant number of students. These papers nicely refl ect the diversity of current research in the fi eld of phycology in Brazil presented at the Workshop, with lectures ranging from the potential uses of bioactive secondary metabolites from algae to the mariculture, ecophysiology and micropropagation of macroalgae. In the last decades, the use of algae and algal products has undergone a substantial increase in the pharmaceutical, cosmetic, veterinary, nutraceutical, biomedicine, bioenergy, food and agricultural industries and in the public health sector. Secondary metabolites extracted from macroalgae are important precursors of vitamins, lipids, proteins and aminoacids, hormones and other molecules that maintain the physiological equilibrium of humans. The diversity and uniqueness of the structures of many algal metabolites refl ect both the diversity of the aquatic environments in which they grow and the unique defense mechanisms developed by algae to protect themselves from predation. The food industry in particular employs a wide range of algal derivatives because they contain high contents of fi ber, polyunsaturated fatty acids, polysaccharides, minerals, vitamins and antioxidants. The nutritional value of a given species of algae depends on several characteristics such as size, shape, digestibility and toxicity. Macroalgae are at the base of the food chain, serving as the source of nutrients for a wide range of aquatic organisms, such as mollusks, crustaceans, zooplankton and several species of fi sh. In impacted marine areas, algae are the most important organisms involved in the bioremediation process. Macroalgae can often metabolize persistent organic pollutants such as pesticides, solvents, organometallic compounds and polycyclic aromatic hydrocarbons and can store enormous amounts of heavy metals in their vacuoles. During photosynthesis, algae consume large amounts of CO2 and release large quantities of molecular oxygen into the atmosphere. In addition, algae are the most important organisms in the marine environment for the assimilation of nitrogen, incorporating it into vital molecules such as aminoacids and nucleic acids. Therefore, macroalgae play a vital ecological role in maintaining the equilibrium of marine environments, in preserving diversity and in mitigating global warming. Finally, the guest editors thank Professor Frank Quina (Instituto de Quimica, Universidade de Sao Paulo) for helpful comments and suggestions in all the papers included in this issue and the support from MCTI, CAPES, CNPq, FAPERJ and FAPESP. Eliane Marinho-Soriano,1 Ernani Pinto,2 Nair S. Yokoya,3 Pio Colepicolo,4 Valeria Laneuville Teixeira,5 Yocie YoneshigueValentin6

Some Items of Interest to Process R&D Chemists and Engineers

ADVERTISEMENT RETURN TO ISSUEPREVHighlights from the ...Highlights from the LiteratureNEXTSome Items of Interest to Process R&D Chemists and EngineersMark McLaughlin, Silvina GarcíaRubio, Matthew Pfeiffer, Ulf Tilstam, Octavio Augusto Ceva Antunes, Andrei A. Zlota, and Trevor Laird*View Author Information Merck & Co. Inc.,Rahway, New Jersey 07065, U.S.A.E-mail: [email protected] Sapphire Therapeutics, Inc., Bridgewater, New Jersey 08807, U.S.A.E-mail: [email protected] Process R&D, PTD, Exelixis Inc.,South San Francisco, California 94080, U.S.A.E-mail: [email protected] CMC-Solutions, BelgiumE-mail: [email protected] Departamento de Quimica Inorganica,Instituto de Quimica, UFRJ, Cidade Universitaria,Rio de Janeiro, RJ 21949-900, BrazilE-mail: [email protected] The Zlota Company,Sharon, Massachusetts 02067-2858, U.S.A.E-mail: [email protected]Cite this: Org. Process Res. Dev. 2009, 13, 1, 2–10Publication Date (Web):December 30, 2008Publication History Received11 December 2008Published online30 December 2008Published inissue 16 January 2009https://doi.org/10.1021/op800306gCopyright © 2008 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views5955Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (261 KB) Get e-AlertsSUBJECTS:Anions,Aromatic compounds,Catalysts,Hydrocarbons,Reagents Get e-Alerts

Sesquiterpene lactones and other bioactive constituents from Schkuhria pinnata var. wislizeni (Asteraceae)

