ABSTRACT In today's Middle East, a number of institutions of research and higher education have American origins, and several maintain archives and special collections. This article offers case studies of repositories at four of these institutions: the American University of Beirut (AUB), the American University in Cairo (AUC), the American Center of Research (ACOR) in Jordan, and New York University Abu Dhabi (NYUAD). The article traces the origins of these archives and how those were shaped by the development of each one's parent organization as an American-inspired institution, as well as by the historical, social, and cultural framework of their host countries. The authors also consider the landscape of archives in the nations where these institutions are based: Lebanon, Egypt, Jordan, and the United Arab Emirates. The evolution of the collecting program of each repository is outlined, with strategies and key acquisitions and collections mentioned. Access and dissemination methods, including digitization initiatives, are also covered. In presenting such activities, the ways in which American traditions and standards of archival practice contrast with or complement those of local archival traditions are examined. A central theme is the way that the archives at AUB, AUC, ACOR, and NYUAD go about documenting not only institutional history but also the heritage of their host countries and the challenges and opportunities inherent in that work.