The genus Schkuhria is known as a source of sesquiterpene lactones of different skeletons, some of which display cytotoxic activity [1]. Due to botanical revision, some Schkuhria species from North America (i.e.: S. anthemoidea, S. virgata) have been reclassified and identified as S. pinnata var. wislizeni [2]. Our current investigation on the aerial parts of this species led to the isolation of the sesquiterpene lactones 1–3 and the phenyl propanoids 4 and 5. 2 represents a Diels Alder adduct derived from a guaia-1(2),4(5)-dienolide as diene and the 11,13-olefin of 1 as dienophile, and the theoretical study of the reactants predicted the product. The spectroscopic analysis of 3 allowed the structural reassignment of a compound previously isolated from S. anthemoidea [3]. The antioxidant assay using a rat pancreas homogenate model indicated that 4 and 5 displayed activity and also DPPH radical scavenger capacity. Acknowledgement: To Direccion General de Asuntos de Personal Academico, UNAM, Chavez M.I., Cogordan J.A., Velasco L., Patino R. (Instituto de Quimica, UNAM).

Some Items of Interest to Process R&D Chemists and Engineers

ADVERTISEMENT RETURN TO ISSUEPREVHighlights from the ...Highlights from the LiteratureNEXTSome Items of Interest to Process R&D Chemists and EngineersMark McLaughlin, Silvina GarcíaRubio, Matthew Pfeiffer, Ulf Tilstam, Joseph Swaroop Mathen, Octavio Augusto Ceva Antunes, and Trevor LairdView Author Information Merck & Co. Inc.,Rahway, New Jersey 07065, U.S.A.E-mail: [email protected] Sapphire Therapeutics, Inc., Bridgewater, New Jersey 08807, U.S.A.E-mail: [email protected] Process R&D, PTD, Exelixis Inc.,South San Francisco, California 94080, U.S.A.E-mail: [email protected] CMC-Solutions, Belgium,E-mail: [email protected] Pharmacore Inc.,High Point, North Carolina 27265, U.S.A. E-mail: [email protected]; [email protected] Departamento de Quimica Inorganica,Instituto de Quimica, UFRJ, Cidade Universitaria,Rio de Janeiro, RJ 21949-900, Brazil,E-mail: [email protected]Cite this: Org. Process Res. Dev. 2008, 12, 3, 358–368Publication Date (Web):May 16, 2008Publication History Received7 April 2008Accepted7 April 2008Published online16 May 2008Published inissue 1 May 2008https://doi.org/10.1021/op800087eCopyright © 2008 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1930Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (299 KB) Get e-AlertsSUBJECTS:Anions,Catalysts,Chemical reactions,Reagents,Substitution reactions Get e-Alerts

Phototoxic compounds and biological activity of extracts from Eupatorium morifolium Mill. (Asteraceae)

2 Instituto de Quimica. Universidad Nacional Autonoma de Mexico. Ciudad Universitaria. 04510. Mexico, D.F. Mexico. Address Correspondence to: Dr. Maria Cristina Perez-Amador; Facultad de Ciencias. UNAM. Circuito Exterior s/n Ciudad Universitaria. C.P. 04510. Mexico D.F.; e-mail: perez_amador@yahoo.com, mcpa@hp.fciencias.unam.mx Recibido/Received 21.IX.2007. Aceptado/Accepted 27.XI.2007. Abstract. Leaves of Eupatorium morifolium Mill. were analyzed for phototoxic compounds, and the toxicity of their hexane extract was evaluated against Bacillus subtilis. The phototoxic compounds were analyzed by TLC. In the plate, pale blue spots indicated the presence of these compounds. This was confirmed by the UV extract spectrum and the antibacterial activity against Bacillus subtilis. The biological activity of the leaf extracts (hexane, ethyl acetate or methanol) was also studied. The antiinflammatory activity was determined using the edema test on mouse ears, and the bactericide activity was assayed against Bacillus subtilis and Escherichia coli. A strong anti-inflammatory activity was shown by the leaf extracts. The ethyl acetate extract exhibited the strongest bactericide activity, followed by the methanol and hexane extracts.

Some Items of Interest to Process R&D Chemists and Engineers

ADVERTISEMENT RETURN TO ISSUEPREVHighlights from the ...Highlights from the LiteratureNEXTSome Items of Interest to Process R&D Chemists and EngineersMark McLaughlin, Silvina García Rubio, Matthew Pfeiffer, Ulf Tilstam, Octavio Augusto Ceva Antunes, Trevor Laird, and Andrei A. ZlotaView Author InformationMerck & Co. Inc.,Rahway, New Jersey 07065, U.S.A.E-mail: [email protected]Sapphire Therapeutics, Inc., Bridgewater, New Jersey 08807, U.S.A.E-mail: [email protected]Process R&D, PTD, Exelixis Inc.,South San Francisco, California 94080, U.S.A.E-mail: [email protected]CMC-Solutions, Belgium,E-mail: [email protected]Departamento de Quimica Inorganica,Instituto de Quimica, UFRJ, Cidade Universitaria,Rio de Janeiro, RJ 21949-900, Brazil,E-mail: [email protected]The Zlota Company,Sharon, Massachusetts 02067-2858, U.S.A.E-mail: [email protected]Cite this: Org. Process Res. Dev. 2008, 12, 1, 2–12Publication Date (Web):January 18, 2008Publication History Published online18 January 2008Published inissue 1 January 2008https://doi.org/10.1021/op700278rCopyright © 2008 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1562Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (270 KB) Get e-AlertsSUBJECTS:Catalysts,Hydrocarbons,Organic compounds,Pharmaceuticals,Solvents Get e-Alerts

Teresa Iwasita—a tribute to an outstanding electrochemist

Teresa Iwasita studied Biochemistry at Cordoba National University in Cordoba at the Institute of Chemical Sciences and obtained her masters degree in 1965 with highest marks (“National University of Cordoba Prize”). Her PhD on “Kinetics of the Bromine-Tribromide-Bromide Redox Process on Platinum Electrodes in Acetonitrile Solutions” was awarded at the end of 1967 (Supervisor M.C. Giordano). From 1967 to 1978, she worked as a research and teaching assistant in the group of M.C. Giordano. With a grant from the Consejo Nacional de Investigationes Cientificas e Tecnicas (Argentina), she started investigations of the anodic oxidation of 1,3-Dioxolan in 1978 in W. Vielstich’s group at the Institut fur Physikalische Chemie of Bonn University. In 1980, she moved to J.W. Schultze’s group at Heinrich–Heine University at Dusseldorf to study the reduction of H3O − ions from 293 K down to 170 K in frozen aqueous solutions in cooperation with W. Schmickler (Bonn). The voltammetric behavior was not different from that in liquid electrolyte solutions—and Teresa was sorry that the temperatures had not been low enough to study quantum effects. Measurements of very fast redox reactions enabling for the first time a comparison with the Marcus theory for the direct electron transfer from the metal to large solvated ions like Ru NH3 ð Þ2þ=3þ 6 in solution with expected exchange current densities near 100 A/cm (or rate constants of k= 1 cm/s) were attempted using a setup with very fast mass transfer. A ring electrode in the turbulent pipe flow through a tube (up to 20 m/s) yielded an exchange current density near 100 A/cm, and—in accord with Marcus theory—independent of electrode material. Back in Bonn in 1986, she applied another new method, just developed in Bonn: Differential Electrochemical Mass Spectrometry (DEMS). Volatile products can be monitored, e.g. during a cyclic voltammogram. In addition, adsorbed species were investigated via in situ FTIR spectroscopy SNIFTIRS (just set up by R. Holze) and electrode transfer from the electrochemical cell to ultrahigh vacuum, followed by thermal desorption. The electrocatalysis of methanol and ethanol oxidation was studied. In cooperation with Jose Giner Inc. in Boston, MA, and in connection with the development of medical sensors employing oxidation of urea and glucose were investigated. Starting from 1994, she continued her research in electrocatalysis and fuel cells at the Universitat der Bundeswehr, Munchen, on the properties of PtRu catalysts for methanol oxidation followed. Since January 1999, Teresa Iwasita is a professor at the Instituto de Quimica de Sao Carlos, University of Sao Paulo, Brazil. The influence of electrode materials on the pathways of methanol oxidation was studied with FTIRS, DEMS, STM and UHV methods. And what will be the future? We, fellow electrochemists, do not expect her just to enjoy life. Anyway, we wish her a very pleasant time for the years to come .... J Solid State Electrochem (2008) 12:471 DOI 10.1007/s10008-007-0411-4

Some Items of Interest to Process R&D Chemists and Engineers

ADVERTISEMENT RETURN TO ISSUEPREVHighlights from the ...Highlights from the LiteratureNEXTSome Items of Interest to Process R&D Chemists and EngineersTrevor Laird, Mark McLaughlin, Silvina García Rubio, Ulf Tilstam, Octavio Augusto Ceva Antunes, Ganapati D. Yadav, and Andrei A. ZlotaView Author Information Editor Merck & Co. Inc., Rahway, New Jersey 07065, U.S.A. E-mail: [email protected] Sapphire Therapeutics, Inc., Bridgewater, New Jersey 08807, U.S.A. E-mail: [email protected] CMC-Solutions, Belgium, E-mail: [email protected] Departamento de Quimica Inorganica, Instituto de Quimica, UFRJ, Cidade Universitaria, Rio de Janeiro, RJ 21949-900, Brazil. E-mail: [email protected] Department of Chemical Engineering, University Institute of Chemical Technology, University of Mumbai, Matunga, Mumbai - 400 019, India. E-mail: [email protected]; [email protected] The Zlota Company, Sharon, Massachusetts 02067-2858, U.S.A. E-mail: [email protected]Cite this: Org. Process Res. Dev. 2007, 11, 2, 166–177Publication Date (Web):March 3, 2007Publication History Published online3 March 2007Published inissue 1 March 2007https://doi.org/10.1021/op700035vCopyright © 2007 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1541Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (276 KB) Get e-AlertsSUBJECTS:Alcohols,Amines,Catalysts,Ethers,Oxidation Get e-Alerts

Eduardo Neves, nosso eterno mestre

Eduardo Fausto de Almeida Neves, Professor Emeritus of the Universidade Federal de Sao Carlos and formerly Full Professor at the Instituto de Quimica - Universidade de Sao Paulo (USP), Sao Paulo, Brazil, was born in November 7, 1933 in Pedra Azul, MG, and deceased in July 2, 2006 in Sao Carlos, SP. He graduated under supervision of Professor Paschoal Senise, pioneer of Analytical Chemistry at USP, and developed his post-doctoral work at Caltech, USA, with Professor Fred Anson. His brilliant career as teacher, scientist, supervisor and mentor resulted in a prolific science school in Analytical Chemistry, with some sixty PhDs and masters supervised by him, amplified to over four hundred in the 2nd to 4th generations (still growing), spread throughout the country and nucleating new research groups. The contents of a hundred papers reflect Prof. Eduardo's wide range of scientific interests. Passionate inclination for creative intellectual activity, rooted in profound knowledge of all branches of Chemistry, broadminded thinking, sound experimentation, generous scientific cooperation and true friendship - that's why friends, colleagues and students referred to him as master or my guru.

Some Items of Interest to Process R&D Chemists and Engineers

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTSome Items of Interest to Process R&D Chemists and EngineersMark McLaughlin, Silvina García Rubio, Ramaiah Muthyala, Octavio Augusto Ceva Antunes, Ulf Tilstam, Andrei Zlota, Ganapati D. Yadav, and Trevor LairdView Author InformationMerck & Co. Inc., Rahway, New Jersey 07065, U.S.A. E-mail: [email protected] Albany Molecular Research Inc., Syracuse Research Center, 7001 Performance Drive, North Syracuse, New York 13212, U.S.A. E-mail: [email protected] Center for Orphan Drug Development, Department of Medicinal Chemistry, University of Minnesota, MTRF 4-210, 2001 6th Street, S.E., Minneapolis Minnesota 55455, U.S.A. E-mail: [email protected] Departamento de Quimica Inorganica, Instituto de Quimica, UFRJ, CT Bloco A, Lab. 641, Cidade Universitaria, Rio de Janeiro, RJ 21949-900, Brazil E-mail: [email protected] Development Centre S.A., Parc Scientifique de Louvain-la-Neuve, Rue Granbonpre 11, B-1348 Mont-Saint-Guibert, Belgium E-mail: [email protected] Chemical R&D, Sepracor Inc., 84 Waterford Drive, Marlborough, Massachusetts 01752, U.S.A. E-mail: [email protected] Department of Chemical Engineering, University Institute of Chemical Technology, University of Mumbai, Matunga, Mumbai - 400 019, India E-mail: [email protected]; [email protected]EditorCite this: Org. Process Res. Dev. 2006, 10, 4, 687–702Publication Date (Web):July 21, 2006Publication History Published online21 July 2006Published inissue 1 July 2006https://doi.org/10.1021/op060120cCopyright © 2006 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views2472Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (355 KB) Get e-AlertsSUBJECTS:Catalysts,Ligands,Nanoparticles,Organic compounds,Solvents Get e-Alerts

Reply to the comments on the paper by H. Shiroishi, Y. Ayato, K. Kunimatsu and T. Okada entitled “Study of adsorbed water on Pt during methanol oxidation by ATR-SEIRAS (surface-enhanced infrared absorption spectroscopy)” [J. Electroanal. Chem. 581 (2005) 132] made by A. Cuesta, Instituto de Química Física “Rocasolano”, CSIC, C. Serrano, 119, E-28006, Madrid, Spain

Abstract This is a reply to comments on the paper by H. Shiroishi, Y. Ayato, K. Kunimatsu and T. Okada entitled “Study of adsorbed water on Pt during methanol oxidation by ATR-SEIRAS (surface-enhanced infrared absorption spectroscopy)” [J. Electroanal. Chem. 581 (2005) 132] made by Angel Cuesta, Instituto de Quimica Fisica “Rocasolano”, CSIC, C. Serrano, 119, E-28006, Madrid, Spain.

Some Items of Interest to Process R&D Chemists and Engineers

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTSome Items of Interest to Process R&D Chemists and EngineersMark McLaughlin, Silvina García Rubio, Ulf Tilstam, Ramaiah Muthyala, Octavio Augusto Ceva Antunes, Ganapati D. Yadav, Andrei Zlota, and Trevor LairdView Author InformationMerck & Co. Inc., Rahway, New Jersey 07065, U.S.A. E-mail: [email protected] Albany Molecular Research Inc., Syracuse Research Center, 7001 Performance Drive, North Syracuse, New York 13212, U.S.A. E-mail: [email protected] Development Centre S.A., Parc Scientifique de Louvain-la-Neuve, Rue Granbonpre 11, B-1348 Mont-Saint-Guibert, Belgium E-mail: [email protected] Center for Orphan Drug Development, Department of Medicinal Chemistry, University of Minnesota, MTRF 4-210, 2001 6th Street S.E., Minneapolis Minnesota 55455, U.S.A. E-mail: [email protected] Departamento de Quimica Inorganica, Instituto de Quimica, UFRJ, CT Bloco A, Lab. 641, Cidade Universitaria, Rio de Janeiro, RJ 21949-900, Brazil E-mail: [email protected] Department of Chemical Engineering, University Institute of Chemical Technology, University of Mumbai, Matunga, Mumbai - 400 019, India E-mail: [email protected]; [email protected] Chemical R&D, Sepracor Inc., 84 Waterford Drive, Marlborough, Massachusetts 01752, U.S.A. E-mail: [email protected] EditorCite this: Org. Process Res. Dev. 2006, 10, 1, 2–18Publication Date (Web):January 5, 2006Publication History Published online5 January 2006Published inissue 1 January 2006https://doi.org/10.1021/op0502405Copyright © 2006 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views2068Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (403 KB) Get e-AlertsSUBJECTS:Salts,Reagents,Alcohols,Catalysts,Solvents Get e-Alerts

Some Items of Interest to Process R&D Chemists and Engineers

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTSome Items of Interest to Process R&D Chemists and EngineersMark McLaughlin, Silvina García-Rubio, Ulf Tilstam, Ramaiah Muthyala, Octavio Augusto Ceva Antunes, Trevor Laird, Ganapati D. Yadav, and Andrei ZlotaView Author InformationMerck & Co. Inc., Rahway, New Jersey 07065, U.S.A. E-mail: [email protected] Albany Molecular Research Inc., Syracuse Research Center, 7001 Performance Drive, North Syracuse, New York 13212, U.S.A. E-mail: [email protected] Lilly Development Centre S.A., Parc Scientifique de Louvain-la-Neuve, Rue Granbonpre 11, B-1348 Mont-Saint-Guibert, Belgium E-mail: [email protected] Department of Medicinal Chemistry, University of Minnesota, College of Pharmacy, 7-125E Weaver-Densford Hall, 308 Harvard Street S.E., Minneapolis Minnesota 55455, U.S.A. E-mail: [email protected] Departamento de Quimica Inorganica, Instituto de Quimica, UFRJ, CT Bloco A, Lab. 641, Cidade Universitaria, Rio de Janeiro, RJ 21949-900, Brazil E-mail: [email protected] Editor Department of Chemical Engineering, University Institute of Chemical Technology, University of Mumbai, Matunga, Mumbai - 400 019, India E-mail: [email protected]; [email protected] Chemical R&D, Sepracor Inc., 84 Waterford Drive, Marlborough, Massachusetts 01752, U.S.A. E-mail: [email protected]Cite this: Org. Process Res. Dev. 2005, 9, 5, 522–536Publication Date (Web):September 16, 2005Publication History Published online16 September 2005Published inissue 1 September 2005https://doi.org/10.1021/op050143bCopyright © 2005 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1675Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (366 KB) Get e-AlertsSUBJECTS:Catalysts,Crystallization,Liquids,Reagents,Solvents Get e-Alerts

Some Items of Interest to Process R&D Chemists and Engineers

ADVERTISEMENT RETURN TO ISSUEPREVEditorialNEXTSome Items of Interest to Process R&D Chemists and EngineersTrevor Laird, Ulf Tilstam, Mark McLaughlin, Joseph Swaroop Mathen, Octavio Augusto Ceva Antunes, and Ramaiah MuthyalaView Author InformationEditor Lilly Development Centre S.A., B-1348 Mont-Saint-Guibert, Belgium E-mail: [email protected] Merck & Co. Inc., Rahway, NJ 07065, U.S.A. E-mail: [email protected] Pharmacore, Inc., High Point, NC 27409, U.S.A. E-mail: [email protected] Instituto de Quimica, UFRJ, Rio de Janeiro RJ21949-900, Brasil E-mail: [email protected]University of Minnesota, Minneapolis, MN 55455, U.S.A. E-mail: [email protected]Cite this: Org. Process Res. Dev. 2005, 9, 4, 376–385Publication Date (Web):June 30, 2005Publication History Published online30 June 2005Published inissue 1 July 2005https://doi.org/10.1021/op050095vCopyright © 2005 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1361Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (267 KB) Get e-AlertsSUBJECTS:Alcohols,Anions,Catalysts,Solvents,Organic compounds Get e-Alerts

Anticancer Agents from Unique Natural Products Sources

The National Cooperative Natural Products Drug Discovery Group (NCNPDDG) “Anticancer Agents from Unique Natural Products Sources, CA 67786” was first awarded in September 1995. The goal of the project is to discover and develop novel anticancer agents from a variety of natural products sources. The key accomplishments of this NCDDG which will be highlighted in this manuscript include:Development of tools to probe fungi for the production of novel natural products by DNA-based probes. Discovery that the majority of these fungi can produce natural products via nonribosomal peptide synthetases, polyketide synthases, or both – a much larger percentage than current culturing techniques reveal.Identification of the MDR-selective cytotoxic agent austocystin D, and use of a novel yeast deletion strain approach to help identify its molecular target(s).Identification of hemiasterlin and other naturally occurring analogs as potent antimitotic agents with excellent in vivo activity against human solid tumors in mouse models.Development of a total synthesis of hemiasterlin. The utilization of this methodology to provide the first SAR for the hemiasterlin family of antimitotic agents and to identify the synthetic analog HTI-286, which is being examined in clinical trials as an anticancer agent.To provided technology transfer, educational opportunities and compensation to countries of origin for collection and study of their natural product resources. This NCNPDDG program has provided funding to research programs at the University of the Philippines, The University of the South Pacific in the Fiji Islands, Colombo University in Sri Lanka, the Instituto de Quimica de Sao Carlos, Universidade de Sao Paulo, Brazil, and the University of Papua New Guinea.

2-[3-Furyl(hydroxy)methyl]-2,3-dimethylcyclohexanone.

Contribution No. 1750 of the Instituto de Quimica, UNAM, Mexico. In the molecule of the title compound, C(13)H(18)O(3), there is a syn relationship between the two vicinal methyl groups. The six-membered ring adopts a chair conformation, with one equatorial and two axial groups, and the furyl group is almost parallel to the ketone group. Intermolecular hydrogen bonds [O[bond]H...O[double bond]C 2.814 (3) A] form chains along [100].